Carcinogenic and inflammatory effects of plutonium-nitrate retention in an exposed nuclear worker and beagle dogs

References

• Abbott A. 2012. Radiation risks: Raiders of the lost archive. Nature 485(7397):162–163.
   PubMed Web of Science ®Google Scholar
• Arama E, Steller H. 2006. Detection of apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and acridine orange in Drosophila embryos and adult male gonads. Nature Protocols 1:1725–1731.
   PubMed Web of Science ®Google Scholar
• Aypar U, Morgan WF, Baulch JE. 2011. Radiation-induced epigenetic alterations after low and high LET irradiations. Mutat Res 707: 24–33.
   PubMed Web of Science ®Google Scholar
• Bair WJ, Thompson RC. 1974. Plutonium: Biomedical research. Science 183:715–722.
   PubMed Web of Science ®Google Scholar
• Bloemen K, Verstraelen S, Van Den Heuvel R, Witters H, Nelissen I, Schoeters G. 2007. The allergic cascade: Review of the most important molecules in the asthmatic lung. Immunol Lett 113:6–18.
   PubMed Web of Science ®Google Scholar
• Buttner C, Skupin A, Reimann T, Rieber EP, Unteregger G, Geyer P, Frank KH. 1997. Local production of interleukin-4 during radiation-induced pneumonitis and pulmonary fibrosis in rats: Macrophages as a prominent source of interleukin-4. Am J Resp Cell Molec Biol 17:315–325.
   PubMed Web of Science ®Google Scholar
• Dagle GE. 1992. Inhaled plutonium nitrate in dogs. PNL Annual Report.
   Google Scholar
• Dagle GE, Weller RE, Filipy RE, Watson CR, Buschbom RL. 1996. The distribution and effects of inhaled 239Pu (NO3)4 deposited in the liver of dogs. Health Phys 71:198–205.
   PubMed Web of Science ®Google Scholar
• Dauer LT, Brooks AL, Hoel DG, Morgan WF, Stram D, Tran P. 2010. Review and evaluation of updated research on the health effects associated with low-dose ionising radiation. Radiat Protect Dosimetry 140:103–136.
   PubMed Web of Science ®Google Scholar
• Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S, Schmidt-Ullrich R. 2003. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res 159:283–300.
   PubMed Web of Science ®Google Scholar
• Duport P, Jiang H, Shilnikova N, Krewski D, Zielinski J. 2012. Database of radiogenic cancer in experimental animals exposed to low doses of ionizing radiation. J Toxicol Environ Health B Crit Rev 15:186–209.
   PubMed Web of Science ®Google Scholar
• Elovic AE, Ohyama H, Sauty A, McBride J, Tsuji T, Nagai M, Weller PF, Wong DT. 1998. IL-4-dependent regulation of TGF-alpha and TGF-beta1 expression in human eosinophils. J Immunol 160:6121–6127.
   PubMed Web of Science ®Google Scholar
• Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE. 2001. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Develop 15:3249–3262.
   PubMed Web of Science ®Google Scholar
• Gilbert ES, Koshurnikova NA, Sokolnikov ME, Shilnikova NS, Preston DL, Ron E, Okatenko PV, Khokhryakov VF, Vasilenko EK, Miller S, et al. 2004. Lung cancer in Mayak workers. Radiat Res 162:505–516.
   PubMed Web of Science ®Google Scholar
• Goodwin A, Jenkins G. 2009. Role of integrin-mediated TGFβ activation in the pathogenesis of pulmonary fibrosis. Biochem Soc Transact 37:849–854.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg Robert A. 2011. Hallmarks of cancer: The next generation. Cell 144:646–674.
   PubMed Web of Science ®Google Scholar
• International Commission on Radiological Protection (ICRP). 1991. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60.
   Google Scholar
• International Commission on Radiological Protection (ICRP). 1994a. Human respiratory tract model for radiological protection. ICRP Publication 66.
   Google Scholar
• Itamochi H, Yamasaki F, Sudo T, Takahashi T, Bartholomeusz C, Das S, Terakawa N, Ueno NT. 2006. Reduction of radiation-induced apoptosis by specific expression of Bcl-2 in normal cells. Cancer Gene Ther 13:451–459.
   PubMed Web of Science ®Google Scholar
• James AC, Sasser LB, Stuit DB, Glover SE, Carbaugh EH. 2007. USTUR whole body case 0269: Demonstrating effectiveness of i.v. Ca-DTPA for Pu. Radiat Protect Dosimetry 127:449–455.
   PubMed Web of Science ®Google Scholar
• Karlsson C, Karlsson MG. 2011. Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides. J Histochem Cytochem 59:1113–1121.
   PubMed Web of Science ®Google Scholar
• Lyubchanskii ER, Kuzmenko OV, Osovets SV, Sokolova SN. 2011. Forward-looking assessment of metabolism and carcinogenicity a-emitters (234,235 U, 237Np, 239 Pu, 241Am) in the lungs and the human skeleton: synthesis of the experimental data are obtained on different biological models. Ozersk, Russia.
   Google Scholar
• National Council on Radiological Protection (NCRP). 1953. Subcommittee on permissible internal dose. Maximum permissible amounts of radioisotopes in the human body and maximum permissible concentrations in air and water. NCRP Report.
   Google Scholar
• National Research Council (NRC). 1990.Health effects of exposure to low levels of ionizing radiation: BEIR V, The National Academies Press.
   Google Scholar
• Neuberger JS, Gesell TF. 2002. Residential radon exposure and lung cancer: Risk in nonsmokers. Health Phys 83:1–18.
   PubMed Web of Science ®Google Scholar
• Nielsen CE, Wilson DA, Brooks AL, McCord SL, Dagle GE, James AC, Tolmachev SY, Thrall BD, Morgan WF. 2012. Microdistribution and long-term retention of plutonium-nitrate in the respiratory tracts of an acutely exposed plutonium worker and experimental beagle dogs. Cancer Res 72:5529–5536.
   PubMed Web of Science ®Google Scholar
• Novakova-Jiresova A, van Luijk P, van Goor H, Kampinga HH, Coppes RP. 2005. Pulmonary radiation injury: Identification of risk factors associated with regional hypersensitivity. Cancer Res 65:3568–3576.
   PubMed Web of Science ®Google Scholar
• Oghiso Y, Yamada Y, Iida H, Inaba J. 1998. Differential dose responses of pulmonary tumor types in the rat after inhalation of plutonium dioxide aerosols. Radiat Res 39:61–72.
   Web of Science ®Google Scholar
• Park JF, Watson CR, Buschbom RL, Dagle GE, Strom DJ, Weller RE. 2012. Biological effects of inhaled 239PuO2 in Beagles. Radiat Res 178:447–467.
   PubMed Web of Science ®Google Scholar
• Paunesku T, Wanzer MB, Kirillova EN, Muksinova KN, Revina VS, Lyubchansky ER, Grosche B, Birschwilks M, Vogt S, Finney L, et al. 2012. X-ray fluorescence microscopy for investigation of archival tissues. Health Phys 103:181–186.
   PubMed Web of Science ®Google Scholar
• Ramos-Vara JA, Webster JD, DuSold D, Miller MA. 2013. Immunohistochemical evaluation of the effects of paraffin section storage on biomarker stability. Veterinary Pathol Online.
   Web of Science ®Google Scholar
• Robbins MEC, Zhao W. 2004. Chronic oxidative stress and radiation-induced late normal tissue injury: A review. Int J Radiat Biol 80: 251–259.
   PubMed Web of Science ®Google Scholar
• Sanders CL, McDonald KE, Lauhala KE. 1988. Promotion of pulmonary carcinogenesis by plutonium particle aggregation following inhalation of 239PuO2. Radiat Res 116:393–405.
   PubMed Web of Science ®Google Scholar
• Schaue D, Kachikwu EL, McBride WH. 2012. Cytokines in radiobiological responses: A review. Radiat Res 178:505–523.
   PubMed Web of Science ®Google Scholar
• Spitz DR, Azzam EI, Li JJ, Gius D. 2004. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology. Cancer Metastasis Rev 23: 311–322.
   PubMed Web of Science ®Google Scholar
• Stannard JN. 1988. Radioactivity and health: A history. In: Baalman RWJ, editor. Office of Scientific and Technical Information/Pacific Northwest Laboratory.
   Google Scholar
• Swanton E, Savory P, Cosulich S, Clarke P, Woodman P. 1999. Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene 18:1781–1787.
   PubMed Web of Science ®Google Scholar
• Thompson RC. 1989. Life-span effects of ionizing radiation in the beagle dog: A summary account of four decades of research funded by the US Department of Energy and its predecessor agencies. PNL-6822; DE89014202.
   Google Scholar
• Todd P. 1981. Biological effects of ionizing radiation at low dose and low dose rate. Radiat Res 87:205–207.
   PubMed Web of Science ®Google Scholar
• Uhal BD. 2008. The role of apoptosis in pulmonary fibrosis. Eur Respirat Rev 17:138–144.
   Google Scholar
• United States Transuranium and Uranium Registries (USTUR). 2009. USTUR 0269: Pathology 2013, http://www.ustur.wsu.edu/Case_Studies/Pathology/0269_Pathology.php
   Google Scholar
• United States Transuranium and Uranium Registries (USTUR). 2011. USTUR 0385: Pathology 2013, http://www.ustur.wsu.edu/Case_Studies/Pathology/0385_Pathology.php.
   Google Scholar
• United States Transuranium and Uranium Registries (USTUR). 2012. Washington State University: College of Pharmacy <http://www.ustur.wsu.edu/index.html>
   Google Scholar
• Wilson MS, Wynn TA. 2009. Pulmonary fibrosis: Pathogenesis, etiology and regulation. Mucosal Immunol 2:103–121.
   PubMed Web of Science ®Google Scholar
• Zhao W, Diz DI, Robbins ME. 2007. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol 80:S23–31.
   PubMed Web of Science ®Google Scholar