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RADIATION-INDUCED CONFORMATIONAL CHANGES IN CHROMATIN STRUCTURE

Radiation-induced conformational changes in chromatin structure in resting human peripheral blood mononuclear cells

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Pages 1143-1151 | Received 13 Dec 2013, Accepted 14 May 2014, Published online: 25 Jun 2014

References

  • Amundson SA, Grace MB, McLeland CB, Epperly MW, Yeager A, Zhang Q, Greenberger JS, Furnace AJ Jr. 2004. Human in vivo radiation induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Res 64:6368–6371.
  • Asaithamby A, Chen DJ. 2009. Cellular responses to DNA double-strand breaks after low-dose γ-irradiation. Nucleic Acids Res 37:3912–3923.
  • Attikum HV, Fritsch O, Hohn B, Gasser SM. 2004. Recruitment of the INO80 complex by H2A phosphorylation links ATP dependent chromatin remodeling with DNA double strand break repair. Cell 119:777–788.
  • Beels L, Werbrouck J, Thierens H. 2010. Dose response and repair kinetics of γ-H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X and γ- radiation. Int J Radiat Biol 86:760–768.
  • Bekker-Jensen S, Mailand N. 2010. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Rep 9:1219–1228.
  • Belyaev IY, Czene S, Harms-Ringdahl M. 2001. Changes in chromatin conformation during radiation induced apoptosis in human lymphocytes. Radiat Res 156:355–364.
  • Berne BJ, Pecora R. 2000. Dynamic Light Scattering: With application to chemistry, biology and physics. 3rd ed. New York: Dover Publications.
  • Bing L, Carey M, Workman J. 2007. The role of chromatin during transcription. Cell 128:707–719.
  • Bloomfield VA. 1981. Quasi-elastic light scattering applications in biochemistry and biology. Ann Rev Biophys Bioengineer 10: 421–450.
  • Bøyum A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Investigat 21:77–89.
  • Campbell AM, Cotter RI, Pardon JF. 1978. Light scattering measurements supporting helical structures for chromatin in solution. Nucleic Acid Res 5:1571–1580.
  • Cheriyan VD, Kurien CJ, Das B, Ramachandran EN, Karuppasamy CV, Thampi MV, George KP, Kesavan PC, Koya PKM, Chauhan PS. 1999. Genetic monitoring of the human population from high level natural radiation areas of Kerala on the southwest coast of India. Incidence of numerical and structural chromosomal aberrations in the lymphocytes of newborn. Radiat Res 152:154–158.
  • Corpet A, Almouzni G. 2009. A histone code for the DNA damage response in mammalian cells. Eur Molec Biol Organizat J 28: 1828–1830.
  • Das B, Karuppasamy CV. 2009. Spontaneous frequency of micronuclei among newborn from high level natural radiation areas of Kerala in southwest coast of India. Int J Radiat Biol 85:272–280.
  • Das B, Divyalakshmi Saini, Seshadri M. 2009. Telomere length in human adults and high level natural background radiation. Public Library Sci One 4(12):e8440.
  • Das B, Divyalakshmi Saini, Seshadri M. 2012. No evidence of telomere length attrition in newborns exposed to high level natural background radiation in Kerala coast, south west India. Int J Radiat Biol 88:642–647.
  • Das C, Hizume K, Batta K, Kumar BRP, Gadad SS, Ganguly S, Lorain S, Verreault A, Sadhale PP, Takeyasu K, Kundu TK. 2006.
  • Transcriptional co-activator PC4, a chromatin associated protein induces chromatin condensation. Molec Cell Biol 26:8303–8315.
  • Dimitrov S, Makarov V, Apostolova T, Pashev I. 1986a. Structure of hyperacetylated chromatin: Light scattering and flow dichroism study. Fed Eur Biochem Soc Lett 197:217–220.
  • Dimitrov SI, Apostolova TM, Makarov VL, Pashev IG. 1986b. Chromatin superstructure – a study with an immobilized trypsin. Fed Eur Biochem Soc Lett 200:322–326.
  • Dinant C, Houtsmuller AB, Vermeulen W. 2008. Chromatin structure and DNA damage repair. Epigenetics Chromatin 1(1):9.
  • Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C Cheng JF, Chen DJ. 2005. Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: A comparative study of low and high doses. Radiat Res 164:17–26.
  • Downs JA, Nussenzweig MC, Nussenzweig A. 2007. Chromatin dynamics and the preservation of genetic information. Nature 447: 951–958.
  • Eisenberg H, Borochov N, Kam Z, Voordouw G. 1979. Conformation of plasmid DNA and of DNA-histone chromatin like complexes by laser light scattering. Philosoph Transact Royal Soc London 293:303–313.
  • Falk M, Lukasova E, Gabeielova B, Ondrej V, Kozubek S. 2007. Chromatin dynamics during DSB repair. Biochim Biophys Acta 1773:1534–1545.
  • Falk M, Lukasova E, Kozubek S. 2010. Higher-order chromatin structure in DSB induction, repair and misrepair. Mutat Res 704:88–100.
  • Fernandez-Capetillo O, Celeste A, Nussenzweig A. 2003. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle 2:426–427.
  • Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. 2004. H2AX: The histone guardian of the genome. DNA Rep 3:959–967.
  • Goodarzi AA, Noon AT, Jeggo A. 2009. The impact of heterochromatin on DSB repair. Biochem Soc Transact 37:569–576.
  • Goodarzi AA, Jeggo A, Löbrich M. 2010. The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA Rep 9(12):1273–1282.
  • Greulich KO, Ausio J, Seger D, Wachtel E. Eisenberg H. 1986. Chromatin folding into higher order structure. Biophys J 49:7–8.
  • Groth A, Rocha W, Verreault A, Almouzni G. 2007. Chromatin challenges during DNA replication and repair. Cell 128:721–733.
  • Grudzenski S, Raths A, Conrad S, Rube CE, Löbrich M. 2010. Inducible response required for repair of low dose radiation damage in human fibroblasts. Proc Natl Acad Sci USA 107:14205–14210.
  • Hada M, Sutherland B. 2006. Spectrum of complex DNA damages depends on the incident radiation. Radiat Res 165(2):223–230.
  • Hada M, Georgakilas AG. 2008. Formation of clustered DNA damage after high LET irradiation: A review. J Radiat Res 49(3):203–210.
  • Hanlon AD, Larkin ML, Reddick RM. 2010. Free-solution, label-free protein-protein interactions characterized by Dynamic Light Scattering. Biophys J 98:297–304.
  • Hittelman WN, Pollard M. 1984. Visualization of chromatin events associated with repair of ultraviolet light-induced damage by premature chromosome condensation. Carcinogenesis 5:1277–1285.
  • Holde KV, Leuba SH, Zlatanova J. 1998. Physical approaches to the study of chromatin fibers. Gene Ther Molec Biol 1:475–482.
  • Horn S, Barnard S, Rothkamm K. 2011. Gamma-H2AX-based dose estimation for whole and partial body radiation exposure. Public Library Sci One 6:e25113.
  • Huang X, Darzynkiewicz Z. 2006. Cytometric assessment of histone H2AX phosphorylation: A reporter of DNA damage. Meth Molec Biol 314:73–80.
  • Ismail IH, Wadhra TI, Hammarsten O. 2007. An optimized method for detecting gamma-H2AX in blood cells reveals a significant inter-individual variation in the gamma-H2AX response among humans. Nucleic Acids Res 35:1–10.
  • Jaikrishan G, Sudheer KR, Andrews VJ, Koya PKM, Madhusoodhanan M, Jagadeesan CK, Seshadri M. 2013. Study of stillbirth and major congenital anomaly among newborns in the high level natural radiation areas of Kerala, India. J Community Genet 4:21–31.
  • Jain V, Das B, Seshadri M. 2011. Transcriptional expression of H2B, CTP synthase and PLK3 genes in whole blood exposed to 60Co gamma radiation. Int J Low Radiat 8:55–65.
  • Kakarougkas A, Jeggo PA. 2014. DNA DSB repair pathway choice: An orchestrated handover mechanism. Br J Radiol 87:20130685.
  • Kinner A, Wu W, Staudt C, Iliakis G. 2008. γ-H2AX in recognition and signaling of DNA double strand breaks in the context of chromatin. Nucleic Acids Res 36:5678–5694.
  • Kovalchuk O, Baulch JE. 2008. Epigenetic changes and non-targeted radiation effects – is there a link. Environ Molec Mutagenesis 49:16–25.
  • Kruhlak MJ, Celeste A, Dellaire G, Capetillo OF, Muller WG, McNally JG, Bazett-Jones DP, Nussenzweig A. 2006. Changes in chromatin structure and mobility in living cells at sites of DNA double strand breaks. J Cell Biol 172:823–834.
  • Leatherbarrow EL, Harper JV, Cucinotta FA, O’Neill P. 2006. Induction and quantification of γ-H2AX foci following low and high LET-irradiation. Int J Radiat Biol 82:111–118.
  • Lee KS, Mandelkern M, Crothers DM. 1981. Solution structural studies of chromatin fibers. Biochemistry 20:1438–1445.
  • Ljungman M. 1989. Pretreatment with UV light renders the chromatin in human fibroblasts more susceptible to the DNA damaging agents bleomycin, gamma radiation and 8-methoxypsoralen. Carcinogenesis 10:447–451.
  • Lorat Y, Schanz S, Schuler N, Wennemuth G, Rübe C, Rübe CB. 2012. Beyond repair foci: DNA double strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. Public Library Sci One 7:e38165.
  • Lydall D, Whitehall S. 2005. Chromatin and the DNA damage response. DNA Rep 4:1195–1207.
  • Majumdar P, Dasgupta D. 2011. Effect of DNA groove binder distamycin A upon chromatin structure. Public Library Sci One 6:e26486.
  • Makarov VL, Smirnov I, Dimitrov SI. 1987. Higher order folding of chromatin is induced in different ways by monovalent and by divalent cations. Fed Eur Biochem Soc Lett 212:263–266.
  • Misteli T, Soutoglou E. 2009. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nature Rev Molec Cell Biol 10:243–254.
  • Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajole BR, Mirny LA, Dekkar J. 2013. Organization of the mitotic chromosome. Science 342:948–953.
  • Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang PoAn, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S, Costes SV. 2012. Evidence for formation of DNA repair centers and dose response nonlinearity in human cells. Proc Natl Acad Sci USA 109:443–448.
  • Pandita TK, Richardson C. 2009. Chromatin remodeling finds its place in the DNA double strand break response. Nucleic Acids Res 37:1363–1377.
  • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886–895.
  • Polo SE, Jackson SP. 2011. Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications. Genes Develop 25:409–433.
  • Ramachandran EN, Karuppasamy CV, Cheriyan VD, Soren DC, Das B, Anilkumar V, Koya PKM, Seshadri M. 2013. Cytogenetic studies on newborns from high and normal level natural radiation areas of Kerala in southwest coast of India. Int J Radiat Biol 89:259–267.
  • Roche J, Girardet JL, Gorka C, Lawrence JJ. 1985. The involvement of histone H1 in chromatin structure. Nucleic Acids Res 13:2843–2853.
  • Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double strand breaks in vivo. J Cell Biol 146:905–915.
  • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biolog Chem 273:5858–5868.
  • Rothkamm K, Löbrich M. 2003. Evidence of a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci USA 100:5057–5062.
  • Rydberg B. 2001. Radiation induced DNA damage and chromatin structure. Acta Oncolog 40:682–685.
  • Saini D, Shelke S, Manivannan A, Toprani S, Jain V, Das B, Seshadri M. 2012. Transcription profile of DNA damage response genes at G0 lymphocytes exposed to gamma radiation. Molec Cellular Biochem 364:271–281.
  • Schmitz KS, Shaw BR. 1977. Hydrodynamic evidence in support of spacer regions in chromatin. Science 197:661–662.
  • Selvi BR, Pradhan SK, Shandilya J, Das Chandrima, Sailaja BD, Shankar GN, Gadad SS, Reddy A, Dasgupta D, Kundu TK. 2009. Sanguinarine interacts with chromatin modulates epigenetic modifications, and transcription in the context of chromatin. Chem Biol 16:203–216.
  • Sutherland BM, Bennett PV, Sidorkina O, Laval J. 2000. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc Natl Acad Sci USA 97:103–108.

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