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Journal of Dermatological Treatment Volume 23, 2012 - Issue 1
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Acne

Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial

Bahare Malek AfzaliDepartment of Dermatology, Islamic Azad University of Tehran Medical Branch, Tehran, Iran
,
Elena YaghoobiDepartment of Dermatology, Islamic Azad University of Tehran Medical Branch, Tehran, Iran
,
Reza YaghoobiDepartment of DermatologyCorrespondence[email protected]
,
Nooshin BagheraniDepartment of Dermatology
&
Mohammad Ali DabbaghFaculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
Pages 21-25 | Received 22 Mar 2010, Accepted 01 Apr 2010, Published online: 22 Oct 2010

References

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  • Kubba R, Bajoj AK, Thappa DM. Principle of topical therapy. Indian J Dermatol Venerol Leprol. 2009;75:526–527.
  • Cunliffe WJ, Bottomley WW. Antiandrogens and acne: A topical approach? Arch Dermatol. 1992;128:1261–1264.
  • Shaw JC. Spironolactone in dermatologic therapy. J Am Acad Dermatol. 1991;24(2 Pt 1):236–243.
  • Shaw JC, Wite LE. Long-term safety of spironolactone in acne: Result of 8-year follow up study. J Cutan Med Surg. 2002;6:541–545.
  • Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G. Topical spironolactone inhibits dihydrotes testosterone receptors in humans sebaceous glands: An autoradio graphic study in subjects with acne vulgaris. Int J Tissue React. 1988;10:115–119.
  • Rey FO, Valterio C, Locatelli L, Ramelet AA, Felber JP. Lack of endocrine systemic side effects after topical application of spironolactone in man. J Endocrinol Invest. 1988;11:273–278.
  • Califano L, Cannavo S, Siragusa M, Girardi R. Experience in the therapy of acne with topical administration on spironolactone as an antiandrogen. Clin Ter. 1990;135:193–199.

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