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RADIATION-INDUCED SKIN FIBROSIS

Inhibition of radiation-induced skin fibrosis with imatinib

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Pages 162-170 | Received 16 Apr 2012, Accepted 02 Oct 2012, Published online: 19 Nov 2012

References

  • Abdollahi A, Li M, Ping G, Plathow C, Domhan S, Kiessling F, Lee LB, McMahon G, Grone HJ, Lipson KE. 2005. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. The Journal of Experimental Medicine 201:925–935.
  • Akhmetshina A, Venalis P, Dees C, Busch N, Zwerina J, Schett G, Distler O, Distler JH. 2009. Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis. Arthritis and Rheumatism 60:219–224.
  • Anscher MS, Thrasher B, Zgonjanin L, Rabbani ZN, Corbley MJ, Fu K, Sun L, Lee WC, Ling LE, Vujaskovic Z. 2008. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. International Journal of Radiation Oncology Biology Physics 71:829–837.
  • Bhattacharyya S, Ishida W, Wu M, Wilkes M, Mori Y, Hinchcliff M, Leof E, Varga J. 2009. A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: Selective modulation by imatinib mesylate. Oncogene 28:1285–1297.
  • Bibi Y, Gottlieb AB. 2008. A potential role for imatinib and other small molecule tyrosine kinase inhibitors in the treatment of systemic and localized sclerosis. Journal of the American Academy of Dermatology 59:654–658.
  • Bonner JC. 2004. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine & Growth Factor Reviews 15:255–273.
  • Bruna A, Darken RS, Rojo F, Ocana A, Penuelas S, Arias A, Paris R, Tortosa A, Mora J, Baselga J. 2007. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11:147–160.
  • Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT, McBride WH. 2007. Molecular mechanisms of late normal tissue injury. Seminars in Radiation Oncology 17:121–130.
  • Choudhury A, Zhao H, Jalali F, Al Rashid S, Ran J, Supiot S, Kiltie AE, Bristow RG. 2009. Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity. Molecular Cancer Therapeutics 8:203–213.
  • Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL. 2009. Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis and Rheumatism 60:584–591.
  • Classen JF, Henrohn D, Rorsman F, Lennartsson J, Lauwerys BR, Wikstrom G, Rorsman C, Lenglez S, Franck-Larsson K, Tomasi JP. 2009. Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. Arthritis and Rheumatism 60:1137–1144.
  • Czuwara-Ladykowska J, Gore EA, Shegogue DA, Smith EA, Trojanowska M. 2001. Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts. The British Journal of Dermatology 145:569–575.
  • Distler JH, Jungel A, Huber LC, Schulze-Horsel U, Zwerina J, Gay RE, Michel BA, Hauser T, Schett G, Gay S. 2007. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis and Rheumatism 56:311–322.
  • Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Deng C, Russo A, Mitchell JB. 2002. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. The American Journal of Pathology 160:1057–1068.
  • Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA. 2003. Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. The American Journal of Pathology 163:2247–2257.
  • Gabrielli A, Svegliati S, Moroncini G, Luchetti M, Tonnini C, Avvedimento EV. 2007. Stimulatory autoantibodies to the PDGF receptor: A link to fibrosis in scleroderma and a pathway for novel therapeutic targets. Autoimmunity Reviews 7:121–126.
  • Garber K. 2009. Companies waver in efforts to target transforming growth factor beta in cancer. Journal of the National Cancer Institute 101:1664–1667.
  • Herskind C, Bamberg M, Rodemann HP. 1998. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlentherapie und Onkologie 174(Suppl. 3):12–15.
  • Kay J, High WA. 2008. Imatinib mesylate treatment of nephrogenic systemic fibrosis. Arthritis and Rheumatism 58:2543–2548.
  • Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ. 2006. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nature Medicine 12:908–916.
  • Li M, Abdollahi A, Grone HJ, Lipson KE, Belka C, Huber PE. 2009. Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model. Radiation Oncology 4:66.
  • Li M, Ping G, Plathow C, Trinh T, Lipson KE, Hauser K, Krempien R, Debus J, Abdollahi A, Huber PE. 2006. Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells. BMC Cancer 6:79.
  • Liu Y, Kudo K, Abe Y, Hu DL, Kijima H, Nakane A, Ono K. 2009. Inhibition of transforming growth factor-beta, hypoxia-inducible factor-1alpha and vascular endothelial growth factor reduced late rectal injury induced by irradiation. Journal of Radiation Research (Tokyo) 50:233–239.
  • Martin M, Lefaix J, Delanian S. 2000. TGF-beta1 and radiation fibrosis: A master switch and a specific therapeutic target?International Journal of Radiation Oncology, Biology, Physics 47:277–290.
  • Maurer B, Stanczyk J, Jungel A, Akhmetshina A, Trenkmann M, Brock M, Kowal-Bielecka O, Gay RE, Michel BA, Distler JH. 2010. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis and Rheumatism 62:1733–1743.
  • Molin J, Sogaard PE, Overgaard J. 1981. Experimental studies on the radiation-modifying effect of bleomycin in malignant and normal mouse tissue in vivo. Cancer Treatment Reports 65:583–589.
  • Muller K, Meineke V. 2010. Advances in the management of localized radiation injuries. Health Physics 98:843–850.
  • Pan D, Yang J, Lu F, Xu D, Zhou L, Shi A, Cao K. 2007. Platelet-derived growth factor BB modulates PCNA protein synthesis partially through the transforming growth factor beta signalling pathway in vascular smooth muscle cells. Biochemistry and Cell Biology (Biochimie et biologie cellulaire) 85:606–615.
  • Panizzon RG, Malkinson FD, Hanson WR, Schwartz DE. 1986. A one-year comparative study of post-irradiation collagen content and microscopic fibrosis in mouse skin. British Journal of Radiology 19:54–57.
  • Panizzon RG, Hanson WR, Schwartz DE, Malkinson FD. 1988. Ionizing radiation induces early, sustained increases in collagen biosynthesis: A 48-week study in mouse skin and skin fibroblast cultures. Radiation Research 116:145–156.
  • Ranza E, Bertolotti A, Facoetti A, Mariotti L, Pasi F, Ottolenghi A, Nano R. 2009. Influence of imatinib mesylate on radiosensitivity of astrocytoma cells. Anticancer Research 29:4575–4578.
  • Rodemann HP, Bamberg M. 1995. Cellular basis of radiation-induced fibrosis. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 35:83–90.
  • Russell JS, Brady K, Burgan WE, Cerra MA, Oswald KA, Camphausen K, Tofilon PJ. 2003. Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity. Cancer Research 63:7377–7383.
  • Stone HB. 1984. Leg contracture in mice: An assay of normal tissue response. International Journal of Radiation Oncology, Biology and Physics 10:1053–1061.
  • Thomas DM, Fox J, Haston CK. 2010. Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse. International Journal of Radiation Biology 86:436–444.
  • Walsh BJ, Thornton SC, Penny R, Breit SN. 1992. Microplate reader-based quantitation of collagens. Analytical Biochemistry 203:187–190.
  • Wright EG, Coates PJ. 2006. Untargeted effects of ionizing radiation: Implications for radiation pathology. Mutation Research 597: 119–132.
  • Wynn TA. 2008. Cellular and molecular mechanisms of fibrosis. The Journal of Pathology 214:199–210.
  • Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S. 2004. Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone. The Journal of Biological Chemistry 279:15167–15176.
  • Yarnold J, Brotons MC. 2010. Pathogenetic mechanisms in radiation fibrosis. Radiotherapy and Oncology 97:149–161.
  • Yi ES, Bedoya A, Lee H, Chin E, Saunders W, Kim SJ, Danielpour D, Remick DG, Yin S, Ulich TR. 1996. Radiation-induced lung injury in vivo: Expression of transforming growth factor-beta precedes fibrosis. Inflammation 20:339–352.
  • Yoshida M, Sakuma J, Hayashi S, Abe K, Saito I, Harada S, Sakatani M, Yamamoto S, Matsumoto N, Kaneda Y. 1995. A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene. Proceedings of the National Academy of Sciences of the USA. 92:9570–9574.

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