Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors

References

• Almeida A, Medina JM. 1998. A rapid method for the isolation of metabolically active mitochondria from rat neurons and astrocytes in primary culture. Brain Research Protocols 2:209–214.
   PubMedGoogle Scholar
• Azzam EI, de Toledo SM, Gooding T, Little JB. 1998. Intercellular communications is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of α-particles. Radiation Research 150:497–504.
   PubMed Web of Science ®Google Scholar
• Blanco FJ, López-Armada MJ, Maneiro E. 2004. Mitochondrial dysfunction in osteoarthritis. Mitochondrion 4:715–728.
   PubMed Web of Science ®Google Scholar
• Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annals of Biochemistry 72:248–254.
   Web of Science ®Google Scholar
• Carew JS, Huang P. 2002. Mitochondrial defects in cancer. Molecular Cancer 1:9–21.
   PubMedGoogle Scholar
• Chen S, Zhao Y, Han W, Zhao G, Zhu L, Wang J, Bao L, Jiang E, Xu A, Hei TK, Yu Z, Wu L. 2008. Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects. British Journal of Cancer 3;98(11):1839–1844.
   Web of Science ®Google Scholar
• Chinnery PF, Samuals DC, Elson J, Turnbull DM. 2002. Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism? The Lancet 360:1323–1325.
   PubMed Web of Science ®Google Scholar
• Chomyn A, Martinuzzi A, Yoneda M, Daga A, Hurko O, Johns D, Lai ST, Nonaka I, Angelini C, Attardi G. 1992. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proceedings of the National Academy of Sciences of the USA 89:4221–4225.
   PubMed Web of Science ®Google Scholar
• Chretien D, Bénit P, Chol M, Lebon S, Rotig A, Munnich A, Rustin P. 2003. Assay of mitochondrial respiratory chain complex I in human lymphocytes and cultured skin fibroblasts. Biochemical and Biophysical Research Communications 301:222–224.
   PubMed Web of Science ®Google Scholar
• DiMauro S. 2004. Mitochondrial diseases. International Journal of Biochemistry, Biophysics and Molecular Biology 1658(1–2):80–88.
   Google Scholar
• Finkel T, Hwang PM. 2009. The Krebs cycle meets the cell cycle: Mitochondria and the G1-S transition. Proceedings of the National Academy of Science of the USA 106(29):11825–11826.
   PubMed Web of Science ®Google Scholar
• Fisher CJ, Goswami PC. 2008. Mitochondria-targeted antioxidant enzyme activity regulates radioresistance in human pancreatic cancer cells. Cancer Biology and Therapy 7(8):1271–1279.
   PubMed Web of Science ®Google Scholar
• Gray MW. 1999. Evolution of organelle genomes. Current Opinions in Genetics and Development 9:678–687.
   PubMed Web of Science ®Google Scholar
• Hanna MG, Nelson IP, Morgan-Hughes JA, Harding AE. 1995. Impaired mitochondrial translation in human myoblasts harboring the mitochondrial DNA tRNA lysine 8344 A- > G (MERRF) mutation: Relationship to proportion of mutant mitochondrial DNA. Journal of Neurological Science 130(2):154–160.
   PubMed Web of Science ®Google Scholar
• Hei TK. 2006. Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect. Molecular Carcinogenesis 45:455–460.
   PubMed Web of Science ®Google Scholar
• Iyer R, Lehnert BE. 2000. Factors underlying the cell growth-related bystander responses to α particles. Cancer Research 60:1290–1298.
   PubMed Web of Science ®Google Scholar
• James A, Wei Y, Pang C, Murphy M. 1996. Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations. Biochemical Journal 318:401–407.
   PubMed Web of Science ®Google Scholar
• Jones CN, Jones CI, Graham WD, Agris PF, Spremulli LL. 2008. A disease causing point mutation in human mitochondrial tRNAMet results in tRNA misfolding leading to defects in translational ignition and elongation. Journal of Biological Chemistry 283(49):34445–34456.
   PubMed Web of Science ®Google Scholar
• Kao FT, Puck TT. 1968. Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proceedings of the National Academy of Sciences of the USA 60(4):1275–1281.
   PubMed Web of Science ®Google Scholar
• Karthikeyan G, Resnick MA. 2005. Impact of mitochondria on nuclear genome stability. DNA Repair 4:141–148.
   PubMed Web of Science ®Google Scholar
• Kim GJ, Fiskum GM, Morgan WF. 2006. A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. Cancer Research 66(21):10377–10383.
   PubMed Web of Science ®Google Scholar
• King MP, Koga Y, Davidson M, Schon EA. 1992. Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Molecular and Cellular Biology 12(2):480–490.
   PubMed Web of Science ®Google Scholar
• Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner VF, Hartmann M, Tan DJ, Martuza RL, Friedrich RE, Driever PH, Wong LJC. 2004. Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Molecular Cancer Research 2(8):433–441.
   PubMed Web of Science ®Google Scholar
• Lee CF, Liu CY, Hsieh RH, Wei YH. 2005. Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cells. Annals of the New York Academy of Sciences 1042:246–254.
   PubMed Web of Science ®Google Scholar
• Lee HC, Hsu LS, Yin PH, Lee LM, Chi CW. 2007. Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion. Mitochondrion 7:157–163.
   PubMed Web of Science ®Google Scholar
• Lesnefsky EJ, Hoppel CL. 2003. Ischemia-reperfusion injury in the aged heart: Role of mitochondria. Archives of Biochemistry and Biophysics 420:287–297.
   PubMed Web of Science ®Google Scholar
• Letellier T, Heinrich R, Malgat M, Mazat JP. 1994. The kinetic basis of the threshold effects observed in mitochondrial diseases: A systemic approach. Biochemical Journal 302:171–174.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W. 2003. Persistent oxidative stress in chromosomally unstable cells. Cancer Research 63:3107–3111.
   PubMed Web of Science ®Google Scholar
• Lorimore SA, Chrystal JA, Robinson JI, Coates PJ, Wright EG. 2008. Chromosomal instability in unirradiated Hemaopoietic cells induced by macrophage exposed in vivo to ionizing radiation. Cancer Research 68(19):8122–8126.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. 2006. The involvement of calcium and MAP kinase signaling pathways in the production of radiation induced bystander effects. Radiation Research 165:400–409.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Seymour CB, Mothersill C. 2000. Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. British Journal of Cancer 83(9):1223–1230.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Seymour CB, Mothersill C. 2002. Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: A possible mechanism for Bystander-induced genomic instability. Radiation Research 157:365–370.
   PubMed Web of Science ®Google Scholar
• Malakhova L, Bezlepkin VG, Antipova V, Ushakova T, Fomenko L, Sirota N, Gaziev AI. 2005. The increase in mitochondrial DNA copy number in tissues of gamma-irradiated mice. Cellular and Molecular Biology Letters 10(4):721–732.
   PubMed Web of Science ®Google Scholar
• Moslemi AR, Tulinius M, Holme E, Oldfors A. 1998. Threshold expression of tRNA(Lys) A8344G mutation in single muscle fibres. Neuromuscular Disorders 8:345–349.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71:421–427.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB, Joiner MC. 2002. Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiation Research 157:526–532.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour RJ, Seymour CB. 2004. Bystander effects in repair-deficient cell lines. Radiation Research 161:256–263.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Stamato TD, Perez ML, Mooney R, Cummins R, Seymour C. 2000. Involvement of energy metabolism in the production of ‘bystander effect’ by radiation. British Journal of Cancer 82:1740–1746.
   PubMed Web of Science ®Google Scholar
• Murphy JE, Nugent S, Seymour C, Mothersill C. 2005. Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells. Mutation Research 585(1–2):127–136.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little JB. 1992. Induction of sister chromatid exchanges by extremely low dose alpha particle. Cancer Research 52:6394–6396.
   PubMed Web of Science ®Google Scholar
• Narayanan PK, La Rue KE, Goodwin EH, Lehnert BE. 1999. Alpha particles induce the production of interleukin-8 by human cells. Radiation Research 152:57–63.
   PubMed Web of Science ®Google Scholar
• Nugent SM, Mothersill CE, Seymour C, McClean B, Lyng FM, Murphy JEJ. 2007. Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors. Radiation Research 168(1):134–142.
   PubMed Web of Science ®Google Scholar
• Owusu-Ansah E, Yavari A, Mandal S, Banerjee U. 2008. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nature Genetics 40(3):356–361.
   PubMed Web of Science ®Google Scholar
• Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. 2004. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. Journal of Biological Chemistry 279(18):18614–18622.
   PubMed Web of Science ®Google Scholar
• Petruzzella V, Moraes C, Sano M, Bonilla E, DiMauro S, Schon E. 1994. Extremely high levels of mutant mtDNAs co-localize with cytochrome c oxidase-negative ragged red fibres in patients harboring a point mutation at nt 3243. Human Molecular Genetics 3:449–454.
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 29(9):2003–2007.
   PubMed Web of Science ®Google Scholar
• Pirisi L, Creek KE, Doniger J, DiPaolo JA. 1998. Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9(9):1573–1579.
   Google Scholar
• Prise KM, Belyakov OV, Folkard M, Michael BD. 1998. Studies of the bystander effect in human fibroblasts using a charged particle microbeam. International Journal of Radiation Biology 74:793–798.
   PubMed Web of Science ®Google Scholar
• Prise KM, O'Sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nature Reviews Cancer 9(5):351–360.
   PubMed Web of Science ®Google Scholar
• Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T. 2003. Mitochondrial threshold effects. Biochemical Journal 370:751–762.
   PubMed Web of Science ®Google Scholar
• Savanger F, Franc B, Guyetant S, Rodien P, Reynier P, Malthiery Y. 2001. Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. Journal of Clinical Endocrinology & Metabolism 86:4920–4925.
   PubMed Web of Science ®Google Scholar
• Schon EA, Bonilla E, DiMauro S. 1997. Mitochondrial DNA mutations and pathogenesis. Journal of Bioenergetics and Biomembranes 29(2):131–149.
   PubMed Web of Science ®Google Scholar
• Seymour CB, Mothersill C. 1997. Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiation Oncology Investigations 5(3):106–110.
   PubMedGoogle Scholar
• Seymour CB, Mothersill C. 2000. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiation Research 153(5 pt 1):508–511.
   PubMed Web of Science ®Google Scholar
• Simonnet H, Alazard N, Pfeiffer K, Gallou C, Béroud C, Demont J, Bouvier R, Schägger H, Godinot C. 2002. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal carcinoma. Carcinogenesis 23(5):759–768.
   PubMed Web of Science ®Google Scholar
• Simonnet H, Demont J, Pfeiffer K, Guenaneche L, Bouvier R, Brandt U, Schagger H, Godinot C. 2003. Mitochondrial complex I is deficient in renal oncocytomas. Carcinogenesis 24(9):1461–1466.
   PubMed Web of Science ®Google Scholar
• Spodnik JH, Wozniak M, Budzko D, Teranishi MA, Karbowski M, Nishizawa Y, Usukura J, Wakabayashi T. 2002. Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Mitochondrion 2:163–179.
   PubMed Web of Science ®Google Scholar
• Taanman JW. 1999. The mitochondrial genome: Structure, transcription, translation and replication. Biochimica et Biophysica Acta 1410(2):103–123.
   PubMed Web of Science ®Google Scholar
• Tan DJ, Chang J, Liu LL, Bai RK, Wang YF, Yeh KT, Wong LJ. 2006. Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer. BMC Cancer 6:93.
   PubMed Web of Science ®Google Scholar
• Tartier L, Gilchrist S, Burdak-Rothkamm S, Folkard M, Prise KM. 2007. Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells. Cancer Research 67(12):5872–5879.
   PubMed Web of Science ®Google Scholar
• Tseng LM, Yin PH, Chi CW, Hsu CY, Wu CW, Lee LM, Wei YH, Lee HC. 2006. Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes, Chromosomes and Cancer 45(7):629–638.
   PubMed Web of Science ®Google Scholar
• Vines AM, Lyng FM, McClean B, Seymour C, Mothersill CE. 2008. Bystander signal production and response are independent processes which are cell line dependent. International Journal of Radiation Biology 84(2):83–90.
   PubMed Web of Science ®Google Scholar
• Visch HJ, Rutter GA, Koopman WJ, Koenderink JB, Verkaart S, de Groot T, Varadi A, Mitchell KJ, van den Heuvel LP, Smeitink JA, Willems PH. 2004. Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency. Journal of Biological Chemistry 279(39):40328–40336.
   PubMed Web of Science ®Google Scholar
• Wang L, Kuwahara Y, Li L, Baba T, Shin RW, Ohkubo Y, Ono K, Fukumoto M. 2007. Analysis of common deletion and a novel deletion of mitochondrial DNA induced by ionizing radiation. International Journal of Radiation Biology 83(7):433–442.
   PubMed Web of Science ®Google Scholar
• Wardell TM, Ferguson E, Chinnery PF, Borthwick GM, Taylor RW, Jackson G, Craft A, Lightowlers RN, Howell N, Turnbull DM. 2003. Changes in the human mitochondrial genome after treatment of malignant disease. Mutation Research 525:19–27.
   PubMed Web of Science ®Google Scholar
• Wright EG. 1998. Radiation-induced genomic instability in haemopoietic cells. International Journal of Radiation Biology 74(6):681–687.
   PubMed Web of Science ®Google Scholar
• Yan Q, Li X, Faye G, Guan MX. 2005. Mutations in MT02 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15S rRNA. Journal of Biological Chemistry 280(32):29151–29157.
   PubMed Web of Science ®Google Scholar
• Yu M, Zhou Y, Shi Y, Ning L, Yang Y, Wei X, Zhang N, Hao X, Niu R. 2007. Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life 59(7):450–457.
   PubMed Web of Science ®Google Scholar
• Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z, Lieberman HB, Hei TK. 2005. Mechanism of radiation induced bystander effect: Role of the cyclooxygenase-2 signaling pathway. Proceedings of the National Academy of Sciences of the USA 102(41):14641–14646.
   PubMed Web of Science ®Google Scholar
• Zhou H, Ivanov VN, Lien YC, Davidson M, Hei TK. 2008. Mitochondrial function and nuclear factor-κB-mediated signaling in radiation induced bystander effects. Cancer Research 68(7):2233–2240.
   PubMed Web of Science ®Google Scholar