Gene expression following ionising radiation: Identification of biomarkers for dose estimation and prediction of individual response

References

• Amundson SA, Do KT, Fornace AJ Jr. 1999. Induction of stress genes by low doses of gamma rays. Radiation Research 152:225–231.
   PubMed Web of Science ®Google Scholar
• Amundson SA, Fornace AJ Jr. 2003. Monitoring human radiation exposure by gene expression profiling: Possibilities and pitfalls. Health Physics 85:36–42.
   PubMed Web of Science ®Google Scholar
• Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM, Fornace AJ Jr. 2003. Differential responses of stress genes to low dose-rate gamma irradiation. Molecular Cancer Research 6:445–452.
   Google Scholar
• Amundson SA, Grace MB, McLeland CB, Epperly MW, Yeager A, Zhan Q, Greenberger JS, Fornace AJ Jr. 2004. Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Research 64:6368–6371.
   PubMed Web of Science ®Google Scholar
• Badie C, Dziwura S, Raffy C, Tsigani T, Alsbeih G, Moody J, Finnon P, Levine E, Scott D, Bouffler S. 2008. Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment. British Journal of Cancer 98:1845–1851.
   PubMed Web of Science ®Google Scholar
• Baker DJ, Jin F, Jeganathan KB, van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16:475–486.
   PubMed Web of Science ®Google Scholar
• Blakely WF, Miller AC, Grace MB, McLeland CB, Luo L, Muderhwa JM, Miner VL, Prasanna PG. 2003. Radiation biodosimetry: Applications for spaceflight. Advanced Space Research 31:1487–1493.
   PubMed Web of Science ®Google Scholar
• Blakely WF, Salter CA, Prasanna PG, 2005. Early-response biological dosimetry – recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Physics 9:494–504.
   Google Scholar
• Brengues M, Paap B, Bittner M, Amundson S, Seligmann B, Korn R, Lenigk R, Zenhausern F. 2010. Biodosimetry on small blood volume using gene expression assay. Health Physics F8:179–185.
   Google Scholar
• Budanov AV, Karin M. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451–460.
   PubMed Web of Science ®Google Scholar
• Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. 2006. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nature Genetics 8:1043–1048.
   Google Scholar
• Chaudhry MA. 2008. Biomarkers for human radiation exposure. Journal of Biomedical Science Sep;15(5):557–563.
   PubMed Web of Science ®Google Scholar
• Cheung VG, Ewens WJ. 2006. Heterozygous carriers of Nijmegen Breakage Syndrome have a distinct gene expression phenotype. Genome Research 8:973–979.
   Google Scholar
• Correa CR, Cheung VG. 2004. Genetic variation in radiation-induced expression phenotypes. American Journal of Human Genetics 5:885–890.
   Google Scholar
• Ding LH, Shingyoji M, Chen F, Chatterjee A, Kasai KE, Chen DJ. 2005. Gene expression changes in normal human skin fibroblasts induced by HZE-particle radiation. Radiation Research 4:523–526.
   Google Scholar
• Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. 2007. Gene expression signatures that predict radiation exposure in mice and humans. PLoS Medicine 4:e106.
   PubMed Web of Science ®Google Scholar
• Fan F, Jin S, Amundson SA, Tong T, Fan W, Zhao H, Zhu X, Mazzacurati L, Li X, Petrik KL, Fornace AJJr, Rajasekaran B, Zhan Q. 2001. ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21:7488–7496.
   Google Scholar
• Finnon P, Robertson N, Dziwura S, Raffy C, Zhang W, Ainsbury L, Kaprio J, Badie C, Bouffler S. 2008. Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation. Human Genetics J3:485–493.
   Google Scholar
• Franco N, Lamartine J, Frouin V, Le Minter P, Petat C, Leplat JJ, Libert F, Gidrol X, Martin MT. 2005. Low-dose exposure to gamma rays induces specific gene regulations in normal human keratinocytes. Radiation Research. 3:623–635.
   Google Scholar
• Fry RC, Svensson JP, Valiathan C, Wang E, Hogan BJ, Bhattacharya S, Bugni JM, Whittaker CA, Samson LD. 2008. Genomic predictors of interindividual differences in response to DNA damaging agents. Genes Development 22:2621–2626.
   PubMedGoogle Scholar
• Garty G, Chen Y, Salerno A, Turner H, Zhang J, Lyulko O, Bertucci A, Xu Y, Wang H, Simaan N, Randers-Pehrson G, Yao YL, Amundson SA, Brenner DJ. 2010. The RABIT: A rapid automated biodosimetry tool for radiological triage. Health Physics 8:209–217.
   Google Scholar
• Geiss GK, Bumgarner RE, Birditt B, Dahl T, Dowidar N, Dunaway DL, Fell HP, Ferree S, George RD, Grogan T, James JJ, Maysuria M, Mitton JD, Oliveri P, Osborn JL, Peng T, Ratcliffe AL, Webster PJ, Davidson EH, Hood L, Dimitrov K. 2008. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nature Biotechnology 3:317–325.
   Google Scholar
• Grace MB, McLeland CB, Blakely WF. 2002. Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry. International Journal of Radiation Biology 8:1011–1021.
   Google Scholar
• Grace MB, McLeland CB, Gagliardi SJ, Smith JM, Jackson WE 3rd, Blakely WF. 2003. Development and assessment of a quantitative reverse transcription-PCR assay for simultaneous measurement of four amplicons. Clinical Chemistry. 49:1467–1475.
   PubMed Web of Science ®Google Scholar
• Gruel G, Lucchesi C, Pawlik A, Frouin V, Alibert O, Kortulewski T, Zarour A, Jacquelin B, Gidrol X, Tronik-Le Roux D. 2006. Novel microarray-based method for estimating exposure to ionizing radiation. Radiation Research. 166:746–756.
   PubMed Web of Science ®Google Scholar
• Gruel G, Voisin P, Vaurijoux A, Roch-Lefevre S, Grégoire E, Maltere P, Petat C, Gidrol X, Voisin P, Roy L. 2008. Broad modulation of gene expression in CD4+ lymphocyte subpopulations in response to low doses of ionizing radiation. Radiation Research 170:335–344.
   PubMed Web of Science ®Google Scholar
• International Atomic Energy Agency (IAEA). 2001. Cytogenetic analysis for radiation dose assessment: A manual. Technical reports Series No. 405, Vienna: IAEA. Available from the website: http://www-pub.iaea.org/MTCD/publications/…/TRS405_scr.pdf
   Google Scholar
• Jen KY, Cheung VG. Transcriptional response of lymphoblastoid cells to ionizing radiation. 2003 Genome Research 132092–132100.
   Google Scholar
• Jen KY, Cheung VG. 2005. Identification of novel p53 target genes in ionizing radiation response. Cancer Research 65:7666–7673.
   PubMedGoogle Scholar
• Kang CM, Park KP, Song JE, Jeoung DI, Cho CK, Kim TH, Bae S, Lee SJ, Lee YS. 2003. Possible biomarkers for ionizing radiation exposure in human peripheral blood lymphocytes. Radiation Research 159:312–319.
   PubMed Web of Science ®Google Scholar
• Li C, Lin M, Liu J. 2004. Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis. Oncogene 23:9336–9347.
   Google Scholar
• Lindholm C, Stricklin D, Jaworska A, Koivistoinen A, Paile W, Arvidsson E, Deperas-Standylo J, Wojcik A. 2010. Premature chromosome condensation (PCC) assay for dose assessment in mass casualty accidents. Radiation Research 173:71–78.
   PubMed Web of Science ®Google Scholar
• Mackay A, Tamber N, Fenwick K, Iravani M, Grigoriadis A, Dexter T, Lord CJ, Reis-Filho JS, Ashworth A. 2009. A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines. Breast Cancer Research Treatment 118:481–498.
   PubMedGoogle Scholar
• Marchetti F, Venkatachalam S. 2010. The multiple roles of Bub1 in chromosome segregation during mitosis and meiosis. Cell Cycle 9:58–63.
   PubMed Web of Science ®Google Scholar
• Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP. 2008. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One 3:e1912.
   PubMed Web of Science ®Google Scholar
• Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. 2001. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409:355–359.
   PubMed Web of Science ®Google Scholar
• O'Donovan MP, Freemantle MR, Hull G, Bell DA, Arlett CF, Cole J. 1995. Extended-term cultures of human T-lymphocytes: A practical alternative to primary human lymphocytes for use in genotoxicity testing. Mutagenesis 10:189–201.
   PubMed Web of Science ®Google Scholar
• Ossetrova NI, Blakely WF. 2009. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. International Journal of Radiation Biology 85:837–850.
   PubMed Web of Science ®Google Scholar
• Paul S, Amundson SA. 2008. Development of gene expression signatures for practical radiation biodosimetry. International Journal of Radiation Oncology Biology Physics 71:1236–1244.
   PubMed Web of Science ®Google Scholar
• Pawlik A, Delmar P, Bosse S, Sainz L, Petat C, Pietu G, Thierry D, Tronik-Le Roux D. 2009. Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response. International Journal of Radiation Biology 85:656–671.
   PubMed Web of Science ®Google Scholar
• Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ. 2009. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. Journal of Clinical Investigation 119:1714–1726.
   PubMed Web of Science ®Google Scholar
• Petrik KL, Fornace AJ Jr, Rajasekaran B, Zhan Q. 2002. ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21:7488–7496.
   PubMedGoogle Scholar
• Smirnov DA, Cheung VG. 2008. ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs. American Journal of Human Genetics 83:243–253.
   PubMed Web of Science ®Google Scholar
• Stassen T, Port M, Nuyken I, Abend M. 2003. Radiation-induced gene expression in MCF-7 cells. International Journal of Radiation Biology 79:319–331.
   PubMed Web of Science ®Google Scholar
• Stoimenov I, Helleday T. 2009. PCNA on the crossroad of cancer. Biochemical Society Transactions 37:605–613.
   PubMed Web of Science ®Google Scholar
• Tusher VG, Tibshirani R, Chu G. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the USA 985116–985121.
   Google Scholar
• Watts JA, Morley M, Burdick JT, Fiori JL, Ewens WJ, Spielman RS, Cheung VG. 2002. Gene expression phenotype in heterozygous carriers of Ataxia telangiectasia. American Journal of Human Genetics 71:791–800.
   PubMedGoogle Scholar
• Willems P, August L, Slabbert J, Romm H, Oestreicher U, Thierens H, Vral A. 2010. Automated micronucleus (MN) scoring for population triage in case of large scale radiation events. International Journal of Radiation Biology 6:2–11.
   Google Scholar
• Wojcik A, Lloyd D, Romm H, Roy L. 2010. Biological dosimetry for triage of casualties in a large-scale radiological emergency:capacity of the EU member states. Radiation Protection Dosimetry 138:397–401.
   PubMed Web of Science ®Google Scholar
• Woloschak GE, Chang-Liu CM. 1995. Modulation of expression of genes encoding nuclear proteins following exposure to JANUS neutrons or gamma-rays. Cancer Letters 97:169–175.
   PubMed Web of Science ®Google Scholar