Bleomycin, neocarzinostatin and ionising radiation-induced bystander effects in normal diploid human lung fibroblasts, bone marrow mesenchymal stem cells, lung adenocarcinoma cells and peripheral blood lymphocytes

References

• Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S. 2010. Mesenchymal stem cell therapy for cutaneous radiation syndrome. Health Physics 98:858–862.
   PubMed Web of Science ®Google Scholar
• Alexandre J, Hu Y, Lu W, Pelicano H, Huang P. 2007. Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species. Cancer Research 67:3512–3517.
   PubMed Web of Science ®Google Scholar
• Asakura H, Hori M, Umezawa H. 1975. Characterization of bleomycin action on DNA. Journal of Antibiotics 28:537–542.
   PubMed Web of Science ®Google Scholar
• Ashby J, Tinwell H. 2001. Continuing ability of the rodent one marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals. Mutation Research 478:211–213.
   PubMed Web of Science ®Google Scholar
• Asur RS, Thomas RA, Tucker JD. 2009. Chemical induction in the bystander effect in normal human lymphoblastoid cells. Mutation Research 676:11–16.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Gooding T, Little JB. 1998. Intracellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low influence of alpha particles. Radiation Research 150:497–504.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Gooding T, Little JB. 2001. Direct involvement of gap junction mediated intracellular communications in the transmission of damage signals from alpha particle irradiated to non-irradiated cells. Proceedings of the National Academy of Sciences of the USA 98:473–478.
   PubMed Web of Science ®Google Scholar
• Bagdonas S, Dahle J, Kaalhus O, Moan J. 1999. Cooperative inactivation of cells in microcolonies treated with UVA radiation. Radiation Research 152:174–179.
   PubMed Web of Science ®Google Scholar
• Belyakov OV, Folkard M, Carmel M, Kevin MP, Michael BD. 2006. Bystander-induced differentiation: A major response to targeted irradiation of a urothelial explant model. Mutation Research 597:43–49.
   PubMed Web of Science ®Google Scholar
• Belyakov OV, Malcolmson AM, Folkard M, Prise KM, Michael BD. 2001. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. British Journal of Cancer 84:674–679.
   PubMed Web of Science ®Google Scholar
• Bishayee A, Rao DV, Howell RW. 1999. Evidence for pronounced bystander effects caused by non uniform distributions of radioactivity using a novel three dimensional tissue culture model. Radiation Research 152:88–97.
   PubMed Web of Science ®Google Scholar
• Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA. 2010. DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutation Research 683:1–8.
   PubMed Web of Science ®Google Scholar
• Dahle J. Bagdonas S, Kaalhus O, Olsen G, Steen HB, Moan J. 2000. The bystander effect in photodynamic inactivation of cells. Biochimca Biophysica Acta 1475:273–280.
   PubMed Web of Science ®Google Scholar
• DeVeaux LC, Durtschi LS, Case JG, Wells DP. 2006. Bystander effects in unicellular organisms. Mutation Research 597:78–86.
   PubMed Web of Science ®Google Scholar
• Ermakov AV, Kon'kova MS, Kostiuk SV, Smirnova TD, Kameneva LV, Veiko RV, Kubasova IIu, Liubchenko LN, Veiko NN. 2010. Bystander effect development in human mesenchymal stem cells after exposure to adaptive dose of X-radiation. Radiation Biology Radioecology 50:42–51.
   PubMedGoogle Scholar
• Fenech M, Chang WP, Kirsch-volders M, Holland N, Bonassi S, Zeiger E. 2003. HUMN project: Detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutation Research 534:65–75.
   PubMed Web of Science ®Google Scholar
• Fenech M, Morley AA. 1985. Measurement of micronuclei in lymphocytes. Mutation Research 147:29–36.
   PubMed Web of Science ®Google Scholar
• Gaugler MH, Neunlist M, Bonnaud S, Aubert P, Benderitter M, Paris F. 2007. Intestinal epithelial cell dysfunction is mediated by an endothelial-specific radiation-induced bystander effect. Radiation Research 167:185–193.
   PubMed Web of Science ®Google Scholar
• Gerashchenko BI, Howell RW. 2003. Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with γ-rays. Cytometry 56A:71–80.
   Google Scholar
• Grifalconi M, Celotti L, Mognato M. 2007. Bystander response in human lymphoblastoid TK6 cells. Mutation Research 625:102–111.
   PubMed Web of Science ®Google Scholar
• Groesser T, Cooper B, Rydberg B. 2008. Lack of bystander effects from high-let radiation for early cytogenetic end points. Radiation Research 170:794–802.
   PubMed Web of Science ®Google Scholar
• Hagelstrom RT, Askin KF, Williams AJ, Ramaiah L, Desaintes C, Goodwin EH, Ullrich RL, Bailey SM. 2008. DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals. Oncogene 27:6761–6769.
   PubMed Web of Science ®Google Scholar
• Hall EJ, Hei TK. 2003. Genomic instability induced by high-LET radiation. Oncogene 22:7034–7042.
   PubMed Web of Science ®Google Scholar
• Hall EJ. 2006. Intensity-modulated radiation therapy, protons, and the risk of second cancers. International Journal of Radiation Oncology Biology Physics 65:1–7.
   PubMed Web of Science ®Google Scholar
• Huang L, Kim PM, Nickloff JA, Morgan WF. 2007. Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells. Cancer Research 67:1099–1104.
   PubMed Web of Science ®Google Scholar
• Lee TK, O'Brien KF, Naves JL, Christie KI, Arastu HH, Eaves GS, Wiley AL Jr, Karlsson UL, Salehpour MR. 2000. Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy. Mutation Research 469:63–70.
   PubMed Web of Science ®Google Scholar
• Lorimore SA, Kadhim MA, Pocock DA, Papworth D, Stevens DL, Goodhead DT, Wright G. 1998. Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation. Proceedings of the National Academy of Sciences of the USA 95:5730–5733.
   PubMed Web of Science ®Google Scholar
• Mahdadi R, Kenani A, Pommery N, Pommery J, Henichart JP, Lhermitte M. 1991. High performance liquid chromatography assay of bleomycin in human plasma and rat hepatocytes in culture. Cancer Chemotherapy Pharmacology 28(1):22–26.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2003. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiation Research 159:581–96.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71:421–427.
   PubMed Web of Science ®Google Scholar
• Müller WU, Rode A. 2002. The micronucleus assay in human lymphocytes after high radiation doses (5–15 Gy). Mutation Research 502:47–51.
   PubMed Web of Science ®Google Scholar
• Nagar S, Smith LE, Morgan WF. 2003. Characterization of a novel epigenetic effect of ionizing radiation: The death-inducing effect. Cancer Research 63:324–328.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little JB. 1999. Unexpected sensitivity to the induction of mutations by very low doses of alpha particle radiation: Evidence for a bystander effect. Radiation Research 152:552–557.
   PubMed Web of Science ®Google Scholar
• Napier MA, Holmquist B, Strydom DJ, Goldberg IH. 1981. Neocarzinostatin chromophore: Purification of the major active form and characterization of its spectral and biological properties. Biochemistry 20:5602–5608.
   PubMed Web of Science ®Google Scholar
• Ponnaiya B, Jenkins-Baker G, Biglew A, Marino S, Geard CR. 2004. Detection of chromosomal instability in alpha irradiated and bystander human fibroblasts. Mutation Research 568:41–48.
   PubMed Web of Science ®Google Scholar
• Porvirk LF. 1996. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes. Mutation Research 355:71–89.
   PubMed Web of Science ®Google Scholar
• Prise KM, O'Sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nature Reviews 9:351–360.
   Web of Science ®Google Scholar
• Rzeszowska-Wolny J, Przybyszewski WM, Widel M. 2009. Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy. European Journal of Pharmacology 625:156–164.
   PubMed Web of Science ®Google Scholar
• Schmid E, Roos H. 2009. Influence of the bystander phenomenon on the chromosome aberration pattern in human lymphocytes induced by in vitro α-particle exposure. Radiation and Environmental Biophysics 48:181–187.
   PubMed Web of Science ®Google Scholar
• Schollnberger H, Mitchel RE, Redpath JL, Crawford-Brown DJ, Hofmann W. 2007. Detrimental and protective bystander effects: A model approach. Radiation Research 168:614–626.
   PubMed Web of Science ®Google Scholar
• Shao C, Folkard M, Michael BD, Prise KM. 2005. Bystander signaling between glioma cells and fibroblasts targeted with counted particles. International Journal of Cancer 116:45–51.
   PubMed Web of Science ®Google Scholar
• Shao C, Folkard M, Michael BD, Prise KM. 2004. Targeted cytoplasmic irradiation induces bystander responses. Proceedings of the National Academy of Sciences of the USA 101:13495–13500.
   PubMed Web of Science ®Google Scholar
• Smilenov LB, Hall EJ, Bonner WM, Sedelnikova OA. 2006. A microbeam study of DNA double strand breaks in bystander primary human fibroblasts. Radiation Protection Dosimetry 122:256–259.
   PubMed Web of Science ®Google Scholar
• Sokolov MV, Smilenov LB, Hall EJ, Panyutin IG, Bonner WM, Sedelnikova OA. 2005. Ionizing radiation induces DNA double strand breaks in bystander primary lung fibroblasts. Oncogene 24:7257–7265.
   PubMed Web of Science ®Google Scholar
• Sowa MB, Goetz W, Baulch JE, Pyles DN, Dziegielewski J, Yovino S, Snyder AR, de Toledo SM, Azzam EI, Morgan WF. 2010. Lack of evidence for low let radiation induced bystander response in normal human fibroblasts and colon carcinoma cells. International Journal of Radiation Biology 86:102–113.
   PubMed Web of Science ®Google Scholar
• Swant SG, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ. 2001. The bystander effect in radiation oncogenesis; Transformation in C3HT1/2 cells in vitro can be initiated in the un-irradiated neighbors of irradiated cells. Radiation Research 156:251–258.
   PubMedGoogle Scholar
• Ward JF. 1988. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation and reparability. Progress in Nucleic Acid Research and Molecular Biology 35:95–125.
   PubMed Web of Science ®Google Scholar