Radiation victim management and the haematologist in the future: Time to revisit therapeutic guidelines?

References

• Adams GB, Scadden DT. 2008. A niche opportunity for stem cell therapeutics. Gene Therapy 15:96–99.
   PubMed Web of Science ®Google Scholar
• Agay D, Garrigou P, Forcheron F, Grenier N, Touvard L, Chancerelle Y, Meineke V, Hérodin F, Drouet M. 2009a. Adipocyte tissue-derived stem cells to treat severe cutaneous radiation syndrome: Preliminary study in a rat model. Bone Marrow Transplantation 43 (Suppl. 1):S205.
   Google Scholar
• Agay D, Forcheron F, Scherthan H, Grenier N, Meineke V, Hérodin F, Drouet M. 2009b. Mesenchymal stem cell grafting to treat cutaneous radiation syndrome: Development of a new minipig model. Blood (ASH Annual Meeting Abstracts) 114:4574.
   Google Scholar
• Agnello D, Bigini P, Villa P, Mennini T, Cerami A, Brines ML, Ghezzi P. 2002. Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Research 952:128–134.
   PubMed Web of Science ®Google Scholar
• Aird WC. 2003. The role of the endothelim in severe sepsis and in multiple organ dysfunction syndrome. Blood 101:3765–3777.
   PubMed Web of Science ®Google Scholar
• Akashi M. Role of infection and bleeding in multiple organ involvement and failure. 2005. British Journal of Radiology (Suppl. 27):69–74.
   Google Scholar
• Araki S, Israel S, Leskov KS, Criswell TL, Beman M, Klokov DY, Sampalth L, Reinicke KE, Cataldo E, Mayo LD, Boothman DA. 2005. Clusterin proteins: Stress-inducible polypeptides with proposed functions in multiple organ dysfunction. British Journal of Radiology (Suppl. 27):106–113.
   Google Scholar
• Baranov A, Gale R, Guskova A, Piatkin E, Selidovkin G, Muravyova L, Champlin RE, Danilovna N, Yevseeva L, Petrosyan L. 1989. Bone marrow transplantation after the Chernobyl nuclear accident. New England Journal of Medicine 321:205–212.
   PubMed Web of Science ®Google Scholar
• Baranov AE, Selidovkin GD, Butturini A, Gale RP. 1994. Hematopoietic recovery after 10-Gy acute total body radiation. Blood 83:596–599.
   PubMed Web of Science ®Google Scholar
• Barton R, Cerra FB. 1989. The hypermetabolism multiple organ failure syndrome. Chest 96:1153–1160.
   PubMed Web of Science ®Google Scholar
• Bertho JM, Roy L, Souidi M, Benderitter M, Guegen Y, Lataillade JJ, Prat M, Fagot T, De Revel T, Gourmelon P. 2008. New biological indicators to evaluate and monitor radiation-induced damage: An accident case report. Radiation Research 169:543–550.
   PubMed Web of Science ®Google Scholar
• Blakely WF, Ossetrova NI, Manglapus GL, Salter CA, Levine IH, Jackson WE, Grace MB, Prasanna PGS, Sandgren DJ, Ledney GD. 2007. Amylase and blood cell-count haematological radiation-injury biomarkers in a rhesus monkey radiation model-use of multiparameter and integrated biological dosimetry. Radiation Measurement 42:1164–1170.
   Web of Science ®Google Scholar
• Bone RC. 1996. Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Annals of Internal Medicine 125:680–687.
   PubMed Web of Science ®Google Scholar
• Bussel JB, Cheng G, Saleh MN, Psaila B, Kovaleva L, Meddeb B, Kloczsko J, Hassani H, Mayer B, Stone NL, Arning M, Provan D, Jenkins JM. 2007. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. New England Journal of Medicine 357:2237–2247.
   PubMed Web of Science ®Google Scholar
• Butturini A, De Souza PC, Gale RP, Cordiero JM, Lopes DM, Neto C, Cunha CB, De Souza CE, Ho WG, Tabak DG, Burla A, The Navy Hospital Radiation Team. 1988. Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident. The Lancet 2:471–475.
   PubMed Web of Science ®Google Scholar
• Chapel A, Bertho JM, Bensidhoum M, Fouillard L, Young RG, Frick J, Demarquay C, Cuvelier F, Mathieu E, Trompier F, Dudoignon N, Germain C, Mazurier C, Aigueperse J, Borneman J, Gorin NC, Gourmelon P, Thierry D. 2003. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. The Journal of Gene Medicine 5:1028–1038.
   PubMed Web of Science ®Google Scholar
• Chaudhry MA. 2008. Biomarkers for human radiation exposure. Journal of Biomedical Science 15:557–563.
   PubMed Web of Science ®Google Scholar
• Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ. 2007. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood 109:2365–2372.
   PubMed Web of Science ®Google Scholar
• Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Péault B. 2009. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3:229–230.
   Web of Science ®Google Scholar
• Dainiak N, Waselenko JK, Armitage JO, MacVittie TJ, Farese AM. 2003. The hematologist and radiation casualties. Hematology American Society of Hematology Education Program. pp 473–496.
   Google Scholar
• Dainiak N, Ricks RC. 2005. The evolving role of haematopoietic cell transplantation in radiation injury: Potentials and limitations. British Journal of Radiology (Suppl. 27):169–174.
   Google Scholar
• Dainiak N, Berger P, Albanese J. 2007. Relevance and feasibility of multi-parameter assessment for management of mass casualties from a radiological event. Experimental Hematology 35(Suppl. 1):17–23.
   PubMedGoogle Scholar
• De Revel T, Fagot T, Malfuson JV, Souleau B, Nedellec G. 2005. Le traitement de l'aplasie médullaire radio-induite. In: De Revel T, Gourmelon P, Vidal D, Renaudeau, editors. The terrorist threat nuclear, radiological, biological, chemical – a medical approach. Montrouge: John Libbey Eurotext. pp 105–111.
   Google Scholar
• Dörr W, Heider K, Spekl K. 2005. Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF. International Journal of Radiation Biology 81:557–565.
   PubMed Web of Science ®Google Scholar
• Drouet M, Mathieu J, Grenier N, Multon E, Sotto JJ, Hérodin F. 1999. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, Flt-3 Ligand, TPO and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Stem Cells 17:273–285.
   PubMed Web of Science ®Google Scholar
• Drouet M, Mourcin F, Grenier N, Leroux V, Denis J, Mayol JF, Lataillade JJ, Hérodin F. 2004. Single administration of stem cell factor, flt-3 ligand, megakaryocyte growth and development factor and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: Long-term follow-up of hematopoïesis. Blood 103:878–885.
   PubMed Web of Science ®Google Scholar
• Drouet M, Mourcin F, Grenier N, Delaunay C, Mayol JF, Lataillade JJ, Peinnequin A, Hérodin F. 2005. Mesenchymal stem cells rescue CD34+ cells from radiation-induced apoptosis and sustain hematopoietic reconstitution after co-culture and co-grafting in lethally irradiated baboons: Is autologous stem cell therapy in nuclear accident settings hype or reality? Bone Marrow Transplantation 35:1201–1209.
   PubMed Web of Science ®Google Scholar
• Drouet M, Garrigou P, Mayol JF, Delaunay C, Peinnequin A, Hérodin F. 2008a. In vivo injection of synthetic small interfering RNA to lethally irradiated mouse as a new model to study apoptotic pathways. Blood 112 (ASH Annual Meeting Abstracts):1336.
   Google Scholar
• Drouet M, Garrigou P, Collombet JM, Grenier N, Mayol JF, Hérodin F. 2008b. Erythropoietin in combination with SCF, FLT3-ligand, TPO and IL-3 promotes survival of lethally irradiated mice: A pleiotropic cytokine to mitigate radiation-induced damages? Experimental Hematology 36 (Suppl. 1):S24.
   Google Scholar
• Drouet M, Garrigou P, Grenier N, Delaunay C, Mayol JF, Hérodin F. 2009a. Hedgehog signaling and hematopoiesis regulation: Preliminary study in myelosuppressed adult non human primate model. Blood (ASH Annual Meeting Abstracts) 114:4603.
   PubMedGoogle Scholar
• Drouet M, Mayol JF, Delaunay C, Mathieu J, Peinnequin A, Hérodin F. 2009b. In vivo injection of synthetic small interfering RNA to lethally irradiated mouse as a new model to study the systemic inflammatory response syndrome. Experimental Hematology 37(Suppl. 1):S78.
   PubMedGoogle Scholar
• Ebrahimian TG, Pouzoulet F, Squiban C, Buard V, André M, Cousin B, Goumelon P, Benderitter M, Casteilla L, Tamarat R. 2009. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arteriosclerosis, Thrombosis, and Vascular Biology 29:503–510.
   PubMed Web of Science ®Google Scholar
• Fagot T, Bottolier JF, Roy L, Samson T, Desangles F, Lataillade JJ, Bertho JM, Cailliot C, Gourmelon P, De Revel T. 2006. A pure haematological syndrome secondary to an accidental radiation exposure treated with G-CSF, Epo, and SCF. Experimental Hematology 34(Suppl. 1):76.
   Google Scholar
• Farese AM, Hunt P, Grab LB, MacVittie TJ. 1996. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. Journal of Clinical Investigation 97:2145–2151.
   PubMed Web of Science ®Google Scholar
• Fliedner TM, Friesecke I, Beyrer K, editors. 2001. Medical management of radiation accidents. Manual on the acute radiation syndrome. British Journal of Radiology.
   Google Scholar
• Fliedner TM, Dörr HD, Meineke V. 2005. Multi-organ involvement as pathogenetic principle of the radiation syndromes: A study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. British Journal of Radiology (Suppl. 27):1–8.
   PubMedGoogle Scholar
• Fliedner TM, Chao NJ, Bader JL, Boettger A, Case C Jr, Chute J, Confer DL, Ganser A, Gorin NC, Gourmelon P, Graessle DH, Krawisz R, Meineke V, Niederwieser D, Port M, Powles R, Sirohi B, Weinstock DM, Wiley A, Coleman CN. 2009. Stem cells, multiorgan failure in radiation emergency medical preparedness: A US/European consultation workshop. Stem Cells 27:1205–1211.
   PubMed Web of Science ®Google Scholar
• François S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, Saché A, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A. 2006. Local irradiation induces not only homing of human mesenchymal stem cells (huMSC) at exposed sites but promotes their widespread engraftment to multiple organs: A study of their quantitative distribution following irradiation damages. Stem Cells 24:1020–1029.
   PubMed Web of Science ®Google Scholar
• François S, Mouissedine M, Mathieu N, Semont A, Monti P, Dudoignon N, Saché A, Boutarfa A, Thierry D, Gourmelon P, Chapel A. 2007. Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model. Annals of Hematology 86:1–8.
   PubMed Web of Science ®Google Scholar
• Gando S, Nakanishi Y, Tedo I. 1995. Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: Relationship to multiple organ dysfunction syndrome. Critical Care Medicine 23:1835–1842.
   PubMed Web of Science ®Google Scholar
• Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA. 2005. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Diseases of the Colon & Rectum 48:1416–1423.
   PubMed Web of Science ®Google Scholar
• Gaugler MH. 2005. A unifying system: Does the vascular endothelium have a role to play in multi-organ failure following radiation exposure? British Journal of Radiology (Suppl. 27):100–105.
   Google Scholar
• Godin PJ, Buchman TG. 1996. Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Critical Care Medicine 24:1107–1116.
   PubMed Web of Science ®Google Scholar
• Gordon B, Lyden E, Lynch J, Tarantolo S, Pavletic ZS, Bishop M, Reed E, Kessinger A, Haire W. 2000. Central nervous system dysfunction as the first manifestation of multiple organ dysfunction in stem cell transplant patients. Bone Marrow Transplantation 25:79–83.
   PubMed Web of Science ®Google Scholar
• Gorin NC, Fliedner TM, Gourmelon P, Ganser A, Meineke V, Sirohi B, Powles R, Apperly J. 2006. Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Annals of Hematology 85:671–679.
   PubMed Web of Science ®Google Scholar
• Gourmelon P, Lebaron-Jacob L, Marquette C, Clarencon D. 2002. Radiation-induced neurovascular injuries. In: Fliedner TM, Feinendegen LE, Hopewel JW, editors. Chronic irradiation: Tolerance and failure in complex biological systems. British Journal of Radiology (Suppl. 26):210–216.
   Google Scholar
• Gourmelon P, Marquette C, Agay D, Mathieu J, Clarençon D. 2005. Involvement of the central nervous system in radiation-induced multi-organ dysfunction and/or failure. British Journal of Radiology (Suppl. 27):62–68.
   PubMedGoogle Scholar
• Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. 2001. Post-injury multiple organ failure: The role of the gut. Shock 15:1–10.
   PubMed Web of Science ®Google Scholar
• Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S. 2003. Erythropoietin is a potent physiological stimulus for endothelial progenitor mobilization. Blood 102:1340–1346.
   PubMed Web of Science ®Google Scholar
• Hérodin F, Bourin P, Mayol JF, Lataillade, Drouet M. 2003. Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma irradiation promotes survival. Blood 101:2609–2616.
   PubMed Web of Science ®Google Scholar
• Hérodin F, Drouet M. 2005. Cytokine-based treatment of accidentally irradiated victims and new approaches. Experimental Hematology 33:1071–1080.
   PubMed Web of Science ®Google Scholar
• Hérodin F, Grenier N, Drouet M. 2007. Revisiting cytokine based-treatment. Experimental Hematology 35(Suppl. 1):28–33.
   PubMedGoogle Scholar
• Hérodin F, Roy L, Vaurijoux A, Gregoire E, Martin C, Grenier N, Alonso A, Mayol JF, Drouet M. 2007. Single injection of Stem Cell Factor, Flt-3 ligand, Thrombopoietin, interleukin-3 combined with Pegylated G-CSF mitigates myelosuppression in highly irradiated nonhuman primates. Experimental Hematology 35:1172–1181.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA. 2009. The sepsis seesaw: Tilting toward immunosuppression. Nature Medicine 15:496–497.
   PubMed Web of Science ®Google Scholar
• International Atomic Energy Agency (IAEA). 1993. The radiological accident in Soreq. Vienna: IAEA.
   Google Scholar
• Jackson WL, Gallagher C, Myhand RC, Waselenko JK. 2005. Medical management of patients with multiple organ dysfunction arising from acute radiation syndrome. British Journal of Radiology (Suppl. 27):161–168.
   PubMedGoogle Scholar
• Kiel MJ, Yilmaz OH, Iwashita T, Terhorst C, Morrison SJ. 2005. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cells 121:1109–1121.
   PubMed Web of Science ®Google Scholar
• Karp JM, Leng Teo GS. 2009. Mesenchymal stem cell homing: The devil is in the details. Cell Stem Cell 4:206–216.
   PubMed Web of Science ®Google Scholar
• Kuter DJ. 2007. New thrombopoietic growth factors. Blood 109:4607–4616.
   PubMed Web of Science ®Google Scholar
• Kuter DJ, Bussel JB, Lyons RM, Pullarkat V, Gernsheimer TB, Senecal FM, Alerdort LM, George JN, Kessler CM, Sanz MA, Liebmnan HA, Slovick ST, De Wolf JT, Bourgeois E, Guthrie TH, Newland A, Wasser JS, Hamburg SI, Grande C, Lefrère F, Lichtin AE, Tarantino MD, Terebelo HR, Viallard JF, Cuevas FJ, Go RS, Henry DH, Redner RL, Rice L, Schipperus MR, Guo DM, Nichol JL. 2008. Efficacy of romiplostim in patients with chronic immune thrombopoietic purpura: A double-blind randomised controlled trial. The Lancet 371:395–403.
   PubMed Web of Science ®Google Scholar
• Lataillade JJ, Doucet C, Bey E, Carsin H, Huet C, Clairand I, Bottollier-Depois JF, Chapel A, Ernou I, Gourven M, Boutin L, Hayden A, Carcamo C, Buglova E, Joussemet M, De Revel T, Gourmelon P. 2007. New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regenerative Medicine 2:785–794.
   PubMed Web of Science ®Google Scholar
• Li XM, Hu Z, Jorgensen ML, Wingard JR, Slayton WB. 2008. Bone marrow sinusoidal endothelial cells undergo non apoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation. Experimental Hematology 36:1143–1156.
   PubMed Web of Science ®Google Scholar
• Linard C, Griffiths NM, Esposito V, Aigueperse J, Gourmelon P. 1997. Changes in gut neurotensin and modified colonic motility following whole-body irradiation in rat. International Journal of Radiation Biology 71:581–585.
   PubMed Web of Science ®Google Scholar
• Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. 2008. Keratinocyte growth factor prevents radiation damage to salivary gland by expansion of the stem/progenitor pool. Stem Cells 26:2595–2601.
   PubMed Web of Science ®Google Scholar
• Maekawa K. 2001. Overview of medical care for highly exposed victims in the Tokaimura accidents. In: Ricks RC, Berger ME, O'Hara FM editors. The medical basis for radiation-accident preparedness. The clinical care of victims. London: The Parthenon Publishing Group. pp 313–318.
   Google Scholar
• McConnell KW, Muenzer JT, Chang KC, Davis CG, McDunn JE, Coopersmith CM, Hilliard CA, Hotchkiss RS, Grigsby PW, Hunt CR. 2007. Anti-apoptotic peptides protect against radiation-induced cell death. Biochemical and Biophysical Research Communications 355:501–507.
   PubMed Web of Science ®Google Scholar
• McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS. 2009. An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochemical and Biophysical Research Communications 382:657–662.
   PubMed Web of Science ®Google Scholar
• MacVittie TJ, Monroy RL, Patchen ML, Souza LM. 1990. Therapeutic use of recombinant human G-CSF in a canine model of sublethal and lethal whole-body irradiation. International Journal of Radiation Biology 57:723–736.
   PubMed Web of Science ®Google Scholar
• Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S. 2006. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 24:1095–1103.
   PubMed Web of Science ®Google Scholar
• Monti P, Wysocki J, Van der Meeren A, Griffiths NM. 2005. The contribution of radiation-induced injury to the gastrointestinal tract in the development of multi-organ dysfunction syndrome or failure. British Journal of Radiology (Suppl. 27):89–94.
   PubMedGoogle Scholar
• Mouiseddine M, Francois S, Semont A, Saché A, Allenet B, Mathieu N, Thierry D, Chapel A. 2007. Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model. British Journal of Radiology 2007;80(Spec. No. 1):S49–S55.
   Google Scholar
• Nagayama H, Misawa K, Tanaka H, Ooi J, Iseki T, Tojo A, Tani K, Yamada Y, Kodo H, Takahashi TA, Yamashita N, Shimazaki S, Asano S. 2002. Transient haematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victims. Bone Marrow Transplantation 29:197–204.
   PubMed Web of Science ®Google Scholar
• Nathan C. 2003. Immunology: Oxygen and the inflammatory cell. Nature 422:675–676.
   PubMed Web of Science ®Google Scholar
• Neelis KJ, Dubbelman YD, Qingliang L, Thomas GR, Eaton DL, Wagemaker G. 1997a. Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitutuion, alleviates neutropenia and promotes the recovery of immature bone marrow cells. Experimental Hematology 25:1084–1093.
   PubMed Web of Science ®Google Scholar
• Neelis KJ, Hartong SC, Egeland T, Thomas GR, Eaton DL, Wagemaker G. 1997b. The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 90:2565–2573.
   PubMed Web of Science ®Google Scholar
• Ossetrova NI, Blakely WF. 2009. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. International Journal of Radiation Biology 85:837–850.
   PubMed Web of Science ®Google Scholar
• Otterson MF. 2007. Effects of radiation upon gastrointestinal motility. World Journal of Gastroenterology 13:2684–2692.
   PubMed Web of Science ®Google Scholar
• Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Kolesnick R. 2001. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293:293–297.
   PubMed Web of Science ®Google Scholar
• Parke AL, Liu PT, Parke DV. 2002. Multiple organ dysfunction syndrome. Inflammopharmacology 11:87–95.
   Google Scholar
• Powles RL, Morgenstern GR, Kay HE, McElwain TJ, Clink HM, Dady PJ, Barrett A, Jameson B, Depledge MH, Watson JG, Sloane J, Leigh M, Lumley H, Hedley, Lawler SD, Filshie J, Robinson D. 1983. Mismatched family donors for bone-marrow transplantation and treatment for acute leukaemia. The Lancet 1:612–615.
   PubMed Web of Science ®Google Scholar
• Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell IL, Chen B, Chao NJ, Chute JP. 2009. Endothelial progenitor cell infusion induces haematopoietic stem cell reconstitution in vivo. Blood 113:2104–2107.
   PubMed Web of Science ®Google Scholar
• Schuening FG, Storb R, Goehle S, Graham TC, Appelbaum FR, Hackman R, Sandmaier BM, Urdal DL. 1989. Effect of recombinant human granulocyte colony-stimulating factor on haematopoiesis of normal dogs and on haematopoietic recovery after otherwise lethal total body irradiation. Blood 74:1308–1313.
   PubMed Web of Science ®Google Scholar
• Schuening FG, Appelbaum FR, Deeg HJ, Sullivan-Pepe M, Graham TC, Hackman R, Szebo KM, Storb R. 1993. Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on haematopoietic recovery after otherwise lethal total body irradiation. Blood 81:20–26.
   PubMed Web of Science ®Google Scholar
• Schuller BW, Binns PJ, Riley KJ, Ma L, Hawthorne MF, Coderre JA. 2006. Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells. Proceedings of the National Academy of Science of the USA 103:3787–3792.
   PubMed Web of Science ®Google Scholar
• Seggewiss R, Loré K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue E, Blazar BR, Dunbar CE, Douek DC. 2007. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110:441–449.
   PubMed Web of Science ®Google Scholar
• Semont A, François S, Mouiseddine M, François A, Saché A, Frick J, Thierry D, Chapel A. 2006. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Advanced Experimental Medical Biology 585:19–30.
   PubMed Web of Science ®Google Scholar
• Singer M, DeSantis V, Vitale D, Jeffcoate W. 2004. Multiorgan failure is an adaptative, endocrine-mediated, metabolic response to overwhelming systemic inflammation. The Lancet 364:545–548.
   PubMed Web of Science ®Google Scholar
• Smolewski P, Bedner E, Du L, Hsieh TC, Wu JM, Phelps DJ, Darzynkiewicz Z. 2001. Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry. Cytometry 44:73–82.
   PubMedGoogle Scholar
• Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J. 2003. RNA interference targeting Fas protects mice from fulminant hepatitis. Nature Medicine 9:347–351.
   PubMed Web of Science ®Google Scholar
• Spielberger R, Stiff P, Bensiger W, Gentile T, Weisdorf D, Kewalramani T, Shea T, Yanovitch S, Hansen K, Noga S, McCarty J, LeMaistre CF, Sung EC, Blazard BR, Elhardt D, Chen MG, Emmanouilides C. 2004. Palifermin for oral mucositis after intensive therapy for hematologic cancers. New England Journal of Medicine 351:2590–2598.
   PubMed Web of Science ®Google Scholar
• Straume T, Amundson SA, Blakely WF, Burns FJ, Chen A, Dainiak N, Franklin S, Leary JA, Loftus DJ, Morgan WF, Pellmar TC, Stolc V, Turteltaub KW, Vaughan AT, Vijayakumar S, Wyrobek AJ. 2008. NASA radiation biomarkers workshop, 27–28 September 2007. Radiation Research 170:393–405.
   PubMedGoogle Scholar
• Taichman RS. 2005. Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 105:2631–2639.
   PubMed Web of Science ®Google Scholar
• Tarte K, Gaillard J, Lataillade JJ, Fouillard L, Becker M, Mossafa H, Tchirkov A, Rouard H, Henry C, Spinglard M, Dulong J, Monnier D, Gourmelon P, Gorin NG, Sensebe L. 2010. Clinical-grade production of human mesenchymal stromal cells: Occurrence of aneuploidy without transformation. Blood 115:1549–1553.
   PubMed Web of Science ®Google Scholar
• Tofilon P, Fike J. 2000. The radioresponse of the central nervous system: A dynamic process. Radiation Research 153:357–370.
   PubMed Web of Science ®Google Scholar
• Van der Meeren A, Vandame M, Squiban C, Gaugler MH, Mouthon MA. 2003. Inflammatory reaction and changes in expression of coagulation proteins on lung endothelial cells after total-body irradiation in mice. Radiation Research 160:637–646.
   PubMed Web of Science ®Google Scholar
• Van der Meeren A, Monti P, Vandamme M, Squiban C, Wysocki J, Griffiths N. 2005. Abdominal radiation exposure elicits inflammatory responses and abscopal effects in the lungs of mice. Radiation Research 163:144–152.
   PubMed Web of Science ®Google Scholar
• Villa P, Bigini T, Mennini D, Agnello D, Laragione A, Cagnotto B, Viviani B, Marinovich M, Cerami A, Coleman TR, Brines M, Ghezzi P. 2003. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. Journal of Experimental Medicine 198:971–975.
   PubMed Web of Science ®Google Scholar
• Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, Lowry P, Armitage JO, Dainiak N. 2004. Medical management of the acute radiation syndrome: Recommendations of the strategic national stockpile radiation working group. Annals of Internal Medicine 140:1037–1051.
   PubMed Web of Science ®Google Scholar
• Weisdorf D, Chao N, Waselenko JK, Dainiak N, Armitage JO, McNiece I, Confer D. 2006. Acute radiation injury: Contingency planning for triage, supportive care, and transplantation. Biology of Blood and Marrow Transplantation 12:672–682.
   PubMed Web of Science ®Google Scholar
• Wesche-soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. 2005. In vivo delivery of caspase-8 or fas siRNA improves the survival of septic mice. Blood 106:2295–2301.
   PubMed Web of Science ®Google Scholar
• Young RW. 1987. Acute radiation syndrome. In: Conklin JJ, Walker IW, editors. Military radiobiology. London: Academic Press. pp 165–190.
   Google Scholar