The effects of electromagnetic pulses (EMP) on the bioactivity of insulin and a preliminary study of mechanism

References

• Adair RK. 1995. Ultrashort microwave signals: A didactic discussion. Aviation, Space, and Environmental Medicine 66:792–794.
   PubMedGoogle Scholar
• Bolli GB. 2006. Insulin treatment in type 1 diabetes. Endocrine Practice 12(Suppl. 1):105–109.
   PubMedGoogle Scholar
• Budi A, Legge FS, Treutlein H, Yarovsky I. 2005. Electric field effects on insulin chain-B conformation. The Journal of Physical Chemistry B 109:22641–22648.
   PubMed Web of Science ®Google Scholar
• Budi A, Legge FS, Treutlein H, Yarovsky I. 2007. Effect of frequency on insulin response to electric field stress. The Journal of Physical Chemistry B 111:5748–5756.
   PubMed Web of Science ®Google Scholar
• Cahill GF Jr. 1971. The Banting Memorial Lecture 1971. Physiology of insulin in man. Diabetes 20:785–799.
   PubMed Web of Science ®Google Scholar
• Ciszak E, Beals JM, Frank BH, Baker JC, Carter ND, Smith GD. 1995. Role of C-terminal B-chain residues in insulin assembly: The structure of hexameric LysB28ProB29-human insulin. Structure 3:615–622.
   PubMedGoogle Scholar
• de Pomerai DI, Smith B, Dawe A, North K, Smith T, Archer DB, Duce IR, Jones D, Candido EP. 2003. Microwave radiation can alter protein conformation without bulk heating. Federation of European Biochemical Societies. Letters 543:93–97.
   Google Scholar
• Hawkins B, Cross K, Craik D. 1995. Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy. Comparison with the crystal structure of the insulin hexamer and with the solution structure of the insulin monomer. International Journal of Peptide and Protein Research 46:424–433.
   PubMedGoogle Scholar
• Kordonouri O, von Schutz W, Meyer N, Aschemeier B, Kracht T, Danne T. 2008. Type 1 diabetes in children and adolescents – new strategies in management and treatment. Medizinische Monatsschrift für Pharmazeuten 31:200–206; quiz 207–208.
   PubMedGoogle Scholar
• Laurence JA, French PW, Lindner RA, McKenzie DR. 2000. Biological effects of electromagnetic fields – mechanisms for the effects of pulsed microwave radiation on protein conformation. Journal of Theoretical Biology 206:291–298.
   PubMed Web of Science ®Google Scholar
• Legge FS, Budi A, Treutlein H, Yarovsky I. 2006. Protein flexibility: Multiple molecular dynamics simulations of insulin chain B. Biophysical Chemistry 119:146–157.
   PubMedGoogle Scholar
• Li BF, Guo GZ, Ren DQ, Li J, Zhang RB. 2007. Electromagnetic pulses induce fluctuations in blood pressure in rats. International Journal of Radiation Biology 83:421–429.
   PubMed Web of Science ®Google Scholar
• Li H, Ying L, Ren X, Balasubramanian S, Klenerman D. 2004. Fluorescence studies of single biomolecules. Biochemical Society Transactions 32:753–756.
   PubMedGoogle Scholar
• Liu H, Tang L, Sun C, Mi Y, Yao C, Li C, Wang Y. 2008. The study of apoptosis and mechanism of cells exposed to steep pulse. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25:637–641.
   PubMedGoogle Scholar
• Lukic ML, Stosic-Grujicic S, Shahin A. 1998. Effector mechanisms in low-dose streptozotocin-induced diabetes. Developmental Immunology 6:119–128.
   PubMedGoogle Scholar
• Medina MA, Schwille P. 2002. Fluorescence correlation spectroscopy for the detection and study of single molecules in biology. Bioessays 24:758–764.
   PubMed Web of Science ®Google Scholar
• Mensah-Brown EPK, Stosic-Grujicic S, Maksimovic D, Jasima A, Shahin A, Lukic ML. 2001. Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes. Molecular Immunology 38:941–946.
   Google Scholar
• Merritt JH, Kiel JL, Hurt WD. 1995. Considerations for human exposure standards for fast-rise-time high-peak-power electromagnetic pulses. Aviation, Space, and Environmental Medicine 66:586–589.
   PubMed Web of Science ®Google Scholar
• Salford LG, Brun AE, Eberhardt JL, Malmgren L, Persson BR. 2003. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environmental Health Perspectives 111:881–883; discussion A408.
   PubMed Web of Science ®Google Scholar
• Schuler B. 2005. Single-molecule fluorescence spectroscopy of protein folding. Chemphyschem 6:1206–1220.
   PubMed Web of Science ®Google Scholar
• Teale FW. 1960. The ultraviolet fluorescence of proteins in neutral solution. Biochemical Journal 76:381–388.
   PubMed Web of Science ®Google Scholar
• Wang XW, Ding GR, Shi CH, Zhao T, Zhang J, Zeng LH, Guo GZ. 2008. Effect of electromagnetic pulse exposure on permeability of blood-testicle barrier in mice. Biomedical and Environmental Sciences 21:218–221.
   PubMed Web of Science ®Google Scholar
• Weiss S. 1999. Fluorescence spectroscopy of single biomolecules. Science 283:1676–1683.
   PubMed Web of Science ®Google Scholar
• Yip CC, Ottensmeyer P. 2003. Three-dimensional structural interactions of insulin and its receptor. Journal of Biological Chemistry 278:27329–27332.
   PubMedGoogle Scholar
• Zinman B. 2000. Basal insulin replacement and use of rapid-acting insulin analogues in patients with type 1 diabetes. Endocrine Practice 6:88–92.
   PubMedGoogle Scholar