The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice

References

• Armstrong GT, Liu Q, Yasui Y, Neglia JP, Leisenring W, Robison LL, Mertens AC. 2009. Late mortality among 5-year survivors of childhood cancer: A summary from the Childhood Cancer Survivor Study. Jounal of Clinical Oncology 27:2328–2338.
   PubMed Web of Science ®Google Scholar
• Ban N, Yoshida K, Aizawa S, Wada S, Kai M. 2002. Cytogenetic analysis of radiation-induced leukemia in Trp53-deficient C3H/He mice. Radiation Research 158:69–77.
   PubMedGoogle Scholar
• Barber RC, Hardwick RJ, Shanks ME, Glen CD, Mughal SK, Voutounou M, Dubrova YE. 2009. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutation Research 664:6–12.
   PubMed Web of Science ®Google Scholar
• Camplejohn RS, Hodgson S, Carter N, Kato BS, Spector TD. 2006. Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. British Journal of Cancer 95:520–524.
   PubMed Web of Science ®Google Scholar
• Camplejohn RS, Rutherford J. 2001. p53 functional assays: Detecting p53 mutations in both the germline and in sporadic tumours. Cell Proliferation 34:1–14.
   PubMed Web of Science ®Google Scholar
• Chen CS, Squire JA, Wells PG. 2009. Reduced tumorigenesis in p53 knockout mice exposed in utero to low-dose vitamin E. Cancer 115:1563–1575.
   PubMedGoogle Scholar
• Chen CS, Wells PG. 2006. Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E. Carcinogenesis 27:1358–1368.
   PubMedGoogle Scholar
• Feng Z, Hu W, Teresky AK, Hernando E, Cordon-Cardo C, Levine AJ. 2007. Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations. Proceedings of the National Academy of Sciences of the USA 104:16633–16638.
   PubMed Web of Science ®Google Scholar
• Gondo Y, Nakamura K, Nakao K, Sasaoka T, Ito K, Kimura M, Katsuki M. 1994. Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Biochemical and Biophysical Research Communications 202:830–837.
   PubMed Web of Science ®Google Scholar
• Green DR, Kroemer G. 2009. Cytoplasmic functions of the tumour suppressor p53. Nature 458:1127–1130.
   PubMed Web of Science ®Google Scholar
• Hainaut P, Hollstein M. 2000. p53 and human cancer: The first ten thousand mutations. Advances in Cancer Research 77:81–137.
   PubMed Web of Science ®Google Scholar
• Hall EJ. 2009. Radiation biology for pediatric radiologists. Pediatric Radiology 39(Suppl. 1):S57–64.
   PubMedGoogle Scholar
• Hamasaki K, Kusunoki Y, Nakashima E, Takahashi N, Nakachi K, Nakamura N, Kodama Y. 2009. Clonally expanded T lymphocytes from atomic bomb survivors in vitro show no evidence of cytogenetic instability. Radiation Research 172:234–243.
   PubMed Web of Science ®Google Scholar
• Hamstra DA, Bhojani MS, Griffin LB, Laxman B, Ross BD, Rehemtulla A. 2006. Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Research 66:7482–7489.
   PubMedGoogle Scholar
• Haynes L, Eaton SM. 2005. The effect of age on the cognate function of CD4+ T cells. Immunological Reviews 205:220–228.
   PubMed Web of Science ®Google Scholar
• Hofman-Huther H, Peuckert H, Ritter S, Virsik-Kopp P. 2006. Chromosomal instability and delayed apoptosis in long-term T-lymphocyte cultures irradiated with carbon ions and X rays. Radiation Research 166:858–869.
   PubMed Web of Science ®Google Scholar
• Igari K, Igari Y, Okazaki R, Kato F, Ootsuyama A, Norimura T. 2006. The delayed manifestation of T-cell receptor (TCR) variants in X-irradiated mice depends on Trp53 status. Radiation Research 166:55–60.
   PubMed Web of Science ®Google Scholar
• Kusunoki Y, Hayashi T. 2008. Long-lasting alterations of the immune system by ionizing radiation exposure: Implications for disease development among atomic bomb survivors. International Journal of Radiation Biology 84:1–14.
   PubMed Web of Science ®Google Scholar
• Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C. 2008. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Journal of Immunology 181:1835–1848.
   PubMed Web of Science ®Google Scholar
• Lambert B, Holmberg K, Hackman P, Wennborg A. 1998. Radiation induced chromosomal instability in human T-lymphocytes. Mutation Research 405:161–170.
   PubMed Web of Science ®Google Scholar
• Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Vina J, Blasco MA, Serrano M. 2007. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448:375–379.
   PubMed Web of Science ®Google Scholar
• Menetrier-Caux C, Gobert M, Caux C. 2009. Differences in tumor regulatory T-cell localization and activation status impact patient outcome. Cancer Research 69:7895–7898.
   PubMed Web of Science ®Google Scholar
• Norimura T, Nomoto S, Katsuki M, Gondo Y, Kondo S. 1996. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Natute Medicine 2:577–580.
   PubMed Web of Science ®Google Scholar
• Okazaki R, Moon Y, Norimura T, Eling T. 2006. Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells. Radiation Research 165:125–130.
   PubMedGoogle Scholar
• Preston DL, Cullings H, Suyama A, Funamoto S, Nishi N, Soda M, Mabuchi K, Kodama K, Kasagi F, Shore RE. 2008. Solid cancer incidence in atomic bomb survivors exposed in utero or as young children. Journal of the National Cancer Institute 100:428–436.
   PubMedGoogle Scholar
• Preston DL, Pierce DA, Shimizu Y, Cullings HM, Fujita S, Funamoto S, Kodama K. 2004. Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiation Research 162:377–389.
   PubMed Web of Science ®Google Scholar
• Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, Mabuchi K, Kodama K. 2007. Solid cancer incidence in atomic bomb survivors: 1958–1998. Radiation Research 168:1–64.
   PubMed Web of Science ®Google Scholar
• Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. 2003. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950–1997. Radiation Research 160:381–407.
   PubMed Web of Science ®Google Scholar
• Salomaa S, Holmberg K, Lindholm C, Mustonen R, Tekkel M, Veidebaum T, Lambert B. 1998. Chromosomal instability in in vivo radiation exposed subjects. International Journal of Radiation Biology 74:771–779.
   PubMed Web of Science ®Google Scholar
• Sunabori T, Tokunaga A, Nagai T, Sawamoto K, Okabe M, Miyawaki A, Matsuzaki Y, Miyata T, Okano H. 2008. Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors. J Cell Sci 121:1204–1212.
   PubMed Web of Science ®Google Scholar
• Takizawa M, Chiba J, Haga S, Asano T, Yamazaki T, Yamamoto N, Honda M. 2006. Novel two-parameter flow cytometry (MIL4/SSC followed by MIL4/CT7) allows for identification of five fractions of guinea pig leukocytes in peripheral blood and lymphoid organs. Journal of Immunological Methods 311:47–56.
   PubMedGoogle Scholar
• Tawn EJ, Whitehouse CA, Winther JF, Curwen GB, Rees GS, Stovall M, Olsen JH, Guldberg P, Rechnitzer C, Schroder H, Boice JD Jr. 2005. Chromosome analysis in childhood cancer survivors and their offspring – no evidence for radiotherapy-induced persistent genomic instability. Mutation Research 583:198–206.
   PubMedGoogle Scholar
• Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415:45–53.
   PubMed Web of Science ®Google Scholar
• Whitehouse CA, Tawn EJ. 2001. No evidence for chromosomal instability in radiation workers with in vivo exposure to plutonium. Radiation Research 156:467–475.
   PubMed Web of Science ®Google Scholar
• Woodland DL, Blackman MA. 2006. Immunity and age: Living in the past? Trends in Immunology 27:303–307.
   PubMed Web of Science ®Google Scholar
• Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. Journal of Experimental Medicine 205:711–723.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Hirabayashi Y, Wada S, Watanabe F, Watanabe K, Aizawa S, Inoue T. 2007. p53 (TRP53) deficiency-mediated antiapoptosis escape after 5 Gy X irradiation still induces stem cell leukemia in C3H/He mice: Comparison between whole-body assay and bone marrow transplantation (BMT) assay. Radiation Research 167:703–710.
   PubMedGoogle Scholar
• Zou W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nature Reviews Immunology 6:295–307.
   PubMed Web of Science ®Google Scholar