Differences in the kinetics of γ-H2AX fluorescence decay after exposure to low and high LET radiation

References

• Anderson RM, Stevens DL, Goodhead DT. 2002. M-FISH analysis shows that complex chromosome aberrations induced by alpha-particle tracks are cumulative products of localised rearrangements. Proceedings of the National Academy of Sciences of the USA 99:12167–12172.
   PubMed Web of Science ®Google Scholar
• Ando K, Koike S, Ohira C, Chen YJ, Nojima K, Ando S, Ohbuchi T, Kobayashi N, Shimizu W, Urano M. 1999. Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation. International Journal of Radiation Biology 75:505–512.
   PubMed Web of Science ®Google Scholar
• Asakawa I, Yoshimura H, Takahashi A, Ohnishi K, Nakagawa H, Ota I, Furusawa Y, Tamamoto T, Ohishi H, Ohnishi T. 2002. Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status. Anticancer Research 22:2037–2043.
   PubMed Web of Science ®Google Scholar
• Bassing CH, Alt FW. 2004. The cellular response to general and programmed DNA double strand breaks. DNA Repair 3:781–796.
   PubMed Web of Science ®Google Scholar
• Bouquet F, Muller C, Salles B. 2006. The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage. Cell Cycle 5:1116–1122.
   PubMed Web of Science ®Google Scholar
• Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. 2005. Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Molecular Cell 20:801–809.
   PubMed Web of Science ®Google Scholar
• Darroudi F, Bezrookove V, Fomina J, Mesker WE, Wiegant JC, Raap AK, Tanke HJ. 2002. Insights into the sites of X-ray and neutron-induced chromosomal aberrations in human lymphocytes using COBRA-MFISH. Radiation Protection Dosimetry 99:189–192.
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z, Huang X, Okafuji M. 2006. Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication). Methods in Molecular Biology 314:81–93.
   PubMedGoogle Scholar
• Desai N, Davis E, O'Neill P, Durante M, Cucinotta FA, Wu H. 2005. Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation. Radiation Research 164:518–522.
   PubMed Web of Science ®Google Scholar
• Durante M, Furusawa Y, George K, Gialanella G, Greco O, Grossi G, Matsufuji N, Pugliese M, Yang TC. 1998. Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiation Research 149:446–454.
   PubMed Web of Science ®Google Scholar
• Durante M, George K, Wu H, Cucinotta FA. 2002. Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiation Research 158:581–590.
   PubMed Web of Science ®Google Scholar
• Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proceedings of the National Academy of Sciences of the USA 97:6630–6633.
   PubMed Web of Science ®Google Scholar
• Fowler JF. 1999. Is repair of DNA strand break damage from ionizing radiation second-order rather than first-order? A simpler explanation of apparently multiexponential repair. Radiation Research 152:124–136.
   PubMed Web of Science ®Google Scholar
• Hauptner A, Dietzel S, Drexler GA, Reichart P, Krucken R, Cremer T, Friedl AA, Dollinger G. 2004. Microirradiation of cells with energetic heavy ions. Radiation Environmental Biophysics 42:237–245.
   PubMed Web of Science ®Google Scholar
• Hauptner A, Friedland W, Dietzel S, Drexler GA, Greubel C, Hable V, Strickfaden H, Cremer T, Friedl AA, Krücken R, Paretzke HG, Dollinger G. 2006a. Spatial distribution of DNA double-strand breaks from ion tracks. Ion beam science: Solved and unsolved problems. P. Sigmund. Copenhagen: Danish Academy of Sciences and Letters. pp 59–85.
   Google Scholar
• Hauptner A, Krucken R, Greubel C, Hable V, Dollinger G, Drexler GA, Deutsch M, Lowe R, Friedl AA, Dietzel S, Strickfaden H, Cremer T. 2006b. DNA-repair protein distribution along the tracks of energetic ions. Radiation Protection Dosimetry 122:147–149.
   PubMed Web of Science ®Google Scholar
• Hofman-Huther H, Scholz M, Rave-Frank M, Virsik-Kopp P. 2004. Induction of reproductive cell death and chromosome aberrations in radioresistant tumour cells by carbon ions. International Journal of Radiation Biology 80:423–435.
   PubMed Web of Science ®Google Scholar
• Huang X, Kurose A, Tanaka T, Traganos F, Dai W, Darzynkiewicz Z. 2006. Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: Relationship to cell-cycle phase and apoptosis. Cytometry A 69:222–229.
   PubMedGoogle Scholar
• Huang X, Okafuji M, Traganos F, Luther E, Holden E, Darzynkiewicz Z. 2004. Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry A 58:99–110.
   PubMed Web of Science ®Google Scholar
• Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G. 2004. Mechanisms of DNA double-strand break repair and chromosome aberration formation. Cytogenetic and Genome Research 104:14–20.
   PubMed Web of Science ®Google Scholar
• Ismail IH, Wadhra TI, Hammarsten O. 2007. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Research 35:e36.
   PubMed Web of Science ®Google Scholar
• Iwadate Y, Mizoe J, Osaka Y, Yamaura A, Tsujii H. 2001. High linear energy transfer carbon radiation effectively kills cultured glioma cells with either mutant or wild-type p53. International Journal of Radiation Oncology Biology Physics 50:803–808.
   PubMed Web of Science ®Google Scholar
• Jenner TJ, deLara CM, O'Neill P, Stevens DL. 1993. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation. International Journal of Radiation Biology 64:265–273.
   PubMed Web of Science ®Google Scholar
• Kataoka Y, Bindokas VP, Duggan RC, Murley JS, Grdina DJ. 2006. Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. Journal of Radiation Research 47:245–257.
   PubMed Web of Science ®Google Scholar
• Kobayashi J, Iwabuchi K, Miyagawa K, Sonoda E, Suzuki K, Takata M, Tauchi H. 2008. Current topics in DNA double-strand break repair. Journal of Radiation Research 49:93–103.
   PubMed Web of Science ®Google Scholar
• Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P. 2006. Induction and quantification of gamma-H2AX foci following low and high LET-irradiation. International Journal of Radiation Biology 82:111–118.
   PubMed Web of Science ®Google Scholar
• Lees-Miller SP, Meek K. 2003. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85:1161–1173.
   PubMed Web of Science ®Google Scholar
• Loucas BD, Cornforth MN. 2001. Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiation Research 155:660–671.
   PubMed Web of Science ®Google Scholar
• Ma Y, Lu H, Schwarz K, Lieber MR. 2005. Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model. Cell Cycle 4:1193–1200.
   PubMed Web of Science ®Google Scholar
• MacPhail SH, Banath JP, Yu TY, Chu EH, Lambur H, Olive PL. 2003a. Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. International Journal of Radiation Biology 79:351–368.
   PubMed Web of Science ®Google Scholar
• MacPhail SH, Banath JP, Yu Y, Chu E, Olive PL. 2003b. Cell cycle-dependent expression of phosphorylated histone H2AX: Reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiation Research 159:759–767.
   PubMed Web of Science ®Google Scholar
• Mladenov E, Kalev P, Anachkova B. 2009. The complexity of double-strand break ends is a factor in the repair pathway choice. Radiation Research 171:397–404.
   PubMed Web of Science ®Google Scholar
• Nakano T, Suzuki M, Abe A, Suzuki Y, Morita S, Mizoe J, Sato S, Miyamoto T, Kamada T, Kato H, Tsujii H. 1999. The phase I/II clinical study of carbon ion therapy for cancer of the uterine cervix. Cancer Journal from Scientific American 5:362–369.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O'Neill P, Terrissol M, Goodhead DT. 1999. Quantitative modelling of DNA damage using Monte Carlo track structure method. Radiation Environmental Biophysics 38:31–38.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. 2001. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiation Research 156:577–583.
   PubMed Web of Science ®Google Scholar
• Nomiya T, Tsuji H, Hirasawa N, Kato H, Kamada T, Mizoe J, Kishi H, Kamura K, Wada H, Nemoto K, Tsujii H. 2008. Carbon ion radiation therapy for primary renal cell carcinoma: Initial clinical experience. International Journal of Radiation Oncology Biology Physics 72:828–833.
   PubMedGoogle Scholar
• Ogata T, Teshima T, Kagawa K, Hishikawa Y, Takahashi Y, Kawaguchi A, Suzumoto Y, Nojima K, Furusawa Y, Matsuura N. 2005. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Research 65:113–120.
   PubMed Web of Science ®Google Scholar
• Olive PL, Banath JP. 1993. Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 125IdUrd. International Journal of Radiation Biology 64:349–358.
   PubMed Web of Science ®Google Scholar
• Oya N, Sasai K, Shibata T, Takagi T, Shibuya K, Koike S, Nojima K, Furusawa Y, Ando K, Hiraoka M. 2001. Time course of reoxygenation in experimental murine tumors after carbon-beam and X-ray irradiation. Journal of Radiation Research 42:131–141.
   PubMed Web of Science ®Google Scholar
• Prise KM, Pinto M, Newman HC, Michael BD. 2001. A review of studies of ionizing radiation-induced double-strand break clustering. Radiation Research 156:572–576.
   PubMed Web of Science ®Google Scholar
• Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. The Journal of Cell Biology 146:905–916.
   PubMed Web of Science ®Google Scholar
• Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. The Journal of Biological Chemistry 273:5858–5868.
   PubMed Web of Science ®Google Scholar
• Rothkamm K, Löbrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proceedings of the National Academy of Sciences of the USA 100:5057–5062.
   PubMed Web of Science ®Google Scholar
• Rothkamm K, Balroop S, Shekhdar J, Fernie P, Goh V. 2007. Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology 242:244–251.
   PubMed Web of Science ®Google Scholar
• Salamin YI, Harman Z, Keitel CH. 2008. Direct high-power laser acceleration of ions for medical applications. Physical Review Letters 100:155004.
   PubMed Web of Science ®Google Scholar
• Schmid TE, Dollinger G, Hauptner A, Hable V, Greubel C, Auer S, Friedl AA, Molls M, Roper B. 2009. No evidence for a different RBE between pulsed and continuous 20 MeV protons. Radiation Research 172:567–574.
   PubMed Web of Science ®Google Scholar
• Speit G, Hartmann A. 1999. The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Methods in Molecular Biology 113:203–212.
   Google Scholar
• Takahashi A, Matsumoto H, Yuki K, Yasumoto J, Kajiwara A, Aoki M, Furusawa Y, Ohnishi K, Ohnishi T. 2004. High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status. International Journal of Radiation Oncology Biology Physics 60:591–597.
   PubMed Web of Science ®Google Scholar
• Weyrather WK, Kraft G. 2004. RBE of carbon ions: Experimental data and the strategy of RBE calculation for treatment planning. Radiotherapy and Oncology 73(Suppl. 2):S161–S169.
   Web of Science ®Google Scholar
• Wyman C, Kanaar R. 2006. DNA double-strand break repair: All's well that ends well. Annual Review of Genetics 40:363–383.
   PubMed Web of Science ®Google Scholar
• Yamamoto N, Ikeda C, Yakushiji T, Nomura T, Katakura A, Shibahara T, Mizoe JE. 2007. Genetic effects of X-ray and carbon ion irradiation in head and neck carcinoma cell lines. The Bulletin of Tokyo Dental College 48:177–185.
   PubMedGoogle Scholar
• Yu T, MacPhail SH, Banath JP, Klokov D, Olive PL. 2006. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair 5:935–946.
   PubMed Web of Science ®Google Scholar