Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells

References

• Abbas AK, Murphy KM, Sher A. 1996. Functional diversity of helper T lymphocytes. Nature 383:787–793.
   PubMed Web of Science ®Google Scholar
• Adewusi OI, Nix NA, Lu X, Colley DG, Secor WE. 1996. Schistosoma mansoni: Relationship of tumor necrosis factor-alpha to morbidity and collagen deposition in chronic experimental infection. Exp Parasitol 84:115–123.
   PubMedGoogle Scholar
• Antonovic L, Brahme A, Furusawa Y, Toma-Dasu I. 2013. Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions. J Radiat Res 54:18–26.
   PubMed Web of Science ®Google Scholar
• Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, Prasad J, Singh S, Samanta N, Sharma RK. 2005. Radioprotection by plant products: Present status and future prospects. Phytother Res 19:1–22.
   PubMed Web of Science ®Google Scholar
• Blankenberg FG. 2009. Imaging the molecular signatures of apoptosis and injury with radiolabeled annexin V. Proc Am Thorac Soc 6:469–476.
   PubMedGoogle Scholar
• Bonecchi R, Bianchi G, Bordignon PP, D’Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, et al. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129–134.
   PubMed Web of Science ®Google Scholar
• Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, et al. 2008. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320:226–230.
   PubMed Web of Science ®Google Scholar
• Chen SC, Lu MK, Cheng JJ, Wang DL. 2005. Antiangiogenic activities of polysaccharides isolated from medicinal fungi. FEMS Microbiol Lett 249:247–254.
   PubMedGoogle Scholar
• Chen YJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM. 2008. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. Int Immunopharmacol 8:458–467.
   PubMed Web of Science ®Google Scholar
• Cheng JJ, Huang NK, Chang TT, Wang DL, Lu MK. 2005. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Life Sci 76: 3029–3042.
   PubMed Web of Science ®Google Scholar
• Cheng PC, Hsu CY, Chen CC, Lee KM. 2008. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicol Appl Pharmacol 227:291–298.
   PubMed Web of Science ®Google Scholar
• Cheng PC, Lin CN, Chen YJ, Chang FS, Tsaihong JC, Lee KM. 2011. Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses. Parasite Immunol 33:276–286.
   PubMed Web of Science ®Google Scholar
• Falzone N, Bohm L, Swarts JC, Van Rensburg CE. 2006. Radiosensitization of CHO cells by two novel rhodium complexes under oxic and hypoxic conditions. Anticancer Res 26:147–152.
   PubMedGoogle Scholar
• Friesen C, Lubatschofski A, Glatting G, Debatin KM, Reske SN. 2008. Activation of intrinsic apoptotic pathway by Re-188 irradiation and paclitaxel in coronary artery smooth muscle cells. Quart J Nuclear Med Molec Imaging 52:289–295.
   PubMedGoogle Scholar
• Friesen C, Lubatschofski A, Kotzerke J, Buchmann I, Reske SN, Debatin KM. 2003. Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells. Eur J Nucl Med Mol Imaging 30:1251–1261.
   PubMed Web of Science ®Google Scholar
• Geethangili M, Tzeng YM. 2011. Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evid Based Complement Alternat Med 2011:212641.
   PubMed Web of Science ®Google Scholar
• Hall EJ. 2000. Radiobiology for the radiologist. 5th ed. Philadelphia, PA: Lippincott Williams and Wilkins. xi, 588 p.
   Google Scholar
• Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL. 2008. Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. J Ethnopharmacol 118:237–245.
   PubMed Web of Science ®Google Scholar
• Hseu YC, Yang HL, Lai YC, Lin JG, Chen GW, Chang YH. 2004. Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutr Cancer 48:189–197.
   PubMed Web of Science ®Google Scholar
• Hseu YC, Chang WC, Hseu YT, Lee CY, Yech YJ, Chen PC, Chen JY, Yang HL. 2002. Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life Sci 71:469–482.
   PubMed Web of Science ®Google Scholar
• Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH, Lu FJ, Lai YC, Yang HL. 2005. Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. Int Immunopharmacol 5:1914–1925.
   PubMed Web of Science ®Google Scholar
• Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR. 2003. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem 51:3302–3308.
   PubMed Web of Science ®Google Scholar
• Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM. 2010. Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant- mediated cofilin- and Bax-triggered mitochondrial pathway. Chem Res Toxicol 23:1256–1267.
   PubMedGoogle Scholar
• Hsieh YC, Rao YK, Whang-Peng J, Huang CY, Shyue SK, Hsu SL, Tzeng YM. 2011. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J Agric Food Chem 59:10943–10954.
   PubMed Web of Science ®Google Scholar
• Hsu HY, Lian SL, Lin CC. 1990. Radioprotective effect of Ganoderma lucidum (Leyss. ex. Fr.) Karst after X-ray irradiation in mice. Am J Chin Med 18:61–69.
   PubMed Web of Science ®Google Scholar
• Hsu YL, Kuo YC, Kuo PL, Ng LT, Kuo YH, Lin CC. 2005. Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer Lett 221:77–89.
   PubMed Web of Science ®Google Scholar
• Hsu YL, Kuo PL, Cho CY, Ni WC, Tzeng TF, Ng LT, Kuo YH, Lin CC. 2007. Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway. Food Chem Toxicol 45:1249–1257.
   PubMed Web of Science ®Google Scholar
• Kidd PM. 2000. The use of mushroom glucans and proteoglycans in cancer treatment. Alt Med Rev 5:4–27.
   PubMedGoogle Scholar
• Lata M, Prasad J, Singh S, Kumar R, Singh L, Chaudhary P, Arora R, Chawla R, Tyagi S, Soni NL, et al. 2009. Whole body protection against lethal ionizing radiation in mice by REC-2001: A semi-purified fraction of Podophyllum hexandrum. Phytomedicine 16:47–55.
   PubMed Web of Science ®Google Scholar
• Lee CC, Yang HL, Way TD, Kumar KJ, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC. 2012. Inhibition of cell growth and induction of apoptosis by Antrodia camphorata in HER-2/neu- overexpressing breast cancer cells through the induction of ROS, depletion of HER-2/neu, and disruption of the PI3K/Akt signaling pathway. Evid Based Complement Alternat Med 2012:702857.
   PubMedGoogle Scholar
• Li L, Story M, Legerski RJ. 2001. Cellular responses to ionizing radiation damage. Int J Radiat Oncol Biol Phys 49:1157–1162.
   PubMed Web of Science ®Google Scholar
• Lin IH, Hau DM, Su MJ, Chen WC. 1996. Effects of Glycyrrhizae and Glycyrrhizic acid on radiation injury in mice. Am J Chin Med 24: 279–288.
   PubMedGoogle Scholar
• Liu JJ, Huang TS, Hsu ML, Chen CC, Lin WS, Lu FJ, Chang WH. 2004. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicol Appl Pharmacol 201:186–193.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408.
   PubMed Web of Science ®Google Scholar
• Lu MC, El-Shazly M, Wu TY, Du YC, Chang TT, Chen CF, Hsu YM, Lai KH, Chiu CP, Chang FR, et al. 2013. Recent research and development of Antrodia cinnamomea. Pharmacol Ther 139:124–156.
   PubMed Web of Science ®Google Scholar
• Lu ZM, Tao WY, Zou XL, Fu HZ, Ao ZH. 2007. Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats. J Ethnopharmacol 110:160–164.
   PubMed Web of Science ®Google Scholar
• Mosmann TR, Coffman RL. 1989. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173.
   PubMed Web of Science ®Google Scholar
• Oh GS, Lee MS, Pae HO, Kwon J, Lee SS, Jeong JG, Shin MK, Kwon TO, Chung HT. 2006. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 28:281–293.
   PubMed Web of Science ®Google Scholar
• Shen YC, Chou CJ, Wang YH, Chen CF, Chou YC, Lu MK. 2004a. Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiol Lett 231: 137–143.
   PubMed Web of Science ®Google Scholar
• Shen YC, Wang YH, Chou YC, Chen CF, Lin LC, Chang TT, Tien JH, Chou CJ. 2004b. Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata. Planta Med 70:310–314.
   PubMed Web of Science ®Google Scholar
• Song TY, Yen GC. 2003. Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. J Agric Food Chem 51:1571–1577.
   PubMed Web of Science ®Google Scholar
• Vikram B, Coleman CN, Deye JA. 2009a. Current status and future potential of advanced technologies in radiation oncology. Part 2. State of the science by anatomic site. Oncology (Williston Park) 23:380–385.
   PubMedGoogle Scholar
• Vikram B, Coleman CN, Deye JA. 2009b. Current status and future potential of advanced technologies in radiation oncology. Part 1. Challenges and resources. Oncology (Williston Park) 23:279–283.
   PubMedGoogle Scholar
• Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK. 1997. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 70:699–705.
   PubMed Web of Science ®Google Scholar
• Wasser SP. 2002. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60:258–274.
   PubMed Web of Science ®Google Scholar
• Wo JY, Viswanathan AN. 2009. Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients. Int J Radiat Oncol Biol Phys 73:1304–1312.
   PubMed Web of Science ®Google Scholar
• Wu YY, Chen CC, Chyau CC, Chung SY, Liu YW. 2007. Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata. Acta Pharmacol Sin 28:258–267.
   PubMedGoogle Scholar