14
Views
10
CrossRef citations to date
0
Altmetric
Review Article

Platelet Function in Uraemia

&
Pages 115-123 | Published online: 07 Jul 2009

References

  • Remuzzi G. Bleeding in renal failure. Lancet 1988; 1: 1205–1208
  • del Greco F, Soper W S, Krumlovsky F A, Levin M L, Baske R. Thrombosis of vascular access for haemodialysis. Haemostasis and the Kidney, G Remuzzi, E C Rossi. Butterworths, London 1989; 303–308
  • Ibels L S, Stewart J H, Mahony J F, Neale F C, Sheil A G R. Occlusive arterial disease in uraemic and haemodialysis patients and renal transplant recipients. Quart J Med 1977; 46: 197–214
  • Gotti E, Remuzzi G. Uraemic bleeding: clinical presentation and management. Haemostasis and the Kidney, G Remuzzi, E C Rossi. Butterworths, London 1989; 131–144
  • Riesman D. Haemorrhage in the course of Bright's disease with especial reference to the occurrence of haemorrhagic diathesis of nephrotic origin. Amer J Med Sci 1907; 134: 709–716
  • Kuhlback B. Bleeding tendency in chronic renal failure. Acta Med Scand 1957; 157: 173–177
  • Lewis J, Zucker M, Ferguson J. Bleeding tendency in uremia. Blood 1956; 11: 1073–1076
  • Rath C E, Maillard J A, Schreiner G E. Bleeding tendency in uremia. N Engl J Med 1957; 257: 808–810
  • Cheney K, Bonnin J A. Haemorrhage, platelet dysfunction and other coagulation defects in uraemia. Br J Haematol 1962; 8: 215–222
  • Steiner R W, Coggins C, Carvalho A C A. Bleeding time in uremia: a useful test to assess clinical bleeding. Am J Hematol 1979; 7: 107–117
  • Lindsay R M, Moorthy A V, Koens F, Linton A L. Platelet function in dialyzed and non-dialyzed patients with chronic renal failure. Clin Nephrol 1975; 4: 52–57
  • Eknoyan G, Wacksman S J, Glueck H I, Will J J. Platelet function in renal failure. N Engl J Med 1969; 280: 677–681
  • Gafter U, Bessler H, Malachi T, Zevin D, Djaldetti M, Levi J. Platelet count and thrombopoietic activity in patients with chronic renal failure. Nephron 1987; 45: 207–210
  • Castaldi P A, Rozenberg M C, Stewart J H. The bleeding disorder of uraemia. A qualitative platelet defect. Lancet 1966; ii: 66–69
  • Evans E P, Branch R A, Bloom A L. A clinical and experimental study of platelet function in chronic renal failure. J Clin Pathol 1972; 25: 745–753
  • Di Minno G, Martinez J, McKean M, De La Rosa J, Burke J F, Murphy S. Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. Am J Med 1985; 79: 552–559
  • Di Minno G, Cerbone A, Usberti M, et al. Platelet dysfunction in uremia. Correction by arachidonic acid of the impaired exposure of fibrinogen receptors by adenosine diphosphate or collagen. J Lab Clin Med 1986; 108: 246–252
  • Lindsay R M, Friesen M, Aronstam A, Andrus F, Clark W F, Linton A L. Improvement of platelet function by increased frequency of haemodialysis. Clin Nephrol 1978; 10: 67–70
  • Lindsay R M, Friesen M, Koens F, Linton A L, Oreopoulos D, De Veber G. Platelet function in patients on long term peritoneal dialysis. Clin Nephrol 1976; 6: 335–339
  • Rabiner S F, Molinas F. The role of phenol and phenolic acid on the thrombocytopathy and defective platelet aggregation of patients with renal failure. Am J Med 1970; 49: 346–351
  • Horowitz H I, Stein I M, Cohen B D, White J G. Further studies on the platelet-inhibiting effect of guanidinosuccinic acid and its role in uremic bleeding. Am J Med 1970; 49: 336–340
  • Horowitz H I. Uremic toxins and platelet function. Arch Int Med 1970; 126: 823–826
  • Bazilinski N, Shaykh M, Dunea G, et al. Inhibition of platelet function by uremic middle molecules. Nephron 1985; 40: 423–428
  • Remuzzi G, Livio M, Marchiaro G, Mecca G, De Gaetano G. Bleeding in renal failure: altered platelet function in chronic uraemia only partially corrected by haemodialysis. Nephron 1978; 22: 347–353
  • Nenci G G, Berrettini M, Agnelli G, Parise P, Buoncristiani U, Ballatori E. Effect of peritoneal dialysis, haemodialysis and kidney transplantation on blood platelet function. Nephron 1979; 23: 287–292
  • Jorgensen K A, Ingeberg S. Platelets and platelet function in patients with chronic uremia on maintenance hemodialysis. Nephron 1979; 23: 233–236
  • Viener A, Aviram M, Better O S, Brook J G. Enhanced in vitro platelet aggregation in haemodialysis patients. Nephron 1986; 43: 139–143
  • Remuzzi G, Benigni A, Dodesini P, et al. Platelet function in patients on maintainence hemodialysis: depressed or enhanced?. Clin Nephrol 1982; 17: 60–63
  • Cameron J S. Platelets in glomerular disease. Ann Rev Med 1984; 35: 175–180
  • Colwell J A, Halushka P V. Platelet function in diabetes mellitus. Br J Haematol 1980; 44: 521–526
  • Jackson C A, Greaves M, Patterson A D, Brown C B, Preston F E. Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. Br J Haematol 1982; 52: 69–77
  • Bennett A, Cameron J S. Platelet hyperaggregability in the nephrotic syndrome which is not dependant on arachidonic acid metabolism or on plasma albumin concentration. Clin Nephrol 1987; 27: 182–188
  • Turney J H, Williams L C, Fewell M R, Parsons V, Weston M J. Platelet protection and heparin sparing with prostacyclin during regular dialysis therapy. Lancet 1980; ii: 219–222
  • Salzman E W, Rosenberg R D, Smith M H, Lindon J N, Favreau L. Effect of heparin and heparin fractions on platelet aggregation. J Clin Invest 1980; 65: 64–73
  • Aviram M, Brook J G. Platelet interaction with high and low density lipoproteins. Atherosclerosis 1983; 46: 259–265
  • Eknoyan G, Brown C H. Biochemical abnormalities of platelets in renal failure. Evidence for decreased platelet serotonin, adenosine diphosphate and Mg-dependent adenosine triphosphatase. Am J Nephrol 1981; 1: 17–23
  • Kyrie P A, Stockenhuber F, Brenner B, et al. Evidence for an increased generation of prostacyclin in the microvasculature and an impairment of the platelet α granule release in chronic renal failure. Thromb Haemostas 1988; 60: 205–208
  • Tison P, Cernacek P, Silvanova E, Dzurik R. Uraemic toxins and blood platelet carbohydrate metabolism. Nephron 1981; 28: 192–195
  • Vlacoyannis J, Schoeppe W. Adenylate cyclase activity and cAMP content of human platelets in uraemia. Eur. J Clin Invest 1982; 12: 379–381
  • Jacobsson B, Ransnas L, Nyberg G, Bergh C-H, Magnusson Y, Hjalmarzon A. Abnormality of adenylate cyclase regulation in human platelet membranes in renal insufficiency. Eur. J Clin Invest 1985; 15: 75–81
  • Massry S G, Goldstein D A. The search for uremic toxin(s) “X”. “X” = PTH. Clin Nephrol 1979; 11: 181–189
  • Benigni A, Livio M, Dodesini P, et al. Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated?. Am J Nephrol 1985; 5: 243–247
  • Vigano G, Gotti E, Comberti E, Giangrande A, Trevisan R, Remuzzi G. Hyperparathyroidism does not influence the abnormal primary haemostasis in patients with chronic renal failure. Nephrol Dial Transplant 1989; 4: 971–974
  • Docci D, Turci F, Delvecchio C, Gollini C, Baldrati L, Pistocchi E. Lack of evidence for the role of secondary hyperparathyroidism in the pathogenesis of uremic thrombocytopathy. Nephron 1986; 43: 28–32
  • Leithner C, Kovarik J, Sinzinger H, Woloszczuk W. Parathyroid hormone does not inhibit platelet aggregation. Lancet 1984; i: 367–368
  • Gura V, Creter D, Levi J. Elevated thrombocyte calcium content in uraemia and its correction by lalpha(OH) vitamin D treatment. Nephron 1982; 30: 237–239
  • Ware J A, Clark B A, Smith M, Salzman E W. Abnormalities of cytoplasmic Ca2+ in platelets from patients with uremia. Blood 1989; 73: 172–176
  • Remuzzi G, Marchesi D, Livio M, et al. Altered platelet and vascular prostaglandin generation in patients with renal failure and prolonged bleeding times. Thromb Res 1978; 13: 1007–1015
  • Fernandez F, Goudable C, Sie P, et al. Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions. Br J Haematol 1985; 59: 139–148
  • Remuzzi G, Benigni A, Dodesini P, et al. Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect. J Clin Invest 1983; 71: 762–768
  • Smith M C, Dunn M J. Impaired platelet thromboxane production in renal failure. Nephron 1981; 29: 133–137
  • Sinzinger H, Leithner C. Eicosanoids of platelets and vascular wall in chronic renal insufficiency. Am J Nephrol 1987; 7: 212–220
  • Winter M, Frampton G, Bennett A, Machin S J, Cameron J S. Synthesis of thromboxane B2 in uraemia and the effects of dialysis. Thromb Res 1983; 30: 265–272
  • Bloom A, Greaves M, Preston F E, Brown C B. Evidence against a platelet cyclooxygenase defect in uraemic subjects on chronic haemodialysis. Br J Haematol 1986; 62: 143–149
  • Andrassy K, Koderisch J, Lamminger C. Defective platelet membrane receptors as a cause of uraemic bleeding. Blut 1988; 53: 243–243, Abstract
  • Castillo R, Lozano T, Escolar G, Revert L, Lopez J, Ordinas A. Defective platelet adhesion on vessel subendothelium in uremic patients. Blood 1986; 68: 337–342
  • Escolar G, Cases A, Bastida E, et al. Uremic platelets have a functional defect affecting the interaction of von Willebrand factor with glycoprotein IIb-IIIa. Blood 1990; 76: 1336–1340
  • Remuzzi G, Marchesi D, Cavenaghi A E, et al. Bleeding in renal failure: a possible role of vascular prostacyclin (PG12). Clin Nephrol 1979; 12: 127–131
  • Defreyn G, Vergara Dauden M, Machin S J, Vermylen J. A plasma factor in uraemia which stimulates prostacyclin release from cultured endothelial cells. Thromb Res 1980; 19: 695–699
  • Zoja C, Vigano G, Bergamelli A, Benighni A, de Gaetano G, Remuzzi G. Prolonted bleeding time and increased vacular prostacyclin in rats with chronic renal failure: effects of conjugated estrogens. J Lab Clin Med 1988; 112: 380–386
  • Janson P A, Jubelirer S J, Weinstein M J, Deykin D. Treatment of the bleeding tendency in uraemia with cryoprecipitate. N Engl J Med 1980; 303: 1318–1322
  • Mannucci P M, Remuzzi G, Pusineri F, et al. Deamino-8-D-arginine vasopressin shortens the bleeding time in uraemia. N Engl J Med 1983; 308: 8–12
  • Mannucci P M. Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders. Blood 1988; 72: 1449–1455
  • Escolar G, Cases A, Monteagudo J, et al. Uremic plasma after infusion of desmopressin (DDAVP) improves the interaction of normal platelets with vessel subendothelium. J Lab Clin Med 1989; 114: 36–42
  • Livio M, Mannucci P M, Vigano G, et al. Conjugated estrogens for the management of bleeding associated with renal failure. N Engl J Med 1986; 315: 731–735
  • Zoja C, Vigano G, Corna D, Salmona M, Remuzzi G, Garattini S. Oral zeranol shortens the prolonged bleeding time of uremic rats. Kidney Int 1990; 38: 96–100
  • Kazatchkine M, Sultan Y, Caen J P, Bariety J. Bleeding in renal failure: a possible cause. Br Med J 1976; 2: 612–615
  • Ruggeri Z M, Ponticelli C, Mannucci P M. Factor VIII and chronic renal failure. Br Med J 1977; 1: 1085–1085
  • Warrell R P, Hultin M B, Coller B S. Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in renal failure. Am J Med 1979; 66: 226–228
  • Turney J H, Woods H F, Fewell M R, Weston M J. Factor VIII complex in uraemia and effects of haemodialysis. Br Med J 1981; 282: 1653–1656
  • Wegmuller E, Gruninger U, Furlan M, Beck E A, Hodler J, Reubi F C. Factor VIII activity in chronic renal disease. Nephron 1981; 28: 157–162
  • Howard M A, Whitworth J A, Hendrix L E, Thomas K B, Firkin B G. Abnormal factor VIII in chronic renal failure. Med J Australia 1979; 1: 148–151
  • Weinstein M J, Chute L E, Schmitt G W, et al. Abnormal factor VIII coagulant antigen in patients with renal dysfunction and in those with disseminated intravascular coagulation. J Clin Invest 1985; 76: 1406–1411
  • Editorial. Factor VIII related antigen and vasculitis. Lancet 1988; i: 1203–1204
  • Milani L, Merkel C, Canel F, Gasparotto M L, Gatta A. Relationship between plasma levels of factor VIII related antigen and reticulo-endothelial function in chronic uraemia. Clin Nephrol 1983; 20: 235–238
  • Pottinger B E, Read R C, Palcolog E M, Higgins P G, Pearson J D. von Willebrand factor is an acute phase reactant in man. Thromb Res 1989; 53: 387–394
  • Remuzzi G, Bertani T, Mecca G, Donati M B, De Gaetano G. Factor VIII related protein on vascular intima of patients with chronic renal failure and prolonged bleeding times. Br Med J 1978; 1: 70–72
  • Gralnick H R, McKeown L P, Williams S B, Shafer B C, Pierce L. Plasma and platelet von Willebrand factor defects in uremia. Am J Med 1988; 85: 806–810
  • Gralnick H R, Williams S B, Morisato D K. Effect of the multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets. Blood 1981; 58: 387–397
  • Winter M, Seghatchian M J, Cameron J S. An abnormal factor VIII molecule in uraemia?. Lancet 1983; i: 1112
  • Cases A, Monteagudo J, Escolar G, et al. Normal binding of native and asiolo-von Willebrand factor to uraemic platelets. Nephrol Dial Transplant 1988; 3: 531–531, Abstract
  • Aznar-Salatti J, Hernandez R, Anton P, Cases A, Escolar G, Ordinas A. Serum obtained from uremic patients modifies the reactivity towards platelets of extracellular matrices produced by endothelial cells. VIth International Symposium on the Biology of Vascular Cells 1990; 1: 57–57, Abstract
  • Hellem A J, Borchgrevink C F, Ames S B. The role of red cells in haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness. Br J Haematol 1961; 7: 42–50
  • Gaarder A, Jonsen J, Laland S, Hellem A, Owren P A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 1961; 192: 531–532
  • Willems C, Stel H V, van Aken W G, van Mourik J A. Binding and inactivation of prostacyclin (PG12) by human erythrocytes. Br J Haematol 1983; 54: 43–52
  • Turitto V T, Weiss H J. Red blood cells: their dual role in thrombus formation. Science 1980; 207: 541–543
  • Livio M, Gotti E, Marchesi D, Mecca G, Remuzzi G, De Gaetano G. Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions. Lancet 1982; 2: 1013–1015
  • Gordge M P, Faint R W, Rylance P B, Neild G H. Platelet function and the bleeding time in progressive renal failure. Thromb Haemostas 1988; 60: 83–87
  • Gordge M P, Dodd N J, Rylance P B, Weston M J. An assessment of whole blood impedance aggregometry using blood from normal subjects and haemodialysis patients. Thromb Res 1984; 36: 17–27
  • Gordge M P, Leaker B R, Patel A, Oviasu E, Cameron J S, Neild G H. Recombinant human erythropoetin corrects uraemic bleeding without causing intravascular haemostatic activation. Thromb Res 1990; 57: 171–182
  • Moia M, Mannucci P M, Vizzotto L, Casati S, Cattaneo M, Ponticelli C. Improvement in the haernostatic defect of uraemia after treatment with recombinant human erythropoeitin. Lancet 1987; ii: 1227–1229
  • van Geet C, Hauglustaine D, Verresen L, Vanrusselt M, Vermylen J. Haemostatic effects of recombinant human erythropoeitin in chronic haemodialysis patients. Thromb Haemostas 1989; 61: 117–121
  • Andrassy K, Ritz E. Uremia as a cause of bleeding. Am J Nephrol 1985; 5: 313–319
  • Livio M, Benigni A, Vigano G, Mecca G, Remuzzi G. Moderate doses of aspirin and risk of bleeding in renal failure. Lancet 1986; i: 414–416
  • Gaspari F, Vigano G, Orisio S, Bonati M, Livio M, Remuzzi G. Aspirin prolongs bleeding time in ureamia by a mechanism distinct from platelet cyclooxygenase inhibition. J Clin Invest 1987; 79: 1788–1797
  • Lindner A, Charra B, Sherrard D J, Scribner B H. Accelerated atherosclerosis in prolonged maintenance hemodialysis. New Engl J Med 1974; 290: 697–701
  • Brunner F P, Brynger H, Chantler C, et al. Combined report on regular dialysis and transplantation in Europe. Proc Eur Dial Transpl Assoc 1978; 16: 28–29
  • Broyer M, Brunner F P, Brynger H, et al. Demography of dialysis and transplantation in Europe, 1984. Nephrol Dial Transplant 1986; 1: 1–8
  • Degoulet P, Legrain M, Reach I, et al. Mortality risk factors in patients treated by chronic hemodialysis. Nephron 1982; 31: 103–110
  • Ritz E, Bommer J, Augustin J. Atherogenesis in uremia. Contr Nephrol 1984; 41: 337–341
  • Lindsay R M, Prentice C R M, Davidson J F, Burton J A, McNicol G P. Haemostatic changes during dialysis associated with thrombus formation on dialysis membranes. Br Med J 1972; 4: 454–458
  • Sultan Y, London G M, Goldfarb B, Toulon P, Marchais S J. Activation of platelets, coagulation and fibrinolysis in patients on long-term haemodialysis: influence of cuprophan and polyacrylonitrile membranes. Nephrol Dial Transplant 1990; 5: 362–368
  • Kristensen S D, Knudsen F, Nielsen A H, Ring T. Decreased platelet sensitivity to prostacyclin (epoprostenol) during hemodialysis. Clin Nephrol 1984; 21: 230–234
  • Wardle E N, Piercy D A. Studies of contact activation of blood in haemodialysis. J Clin Pathol 1972; 25: 1045–1049
  • Speiser W, Wojta J, Korninger C, Kirchheimer J C, Zazgornik J, Binder B R. Enhanced fibrinolysis caused by tissue plasminogen activator release in hemodialysis. Kidney Int 1987; 32: 280–283
  • Chenoweth D E, Cheung A K, Henderson L W. Anaphylotoxin formation during hemodialysis: effects of different dialyzer membranes. Kidney Int 1983; 24: 764–769
  • Rylance P B, Gordge M P, Ireland H, Lane D A, Weston M J. Haemodialysis with prostacyclin (epoprostenol) alone. Proc Eur Dial Transpl Assoc 1984; 21: 281–286
  • Schmitt G W, Moake J L, Rudy C K, Vicks S L, Hamburger R J. Alterations in hemostatic parameters during hemodialysis with dialyzers of different membrane composition and flow design. Am J Med 1987; 83: 411–418
  • Notohamiprodjo M, Andrassy K, Bommer J, Ritz E. Dialysis membranes and coagulation system. Blood Purification 1986; 4: 130–141
  • Lindsay R M, Prentice C R M, Ferguson D, Burton J A, McNicol G P. Reduction of thrombus formation on dialyser membranes by aspirin and RA 233. Lancet 1972; ii: 1287–1290
  • Woods H F, Ash G, Parsons V, Weston M J. Reduction of dialyzer fibrin deposition with sulphinpyrazone. Clin Nephrol 1979; 12: 122–126
  • Dodd N J, Gordge M P, Weston M J. Use of a thromboxane synthetase inhibitor, Dazoxiben, during haemodialysis. Br J Clin Pharmacol 1983; 15: 67S–70S
  • Zusman R M, Rubin R H, Cato A E, Cocchetto D M, Crow J W. Tolkoff-Rubin N. Hemodialysis using prostacyclin instead of heparin as the sole antithrombotic agent. N Engl J Med 1981; 304: 934–939
  • Casati S, Moia M, Graziani G, et al. Hemodialysis withou anticoagulants: efficiency and hemostatic aspects. Clin Nephrol 1984; 21: 102–105
  • Ireland H, Lane D A, Curtis J R. Objective assessment of heparin requirements for haemodialysis in humans. J Lab Clin Med 1984; 103: 643–652
  • Radomski M W, Palmer R M J, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Comm 1987; 148: 1482–1489

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.