291
Views
13
CrossRef citations to date
0
Altmetric
EFFECT OF ELF-MF ON γ-H2AX

Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines

, , &
Pages 291-298 | Received 27 Jun 2013, Accepted 21 Jan 2014, Published online: 24 Feb 2014

References

  • Ames BN. 1989. Endogenous DNA damage as related to cancer and aging. Mutat Res 214: 41–46.
  • Baum A, Mevissen M, Kamino K, Mohr U, Löscher W. 1995. A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 muT magnetic field exposure. Carcinogenesis 16:119–125.
  • Cho YH, Chung HW. 2003. The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene. Toxicol Lett 143:37–44.
  • Cho YH, Jeon HK, Chung HW. 2007. Effects of extremely low-frequency electromagnetic fields on delayed chromosomal instability induced by bleomycin in normal human fibroblast cells. J Toxicol Environ Health A 70:1252–1258.
  • Hart RW, Setlow RB. 1974. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc Natl Acad Sci USA 71:2169–2173.
  • Hintenlang DE. 1993. Synergistic effects of ionizing radiation and 60 Hz magnetic fields. Bioelectromagnetics 14:545–551.
  • Hong MN, Han NK, Lee HC, Ko YK, Chi SG, Lee YS, Gimm YM, Myung SH, Lee JS. 2012. Extremely low frequency magnetic fields do not elicit oxidative stress in MCF10A cells. Int J Radiat Biol 53:79–86.
  • International Agency for Research on Cancer (IARC). 2002. Non-ionizing radiation. Part 1:Static and extremely low frequency (ELF) electric and magnetic fields. Lyon: IARC.
  • International Commission on Non-Ionizing Radiation Protection (ICNIRP). 2010. International Commission on Non-Ionizing Radiation Protection guidelines for limiting exposure to time- varying electric and magnetic fields (1 Hz to 100 kHz). Bonn, Germany: ICNIRP.
  • Ismail IH, Wadhra TI, Hammarsten O. 2007. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res 35:e36.
  • Ivancsits S, Diem E, Pilger A, Rüdiger HW, Jahn O. 2002. Induction of DNA strand breaks by intermittent exposure to extremely-low- frequency electromagnetic fields in human diploid fibroblasts. Mutat Res 519:1–13.
  • Jin YB, Kang GY, Lee JS, Choi JI, Lee JW, Hong SC, Myung SH, Lee YS. 2012. Effects on micronuclei formation of 60-Hz electromagnetic field exposure with ionizing radiation, hydrogen peroxide, or c-Myc overexpression. Int J Radiat Biol 88:374–380.
  • Lagroye I, Poncy JL. 1997. The effect of 50 Hz electromagnetic fields on the formation of micronuclei in rodent cell lines exposed to gamma radiation. Int J Radiat Biol 72:249–254.
  • Lai H, Singh NP. 1997. Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18:156–165.
  • Lee HJ, Jin YB, Lee JS, Choi JI, Lee JW, Myung SH, Lee YS. 2012. Combined effects of 60 Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells. Bioelectromagnetics 33:207–214.
  • Löscher W, Mevissen M. 1994. Animal studies on the role of 50/60-Hertz magnetic fields in carcinogenesis. Life Sci 54:1531–1543.
  • Maes A, Collier M, Vandoninck S, Scarpa P, Verschaeve L. 2000. Cytogenetic effects of 50 Hz magnetic fields of different magnetic flux densities. Bioelectromagnetics 21:589–596.
  • McCann J, Dietrich F, Rafferty C. 1998. The genotoxic potential of electric and magnetic fields: An update. Mutat Res 411:45–86.
  • Mevissen M, Häussler M, Lerchl A, Löscher W. 1998. Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: Replication study. J Toxicol Environ Health A 53:401–418.
  • Miyakoshi J, Koji Y, Wakasa T, Takebe H. 1999. Long-term exposure to a magnetic field (5 mT at 60 Hz) increases X-ray-induced mutations. J Radiat Res 40:13–21.
  • Miyakoshi J, Yoshida M, Shibuya K, Hiraoka M. 2000. Exposure to strong magnetic fields at power frequency potentiates X-ray-induced DNA strand breaks. J Radiat Res 41:293–302.
  • Mullaart E, Boerrigter ME, Ravid R, Swaab DF, Vijg J. 1990. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiol Aging 11:169–173.
  • Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905–916.
  • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biolog Chem 273:5858–5868.
  • Rosenthal M, Obe G. 1989. Effects of 50-hertz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. Mutat Res 210:329–335.
  • Ruiz-Gómez MJ, Sendra-Portero F, Martínez-Morillo M. 2010. Effect of 2.45 mT sinusoidal 50 Hz magnetic field on Saccharomyces cerevisiae strains deficient in DNA strand breaks repair. Int J Radiat Biol 86:602–611.
  • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. 2002. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 158:486–492.
  • Svedenstål BM, Johanson KJ, Mattsson MO, Paulsson LE. 1999a. DNA damage, cell kinetics and ODC activities studied in CBA mice exposed to electromagnetic fields generated by transmission lines. In Vivo 13:507–513.
  • Svedenstål BM, Johanson KJ, Mild KH. 1999b. DNA damage induced in brain cells of CBA mice exposed to magnetic fields. In Vivo 13: 551–552.
  • Takahashi A, Ohnishi T. 2005. Does gamma H2AX foci formation depend on the presence of DNA double strand breaks?Cancer Lett 229:171–179.
  • Trosko JE. 2000. Human health consequences of environmentally-modulated gene expression: Potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease. Bioelectromagnetics 21:402–406.
  • Walleczek J, Shiu EC, Hahn GM. 1999. Increase in radiation-induced HPRT gene mutation frequency after nonthermal exposure to nonionizing 60 Hz electromagnetic fields. Radiat Res 151:489–497.
  • Ward JF. 1990. The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int J Radiat Biol 57:1141–1150.
  • Wertheimer N, Leeper E. 1979. Electrical wiring configurations and childhood cancer. Am J Epidemiol 109:273–284.
  • World Health Organization (WHO). 2007. Extremely low frequency fields. Geneva: WHO. Environmental Health Criteria, 238.
  • Yokus B, Akdag MZ, Dasdag S, Cakir DU, Kizil M. 2008. Extremely low frequency magnetic fields cause oxidative DNA damage in rats. Int J Radiat Biol 84:789–795.
  • Zeni O, Bersani F, Scarfì MR. 2002. Radiological workers sensitivity to 50 Hz pulsed magnetic fields: Preliminary results. Radiat Environ Biophys 41:275–279.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.