182
Views
25
CrossRef citations to date
0
Altmetric
Chromosomal Radiosensitivity in Cancer Survivor Families

The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring

, , , , , , , , , & show all
Pages 986-995 | Received 15 Dec 2009, Accepted 19 May 2010, Published online: 01 Sep 2010

References

  • Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. American Journal of Human Genetics 62:1198–1211.
  • Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A. 2002. Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. British Journal of Cancer 87:1379–1385.
  • Baeyens A, Vandersickel V, Thierens H, Ridder LD, Vral A. 2005. Effects of estradiol and progesterone on the variability of the micronucleus assay. Mutation Research 578:308–316.
  • Baria K, Warren C, Roberts SA, West CM, Scott D. 2001. Chromosomal radiosensitivity as a marker of predisposition to common cancers? British Journal of Cancer 84:892–896.
  • Baria K, Warren C, Eden OB, Roberts SA, West CM, Scott D. 2002. Chromosomal radiosensitivity in young cancer patients: Possible evidence of genetic predisposition. International Journal of Radiation Biology 78:341–346.
  • Boice JD Jr, Tawn EJ, Winther JF, Donaldson SS, Green DM, Mertens AC, Mulvihill JJ, Olsen JH, Robison LL, Stovall M. 2003. Genetic effects of radiotherapy for childhood cancer. Health Physics 85:65–80.
  • Bryant PE, Gray L, Riches AC, Steel CM, Finnon P, Howe O, Kesterton I, Vral A, Curwen GB, Smart V, Tawn EJ, Whitehouse CA. 2002. The G2 chromosomal radiosensitivity assay. International Journal of Radiation Biology 78:863–866.
  • Curwen GB, Winther JF, Tawn EJ, Smart V, Whitehouse CA, Rees GS, Olsen JH, Guldberg P, Rechnitzer C, Schroder H, Bryant PE, Sheng X, Lee HS, Chakraborty R, Boice JD. 2005. G2 chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. British Journal of Cancer 93:1038–1045.
  • De Ruyck K, de Gelder V, Van Eijkeren M, Boterberg T, De Neve W, Vral A, Thierens H. 2008. Chromosomal radiosensitivity in head and neck cancer patients: Evidence for genetic predisposition? British Journal of Cancer 98:1723–1738.
  • Hemminki K, Bermejo JL. 2005. Relationships between familial risks of cancer and the effects of heritable genes and their SNP variants. Mutation Research 592:6–17.
  • Hemminki K, Forsti A, Lorenzo Bermejo J. 2005. Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events. Journal of Carcinogenesis 4:2.
  • Howe O, Daly P, Seymour C, Ormiston W, Nolan C, Mothersill C. 2005. Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: A comparison with other studies. International Journal of Radiation Biology 81:373–378.
  • Lisowska H, Lankoff A, Wieczorek A, Florek A, Kuszewski T, Gozdz S, Wojcik A. 2006. Enhanced chromosomal radiosensitivity in peripheral blood lymphocytes of larynx cancer patients. International Journal of Radiation Oncology Biology Physics 66:1245–1252.
  • Papworth R, Slevin N, Roberts SA, Scott D. 2001. Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients. British Journal of Cancer 84:776–782.
  • Riches AC, Bryant PE, Steel CM, Gleig A, Robertson AJ, Preece PE, Thompson AM. 2001. Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. British Journal of Cancer 85:1157–1161.
  • Ricoul M, Lebeau J, Sabatier L, Dutrillaux B. 1998. Increased radiation-induced chromosome breakage after progesterone addition at the G1/S-phase transition. Mutation Research 403:177–183.
  • Roberts CJ, Morgan GR, Danford N. 1997. Effect of hormones on the variation of radiosensitivity in females as measured by induction of chromosomal aberrations. Environmental Health Perspectives 105:1467–1471.
  • Roberts SA, Spreadborough AR, Bulman B, Barber JB, Evans DG, Scott D. 1999. Heritability of cellular radiosensitivity: A marker of low-penetrance predisposition genes in breast cancer? American Journal of Human Genetics 65:784–794.
  • S.A.G.E. [2009] Statistical Analysis for Genetic Epidemiology, Release 6.0.1: http://darwin.cwru.edu/.
  • Savage JRK. 1970. Sites of radiation induced chromosome exchanges. Current Topics in Radiation Research 6:129–194.
  • Schottenfeld D, Fraumeni JF Jr. 2006. Cancer epidemiology and prevention. 3rd ed. Oxford, UK: Oxford University Press.
  • Scott D, Spreadborough A, Levine E, Roberts SA. 1994. Genetic predisposition in breast cancer. Lancet 344:1444.
  • Scott D, Spreadborough AR, Jones LA, Roberts SA, Moore CJ. 1996. Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiation Research 145:3–16.
  • Scott D, Barber JB, Spreadborough AR, Burrill W, Roberts SA. 1999. Increased chromosomal radiosensitivity in breast cancer patients: A comparison of two assays. International Journal of Radiation Biology 75:1–10.
  • Scott D. 2000. Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy. Strahlentherapie Onkologie 176:229–234.
  • Scott D. 2004. Chromosomal radiosensitivity and low penetrance predisposition to cancer. Cytogenetic and Genome Research 104:365–370.
  • Smart V, Curwen GB, Whitehouse CA, Edwards A, Tawn EJ. 2003. Chromosomal radiosensitivity: A study of the chromosomal G2 assay in human blood lymphocytes indicating significant inter-individual variability. Mutation Research 528:105–110.
  • Vral A, Thierens H, Baeyens A, De Ridder L. 2002. The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionizing radiation: Limitations imposed by intraindividual variability. Radiation Research 157:472–477.
  • Vral A, Thierens H, Baeyens A, De Ridder L. 2004. Chromosomal aberrations and in vitro radiosensitivity: Intra-individual versus inter-individual variability. Toxicology Letters 149:345–352.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.