A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide

References

• Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ, Logan RM, Nair RG, Stringer AM, Yazbeck R, Elad S, Lalla RV. 2013. Emerging evidence on the pathobiology of mucositis. Support Care Cancer 21:2075–2083.
   PubMed Web of Science ®Google Scholar
• Bradley PP, Christensen RD, Rothstein G. 1982. Cellular and extracellular myeloperoxidase in pyogenic inflammation. Blood 60: 618–622.
   PubMed Web of Science ®Google Scholar
• Burdelya LG, Gleiberman AS, Toshkov I, Aygun-Sunar S, Bapardekar M, Manderscheid-Kern P, Bellnier D, Krivokrysenko VI, Feinstein E, Gudkov AV. 2012. Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: Implications for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys 83:228–234.
   PubMed Web of Science ®Google Scholar
• Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB. 2003. The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98:1531–1539.
   Google Scholar
• Epstein JB, Robertson M, Emerton S, Phillips N, Stevenson-Moore P. 2001. Quality of life and oral function in patients treated with radiation therapy for head and neck cancer. Head Neck 23: 389–398.
   PubMed Web of Science ®Google Scholar
• Griffiths MJ, Messent M, MacAllister RJ, Evans TW. 1993. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 110:963–968.
   PubMed Web of Science ®Google Scholar
• Han J, Thompson P, Beutler B. 1990. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med 172:391–394.
   PubMed Web of Science ®Google Scholar
• Hsu SM, Raine L. 1981. Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem 29:1349–1353.
   PubMed Web of Science ®Google Scholar
• Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS. 2012. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell 11:401–414.
   PubMed Web of Science ®Google Scholar
• Joshi CP, Dhanesar S, Darko J, Kerr A, Vidyasagar PB, Schreiner LJ. 2009. Practical and clinical considerations in Cobalt-60 tomotherapy. J Med Phys 34:137–140.
   PubMedGoogle Scholar
• Lalla RV, Saunders DP, Peterson DE. 2014. Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am 58:341–349.
   PubMedGoogle Scholar
• Lambros MP, Parsa C, Mulamalla H, Orlando R, Lau B, Huang Y, Pon D, Chow M. 2011. Identifying cell and molecular stress after radiation in a three-dimensional (3-D) model of oral mucositis. Biochem Biophys Res Commun 405:102–106.
   PubMed Web of Science ®Google Scholar
• Lee AW, Ng WT, Chan YH, Sze H, Chan C, Lam TH. 2012. The battle against nasopharyngeal cancer. Radiother Oncol 104:272–278.
   PubMed Web of Science ®Google Scholar
• Leitão RF, Ribeiro RA, Bellaguarda EA, Macedo FD, Silva LR, Oriá RB, Vale ML, Cunha FQ, Brito GA. 2007. Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral mucositis in hamster. Cancer Chemother Pharmacol 59:603–612.
   PubMed Web of Science ®Google Scholar
• Lima V, Brito GA, Cunha FQ, Rebouças CG, Falcão BA, Augusto RF, Souza ML, Leitão BT, Ribeiro RA. 2005. Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. Eur J Oral Sci 113:210–217.
   PubMed Web of Science ®Google Scholar
• Lima-Júnior RC, Figueiredo AA, Freitas HC, Melo ML, Wong DV, Leite CA, Medeiros RP, Marques-Neto RD, Val, ML, Brito, GA, Oriá RB, Souza MH, Cunha FQ, Ribeiro RA. 2012. Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: Role of cytokines on inducible nitric oxide synthase activation. Cancer Chemother Pharmacol 69:931–942.
   PubMed Web of Science ®Google Scholar
• Marcinkiewicz J, Grabowska A, Lauterbac R, Bobek M. 2000. Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages. Immunopharmacology 49: 335–343.
   Google Scholar
• Melo ML, Brito, GA, Soares, RC, Carvalho SB, Silva JV, Soares PM, Vale ML, Souza MH, Cunha FQ, Ribeiro RA. 2008. Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: Effect of pentoxifylline and thalidomide. Cancer Chemother Pharmacol 61:775–784.
   PubMed Web of Science ®Google Scholar
• Neuner P, Klosner G, Schauer E, Pourmojib M, Macheiner W, Grünwald C, Knobler R, Schwarz A, Luger TA, Schwarz T. 1994. Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells. Immunology 83:262–267.
   PubMed Web of Science ®Google Scholar
• Poitevin-Chacón A, Hinojosa-Gómez J. 2012. Patterns of care of radiotherapy in México. Reports Pract Oncol Radiother J Gt Cancer Cent Poznań Polish Soc Radiat Oncol 18:57–60.
   PubMedGoogle Scholar
• Ravichandran R. 2009. Has the time come for doing away with Cobalt-60 teletherapy for cancer treatments. J Med Phys 34:63–65.
   PubMedGoogle Scholar
• Shin YS, Shin HA, Kang SU, Kim JH, Oh Y, Park KH, Kim C. 2013. Effect of epicatechin against radiation-induced oral mucositis: in vitro and in vivo study. PLoS One 8:e69151.
   Google Scholar
• Sonis ST. 2009. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 45:1015–1020.
   PubMed Web of Science ®Google Scholar
• Sonis ST. 2010. New thoughts on the initiation of mucositis. Oral Dis 16:597–600.
   PubMed Web of Science ®Google Scholar
• Sonis ST. 2011. Oral mucositis. Anticancer. Drugs 22:607–612.
   PubMed Web of Science ®Google Scholar
• Sonis ST, O’Donnell KE, Popat R, Bragdon C, Phelan S, Cocks D, Epstein JB. 2004b. The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. Oral Oncol 40:170–176.
   PubMed Web of Science ®Google Scholar
• Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB. 2004a. Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995–2025.
   PubMed Web of Science ®Google Scholar
• Sonis ST, Tracey C, Shklar G, Jenson J, Florine D. 1990. An animal model for mucositis induced by cancer chemotherapy. Oral Surg. Oral Med Oral Pathol 69:437–443.
   PubMedGoogle Scholar
• Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W. 2000. Common toxicity criteria: Version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radio- therapy. Int J Radiat Oncol Biol Phys 47:13–47.
   PubMed Web of Science ®Google Scholar
• Yeoh AS, Gibson RJ, Yeoh EE, Bowen JM, Stringer AM, Giam KA, Keefe DM. 2007. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: The role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Mol. Cancer Ther 6:2319–2327.
   PubMed Web of Science ®Google Scholar