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MODELLING RADIATION-INDUCED CELL KILLING

Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation

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Pages 782-793 | Received 02 Oct 2012, Accepted 21 Apr 2013, Published online: 26 Jun 2013

References

  • Alpen E. 1990. Radiation biophysics. Englewood Cliffs, NJ: Prentice-Hall.
  • Asaithamby A, Chen DJ. 2009. Cellular responses to DNA double-strand breaks after low-dose γ-irradiation. Nucleic Acids Research 37(12):3912–3923.
  • Astrahan M. 2008. Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation. Medical Physics 35(9):4161–4172.
  • Ballarini F. 2010. From DNA radiation damage to cell death: Theoretical approaches. Journal of Nucleic Acids 350608:1–8.
  • Barendsen GW, Koot CJ, Van Kersen GR, Bewley DK, Field SB, Parnell CJ. 1966. The effect of oxygen on impairment of the proliferative capacity of human cells in culture by ionizing radiations of different LET. International Journal of Radiation Biology 10:317–327.
  • Bohn M, Heermann DW. 2010. Diffusion-driven looping provides a consistent framework for chromatin organization. PLoS ONE 5(8):e12218, doi:10.1371/journal.pone.0012218
  • Brenner DJ. 1990. Track structure, lesion development, and cell survival. Radiation Research 124:S29–37.
  • Brenner DJ, Hlatky LR, Hahnfeldt PJ, Huang Y, Sachs RK. 1998. The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships. Radiation Research 150:83–91.
  • Calladine C, Drew H, Luisi B, Travers A. 2004. Understanding DNA, the molecule and how it works. 3rd ed. Amsterdam: Elsevier Academic Press.
  • Carlson DJ, Stewart RD, Semenenko VA. 2006. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters. Medical Physics 33:3105–3115.
  • Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. 2011. Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia. International Journal of Radiation Oncology Biology Physics 79(4):1188–1195.
  • Combs SE, Bohl J, Elsässer J, Webber KJ, Schulz-Ertner D, Debus J, Weyrather WK. 2009. Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines. International Journal of Radiation Biology 85(2):126–136.
  • Curtis SB. 1986. Lethal and potentially lethal lesions induced by radiation – a unified repair model. Radiation Research 106:252–270.
  • Durante M, Cucinotta FA. 2008. Heavy ion carcinogenesis and human space exploration. Nature reviews, Cancer 8(6):465–472.
  • Elsässer T, Weyrather WK, Friedrich T, Durante M, Iancu G, Krämer M, Kragl G, Brons S, Winter M, Weber KJ, et al. 2010. Quantification of the relative biological effectiveness for ion beam radiotherapy: Direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning. International Journal of Radiation Oncology Biology Physics 78:1177–1183.
  • Frankenberg-Schwager M. 1989. Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiotherapy and Oncology 14:307–320.
  • Freyer JP, Jarrett K, Carpenter S, Raju MR. 1991. Oxygen enhancement ratio as a function of dose and cell cycle phase for radiation-resistant and sensitive CHO cells. Radiation Research 127:297–307.
  • Friedrich T, Scholz U, Elsässer T, Durante M, Scholz M. 2012. Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern. International Journal of Radiation Biology 88:103–107.
  • Garcia L, Wilkins D, Raaphorst G. 2007. α/β ratio, a dose range dependence study. International Journal of Radiation Oncology Biology Physics 67:587–593.
  • Gauter B, Zlobinskaya O, Weber KJ. 2002. Rejoining of radiation-induced DNA double-strand breaks: Pulsed-field electrophoresis analysis of fragment size distributions after incubation for repair. Radiation Research 157(6):721–733.
  • Guerrero M, Stewart RD, Wang JZ, Li A. 2002. Equivalence of the linear-quadratic and two-lesion kinetic models. Physics Medicine and Biology 38:653–666.
  • Han A, Hill AC, Elkind M. 1980. Repair of cell killing and neoplastic transformation at reduced dose rates for 60Co γ-rays. Cancer Research 40:3328–3332.
  • Hirayama R, Furusawa Y, Fukawa T, Ando K. 2005. Repair kinetics of DNA-DSB induced by X-rays or carbon ions under oxic and hypoxic conditions. Journal of Radiation Research 46:325–332.
  • Johnston PJ, Olive PL, Bryant PE. 1997. Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Modeling the elution of DNA from nucleoids. Radiation Research 148: 561–567.
  • Nygren J, Ahnstrom G. 1997. The oxygen effect in permeabilized and histone-depleted cells: An enhanced OER for DNA double-strand breaks, compared to single-strand breaks, is abolished by soluble scavengers. International Journal of Radiation Biology 72:163–170.
  • Ostashevsky J. 1998. A polymer model for the structural organization of chromatin loops and minibands in interphase chromosomes. Molecular Biology of the Cell 9:3031–3040.
  • Prise KM, Davies S, Michael BD. 1987. The relationship between radiation-induced DNA double-strand breaks and cell kill in hamster V79 fibroblasts irradiated with 250 kVp X-rays, 2.3 MeV neutrons or 238Pu alpha-particles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 52:893–902.
  • Prise KM, Ahnstrom G, Belli M, Carlsson J, Frankenberg D, Kiefer J, et al. 1998. A review of dsb induction data for varying quality radiations. International Journal of Radiation Biology 74:173–184.
  • Prise KM, Pinto M, Newman HC, Michael BD. 2001. A review of studies of ionizing radiation-induced double-strand break clustering. Radiation Research 156:572–576.
  • Raju MR, Amols HI, Bain E, Carpenter SG, Cox RA, Robertson JB. 1978. A heavy particle comparative study. Part III: OER and RBE. The British Journal of Radiology 51:712–719.
  • Sachs RK, Hahnfeld P, Brenner DJ. 1997. Review: The link between low-LET dose- response relations and the underlying kinetics of damage production/repair/misrepair. International Journal of Radiation Biology 72:351–374.
  • Schardt D, Elsässer T, Schulz-Ertner. 2010. Heavy-ion tumor therapy: Physical and radiobiological benefits. Reviews of Modern Physics 82:383–425.
  • Schicker C, Neubeck Cv, Iancu G, Kopf U, Weyrather WK. 2007. A system for OER measurements. Radiation Biophysics 16: 370. Available from http://www-alt.gsi.de/informationen/wti/library/scientificreport2007/PAPERS/RADIATION-BIOPHYSICS-16.pdf
  • Solovjeva L, Svetlova M, Stein G, Chagin V, Rozanov Y, Zannis- Hadjopoulos M, Price G, Tomilin N. 1998. Conformation of replicated segments of chromosome fibres in human S-phase nucleus. Chromosome Research 6:595–602.
  • Spiro IJ, Ling CC, Stickler R, Gaskill J. 1985. Oxygen radiosensitisation at low dose rate. The British Journal of Radiology 58:357–363.
  • Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. 2011. Effects of radiation quality and oxygen on clustered DNA lesions and cell death. Radiation Research 176:587–602.
  • Suzuki M, Kase Y, Yamaguchi H, Kanai T, Ando K. 2000. Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams. International Journal of Radiation Oncology, Biology, Physics 48:241–250.
  • Tobias CA. 1985. The repair-misrepair model in radiobiology: Comparison to other models. Radiation Research 104(Suppl.):77–95.
  • Turkey N. 1949. Moments of random group size distributions. The Annals of Mathematical Statistics 20(4):523–529.
  • Van der Kogel A, Joiner M. 2009. Basic clinical radiobiology. 4th ed. London, UK: Hodder Arnold.
  • Wenzl T, Wilkens JJ. 2011. Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications. Radiation Oncology 6:171.
  • Yokota H, Van den Engh G, Hearst JE, Sachs RK, Trask BJ. 1995. Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus. The Journal of Cell Biology 130: 1239–1249.

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