Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells

References

• Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M, Shinkai Y. 2006. Rad54 is dispensable for the ALT pathway. Genes to Cells 11:1305–1315.
   PubMed Web of Science ®Google Scholar
• Antoccia A, Stumm M, Saar K, Ricordy R, Maraschio P, Tanzarella C. 1999. Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int J Radiat Biol 75:583–591.
   PubMed Web of Science ®Google Scholar
• Bailey SM, Goodwin EH, Cornforth MN. 2004. Strand-specific fluorescence in situ hybridization: The CO-FISH family. Cytogenetic Genome Res 107:14–17.
   PubMed Web of Science ®Google Scholar
• Berardinelli F, Antoccia A, Buonsante R, Gerardi S, Cherubini R, De Nadal V, Tanzarella C, Sgura A. 2013. The role of telomere length modulation in delayed chromosome instability induced by ionizing radiation in human primary fibroblasts. Environ Molec Mutagenesis 54:172–179.
   PubMed Web of Science ®Google Scholar
• Berardinelli F, Antoccia A, Cherubini R, De N, V, Gerardi S, Cirrone GA, Tanzarella C, Sgura A. 2010. Transient activation of the ALT pathway in human primary fibroblasts exposed to high-LET radiation. Radiat Res 174:539–549.
   PubMed Web of Science ®Google Scholar
• Berardinelli F, Nieri D, Sgura A, Tanzarella C, Antoccia A. 2012. Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells. Mutat Res 740:13–20.
   PubMed Web of Science ®Google Scholar
• Callen E, Surralles J. 2004. Telomere dysfunction in genome instability syndromes. Mutat Res 567:85–104.
   PubMed Web of Science ®Google Scholar
• Castella M, Puerto S, Creus A, Marcos R, Surralles J. 2007. Telomere length modulates human radiation sensitivity in vitro. Toxicol Lett 172:29–36.
   PubMed Web of Science ®Google Scholar
• Cornforth MN, Eberle RL. 2001. Termini of human chromosomes display elevated rates of mitotic recombination. Mutagenesis 16: 85–89.
   PubMed Web of Science ®Google Scholar
• d’Adda di Fagagna, Teo SH, Jackson SP. 2004. Functional links between telomeres and proteins of the DNA-damage response. Genes Develop 18:1781–1799.
   PubMed Web of Science ®Google Scholar
• D’Amours D, Jackson SP. 2002. The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling. Nature Rev Molec Cell Biol 3:317–327.
   PubMed Web of Science ®Google Scholar
• de Lange T. 2005. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Develop 19:2100–2110.
   PubMed Web of Science ®Google Scholar
• Deng Y, Guo X, Ferguson DO, Chang S. 2009. Multiple roles for MRE11 at uncapped telomeres. Nature 460:914–918.
   PubMed Web of Science ®Google Scholar
• Digweed M, Sperling K. 2004. Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst) 3:1207–1217.
   PubMed Web of Science ®Google Scholar
• Dunham MA, Neumann AA, Fasching CL, Reddel RR. 2000. Telomere maintenance by recombination in human cells. Nature Genet 26:447–450.
   PubMed Web of Science ®Google Scholar
• Durante M, Furusawa Y, Gotoh E. 1998. A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. Int J Radiat Biol 74:457–462.
   PubMed Web of Science ®Google Scholar
• Genesca A, Martin M, Latre L, Soler D, Pampalona J, Tusell L. 2006. Telomere dysfunction: A new player in radiation sensitivity. Bioessays 28:1172–1180.
   PubMed Web of Science ®Google Scholar
• Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA. 2006. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nature Cell Biol 8:416–424.
   PubMed Web of Science ®Google Scholar
• Goytisolo FA, Samper E, Martin-Caballero J, Finnon P, Herrera E, Flores JM, Bouffler SD, Blasco MA. 2000. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Experim Med 192:1625–1636.
   PubMed Web of Science ®Google Scholar
• Henson JD, Neumann AA, Yeager TR, Reddel RR. 2002. Alternative lengthening of telomeres in mammalian cells. Oncogene 21: 598–610.
   PubMed Web of Science ®Google Scholar
• Iijima K, Ohara M, Seki R, Tauchi H. 2008. Dancing on damaged chromatin: Functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage. J Radiat Res 49:451–464.
   PubMed Web of Science ®Google Scholar
• Kavitha CV, Choudhary B, Raghavan SC, Muniyappa K. 2010. Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. Biochem Biophys Res Commun 399:575–580.
   PubMed Web of Science ®Google Scholar
• Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. 2004. NBS1 and its functional role in the DNA damage response. DNA Repair (Amst) 3:855–861.
   PubMed Web of Science ®Google Scholar
• Lamarche BJ, Orazio NI, Weitzman MD. 2010. The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett 584:3682–3695.
   PubMed Web of Science ®Google Scholar
• Londono-Vallejo JA, Der-Sarkissian H, Cazes L, Bacchetti S, Reddel RR. 2004. Alternative lengthening of telomeres is characterized by high rates of telomeric exchange. Cancer Res 64:2324–2327.
   PubMed Web of Science ®Google Scholar
• Manti L, Durante M, Cirrone GAP, Grossi G., Lattuada M, Pugliese M, Sabini MG, Scampoli P, Valastro L, Gialanella G. 2005. Modelled microgravity does not modify the yield of chromosome aberrations induced by high-energy protons in human lymphocytes. Int J Radiat Biol 81:147–155.
   PubMed Web of Science ®Google Scholar
• Maser RS, Zinkel R, Petrini JH. 2001. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nature Genet 27:417–421.
   PubMed Web of Science ®Google Scholar
• Muntoni A, Reddel RR. 2005. The first molecular details of ALT in human tumor cells. Human Molec Genet 14(2):R191–196.
   PubMedGoogle Scholar
• Paull TT, Gellert M. 1998. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Molec Cell 1: 969–979.
   PubMed Web of Science ®Google Scholar
• Perner S, Bruderlein S, Hasel C, Waibel I, Holdenried A, Ciloglu N, Chopurian H, Nielsen KV, Plesch A, Hogel J, Moller P. 2003. Quantifying telomere lengths of human individual chromosome arms by centromere-calibrated fluorescence in situ hybridization and digital imaging. Am J Pathol 163:1751–1756.
   PubMed Web of Science ®Google Scholar
• Rai R, Zheng H, He H, Luo Y, Multani A, Carpenter PB, Chang S. 2010. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J 29:2598–2610.
   PubMed Web of Science ®Google Scholar
• Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. 2001. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Current Biol 11:962–966.
   PubMed Web of Science ®Google Scholar
• Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS. 2009. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nature Struct Molec Biol 16:819–824.
   PubMed Web of Science ®Google Scholar
• Reddel RR, Bryan TM, Colgin LM, Perrem KT, Yeager TR. 2001. Alternative lengthening of telomeres in human cells. Radiat Res 155:194–200.
   PubMed Web of Science ®Google Scholar
• Rupnik A, Lowndes NF, Grenon M. 2010. MRN and the race to the break. Chromosoma 119:115–135.
   PubMed Web of Science ®Google Scholar
• Sakamoto S, Iijima K, Mochizuki D, Nakamura K, Teshigawara K, Kobayashi J, Matsuura S, Tauchi H, Komatsu K. 2007. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions. Oncogene 26:6002–6009.
   PubMed Web of Science ®Google Scholar
• Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP. 2007. Human CtIP promotes DNA end resection. Nature 450:509–514.
   PubMed Web of Science ®Google Scholar
• Sgura A, Antoccia A, Berardinelli F, Cherubini R, Gerardi S, Zilio C, Tanzarella C. 2006. Telomere length in mammalian cells exposed to low- and high-LET radiations. Radiat Protect Dosim 122:176–179.
   PubMed Web of Science ®Google Scholar
• Slijepcevic P, Al Wahiby S. 2005. Telomere biology: Integrating chromosomal end protection with DNA damage response. Chromosoma 114:275–285.
   PubMed Web of Science ®Google Scholar
• Sonoda E, Sasaki MS, Morrison C, Yamaguchi-Iwai Y, Takata M, Takeda S. 1999. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Molec Cell Biol 19:5166–5169.
   PubMed Web of Science ®Google Scholar
• Tauchi H, Kobayashi J, Morishima K, van Gent DC, Shiraishi T, Verkaik NS, van Heems D, Ito E, Nakamura A, Sonoda E, Takata M, Takeda S, Matsuura S, Komatsu K. 2002. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 420:93–98.
   PubMed Web of Science ®Google Scholar
• Varley H, Pickett HA, Foxon JL, Reddel RR, Royle NJ. 2002. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genet 30:301–305.
   PubMed Web of Science ®Google Scholar
• Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanova E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A. 1998. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93:467–476.
   PubMed Web of Science ®Google Scholar
• Williams BR, Mirzoeva OK, Morgan WF, Lin J, Dunnick W, Petrini JH. 2002. A murine model of Nijmegen breakage syndrome. Current Biol 12:648–653.
   PubMed Web of Science ®Google Scholar
• Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P, Tainer JA. 2009. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell 139:87–99.
   PubMed Web of Science ®Google Scholar
• Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, Groocock LM, Cahill D, Hitomi C, Guenther G, Moiani D, Carney JP, Russell P, Tainer JA. 2008. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell 135:97–109.
   PubMed Web of Science ®Google Scholar
• Xie A, Kwok A, Scully R. 2009. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nature Struct Molec Biol 16:814–818.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lim CU, Williams ES, Zhou J, Zhang Q, Fox MH, Bailey SM, Liber HL. 2005. NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells. Cancer Res 65:5544–5553.
   PubMed Web of Science ®Google Scholar
• Zhu XD, Kuster B, Mann M, Petrini JH, de Lange T. 2000. Cell-cycle- regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet 25:347–352.
   PubMed Web of Science ®Google Scholar