Neuroimaging as a potential biomarker to optimize psychiatric research and treatment

References

• Abbott, C.C., Lemke, N.T., Gopal, S., Thoma, R.J., Bustillo, J., Calhoun, V.D. & Turner, J.A. (2013). Electroconvulsive therapy response in major depressive disorder: A pilot functional network connectivity resting state FMRI investigation. Frontiers in Psychiatry, 4, 10.
   PubMedGoogle Scholar
• Abdolmaleky, H.M., Cheng, K.-H., Faraone, S.V., Wilcox, M., Glatt, S.J., Gao, F., … Thiagalingam, S. (2006). Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Human Molecular Genetics, 15, 3132–3145.
   PubMed Web of Science ®Google Scholar
• Abdolmaleky, H.M., Smith, C.L., Faraone, S.V., Shafa, R., Stone, W., Glatt, S.J. & Tsuang, M.T. (2004). Methylomics in psychiatry: Modulation of gene–environment interactions may be through DNA methylation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127B, 51–59.
   PubMed Web of Science ®Google Scholar
• Alasaari, J.S., Lagus, M., Ollila, H.M., Toivola, A., Kivimäki, M., Vahtera, J., … Paunio, T. (2012). Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort. PloS ONE, 7, e45813.
   PubMed Web of Science ®Google Scholar
• Alkelai, A., Lupoli, S., Greenbaum, L., Giegling, I., Kohn, Y., Sarner-Kanyas, K., … Lerer, B. (2011). Identification of new schizophrenia susceptibility loci in an ethnically homogeneous, family-based, Arab-Israeli sample. FASEB Journal, 25, 4011–4023.
   PubMedGoogle Scholar
• Alkelai, A., Lupoli, S., Greenbaum, L., Kohn, Y., Kanyas-Sarner, K., Ben-Asher, E., … Lerer, B. (2012). DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. International Journal of Neuropsychopharmacology, 15, 459–469.
   PubMed Web of Science ®Google Scholar
• Almasy, L. & Blangero, J. (2001). Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design. American Journal of Medical Genetics, 105, 42–44.
   PubMed Web of Science ®Google Scholar
• Arndt, S., Andreasen, N.C., Flaum, M., Miller, D. & Nopoulos, P. (1995). A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change. Archives of General Psychiatry, 52, 352–360.
   PubMed Web of Science ®Google Scholar
• Athanasiu, L., Mattingsdal, M., Kähler, A.K., Brown, A., Gustafsson, O., Agartz, I., … Andreassen, O.A. (2010). Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. Journal of Psychiatric Research, 44, 748–753.
   PubMed Web of Science ®Google Scholar
• Barch, D.M., Moore, H., Nee, D.E., Manoach, D.S. & Luck, S.J. (2012). CNTRICS imaging biomarkers selection: Working memory. Schizophrenia Bulletin, 38, 43–52.
   PubMedGoogle Scholar
• Barrès, R., Yan, J., Egan, B., Treebak, J.T., Rasmussen, M., Fritz, T., … Zierath, J.R. (2012). Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metabolism, 15, 405–411.
   PubMed Web of Science ®Google Scholar
• Bergen, S.E., O’Dushlaine, C.T., Ripke, S., Lee, P.H., Ruderfer, D.M., Akterin, S., … Sullivan, P.F. (2012). Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Molecular Psychiatry, 17, 880–886.
   PubMed Web of Science ®Google Scholar
• Bertolino, A., Caforio, G., Blasi, G., De Candia, M., Latorre, V., Petruzzella, V., … Nardini, M. (2004). Interaction of COMT Val 108/158 Met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry, 161, 1798–1805.
   PubMed Web of Science ®Google Scholar
• Betcheva, E.T., Yosifova, A.G., Mushiroda, T., Kubo, M., Takahashi, A., Karachanak, S. K., … Nakamura, Y. (2013). Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatric Genetics, 23, 11–19.
   PubMedGoogle Scholar
• Brauns, S., Gollub, R.L., Roffman, J.L., Yendiki, A., Ho, B.-C., Wassink, T.H., … Ehrlich, S. (2011). DISC1 is associated with cortical thickness and neural efficiency. NeuroImage, 57, 1591–1600.
   PubMedGoogle Scholar
• Brauns, S., Gollub, R.L., Walton, E., Hass, J., Smolka, M.N., White, T., … Ehrlich, S. (2013). Genetic variation in GAD1 is associated with cortical thickness in the parahippocampal gyrus. Journal of Psychiatric Research, 47, 872–879.
   PubMed Web of Science ®Google Scholar
• Callicott, J.H., Mattay, V.S., Verchinski, B.A., Marenco, S., Egan, M.F. & Weinberger, D.R. (2003). Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. American Journal of Psychiatry, 160, 2209–2215.
   PubMed Web of Science ®Google Scholar
• Cantor, R.M., Lange, K. & Sinsheimer, J.S. (2010). Prioritizing GWAS results: A review of statistical methods and recommendations for their application. American Journal of Human Genetics, 86, 6–22.
   PubMed Web of Science ®Google Scholar
• Carter, C.S. & Barch, D.M. (2012). Imaging biomarkers for treatment development for impaired cognition: Report of the sixth CNTRICS meeting: Biomarkers recommended for further development. Schizophrenia Bulletin, 38, 26–33.
   PubMed Web of Science ®Google Scholar
• Carter, C.S., Barch, D.M., Buchanan, R.W., Bullmore, E., Krystal, J.H., Cohen, J., … Heinssen, R. (2008). Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biological Psychiatry, 64, 4–10.
   PubMed Web of Science ®Google Scholar
• Castellanos, F.X., Di Martino, A., Craddock, R.C., Mehta, A.D. & Milham, M.P. (2013). Clinical applications of the functional connectome. NeuroImage. doi:10.1016/j.neuroimage.2013.04.083
   Google Scholar
• Chen, J., Calhoun, V.D. & Liu, J. (2012). ICA order selection based on consistency: application to genotype data. Conference proceedings of the IEEE Engineering in Medicine and Biology Society, 2012, 360–363.
   Google Scholar
• Chen, J., Lee, G., Fanous, A. H., Zhao, Z., Jia, P., O’Neill, A., … International Schizophrenia Consortium. (2011). Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research, 131, 43–51.
   PubMed Web of Science ®Google Scholar
• Craddock, N. & Owen, M.J. (2007). Rethinking psychosis: The disadvantages of a dichotomous classification now outweigh the advantages. World Psychiatry, 6, 84–91.
   PubMed Web of Science ®Google Scholar
• Cross-Disorder Group of the Psychiatric Genomics Consortium. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. Lancet, 381(9875), 1371–1379.
   PubMedGoogle Scholar
• Cuthbert, B.N. & Insel, T.R. (2010). Toward new approaches to psychotic disorders: The NIMH Research Domain Criteria project. Schizophrenia Bulletin, 36, 1061–1062.
   PubMed Web of Science ®Google Scholar
• Daxinger, L. & Whitelaw, E. (2012). Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nature Reviews Genetics, 13, 153–162.
   PubMed Web of Science ®Google Scholar
• Day, J.J. & Sweatt, J.D. (2011). Epigenetic mechanisms in cognition. Neuron, 70, 813–829.
   PubMed Web of Science ®Google Scholar
• Dazzan, P., Morgan, K.D., Orr, K., Hutchinson, G., Chitnis, X., Suckling, J., … Murray, R.M. (2005). Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: The AESOP study. Neuropsychopharmacology, 30, 765–774.
   PubMed Web of Science ®Google Scholar
• Deister, A. & Marneros, A. (1993). Long-term stability of subtypes in schizophrenic disorders: A comparison of four diagnostic systems. European Archives of Psychiatry and Clinical Neuroscience, 242, 184–190.
   PubMedGoogle Scholar
• Dempster, E.L., Pidsley, R., Schalkwyk, L.C., Owens, S., Georgiades, A., Kane, F., … Mill, J. (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics, 20, 4786–4796.
   PubMed Web of Science ®Google Scholar
• Edwards, A.O., Ritter, R., Abel, K.J., Manning, A., Panhuysen, C. & Farrer, L.A. (2005). Complement factor H polymorphism and age-related macular degeneration. Science, 308, 421–424.
   PubMed Web of Science ®Google Scholar
• Ehrlich, S., Brauns, S., Yendiki, A., Ho, B.-C., Calhoun, V., Schulz, S.C., … Sponheim, S.R. (2012). Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls. Schizophrenia Bulletin, 38, 1050–1062.
   PubMedGoogle Scholar
• Ehrlich, S., Morrow, E.M., Roffman, J.L., Wallace, S.R., Naylor, M., Bockholt, H.J., … Holt, D.J. (2010). The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. NeuroImage, 53, 992–1000.
   PubMed Web of Science ®Google Scholar
• Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., … Meyer-Lindenberg, A. (2009). Neural mechanisms of a genome-wide supported psychosis variant. Science, 324, 605.
   PubMed Web of Science ®Google Scholar
• Ettinger, U., Williams, S. C. R., Fannon, D., Premkumar, P., Kuipers, E., Möller, H.-J. & Kumari, V. (2011). Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: Relationship with performance and effects of antipsychotic treatment. Psychopharmacology, 216, 17–27.
   PubMed Web of Science ®Google Scholar
• Fan, J.-B., Zhang, C.-S., Gu, N.-F., Li, X.-W., Sun, W.-W., Wang, H.-Y., … He, L. (2005). Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis. Biological Psychiatry, 57, 139–144.
   PubMed Web of Science ®Google Scholar
• Franke, A., McGovern, D.P.B., Barrett, J.C., Wang, K., Radford-Smith, G.L., Ahmad, T., … Roberts, R. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genetics, 42, 1118–1125.
   PubMed Web of Science ®Google Scholar
• Friedman, J.I., Carpenter, D., Lu, J., Fan, J., Tang, C.Y., White, L., … Harvey, P.D. (2008). A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Journal of Clinical Psychopharmacology, 28, 59–63.
   PubMed Web of Science ®Google Scholar
• Fusar-Poli, P., Howes, O.D., Allen, P., Broome, M., Valli, I., Asselin, M.-C., … McGuire, P.K. (2010). Abnormal frontostriatal interactions in people with prodromal signs of psychosis: A multimodal imaging study. Archives of General Psychiatry, 67, 683–691.
   PubMed Web of Science ®Google Scholar
• Ge, T., Feng, J., Hibar, D.P., Thompson, P.M. & Nichols, T.E. (2012). Increasing power for voxel-wise genome-wide association studies: The random field theory, least square kernel machines and fast permutation procedures. NeuroImage, 63, 858–873.
   PubMed Web of Science ®Google Scholar
• Glahn, D.C., Winkler, A.M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M.A., … Blangero, J. (2010). Genetic control over the resting brain. Proceedings of the National Academy of Sciences of the United States of America, 107, 1223–1228.
   PubMed Web of Science ®Google Scholar
• Goghari, V.M. (2010). Executive functioning-related brain abnormalities associated with the genetic liability for schizophrenia: An activation likelihood estimation meta-analysis. Psychological Medicine, 1–14.
   Google Scholar
• Goldberg, T.E., Torrey, E.F., Berman, K.F. & Weinberger, D.R. (1994). Relations between neuropsychological performance and brain morphological and physiological measures in monozygotic twins discordant for schizophrenia. Psychiatry Research, 55, 51–61.
   PubMed Web of Science ®Google Scholar
• Goldman, A.L. (2009). Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Archives of General Psychiatry, 66, 467.
   PubMed Web of Science ®Google Scholar
• Goldman, D. & Ducci, F. (2007). Deconstruction of vulnerability to complex diseases: Enhanced effect sizes and power of intermediate phenotypes. Scientific World Journal, 7, 124–130.
   Google Scholar
• Goldman, A.L., Pezawas, L., Mattay, V.S., Fischl, B., Verchinski, B.A., Zoltick, B., … Meyer-Lindenberg, A. (2008). Heritability of brain morphology related to schizophrenia: A large-scale automated magnetic resonance imaging segmentation study. Biological Psychiatry, 63, 475–483.
   PubMed Web of Science ®Google Scholar
• Gottesman, I. & Gould, T.D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645.
   PubMed Web of Science ®Google Scholar
• Grayson, D.R., Jia, X., Chen, Y., Sharma, R.P., Mitchell, C.P., Guidotti, A. & Costa, E. (2005). Reelin promoter hypermethylation in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 102, 9341–9346.
   PubMed Web of Science ®Google Scholar
• Gur, R.E., Turetsky, B.I., Cowell, P.E., Finkelman, C., Maany, V., Grossman, R.I., … Gur, R.C. (2000). Temporolimbic volume reductions in schizophrenia. Archives of General Psychiatry, 57, 769–775.
   PubMed Web of Science ®Google Scholar
• Haines, J.L., Hauser, M.A., Schmidt, S., Scott, W.K., Olson, L.M., Gallins, P., … Pericak-Vance, M.A. (2005). Complement factor H variant increases the risk of age-related macular degeneration. Science, 308, 419–421.
   PubMed Web of Science ®Google Scholar
• Hajek, T., Kopecek, M. & Höschl, C. (2012). Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis. World Journal of Biological Psychiatry, 13, 178–187.
   PubMed Web of Science ®Google Scholar
• Hall, M. & Smoller, J.W. (2010). A new role for endophenotypes in the GWAS era: Functional characterization of risk variants. Harvard Review of Psychiatry, 18, 67–74.
   PubMed Web of Science ®Google Scholar
• Harvey, P.D., Howanitz, E., Parrella, M., White, L., Davidson, M., Mohs, R.C., … Davis, K. L. (1998). Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia: A comparison across treatment sites. American Journal of Psychiatry, 155, 1080–1086.
   PubMed Web of Science ®Google Scholar
• Hass, J., Walton, E., Kirsten, H., Liu, J., Priebe, L., Wolf, C., … Ehrlich, S. (2013). A genome-wide association study suggests novel loci associated with a schizophrenia-related brain-based phenotype. PLoS One, 8, e64872. doi:10.1371/journal.pone.0064872
   PubMedGoogle Scholar
• Heckers, S. (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus, 11, 520–528.
   PubMed Web of Science ®Google Scholar
• Heckers, S., Heinsen, H., Geiger, B. & Beckmann, H. (1991). Hippocampal neuron number in schizophrenia. A stereological study. Archives of General Psychiatry, 48, 1002–1008.
   PubMed Web of Science ®Google Scholar
• Huang, Y., Chang, X., Lee, J., Cho, Y.G., Zhong, X., Park, I.-S., … Kim, M.S. (2011). Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. International Journal of cancer, 128, 2261–2273.
   PubMed Web of Science ®Google Scholar
• Ikeda, M., Aleksic, B., Kinoshita, Y., Okochi, T., Kawashima, K., Kushima, I., … Iwata, N. (2011). Genome-wide association study of schizophrenia in a Japanese population. Biological Psychiatry, 69, 472–478.
   PubMed Web of Science ®Google Scholar
• Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium 2. (2012). Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biological Psychiatry, 72, 620–628.
   Google Scholar
• Ivleva, E.I., Morris, D.W., Moates, A.F., Suppes, T., Thaker, G.K. & Tamminga, C.A. (2010). Genetics and intermediate phenotypes of the schizophrenia–bipolar disorder boundary. Neuroscience and Biobehavioral Reviews, 34, 897–921.
   PubMed Web of Science ®Google Scholar
• Jirtle, R.L. & Skinner, M.K. (2007). Environmental epigenomics and disease susceptibility. Nature Reviews Genetics, 8, 253–262.
   PubMed Web of Science ®Google Scholar
• Job, D.E., Whalley, H.C., Johnstone, E.C. & Lawrie, S.M. (2005). Grey matter changes over time in high risk subjects developing schizophrenia. NeuroImage, 25, 1023–1030.
   PubMed Web of Science ®Google Scholar
• Karlsgodt, K.H., Glahn, D.C., van Erp, T.G.M., Therman, S., Huttunen, M., Manninen, M., … Cannon, T.D. (2007). The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophrenia Research, 89, 191–197.
   PubMed Web of Science ®Google Scholar
• Kaymaz, N. & van Os, J. (2009). Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia. International Review of Neurobiology, 89, 85–130.
   PubMedGoogle Scholar
• Kirov, G., Zaharieva, I., Georgieva, L., Moskvina, V., Nikolov, I., Cichon, S., … O’Donovan, M.C. (2009). A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular Psychiatry, 14, 796–803.
   PubMed Web of Science ®Google Scholar
• Klein, R.J., Zeiss, C., Chew, E.Y., Tsai, J.-Y., Sackler, R.S., Haynes, C., … Hoh, J. (2005). Complement factor H polymorphism in age-related macular degeneration. Science, 308, 385–389.
   PubMed Web of Science ®Google Scholar
• Lahti, A.C., Weiler, M.A., Holcomb, H.H., Tamminga, C.A. & Cropsey, K.L. (2009). Modulation of limbic circuitry predicts treatment response to antipsychotic medication: A functional imaging study in schizophrenia. Neuropsychopharmacology, 34, 2675–2690.
   PubMedGoogle Scholar
• Lencz, T., Morgan, T.V., Athanasiou, M., Dain, B., Reed, C.R., Kane, J.M., … Malhotra, A.K. (2007). Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Molecular Psychiatry, 12, 572–580.
   PubMed Web of Science ®Google Scholar
• Lett, T.A., Chakavarty, M.M., Felsky, D., Brandl, E.J., Tiwari, A.K., Gonçalves, V.F., … Voineskos, A.N. (2013). The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia. Molecular Psychiatry, 18, 443–450.
   PubMed Web of Science ®Google Scholar
• Leucht, S., Kane, J.M., Kissling, W., Hamann, J., Etschel, E. & Engel, R.R. (2005). What does the PANSS mean?Schizophrenia Research, 79, 231–238.
   PubMed Web of Science ®Google Scholar
• Levinson, D.F., Shi, J., Wang, K., Oh, S., Riley, B., Pulver, A.E., … Holmans, P.A. (2012). Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry, 169, 963–973.
   PubMedGoogle Scholar
• Lieberman, J.A., Phillips, M., Gu, H., Stroup, S., Zhang, P., Kong, L., … Hamer, R.M. (2003). Atypical and conventional antipsychotic drugs in treatment-naive first-episode schizophrenia: A 52-week randomized trial of clozapine vs chlorpromazine. Neuropsychopharmacology, 28(5), 995–1003.
   PubMedGoogle Scholar
• Lieberman, J.A., Stroup, T.S., McEvoy, J.P., Swartz, M.S., Rosenheck, R.A., Perkins, D.O., … Hsiao, J.K. (2005). Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New England Journal of Medicine, 353, 1209–1223.
   PubMed Web of Science ®Google Scholar
• Liu, J., Chen, J., Ehrlich, S., Walton, E., White, T., Perrone- Bizzozero, N., … Calhoun, V.D. (2013). Methylation patterns of whole blood indicate status of schizophrenia patients. Schizophrenia Bulletin. doi:10.1093/schbul/sbt080
   Google Scholar
• Liu, J., Ghassemi, M.M., Michael, A.M., Boutte, D., Wells, W., Perrone-Bizzozero, N., … Calhoun, V.D. (2012). An ICA with reference approach in identification of genetic variation and associated brain networks. Frontiers in Human Neuroscience, 6, 21.
   PubMedGoogle Scholar
• Lui, S., Li, T., Deng, W., Jiang, L., Wu, Q., Tang, H., … Gong, Q. (2010). Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by ‘resting state’ functional magnetic resonance imaging. Archives of General Psychiatry, 67, 783–792.
   PubMed Web of Science ®Google Scholar
• Ma, X., Deng, W., Liu, X., Li, M., Chen, Z., He, Z., … Li, T. (2011). A genome-wide association study for quantitative traits in schizophrenia in China. Genes, Brain and Behavior, 10, 734–739.
   PubMed Web of Science ®Google Scholar
• MacDonald, A.W., III, Thermenos, H.W., Barch, D.M. & Seidman, L.J. (2009). Imaging genetic liability to schizophrenia: Systematic review of FMRI studies of patients’ nonpsychotic relatives. Schizophrenia Bulletin, 35, 1142–1162.
   PubMed Web of Science ®Google Scholar
• Manoach, D.S., Halpern, E.F., Kramer, T.S., Chang, Y., Goff, D.C., Rauch, S.L., … Gollub, R.L. (2001). Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. American Journal of Psychiatry, 158, 955–958.
   PubMed Web of Science ®Google Scholar
• Manoach, D.S., Press, D.Z., Thangaraj, V., Searl, M.M., Goff, D.C., Halpern, E., … Warach, S. (1999). Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry, 45, 1128–1137.
   PubMed Web of Science ®Google Scholar
• Melas, P.A., Rogdaki, M., Ösby, U., Schalling, M., Lavebratt, C. & Ekström, T.J. (2012). Epigenetic aberrations in leukocytes of patients with schizophrenia: Association of global DNA methylation with antipsychotic drug treatment and disease onset. FASEB Journal, 26, 2712–2718.
   PubMed Web of Science ®Google Scholar
• Meyer-Lindenberg, A. (2010a). From maps to mechanisms through neuroimaging of schizophrenia. Nature, 468, 194–202.
   PubMed Web of Science ®Google Scholar
• Meyer-Lindenberg, A. (2010b). Intermediate or brainless phenotypes for psychiatric research?Psychological Medicine, 40, 1057–1062.
   PubMed Web of Science ®Google Scholar
• Meyer-Lindenberg, A. & Weinberger, D.R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience, 7, 818–827.
   PubMed Web of Science ®Google Scholar
• Mier, D., Kirsch, P. & Meyer-Lindenberg, A. (2010). Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis. Molecular Psychiatry, 15, 918–927.
   PubMed Web of Science ®Google Scholar
• Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., … Petronis, A. (2008). Epigenomic profiling reveals DNA-Methylation Changes Associated with Major Psychosis. American Journal of Human Genetics, 82, 696–711.
   PubMed Web of Science ®Google Scholar
• Munafò, M.R., Bowes, L., Clark, T.G. & Flint, J. (2005). Lack of association of the COMT (Val 158/108 Met) gene and schizophrenia: A meta-analysis of case-control studies. Molecular Psychiatry, 10, 765–770.
   PubMed Web of Science ®Google Scholar
• Nesvåg, R., Frigessi, A., Jönsson, E.G. & Agartz, I. (2007). Effects of alcohol consumption and antipsychotic medication on brain morphology in schizophrenia. Schizophrenia Research, 90, 52–61.
   PubMed Web of Science ®Google Scholar
• Nesvåg, R., Lawyer, G., Varnäs, K., Fjell, A.M., Walhovd, K.B., Frigessi, A., … Agartz, I. (2008). Regional thinning of the cerebral cortex in schizophrenia: Effects of diagnosis, age and antipsychotic medication. Schizophrenia Research, 98, 16–28.
   PubMed Web of Science ®Google Scholar
• Nicodemus, K.K., Law, A.J., Radulescu, E., Luna, A., Kolachana, B., Vakkalanka, R., … Weinberger, D.R. (2010). Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Archives of General Psychiatry, 67, 991–1001.
   PubMed Web of Science ®Google Scholar
• Nikolova, Y.S., Ferrell, R.E., Manuck, S.B. & Hariri, A.R. (2011). Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology, 36, 1940–1947.
   PubMed Web of Science ®Google Scholar
• Nohesara, S., Ghadirivasfi, M., Mostafavi, S., Eskandari, M.-R., Ahmadkhaniha, H., Thiagalingam, S. & Abdolmaleky, H.M. (2011). DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. Journal of Psychiatric Research, 45, 1432–1438.
   PubMed Web of Science ®Google Scholar
• Nymberg, C., Jia, T., Ruggeri, B. & Schumann, G. (2013). Analytical strategies for large imaging genetic datasets: Experiences from the IMAGEN study. Annals of the New York Academy of Sciences, 1282, 92–106.
   PubMedGoogle Scholar
• O’Donovan, M.C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., … Georgieva, L. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40, 1053–1055.
   PubMed Web of Science ®Google Scholar
• Okochi, T., Ikeda, M., Kishi, T., Kawashima, K., Kinoshita, Y., Kitajima, T., … Iwata, N. (2009). Meta-analysis of association between genetic variants in COMT and schizophrenia: An update. Schizophrenia Research, 110, 140–148.
   PubMed Web of Science ®Google Scholar
• Panizzon, M.S., Fennema-Notestine, C., Eyler, L.T., Jernigan, T.L., Prom-Wormley, E., Neale, M., … Kremen, W.S. (2009). Distinct genetic influences on cortical surface area and cortical thickness. Cerebral Cortex, 19, 2728–2735.
   PubMed Web of Science ®Google Scholar
• Peper, J.S., Brouwer, R.M., Boomsma, D.I., Kahn, R.S. & Hulshoff Pol, H.E. (2007). Genetic influences on human brain structure: a review of brain imaging studies in twins. Human Brain Mapping, 28, 464–473.
   PubMed Web of Science ®Google Scholar
• Potkin, S.G., Turner, J.A., Fallon, J.A., Lakatos, A., Keator, D.B., Guffanti, G. & Macciardi, F. (2008). Gene discovery through imaging genetics: Identification of two novel genes associated with schizophrenia. Molecular Psychiatry, 14, 416–428.
   PubMedGoogle Scholar
• Potkin, S.G., Turner, J.A., Guffanti, G., Lakatos, A., Fallon, J.H., Nguyen, D.D., … Macciardi, F. (2009a). A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophrenia Bulletin, 35, 96–108.
   PubMed Web of Science ®Google Scholar
• Potkin, S.G., Turner, J.A., Brown, G.G., McCarthy, G., Greve, D.N., Glover, G.H., … Lim, K.O. (2009b). Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophrenia Bulletin, 35, 19–31.
   PubMed Web of Science ®Google Scholar
• Purcell, S.M., Wray, N.R., Stone, J.L., Visscher, P.M., O’Donovan, M.C., Sullivan, P.F. & Sklar, P. (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460, 748–752.
   PubMed Web of Science ®Google Scholar
• Rietschel, M., Mattheisen, M., Degenhardt, F., Kahn, R.S., Linszen, D.H., van Os, J., … de Haan, L. (2011). Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Molecular Psychiatry, 17(9), 906–917.
   PubMedGoogle Scholar
• Ripke, S., Sanders, A.R., Kendler, K.S., Levinson, D.F., Sklar, P., Holmans, P.A., … Andreassen, O.A. (2011). Genome-wide association study identifies five new schizophrenia loci. Nature genetics, 43, 969–976.
   PubMed Web of Science ®Google Scholar
• Roffman, J.L., Gollub, R.L., Calhoun, V.D., Wassink, T.H., Weiss, A.P., Ho, B.C., … Manoach, D.S. (2008). MTHFR 677C –> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val –> Met. Proceedings of the National Academy of Sciences of the United States of America, 105, 17573–17578.
   PubMedGoogle Scholar
• Rose, E.J. & Donohoe, G. (2012). Brain vs behavior: An effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia. Schizophrenia Bulletin, 39, 518–526.
   PubMedGoogle Scholar
• Sambataro, F., Blasi, G., Fazio, L., Caforio, G., Taurisano, P., Romano, R., … Bertolino, A. (2010). Treatment with olanzapine is associated with modulation of the default mode network in patients with schizophrenia. Neuropsychopharmacology, 35, 904–912.
   PubMed Web of Science ®Google Scholar
• Sanseau, P., Agarwal, P., Barnes, M.R., Pastinen, T., Richards, J.B., Cardon, L.R. & Mooser, V. (2012). Use of genome-wide association studies for drug repositioning. Nature Biotechnology, 30, 317–320.
   PubMed Web of Science ®Google Scholar
• Schlagenhauf, F., Dinges, M., Beck, A., Wüstenberg, T., Friedel, E., Dembler, T., … Heinz, A. (2010). Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation. Schizophrenia Research, 118, 189–200.
   PubMedGoogle Scholar
• Schultz, C.C., Koch, K., Wagner, G., Roebel, M., Schachtzabel, C., Gaser, C., … Schlösser, R.G.M. (2010). Reduced cortical thickness in first episode schizophrenia. Schizophrenia Research, 116, 204–209.
   PubMedGoogle Scholar
• Schulze, T.G. & McMahon, F.J. (2004). Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Human Heredity, 58, 131–138.
   PubMed Web of Science ®Google Scholar
• Shi, J., Levinson, D.F., Duan, J., Sanders, A.R., Zheng, Y., Pe'er, I., … Gejman, P.V. (2009). Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature, 460, 753–757.
   PubMed Web of Science ®Google Scholar
• Shifman, S., Johannesson, M., Bronstein, M., Chen, S.X., Collier, D.A., Craddock, N.J., … Darvasi, A. (2008). Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genetics, 4, e28.
   PubMed Web of Science ®Google Scholar
• Stingo, F.C., Guindani, M., Vannucci, M. & Calhoun, V. (2013). An Integrative Bayesian Modeling Approach to Imaging Genetics. Journal of the American Statistical Association. doi: 10.1080/01621459.2013.804409
   PubMedGoogle Scholar
• Smieskova, R., Fusar-Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R.D., Drewe, J., … Borgwardt, S.J. (2009). The effects of antipsychotics on the brain: What have we learnt from structural imaging of schizophrenia? A systematic review. Current Pharmaceutical Design, 15, 2535–2549.
   PubMed Web of Science ®Google Scholar
• Smith, G.N., Thornton, A.E., Lang, D.J., Macewan, G.W., Ehmann, T.S., Kopala, L.C., … Honer, W.G. (2012). Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis. Schizophrenia Research, 134(2–3), 253–259.
   PubMedGoogle Scholar
• Sommers, A.A. (1985). ‘Negative symptoms’: Conceptual and methodological problems. Schizophrenia Bulletin, 11, 364–379.
   PubMed Web of Science ®Google Scholar
• Staal, W.G., Hulshoff Pol, H.E., Schnack, H.G., Hoogendoorn, M.L., Jellema, K. & Kahn, R.S. (2000). Structural brain abnormalities in patients with schizophrenia and their healthy siblings. American Journal of Psychiatry, 157, 416–421.
   PubMed Web of Science ®Google Scholar
• Stefansson, H., Ophoff, R.A., Steinberg, S., Andreassen, O.A., Cichon, S., Rujescu, D., … Mortensen, P.B. (2009). Common variants conferring risk of schizophrenia. Nature, 460, 744–747.
   PubMed Web of Science ®Google Scholar
• Stein, J.L., Medland, S.E., Vasquez, A.A., Hibar, D.P., Senstad, R.E., Winkler, A.M., … Bergmann, Ø. (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44, 552–561.
   PubMed Web of Science ®Google Scholar
• Stroup, T.S., McEvoy, J.P., Swartz, M.S., Byerly, M.J., Glick, I.D., Canive, J.M., … Lieberman, J.A. (2003). The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: Schizophrenia trial design and protocol development. Schizophrenia Bulletin, 29, 15–31.
   PubMed Web of Science ®Google Scholar
• Sullivan, P.F., Lin, D., Tzeng, J.-Y., van den Oord, E., Perkins, D., Stroup, T.S., … Close, S.L. (2008). Genomewide association for schizophrenia in the CATIE study: Results of stage 1. Molecular Psychiatry, 13, 570–584.
   PubMed Web of Science ®Google Scholar
• Surguladze, S.A., Chu, E.M., Evans, A., Anilkumar, A.P.P., Patel, M.X., Timehin, C. & David, A.S. (2007). The effect of long-acting risperidone on working memory in schizophrenia: A functional magnetic resonance imaging study. Journal of Clinical Psychopharmacology, 27, 560–570.
   PubMed Web of Science ®Google Scholar
• Szeszko, P.R., Strous, R.D., Goldman, R.S., Ashtari, M., Knuth, K.H., Lieberman, J.A. & Bilder, R.M. (2002). Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophrenia. American Journal of Psychiatry, 159, 217–226.
   PubMed Web of Science ®Google Scholar
• Tammen, S.A., Friso, S. & Choi, S.-W. (2012). Epigenetics: The link between nature and nurture. Molecular Aspects of Medicine, 34, 753–764.
   PubMedGoogle Scholar
• Tura, E., Turner, J.A., Fallon, J.H., Kennedy, J.L. & Potkin, S.G. (2008). Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia. Neuroreport, 19, 603–607.
   PubMedGoogle Scholar
• Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., … Bertolino, A. (2011). Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity. Journal of Neuroscience, 31, 6692–6698.
   PubMed Web of Science ®Google Scholar
• Van Veelen, N.M.J., Vink, M., Ramsey, N.F. & Kahn, R.S. (2010). Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia. Schizophrenia Research, 123, 22–29.
   PubMedGoogle Scholar
• Van Veelen, N.M.J., Vink, M., Ramsey, N.F., van Buuren, M., Hoogendam, J.M. & Kahn, R.S. (2011). Prefrontal lobe dysfunction predicts treatment response in medication-naive first-episode schizophrenia. Schizophrenia Research, 129, 156–162.
   PubMed Web of Science ®Google Scholar
• Van Winkel, R., Esquivel, G., Kenis, G., Wichers, M., Collip, D., Peerbooms, O., … Van Os, J. (2010). Review: Genome-wide findings in schizophrenia and the role of gene– environment interplay. CNS Neuroscience and Therapeutics, 16, e185–e192.
   PubMed Web of Science ®Google Scholar
• Velakoulis, D., Wood, S.J., Wong, M.T.H., McGorry, P.D., Yung, A., Phillips, L., … Pantelis, C. (2006). Hippocampal and amygdala volumes according to psychosis stage and diagnosis: A magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry, 63, 139–149.
   PubMed Web of Science ®Google Scholar
• Velligan, D.I., Mahurin, R.K., Diamond, P.L., Hazleton, B.C., Eckert, S.L. & Miller, A.L. (1997). The functional significance of symptomatology and cognitive function in schizophrenia. Schizophrenia Research, 25, 21–31.
   PubMed Web of Science ®Google Scholar
• Voineskos, A.N., Lerch, J.P., Felsky, D., Tiwari, A., Rajji, T.K., Miranda, D., … Kennedy, J.L. (2011). The ZNF804A gene: Characterization of a novel neural risk mechanism for the major psychoses. Neuropsychopharmacology, 36, 1871–1878.
   PubMedGoogle Scholar
• Walton, E., Geisler, D., Hass, J., Liu, J., Turner, J., Yendiki, A., … Ehrlich, S. (submitted). The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function.
   Google Scholar
• Walton, E., Turner, J., Gollub, R.L., Manoach, D.S., Yendiki, A., Ho, B.-C., … Ehrlich, S. (2013). Cumulative genetic risk and prefrontal activity in patients with schizophrenia. Schizophrenia Bulletin, 39, 703–711.
   PubMedGoogle Scholar
• Weinberger, D.R., DeLisi, L.E., Neophytides, A.N. & Wyatt, R.J. (1981). Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiatry Research, 4, 65–71.
   PubMed Web of Science ®Google Scholar
• Winkler, A.M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P.T., … Glahn, D. C. (2010). Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. NeuroImage, 53, 1135–1146.
   Google Scholar
• Yamada, K., Iwayama, Y., Hattori, E., Iwamoto, K., Toyota, T., Ohnishi, T., … Yoshikawa, T. (2011). Genome-wide association study of schizophrenia in Japanese population. PloS ONE, 6, e20468.
   PubMedGoogle Scholar
• Yue, W.-H., Wang, H.-F., Sun, L.-D., Tang, F.-L., Liu, Z.-H., Zhang, H.-X., … Ma, C.-C. (2011). Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics, 43, 1228–1231.
   PubMed Web of Science ®Google Scholar