Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation

References

• Anders HJ, Ryu M. 2011. Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney Int 80:915–925.
   PubMed Web of Science ®Google Scholar
• Arthur HM, Ure J, Smith AJ, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG. 2000. Endoglin, an ancillary TGF-β receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol 217:42–53.
   PubMed Web of Science ®Google Scholar
• Bahlmann FH, Speer T, Fliser D. 2010. Endothelial progenitor cells in chronic kidney disease. Nephrol Dial Transplant 25:341–346.
   PubMed Web of Science ®Google Scholar
• Billiau A, Matthys P. 2009. Interferon-gamma: A historical perspective. Cytokine Growth Factor Rev 20:97–113.
   PubMed Web of Science ®Google Scholar
• Carvalho-Pinto CE, Garcia MI, Mellado M, Rodriguez-Frade JM, Martin-Caballero J, Flores J, Martinez A, Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169:1058–1067.
   PubMed Web of Science ®Google Scholar
• Cohen EP, Robbins ME. 2003. Radiation nephropathy. Semin Nephrol 23:486–499.
   PubMed Web of Science ®Google Scholar
• Docherty NG, Lopez-Novoa JM, Arevalo M, Duwel A, Rodriguez- Pena A, Perez-Barriocanal F, Bernabeu C, Eleno N. 2006. Endoglin regulates renal ischaemia-reperfusion injury. Nephrol Dial Transplant 21:2106–2119.
   PubMedGoogle Scholar
• Govani FS, Shovlin CL. 2009. Hereditary haemorrhagic telangiectasia: A clinical and scientific review. Eur J Hum Genet 17:860–871.
   PubMed Web of Science ®Google Scholar
• Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. 2003. Interferon- gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. J Am Soc Nephrol 14: 888–898.
   PubMedGoogle Scholar
• Kluth DC, Erwig LP, Rees AJ. 2004. Multiple facets of macrophages in renal injury. Kidney Int 66:542–557.
   PubMed Web of Science ®Google Scholar
• Lastres P, Bellon T, Cabanas C, Sanchez-Madrid F, Acevedo A, Gougos A, Letarte M, Bernabeu C. 1992. Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen. Eur J Immunol 22:393–397.
   PubMed Web of Science ®Google Scholar
• Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, Wendel DP. 1999. Defective angiogenesis in mice lacking endoglin. Science 284:1534–1537.
   PubMed Web of Science ®Google Scholar
• Lopez-Novoa JM, Rodriguez-Pena AB, Ortiz A, Martinez-Salgado C, Lopez Hernandez FJ. 2011. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications. J Transl Med 9:13.
   PubMedGoogle Scholar
• Moulder JE, Cohen EP. 2007. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Radiat Oncol 17:141–148.
   PubMed Web of Science ®Google Scholar
• O’Connell PJ, McKenzie A, Fisicaro N, Rockman SP, Pearse MJ, d’Apice AJ. 1992. Endoglin: A 180-kD endothelial cell and macrophage restricted differentiation molecule. Clin Exp Immunol 90:154–159.
   PubMedGoogle Scholar
• Prieto M, Rodriguez-Pena A, Arevalo M, Rivas JV, Duwel A, Eleno N, Sanchez RJ, Morales AI, Lopez-Novoa JM, Perez-Barriocanal F. 2005a. Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction. Kidney Blood Press Res 28:32–40.
   PubMedGoogle Scholar
• Prieto M, Rodriguez-Pena AB, Duwel A, Rivas JV, Docherty N, Perez-Barriocanal F, Arevalo M, Vary CP, Bernabeu C, Lopez-Novoa JM, Eleno N. 2005b. Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats. J Physiol Biochem 61:457–467.
   PubMedGoogle Scholar
• Ricardo SD, van Goor H, Eddy AA. 2008. Macrophage diversity in renal injury and repair. J Clin Invest 118:3522–3530.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Pons H, Herrera-Acosta J, Johnson RJ. 2001. Role of immunocompetent cells in nonimmune renal diseases. Kidney Int 59:1626–1640.
   PubMed Web of Science ®Google Scholar
• Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco FJ, Langa C, Botella LM, Cabanas C, Lopez-Novoa JM, Bernabeu C. 2013. Endothelial endoglin is involved in inflammation: Role in leukocyte adhesion and transmigration. Blood 121:403–415.
   PubMed Web of Science ®Google Scholar
• Roy-Chaudhury P, Simpson JG, Power DA. 1997. Endoglin, a transforming growth factor-β-binding protein, is upregulated in chronic progressive renal disease. Exp Nephrol 5:55–60.
   PubMedGoogle Scholar
• Sanchez-Elsner T, Ramirez JR, Sanz-Rodriguez F, Varela E, Bernabeu C, Botella LM. 2004. A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol 336:9–24.
   PubMedGoogle Scholar
• Scharpfenecker M, Floot B, Russell NS, Coppes RP, Stewart FA. 2013. Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice. Radiother Oncol 108: 464–468.
   PubMed Web of Science ®Google Scholar
• Scharpfenecker M, Floot B, Russell NS, Stewart FA. 2012. The TGF-beta co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Radiother Oncol 105:313–320.
   PubMedGoogle Scholar
• Scharpfenecker M, Floot B, Russell NS, Ten Dijke P, Stewart FA. 2009. Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys. Radiother Oncol 92:484–491.
   PubMedGoogle Scholar
• ten Dijke P, Goumans MJ, Pardali E. 2008. Endoglin in angiogenesis and vascular diseases. Angiogenesis 11:79–89.
   PubMed Web of Science ®Google Scholar
• Wang Y, Harris DC. 2011. Macrophages in renal disease. J Am Soc Nephrol 22:21–27.
   PubMed Web of Science ®Google Scholar
• Zhao W, Robbins ME. 2009. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: Therapeutic implications. Curr Med Chem 16:130–143.
   PubMed Web of Science ®Google Scholar