Mitigation of radiation-induced lung injury by genistein and EUK-207

References

• Abou-Seif MA, El-Naggar MM, El-Far M, Ramadan M, Salah N. 2003. Amelioration of radiation-induced oxidative stress and biochemical alteration by SOD model compounds in pre-treated gamma-irradiated rats. Clinica Chimica Acta 337:23–33.
   PubMed Web of Science ®Google Scholar
• Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinases. The Journal of Biological Chemistry 262:5592–5595.
   PubMed Web of Science ®Google Scholar
• Anscher MS, Thrasher B, Zgonjanin L, Rabbani ZN, Corbley MJ, Fu K, Sun L, Lee WC, Ling LE, Vujaskovic Z. 2008. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. International Journal of Radiation Oncology Biology Physics 71:829–837.
   PubMed Web of Science ®Google Scholar
• Baxa DM, Yoshimura FK. 2003. Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha. Biochemical Pharmacology 66:1009–1018.
   PubMed Web of Science ®Google Scholar
• Bristow RG, Hill RP. 1990. Comparison between in vitro radiosensitivity and in vivo Radioresponse of murine tumor cell lines. II. International Journal of Radiation Oncology Biology Physics 18:331–345.
   PubMed Web of Science ®Google Scholar
• Calveley VL, Jelveh S, Langan A, Mahmood J, Yeung IW, Van Dyk J, Hill RP. 2010 Genistein can mitigate the effect of radiation on rat lung tissue. Radiation Research 173:602–611.
   PubMed Web of Science ®Google Scholar
• Calveley VL, Khan MA, Yeung IW, Vandyk J, Hill RP. 2005. Partial volume rat lung irradiation: Temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. International Journal of Radiation Biology 81:887–899.
   PubMed Web of Science ®Google Scholar
• Choi C, Cho H, Park J, Cho C, Song Y. 2003. Suppressive effects of genistein on oxidative stress and NFkappaB activation in RAW 264.7 macrophages. Bioscience Biotechnology and Biochemistry 67:1916–1922.
   PubMed Web of Science ®Google Scholar
• Clausen A, Doctrow S, Baudry M. 2010 Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. Neurobiology of Aging 31:425–433.
   PubMed Web of Science ®Google Scholar
• Coldham NG, Zhang AQ, Key P, Sauer MJ. 2002. Absolute bioavailability of (14C) genistein in the rat; plasma pharmacokinetics of parent compound, genistein glucuronide and total radioactivity. European Journal of Drug Metabolism and Pharmacokinetics 27:249–258.
   PubMed Web of Science ®Google Scholar
• Down JD, Yanch JC. 2010. Identifying the high radiosensitivity of the lungs of C57L mice in a model of total-body irradiation and bone marrow transplantation. Radiation Research 174:258–263.
   PubMed Web of Science ®Google Scholar
• Epperly M, Bray J, Kraeger S, Zwacka R, Engelhardt J, Travis E, Greenberger J. 1998. Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Therapy 5:196–208.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Defilippi S, Sikora C, Gretton J, Kalend A, Greenberger JS. 2000. Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation. Gene Therapy 7:1011–1018.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Kagan VE, Sikora CA, Gretton JE, Defilippi SJ, Bar-Sagi D, Greenberger JS. 2001. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. International Journal of Cancer 96:221–231.
   PubMed Web of Science ®Google Scholar
• Finkelstein JN, Johnston CJ, Baggs R, Rubin P. 1994. Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis. International Journal of Radiation Oncology Biology Physics 28:621–631.
   PubMed Web of Science ®Google Scholar
• Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, Rabbani Z, Anscher M, Vujaskovic Z. 2007. Using biological markers to predict risk of radiation injury. Seminars in Radiation Oncology 17:89–98.
   PubMed Web of Science ®Google Scholar
• Franko AJ, Sharplin J, Ward WF, Hinz JM. 1991. The genetic basis of strain-dependent differences in the early phase of radiation injury in mouse lung. Radiation Research 126:349–356.
   PubMed Web of Science ®Google Scholar
• Franko AJ, Sharplin J, Ward WF, Taylor JM. 1996. Evidence for two patterns of inheritance of sensitivity to induction of lung fibrosis in mice by radiation, one of which involves two genes. Radiation Research 146:68–74.
   PubMed Web of Science ®Google Scholar
• Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Reboucas JS, Batinic-Haberle I, Vujaskovic Z. 2010. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radical Biology and Medicine 48:1034–1043.
   PubMed Web of Science ®Google Scholar
• Ghafoori P, Marks LB, Vujaskovic Z, Kelsey CR. 2008. Radiation-induced lung injury. Assessment, management, and prevention. Oncology (Williston Park) 22:37–47; discussion 52–33.
   PubMed Web of Science ®Google Scholar
• Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M. 2009. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis. International Journal of Radiation Oncology Biology Physics 75:1528–1536.
   PubMed Web of Science ®Google Scholar
• Haston CK, Begin M, Dorion G, Cory SM. 2007. Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Research 67:10796–10803.
   PubMed Web of Science ®Google Scholar
• Haston CK, Hill RP, Newcomb CH, Van Dyk J. 1994. Radiation-induced lung damage in rats: The influence of fraction spacing on effect per fraction. International Journal of Radiation Oncology Biology Physics 28:633–640.
   PubMed Web of Science ®Google Scholar
• Haston CK, Zhou X, Gumbiner-Russo L, Irani R, Dejournett R, Gu X, Weil M, Amos CI, Travis EL. 2002. Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis. Cancer Research 62:3782–3788.
   PubMed Web of Science ®Google Scholar
• Iliakis G. 1991. The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays 13:641–648.
   PubMed Web of Science ®Google Scholar
• Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. 1996. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiation Research 145:762–767.
   PubMed Web of Science ®Google Scholar
• Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. 2004. Inflammatory cell recruitment following thoracic irradiation. Experimental Lung Research 30:369–382.
   PubMed Web of Science ®Google Scholar
• Kang JL, Lee HW, Lee HS, Pack IS, Chong Y, Castranova V, Koh Y. 2001. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine 164:2206–2212.
   PubMed Web of Science ®Google Scholar
• Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, Samulski TS, Dewhirst MW, Anscher MS, Vujaskovic Z. 2003. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International Journal of Radiation Oncology Biology Physics 57:1056–1066.
   PubMed Web of Science ®Google Scholar
• Khan MA, Hill RP, Van Dyk J. 1998. Partial volume rat lung irradiation: An evaluation of early DNA damage. International Journal of Radiation Oncology Biology Physics 40:467–476.
   PubMed Web of Science ®Google Scholar
• Khan MA, Van Dyk J, Yeung IW, Hill RP. 2003. Partial volume rat lung irradiation: Assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiotherapy and Oncology 66:95–102.
   PubMed Web of Science ®Google Scholar
• Langan AR, Khan MA, Yeung IW, Van Dyk J, Hill RP. 2006. Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiotherapy and Oncology 79:231–238.
   PubMed Web of Science ®Google Scholar
• Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M. 2003. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proceedings of the National Academy of Sciences of the USA 100:8526–8531.
   PubMed Web of Science ®Google Scholar
• Marks LB, Yu X, Vujaskovic Z, Small W Jr, Folz R, Anscher MS. 2003. Radiation-induced lung injury. Seminars in Radiation Oncology 13:333–345.
   PubMed Web of Science ®Google Scholar
• McCord JM, Fridovich I. 1969a. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). The Journal of Biological Chemistry 244:6049–6055.
   PubMed Web of Science ®Google Scholar
• McCord JM, Fridovich I. 1969b. The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. The Journal of Biological Chemistry 244:6056–6063.
   PubMed Web of Science ®Google Scholar
• Michael McClain R, Wolz E, Davidovich A, Bausch J. 2006. Genetic toxicity studies with gensitein. Food Chemistry and Toxicity 44:42–55.
   PubMed Web of Science ®Google Scholar
• Newcomb CH, Van Dyk J, Hill RP. 1993. Evaluation of isoeffect formulae for predicting radiation-induced lung damage. Radiotherapy and Oncology 26:51–63.
   PubMed Web of Science ®Google Scholar
• Olive PL. 1998. The role of DNA single- and double-strand breaks in cell killing by ionizing radiation. Radiation Research 150(5 Suppl.):S42–51.
   Web of Science ®Google Scholar
• Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP. 2009. Effects of genistein following fractionated lung irradiation in mice. Radiotherapy and Oncology 92:500–510.
   PubMed Web of Science ®Google Scholar
• Peng J, Stevenson FF, Doctrow SR, Andersen JK. 2005. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: Implications for Parkinson disease. The Journal of Biological Chemistry 280:29194–29198.
   PubMed Web of Science ®Google Scholar
• Petkau A. 1987. Role of superoxide dismutase in modification of radiation injury. British Journal of Cancer (Suppl.)8:87–95.
   PubMedGoogle Scholar
• Quinlan T, Spivack S, Mossman BT. 1994. Regulation of antioxidant enzymes in lung after oxidant injury. Environmental Health Perspectives 102(Suppl. 2):79–87.
   PubMedGoogle Scholar
• Rabbani ZN, Anscher MS, Folz RJ, Archer E, Huang H, Chen L, Golson ML, Samulski TS, Dewhirst MW, Vujaskovic Z. 2005. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BioMedCentral Cancer 5:59.
   PubMed Web of Science ®Google Scholar
• Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, Dewhirst MW, Vujaskovic Z. 2007a. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. International Journal of Radiation Oncology Biology Physics 67:573–580.
   PubMed Web of Science ®Google Scholar
• Rabbani ZN, Salahuddin FK, Yarmolenko P, Batinic-Haberle I, Thrasher BA, Gauter-Fleckenstein B, Dewhirst MW, Anscher MS, Vujaskovic Z. 2007b. Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free Radical Research 41:1273–1282.
   PubMed Web of Science ®Google Scholar
• Ritzenthaler JD, Goldstein RH, Fine A, Smith BD. 1993. Regulation of the alpha 1(I) collagen promoter via a transforming growth factor-beta activation element. The Journal of Biological Chemistry 268:13625–13631.
   PubMed Web of Science ®Google Scholar
• Robbins ME, Zhao W. 2004. Chronic oxidative stress and radiation-induced late normal tissue injury: A review. International Journal of Radiation Biology 80:251–259.
   PubMed Web of Science ®Google Scholar
• Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, et al. 1986. Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proceedings of the National Academy of Sciences of the USA 83:4167–4171.
   PubMed Web of Science ®Google Scholar
• Rong Y, Doctrow SR, Tocco G, Baudry M. 1999. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proceedings of the National Academy of Sciences of the USA 96:9897–9902.
   PubMed Web of Science ®Google Scholar
• Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, Doctrow SR. 2009. Orally available Mn porphyrins with superoxide dismutase and catalase activities. The Journal of Biological Inorganic Chemistry 14:979–991.
   PubMed Web of Science ®Google Scholar
• Rube CE, Fricke A, Wendorf J, Stutzel A, Kuhne M, Ong MF, Lipp P, Rube C. 2010. Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation. International Journal of Radiation Oncology Biology Physics 76:1206–1213.
   PubMed Web of Science ®Google Scholar
• Rube CE, Palm J, Erren M, Fleckenstein J, Konig J, Remberger K, Rube C. 2008. Cytokine plasma levels: Reliable predictors for radiation pneumonitis? PLoS One 3:e2898.
   PubMed Web of Science ®Google Scholar
• Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, Willich N, Rube C. 2000. Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation. International Journal of Radiation Oncology Biology Physics 47:1033–1042.
   PubMed Web of Science ®Google Scholar
• Rube C, Uthe D, Wilfert F, Ludwig D, Yang K, Konig J, Palm J, Schuck A, Remberger K, Rube C. 2005. The bronchiolar epithelium as a prominent source of proinflammatory cytokines after lung irradiation. International Journal of Radiation Oncology Biology Physics 61:1482–1492.
   PubMed Web of Science ®Google Scholar
• Rube CE, Wilfert F, Palm J, Konig J, Burdak-Rothkamm S, Liu L, Schuck A, Willich N, Rube C. 2004a. Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung. Strahlentherapie und Onkologie 180:442–448.
   PubMedGoogle Scholar
• Rube CE, Wilfert F, Uthe D, Konig J, Liu L, Schuck A, Willich N, Remberger K, Rube C. 2004b. Increased expression of pro-inflammatory cytokines as a cause of lung toxicity after combined treatment with gemcitabine and thoracic irradiation. Radiotherapy and Oncology 72:231–241.
   PubMed Web of Science ®Google Scholar
• Rubin P, Finkelstein J, Shapiro D. 1992. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast. International Journal of Radiation Oncology Biology Physics 24:93–101.
   PubMed Web of Science ®Google Scholar
• Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. 1995. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. International Journal of Radiation Oncology Biology Physics 33:99–109.
   PubMed Web of Science ®Google Scholar
• Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. 1997. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. Journal of Clinical Investigation 100:768–776.
   PubMed Web of Science ®Google Scholar
• Soucy NV, Parkinson HD, Sochaski MA, Borghoff SJ. 2006. Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicological Sciences 90:230–240.
   PubMed Web of Science ®Google Scholar
• Tai Y, Inoue H, Sakurai T, Yamada H, Morito M, Ide F, Mishima K, Saito I. 2009. Protective effect of lecithinized SOD on reactive oxygen species-induced xerostomia. Radiation Research 172:331–338.
   PubMed Web of Science ®Google Scholar
• Tsan MF. 1997. Superoxide dismutase and pulmonary oxygen toxicity. Proceedings of the Society for Experimental Biology and Medicine 214:107–113.
   PubMed Web of Science ®Google Scholar
• Van Eerde MR, Kampinga HH, Szabo BG, Vujaskovic Z. 2001. Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation. Radiotherapy and Oncology 58:313–316.
   PubMed Web of Science ®Google Scholar
• Van Loon B, Markkanen E, Hubscher U. 2010. Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. DNA Repair 9:604–616.
   PubMed Web of Science ®Google Scholar
• Vorotnikova E, Rosenthal RA, Tries M, Doctrow SR, Braunhut SJ. 2010. Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation. Radiation Research 173:748–759.
   PubMed Web of Science ®Google Scholar
• Wang GJ, Lapcik O, Hampl R, Uehara M, Al-Maharik N, Stumpf K, Mikola H, Wahala K, Adlercreutz H. 2000. Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 65:339–348.
   PubMed Web of Science ®Google Scholar
• Yakovlev VA, Rabender CS, Sankala H, Gauter-Fleckenstein B, Fleckenstein K, Batinic-Haberle I, Jackson I, Vujaskovic Z, Anscher MS, Mikkelsen RB, Graves PR. 2010. Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). International Journal of Radiation Oncology Biology Physics 78:547–554.
   PubMed Web of Science ®Google Scholar
• Zhang HJ, Doctrow SR, Xu L, Oberley LW, Beecher B, Morrison J, Oberley TD, Kregel KC. 2004. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. The Journal of the Federation of American Societies for Experimental Biology 18:1547–1549.
   PubMed Web of Science ®Google Scholar
• Zhao W, Robbins ME. 2009. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: Therapeutic implications. Current Medicinal Chemistry 16:130–143.
   PubMed Web of Science ®Google Scholar