Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats

References

• Alexandrov VA, Bespalov VG, Boone CW, Kelloff GJ, Malone WF. 1991. Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, α-tocopherol acetate, thiamine chloride, sodium selenite, and α-difluoromethylornithine. Cancer Lett 60:177–184.
   PubMedGoogle Scholar
• Andreassen CN, Grau C, Lindegaard JC. 2003. Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy. Semin Radiat Oncol 13:62–72.
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Belous NM, Prokudina EA. 1982a. [Inhibition of radiation carcinogenesis in female rats by phenformin]. Experim Oncol 4:26–29 [in Russian].
   Google Scholar
• Anisimov VN, Miretskii GI, Morozov V.G., Khavinson VKh. 1982b. [Effect of polypeptide factors of the thymus and epiphysis on radiation carcinogenesis]. Bull Experim Biol Med 94:80–82 [in Russian].
   Google Scholar
• Bailey HH, Kim K, Verma AK, Sielaff K, Larson PO, Snow S, Lenaghan T, Viner JL, Douglas J, Dreckschmidt NE, Hamielec M, Pomplun M, Sharata HH, Puchalsky D, Berg ER, Havighurst TC, Carbone PP. 2010. A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of alpha-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prevent Res (Philadelphia, PA) 3:35–47.
   PubMed Web of Science ®Google Scholar
• Bespalov VG, Alexandrov VA, Limarenko AY, Voytenkov BO, Okulov VB, Kabulov MK, Peresunko AP, Slepyan LI, Davydov VV. 2001. Chemoprevention of mammary, cervix and nervous system carcinogenesis in animals using cultured Panax ginseng drugs and preliminary clinical trials in patients with precancerous lesions of the esophagus and endometrium. J Korean Med Sci 16 (Suppl.):42–53.
   Google Scholar
• Bespalov VG, Alexandrov VA, Petrov AS, Troyan DN. 1992a. [Influence of α-difluoromethylornithine on development of tumors of esophagus, nervous system and kidney in rats inducing by N-methyl-N-benzylnitrosamine.] Experim Oncol 14:26–30 [in Russian].
   Google Scholar
• Bespalov VG, Alexandrov VA, Yaremenko KV, Davydov VV, Lazareva NL, Limarenko AY, Slepyan LI, Petrov AS, Troyan DN. 1992b. [The inhibitory effect of fitoadaptogenic preparations bioginzeng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of the nervous system tumors induced by N-nitrosoethylurea in rats.] Voprosy Onkologii 38:1073–1080 [in Russian].
   PubMedGoogle Scholar
• Bespalov VG, Alexandrov VA, Yaremenko KV, Limarenko AY, Petrov AS, Troyan DN. 1993. [The inhibitory effect of Eleutherococcus senticosus extract on the development of experimentally induced tumors of the nervous system, cervix and vagina.] Pharmaceut Chem J 27:63–65 [in Russian].
   Google Scholar
• Bonovas S, Tsantes A, Drosos T, Sitaras NM. 2008. Cancer chemoprevention: A summary of the current evidence. Anticancer Res 28:1857–1866.
   PubMedGoogle Scholar
• Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP. 2011. Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice. Am J Chinese Med 39:779–788.
   PubMed Web of Science ®Google Scholar
• Davis JS, Wu X. 2012. Current state and future challenges of chemoprevention. Discov Med 13:385–390.
   PubMedGoogle Scholar
• Einspahr JG, Nelson MA, Saboda K, Warneke J, Bowden GT, Alberts DS. 2002. Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer. Clin Cancer Res 8:149–155.
   PubMedGoogle Scholar
• Fukushima S, Wanibuchi H, Li W. 2001. Inhibition by ginseng of colon carcinogenesis in rats. J Korean Med Sci 16 (Suppl.):75–80.
   PubMedGoogle Scholar
• Fong LY, Pegg AE, Magee PN. 1998. Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: Effects on esophageal cell proliferation and apoptosis. Cancer Res 58:5380–5388.
   PubMedGoogle Scholar
• Gross L, Dreyfuss Y. 1990. Prevention of spontaneous and radiation-induced tumors in rats by reduction of food intake. Proc Natl Acad Sci USA 87:6795–6797.
   PubMed Web of Science ®Google Scholar
• Huang L, Zhao H, Huang B, Zheng C, Peng W, Qin L. 2011. Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Die Pharmazie 66:83–97.
   PubMed Web of Science ®Google Scholar
• Huang Y, Pledgie A, Casero RA Jr, Davidson NE. 2005. Molecular mechanisms of polyamine analogs in cancer cells. Anticancer Drugs 16:229–241.
   PubMed Web of Science ®Google Scholar
• International Agency for Research on Cancer (IARC) Monographs. On evaluation of carcinogenic risks to human. 2000. Ionizing radiation. Part 1: X- and gamma (γ)-radiation, and neutrons. IARC Science Publications 75. Lyon: IARC.
   Google Scholar
• Inano H, Ishii-Ohba H, Suzuki K, Yamanouchi H, Onoda M, Wakabayashi K. 1995. Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. J Steroid Biochem Molec Biol 54:47–53.
   PubMed Web of Science ®Google Scholar
• Inano H, Onoda M, Inafuku N, Kubota M, Kamada Y, Osawa T, Kobayashi H, Wakabayashi K. 1999. Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis 20:1011–1018.
   PubMed Web of Science ®Google Scholar
• Inano H, Suzuki K, Onoda M, Wakabayashi K. 1997. Anti-carcinogenic activity of simvastatin during the promotion phase of radiation-induced mammary tumorigenesis of rats. Carcinogenesis 18:1723–1727.
   PubMed Web of Science ®Google Scholar
• Inano H, Suzuki K, Wakabayashi K. 1996. Chemoprevention of radiation-induced mammary tumors in rats by bezafibrate administered together with diethylstilbestrol as a promoter. Carcinogenesis 17:2641–2646.
   PubMed Web of Science ®Google Scholar
• Jia L, Zhao Y, Liang XJ. 2009. Current evaluation of the millennium phytomedicine – ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Medicinal Chem 16:2924–2942.
   PubMed Web of Science ®Google Scholar
• Kelloff GJ. 2000. Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 78:199–334.
   PubMed Web of Science ®Google Scholar
• Kim JP, Park JG, Lee MD, Han MD, Park ST, Lee BH, Jung SE. 1985. Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats. Japanese J Surgery 15:427–437.
   PubMedGoogle Scholar
• Kokoska L, Janovska D. 2009. Chemistry and pharmacology of Rhaponticum carthamoides: A review. Phytochemistry 70:842–855.
   PubMed Web of Science ®Google Scholar
• Kostyleva VV, Borts MS, Nikolaeva EG, Ryzhak GA. 2010. [Radiation-protective action of bioantioxidant complex of ginseng extract in the model of the radiation-induced aging during development of radiation-induced neoplasms.] Adv Gerontol 23:86–89 [in Russian].
   PubMedGoogle Scholar
• Laukaitis CM, Gerner EW. 2011. DFMO: Targeted risk reduction therapy for colorectal neoplasia. Best practice and research. Clin Gastroenterol 25:495–506.
   PubMedGoogle Scholar
• Lee TK, Johnke RM, Allison RR, O’Brien KF, Dobbs LJ Jr. 2005. Radioprotective potential of ginseng. Mutagenesis 20:237–243.
   PubMed Web of Science ®Google Scholar
• Lee TK, O’Brien KF, Wang W, Johnke RM, Sheng C, Benhabib SM, Wang T, Allison RR. 2010. Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: A study of 40 cases. J Alternat Complement Med 16:561–567.
   PubMed Web of Science ®Google Scholar
• Lü J-M, Yao Q, Chen C. 2009. Ginseng compounds: An update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 7:293–302.
   PubMed Web of Science ®Google Scholar
• Meyskens FL Jr, Gerner EW. 1995. Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. J Cellular Biochem (Suppl. 22):126–131.
   Google Scholar
• Meyskens FL Jr, Gerner EW. 1999. Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res 5:945–951.
   PubMed Web of Science ®Google Scholar
• Meyskens FL Jr, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW. 2008. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial. Cancer Prevent Res (Philadelphia, PA) 1:9–11.
   PubMedGoogle Scholar
• Nishino H, Tokuda H, Ii T, Takemura M, Kuchide M, Kanazawa M, Mou XY, Bu P, Takayasu J, Onozuka M, Masuda M, Satomi Y, Konoshima T, Kishi N, Baba M, Okada Y, Okuyama T. 2001. Cancer chemoprevention by ginseng in mouse liver and other organs. J Korean Med Sci 16(Suppl.):66–69.
   Google Scholar
• Ootsuyama A, Tanooka H. 1993. Effect of an inhibitor of tumor promotion, alpha-Difluoromethylornithine, on tumor induction by repeated beta irradiation in mice. Japanese J Cancer Res: Gann 84:34–36.
   PubMedGoogle Scholar
• Ozasa K, Shimizu Y, Sakata R, Sugiyama H, Grant EJ, Soda M, Kasagi F, Suyama A. 2011. Risk of cancer and non-cancer diseases in the atomic bomb survivors. Radiat Protect Dosim 146:272–275.
   PubMed Web of Science ®Google Scholar
• Paunesku D, Paunesku T, Wahl A, Kataoka Y, Murley J, Grdina DJ, Woloschak GE. 2008. Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol 84:623–634.
   PubMed Web of Science ®Google Scholar
• Rades D, Fehlauer F, Bajrovic A, Mahlmann B, Richter E, Alberti W. 2004. Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients. Radiother Oncol 70:261–264.
   PubMed Web of Science ®Google Scholar
• Simoneau AR, Gerner EW, Nagle R, Ziogas A, Fujikawa-Brooks S, Yerushalmi H, Ahlering TE, Lieberman R, McLaren CE, Anton- Culver H, Meyskens FL Jr. 2008The effect of difluoromethylornithineon decreasing prostate size and polyamines in men: Results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol, Biomark Prevent 17:292–929.
   PubMed Web of Science ®Google Scholar
• Sinicrope FA, Broaddus R, Joshi N, Gerner E, Half E, Kirsch I, Lewin J, Morlan B, Hong WK. 2011. Evaluation of difluoromethylornithine for the chemoprevention of Barrett’s esophagus and mucosal dysplasia. Cancer Prevent Res (Philadelphia, PA) 6:829–839.
   Google Scholar
• Sokolov SYa. 2000. [Phytotherapy and phytopharmacology: Guide for the physician.] Moscow: Medical Informational Agency [in Russian].
   Google Scholar
• Turusov VS, Mohr U, editors. 1990. Pathology of tumours in laboratory animals. Vol. 1. Tumours of the rat. IARC Science Publications 99. Lyon: IARC.
   Google Scholar
• Vinogradova IA, Anisimov VN, Bukalev AV, Semenchenko AV, Zabezhinski MA. 2009. Circadian disruption induced by light‐at‐night accelerates aging and promotes tumorigenesis in rats. Aging 1:855–865.
   PubMedGoogle Scholar
• Wattenberg LW, Wiedmann TS, Estensen RD. 2004. Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. Cancer Res 64:2347–2349.
   PubMed Web of Science ®Google Scholar
• Wu XG, Zhu DH. 1990. Influence of ginseng upon the development of liver cancer induced by diethylnitrosamine in rats. J Tongji Med Univ 10:141–145,133.
   PubMedGoogle Scholar
• Yun ТK, Choi SY. 1995. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidemiol, Biomark Prevent 4:401–408.
   PubMed Web of Science ®Google Scholar
• Yun ТK, Choi SY. 1998. Non-organic specific cancer prevention of ginseng: A prospective study in Korea. Int J Epidemiol 27:359–364.
   PubMed Web of Science ®Google Scholar
• Yun ТK, Choi SY, Yun HY. 2001a. Epidemiological study on cancer prevention by ginseng: Are all kinds of cancer preventable by ginseng? J Korean Med Sci 16(Suppl.):19–27.
   Google Scholar
• Yun NK, Lee YS, Lee YH, Kim SI, Yun HY. 2001b. Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci 16(Suppl.):6–18.
   Google Scholar
• Yun TK, Zheng S, Choi SY, Cai SR, Lee YS, Liu XY, Cho KJ, Park KY. 2010. Non-organ-specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers. J Medicinal Food 13:489–494.
   PubMed Web of Science ®Google Scholar