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Research Article

The neuropsychiatry of multiple sclerosis: Focus on disorders of mood, affect and behaviour

, , , &
Pages 14-21 | Published online: 11 Mar 2010

References

  • Arnett PA, Higginson CI, Voss WD, Bender WI, Wurst JM, Tippin JM. Depression in multiple sclerosis: Relationship to working memory capacity. Neuropsychology 1999; 13: 546–556
  • Attarian HP, Brown KM, Duntley SP, Carter JD, Cross AH. The relationship of sleep disturbances and fatigue in multiple sclerosis. Archives of Neurology 2004; 61: 525–528
  • Bakshi R, Czarnecki D, Shaikh ZA, Priore RL, Janardhan V, Kaliszky Z, et al. Brain MRI lesions and atrophy are related to depression in multiple sclerosis. Neuroreport 2000a; 11: 1153–1158
  • Bakshi R, Miletich RS, Henschel K, Shaikh ZA, Janardhan V, Wasay M, et al. Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients. Neurology 1999; 53: 1151–1153
  • Bakshi R, Shaikh ZA, Miletich RS, Czarnecki D, Dmochowski J, Henschel K, et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Multiple Sclerosis 2000b; 6: 181–185
  • Bamer AM, Johnson KL, Amtmann D, Kraft GH. Prevalence of sleep problems in individuals with multiple sclerosis. Multiple Sclerosis 2008; 14: 1127–1130
  • Barak Y, Ur E, Achiron A. Moclobemide treatment in multiple sclerosis patients with comorbid depression: An open-label safety trial. Journal of Neuropsychiatry and Clinical Neurosciences 1999; 11: 271–273
  • Beck AT, Steer RA, Brown GK. BDI-Fast screen for medical patients: Manual. The Psychological Corporation, San Antonio, TX 2000
  • Beiske AG, Svensson E, Sandanger I, Czujko B, Pedersen ED, Aarseth JH, et al. Depression and anxiety amongst multiple sclerosis patients. European Journal of Neurology 2008; 15: 239–245
  • Benedict RH, Fishman I, McClellan MM, Bakshi R, Weinstock-Guttman B. Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis. Multiple Sclerosis 2003; 9: 393–396
  • Buljevac D, Hop WC, Reedeker W, Janssens AC, van der Meche FG, van Doorn PA, et al. Self reported stressful life events and exacerbations in multiple sclerosis: Prospective study. British Medical Journal 2003; 327: 646
  • Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH. Depressive symptoms and severity of illness in multiple sclerosis: Epidemiologic study of a large community sample. American Journal of Psychiatry 2002; 159: 1862–1868
  • Cottrell SS, Wilson SAK. The affective symptomatology of disseminated sclerosis. Journal of Neurology and Psychopathology 1926; 7: 1–30
  • Cummings JL. Frontal-subcortical circuits and human behavior. Archives of Neurology 1993; 50: 873–880
  • Cummings JL. Involuntary emotional expression disorder: Definition, diagnosis, and measurement scales. CNS Spectrum 2007; 12: 11–16
  • Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–2314
  • D’Alisa S, Miscio G, Baudo S, Simone A, Tesio L, Mauro A. Depression is the main determinant of quality of life in multiple sclerosis: A classification-regression (CART) study. Disability and Rehabilitation 2006; 28: 307–314
  • Dalos NP, Rabins PV, Brooks BR, O’Donnell P. Disease activity and emotional state in multiple sclerosis. Annals of Neurology 1983; 13: 573–577
  • Davison K, Bagley CR. Schizophrenia-like psychoses associated with organic disorders of the central nervous system: A review of the literature. British Journal of Psychiatry 1969; 4: 113–184
  • Demaree HA, Gaudino E, DeLuca J. The relationship between depressive symptoms and cognitive dysfunction in multiple sclerosis. Cognitive Neuropsychiatry 2003; 8: 161–171
  • Diaz-Olavarrieta C, Cummings JL, Velazquez J, Garcia de la Cadena C. Neuropsychiatric manifestations of multiple sclerosis. Journal of Neuropsychiatry and Clinical Neurosciences 1999; 11: 51–57
  • Falk WE, Mahnke MW, Poskanzer DC. Lithium prophylaxis of corticotropin-induced psychosis. Journal of the American Medical Association 1979; 241: 1011–1012
  • Fassbender K, Schmidt R, Mossner R, Kischka U, Kuhnen J, Schwartz A, et al. Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: Association with cerebral inflammation. Archives of Neurology 1998; 55: 66–72
  • Feinstein A. Multiple sclerosis, disease modifying treatments and depression: A critical methodological review. Multiple Sclerosis 2000; 6: 343–348
  • Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology 2002; 59: 674–678
  • Feinstein A. Mood disorders in multiple sclerosis and the effects on cognition. Journal of Neurological Science 2006; 245: 63–66
  • Feinstein A, du Boulay G, Ron MA. Psychotic illness in multiple sclerosis. A clinical and magnetic resonance imaging study. British Journal of Psychiatry 1992a; 161: 680–685
  • Feinstein A, Kartsounis LD, Miller DH, Youl BD, Ron MA. Clinically isolated lesions of the type seen in multiple sclerosis: A cognitive, psychiatric, and MRI follow up study. Journal of Neurology Neurosurgery and Psychiatry 1992b; 55: 869–876
  • Feinstein A, O’Connor P, Gray T, Feinstein K. The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis. Multiple Sclerosis 1999a; 5: 323–326
  • Feinstein A, O’Connor P, Gray T, Feinstein K. Pathological laughing and crying in multiple sclerosis: A preliminary report suggesting a role for the prefrontal cortex. Multiple Sclerosis 1999b; 5: 69–73
  • Feinstein A, Feinstein K, Gray T, O’Connor P. Prevalence and neurobehavioral correlates of pathological laughing and crying in multiple sclerosis. Archives of Neurology 1997; 54: 1116–1121
  • Feinstein A, Roy P, Lobaugh N, Feinstein K, O’Connor P, Black S. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology 2004; 62: 586–590
  • Ferentinos P, Kontaxakis V, Havaki-Kontaxaki B, Paparrigopoulos T, Dikeos D, Ktonas P, et al. Sleep disturbances in relation to fatigue in major depression. Journal of Psychosomatic Research 2009a; 66: 37–42
  • Ferentinos P, Paparrigopoulos T, Rentzos M, Evdokimidis I. Duloxetine for pathological laughing and crying. International Journal of Neuropsychopharmacology 2009b; 12: 1429–1430
  • Ferentinos PP, Kontaxakis VP, Havaki-Kontaxaki BJ, Paplos KG, Soldatos CR. The measurement of fatigue in depression. Psychopathology 2007; 40: 133–134
  • Figved N, Benedict R, Klevan G, Myhr KM, Nyland HI, Landro NI, et al. Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis. Multiple Sclerosis 2008; 14: 1084–1090
  • Figved N, Klevan G, Myhr KM, Glad S, Nyland H, Larsen JP, et al. Neuropsychiatric symptoms in patients with multiple sclerosis. Acta Psychiatrica Scandinavica 2005; 112: 463–468
  • Figved N, Myhr KM, Larsen JP, Aarsland D. Caregiver burden in multiple sclerosis: The impact of neuropsychiatric symptoms. Journal of Neurology Neurosurgery and Psychiatry 2007; 78: 1097–1102
  • Fishman I, Benedict RH, Bakshi R, Priore R, Weinstock-Guttman B. Construct validity and frequency of euphoria sclerotica in multiple sclerosis. Journal of Neuropsychiatry and Clinical Neurosciences 2004; 16: 350–356
  • Flax JW, Gray J, Herbert J. Effect of fluoxetine on patients with multiple sclerosis. American Journal of Psychiatry 1991; 148: 1603
  • Ford H, Trigwell P, Johnson M. The nature of fatigue in multiple sclerosis. Journal of Psychosomatic Research 1998; 45: 33–38
  • Freal JE, Kraft GH, Coryell JK. Symptomatic fatigue in multiple sclerosis. Archives of Physical Medicine and Rehabilitation 1984; 65: 135–138
  • Janssens AC, Buljevac D, van Doorn PA, van der Meche FG, Polman CH, Passchier J, et al. Prediction of anxiety and distress following diagnosis of multiple sclerosis: A two-year longitudinal study. Multiple Sclerosis 2006; 12: 794–801
  • Janssens AC, van Doorn PA, de Boer JB, van der Meche FG, Passchier J, Hintzen RQ. Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners. Acta Neurologica Scandinavica 2003; 108: 389–395
  • Joffe RT, Lippert GP, Gray TA. Personal and family history of affective illness in patients with multiple sclerosis. Journal of Affective Disorders 1987; 12: 63–65
  • Iriarte J, Subirá ML, Castro P. Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. Multiple Sclerosis 2000; 6: 124–130
  • Kim SW, Shin IS, Kim JM, Lim SY, Yang SJ, Yoon JS. Mirtazapine treatment for pathological laughing and crying after stroke. Clinical Neuropharmacology 2005; 28: 249–251
  • Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Multiple Sclerosis 2007; 13: 67–72
  • Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC. Fatigue in multiple sclerosis. Archives of Neurology 1988; 45: 435–437
  • Krupp LB, Coyle PK, Doscher C, Miller A, Cross AH, Jandorf L, et al. Fatigue therapy in multiple sclerosis: Results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo. Neurology 1995; 45: 1956–1961
  • Krystal AD, Coffey CE. Neuropsychiatric considerations in the use of electroconvulsive therapy. Journal of Neuropsychiatry and Clinical Neurosciences 1997; 9: 283–292
  • Larcombe NA, Wilson PH. An evaluation of cognitive-behaviour therapy for depression in patients with multiple sclerosis. British Journal of Psychiatry 1984; 145: 366–371
  • Lobentanz IS, Asenbaum S, Vass K, Sauter C, Klosch G, Kollegger H, et al. Factors influencing quality of life in multiple sclerosis patients: Disability, depressive mood, fatigue and sleep quality. Acta Neurologica Scandinavica 2004; 110: 6–13
  • Lynch SG, Kroencke DC, Denney DR. The relationship between disability and depression in multiple sclerosis: The role of uncertainty, coping, and hope. Multiple Sclerosis 2001; 7: 411–416
  • Mattingly G, Baker K, Zorumski CF, Figiel GS. Multiple sclerosis and ECT: Possible value of gadolinium-enhanced magnetic resonance scans for identifying high-risk patients. Journal of Neuropsychiatry and Clinical Neurosciences 1992; 4: 145–151
  • McGuigan C, Hutchinson M. Unrecognized symptoms of depression in a community-based population with multiple sclerosis. Journal of Neurology 2006; 253: 219–223
  • Merkelbach S, Dillmann U, Kolmel C, Holz I, Muller M. Cardiovascular autonomic dysregulation and fatigue in multiple sclerosis. Multiple Sclerosis 2001; 7: 320–326
  • Merlino G, Fratticci L, Lenchig C, Valente M, Cargnelutti D, Picello M, et al. Prevalence of ‘poor sleep’ among patients with multiple sclerosis: An independent predictor of mental and physical status. Sleep Medicine 2009; 10: 26–34
  • Michelson D, Stone L, Galliven E, Magiakou MA, Chrousos GP, Sternberg EM, et al. Multiple sclerosis is associated with alterations in hypothalamic-pituitary-adrenal axis function. Journal of Clinical Endocrinology and Metabolism 1994; 79: 848–853
  • Minden SL, Orav J, Reich P. Depression in multiple sclerosis. General Hospital Psychiatry 1987; 9: 426–434
  • Minden SL, Orav J, Schildkraut JJ. Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis. Neurology 1988; 38: 1631–1634
  • Minden SL, Schiffer RB. Affective disorders in multiple sclerosis. Review and recommendations for clinical research. Archives of Neurology 1990; 47: 98–103
  • Mohr DC, Boudewyn AC, Goodkin DE, Bostrom A, Epstein L. Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis. Journal of Consulting and Clinical Psychology 2001; 69: 942–949
  • Mohr DC, Goodkin DE, Likosky W, Gatto N, Baumann KA, Rudick RA. Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Archives of Neurology 1997; 54: 531–533
  • Moore SR, Gresham LS, Bromberg MB, Kasarkis EJ, Smith RA. A self report measure of affective lability. Journal of Neurology Neurosurgery and Psychiatry 1997; 63: 89–93
  • Mostert S, Kesselring J. Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis. Multiple Sclerosis 2002; 8: 161–168
  • Multiple Sclerosis Council for Clinical Practice Guidelines. Fatigue and multiple sclerosis. Paralyzed Veterans of America, Washington, DC 1998
  • Nahas Z, Arlinghaus KA, Kotrla KJ, Clearman RR, George MS. Rapid response of emotional incontinence to selective serotonin reuptake inhibitors. Journal of Neuropsychiatry and Clinical Neurosciences 1998; 10: 453–455
  • Oken BS, Kishiyama S, Zajdel D, Bourdette D, Carlsen J, Haas M, et al. Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology 2004; 62: 2058–2064
  • Panitch HS, Thisted RA, Smith RA, Wynn DR, Wymer JP, Achiron A, et al. Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Annals of Neurology 2006; 59: 780–787
  • Parvizi J, Anderson SW, Martin CO, Damasio H, Damasio AR. Pathological laughter and crying: A link to the cerebellum. Brain 2001; 124: 1708–1719
  • Patten SB, Beck CA, Williams JVA, Barbui C, Metz LM. Major depression in multiple sclerosis: A population-based perspective. Neurology 2003; 61: 1524–1527
  • Patten SB, Metz LM, Reimer MA. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Multiple Sclerosis 2000; 6: 115–120
  • Patten SB, Svenson LW, Metz LM. Psychotic disorders in MS: Population-based evidence of an association. Neurology 2005; 65: 1123–1125
  • Pucak ML, Carroll KA, Kerr DA, Kaplin AI. Neuropsychiatric manifestations of depression in multiple sclerosis: Neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression. Dialogues in Clinical Neuroscience 2007; 9: 125–139
  • Pujol J, Bello J, Deus J, Marti-Vilalta JL, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology 1997; 49: 1105–1110
  • Rabins PV. Euphoria in multiple sclerosis. Neurobehavioral aspects of multiple sclerosis, SM Rao. Oxford University Press, New York 1990; 180–185
  • Ramasubbu R. Lamotrigine treatment for post-stroke pathological laughing and crying. Clinical Neuropharmacology 2003; 26: 233–235
  • Rammohan KW, Rosenberg JH, Lynn DJ, Blumenfeld AM, Pollak CP, Nagaraja HN. Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: A two centre phase 2 study. Journal of Neurology Neurosurgery and Psychiatry 2002; 72: 179–183
  • Robinson RG, Parikh RM, Lipsey JR, Starkstein SE, Price TR. Pathological laughing and crying following stroke: Validation of a measurement scale and a double-blind treatment study. American Journal of Psychiatry 1993; 150: 286–293
  • Rosenberg JH, Shafor R. Fatigue in multiple sclerosis: A rational approach to evaluation and treatment. Current Neurology and Neuroscience Reports 2005; 5: 140–146
  • Sabatini U, Pozzilli C, Pantano P, Koudriavtseva T, Padovani A, Millefiorini E, et al. Involvement of the limbic system in multiple sclerosis patients with depressive disorders. Biological Psychiatry 1996; 39: 970–975
  • Sadovnick AD, Eisen K, Ebers GC, Paty DW. Cause of death in patients attending multiple sclerosis clinics. Neurology 1991; 41: 1193–1196
  • Sanders VJ, Waddell AE, Felisan SL, Li X, Conrad AJ, Tourtellotte WW. Herpes simplex virus in postmortem multiple sclerosis brain tissue. Archives of Neurology 1996; 53: 125–133
  • Schiffer RB, Arnett P, Ben-Zacharia A, Benedict R, Bobholz J, Caruso L, et al. The Goldman Consensus statement on depression in multiple sclerosis. Multiple Sclerosis 2005; 11: 328–337
  • Schiffer RB, Herndon RM, Rudick RA. Treatment of pathologic laughing and weeping with amitriptyline. New England Journal of Medicine 1985; 312: 1480–1482
  • Schiffer RB, Wineman NM. Antidepressant pharmacotherapy of depression associated with multiple sclerosis. American Journal of Psychiatry 1990; 147: 1493–1497
  • Schiffer RB, Wineman N, Weitkamp MLR. Association between bipolar affective disorder and multiple sclerosis. American Journal of Psychiatry 1986; 143: 94–95
  • Schreurs KM, de Ridder DT, Bensing JM. Fatigue in multiple sclerosis: Reciprocal relationships with physical disabilities and depression. Journal of Psychosomatic Research 2002; 53: 775–781
  • Schubert DSP, Foliart RH. Increased depression in multiple sclerosis patients: A meta-analysis. Psychosomatics 1993; 34: 124–130
  • Sechi GP, Piras MR, Demurtas A, Tanca S, Rosati G. Dexamethasone-induced schizoaffective-like state in multiple sclerosis: Prophylaxis and treatment with carbamazepine. Clinical Neuropharmacology 1987; 10: 453–457
  • Smith AG, Montealegre-Orjuela M, Douglas JE, Jenkins EA. Venlafaxine for pathological crying after stroke. Journal of Clinical Psychiatry 2003; 64: 731–732
  • Soldatos CR, Paparrigopoulos TJ. Sleep physiology and pathology: Pertinence to psychiatry. International Review of Psychiatry 2005; 17: 213–228
  • Stenager EN, Koch-Henriksen N, Stenager E. Risk factors for suicide in multiple sclerosis. Psychotherapy and Psychosomatics 1996; 65: 86–90
  • Surridge D. An investigation into some psychiatric aspects of multiple sclerosis. British Journal of Psychiatry 1969; 115: 749–764
  • Trojan DA, Arnold D, Collet JP, Shapiro S, Bar-Or A, Robinson A, et al. Fatigue in multiple sclerosis: Association with disease-related, behavioural and psychosocial factors. Multiple Sclerosis 2007; 13: 985–995
  • Udaka F, Yamao S, Nagata H, Nakamura S, Kameyama M. Pathologic laughing and crying treated with levodopa. Archives of Neurology 1984; 41: 1095–1096
  • Vercoulen JH, Hommes OR, Swanink CM, Jongen PJ, Fennis JF, Galama JM, et al. The measurement of fatigue in patients with multiple sclerosis. A multidimensional comparison with patients with chronic fatigue syndrome and healthy subjects. Archives of Neurology 1996; 53: 642–649
  • Wortzel HS, Oster TJ, Anderson CA, Arciniegas DB. Pathological laughing and crying: Epidemiology, pathophysiology and treatment. CNS Drugs 2008; 22: 531–545

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