DNA damage at respiratory distress, but not acute time-points, correlates with tissue fibrosis following thoracic radiation exposure in mice

References

• Barnett GC, West CM, Dunning AM, Elliott RM, Coles CE, Pharoah PD, Burnet NG. 2009. Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype. Nat Rev Cancer 9:134–142.
   PubMed Web of Science ®Google Scholar
• Barnett GC, Coles CE, Burnet NG, Pharoah PD, Wilkinson J, West CM, Elliott RM, Baynes C, Dunning AM. 2010. No association between SNPs regulating TGF-b1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study. Radiother Oncol 97: 9–14.
   PubMedGoogle Scholar
• Bhogal N, Jalali F, Bristow RG. 2009. Microscopic imaging of DNA repair foci in irradiated normal tissues. Int J Radiat Biol 85:732–746.
   PubMed Web of Science ®Google Scholar
• Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. 2010. Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo. Radiat Res 173:1–9.
   PubMed Web of Science ®Google Scholar
• Borgmann K, Röper B, El-Awady R, Brackrock S, Bigalke M, Dörk T, Alberti W, Dikomey E, Dahm-Daphi J. 2002. Indicators of late normal tissue response after radiotherapy for head and neck cancer: Fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 64:141–152.
   PubMed Web of Science ®Google Scholar
• Brunner AH, Hinterholzer S, Riss P, Heinze G, Weiss K, Brustmann H. 2011. Expression of γ-H2AX in endometrial carcinomas: An immunohistochemical study with p53. Gynecol Oncol 121:206–211.
   PubMedGoogle Scholar
• Carver JR, Shapiro CL, Ng A, Jacobs L, Schwartz C, Virgo KS, Hagerty KL, Somerfield MR, Vaughn DJ. 2007. ASCO Cancer Survivorship Expert Panel; American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: Cardiac and pulmonary late effects. J Clin Oncol 25:3991–4008.
   PubMed Web of Science ®Google Scholar
• Chua ML, Rothkamm K. 2013. Biomarkers of radiation exposure: Can they predict normal tissue radiosensitivity? Clin Oncol 25:610–616.
   PubMed Web of Science ®Google Scholar
• Ding X, Ji W, Li J, Zhang X, Wang L. 2011. Radiation recall pneumonitis induced by chemotherapy after thoracic radiotherapy for lung cancer. Radiat Oncol 6:24.
   PubMed Web of Science ®Google Scholar
• Dupré-Crochet S, Erard M, Nübe O. 2013. ROS production in phagocytes: Why, when, and where? J Leukoc Biol 94:657–670.
   PubMed Web of Science ®Google Scholar
• Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, Rabbani Z, Anscher M, Vujaskovic Z. 2007. Using biological markers to predict risk of radiation injury. Semin Radiat Oncol 17:89–98.
   PubMed Web of Science ®Google Scholar
• Fox J, Haston CK. 2013. CXC receptor 1 and 2 and neutrophil elastase inhibitors alter radiation-induced lung disease in the mouse. Int J Radiat Oncol Biol Phys 85:215–222.
   PubMed Web of Science ®Google Scholar
• Freeman TA, Parvizi J, Della Valle CJ, Steinbeck MJ. 2009. Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty. Fibrogenesis Tissue Repair 2:5.
   Google Scholar
• Haston CK, Begin M, Dorion G, Cory SM. 2007. Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Res 67:10796–10803.
   PubMed Web of Science ®Google Scholar
• Ivashkevich A, Redon CE, Nakamura AJ, Martin RF, Martin OA. 2012. Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett 327:123–133.
   PubMed Web of Science ®Google Scholar
• Jérôme L, David A, Alain M, Jérôme S. 2013. Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes. Expert Rev Proteomics 10:33–42.
   PubMedGoogle Scholar
• Khan MA, Hill RP, Van Dyk J. 1998. Partial volume rat lung irradiation: An evaluation of early DNA damage. Int J Radiat Oncol Biol Phys 40:467–476.
   PubMed Web of Science ®Google Scholar
• Khan MA, Van Dyk J, Yeung IW, Hill RP. 2003. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol 66:95–102.
   PubMed Web of Science ®Google Scholar
• Kong FM, Haken RT, Eisbruch A, Lawrence TS. 2005. Non-small cell lung cancer therapy-related pulmonary toxicity: An update on radiation pneumonitis and fibrosis. Semin Oncol 32:S42–54.
   PubMedGoogle Scholar
• Langan AR, Khan MA, Yeung IW, Van Dyk J, Hill RP. 2006. Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiother Oncol 79:231–8.
   PubMed Web of Science ®Google Scholar
• O’Brien TJ, Letuve S, Haston CK. 2005. Radiation-induced strain differences in mouse alveolar inflammatory cell apoptosis. Can J Physiol Pharmacol 83:117–122.
   PubMed Web of Science ®Google Scholar
• Olive PL, Banáth JP, Durand RE. 1990. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the ‘comet’ assay. Radiat Res 122:86–94.
   PubMed Web of Science ®Google Scholar
• Ozsahin M, Crompton NE, Gourgou S, Kramar A, Li L, Shi Y, Sozzi WJ, Zouhair A, Mirimanoff RO, Azria D. 2005. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: A prospective study in 399 patients. Clin Cancer Res 11:7426–7433.
   PubMed Web of Science ®Google Scholar
• Pastukh VM, Zhang L, Ruchko MV, Gorodnya O, Bardwell GC, Tuder RM, Gillespie MN. 2011. Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences. Int J Chron Obstruct Pulmon Dis 6:209–217.
   PubMed Web of Science ®Google Scholar
• Paun A, Haston CK. 2012. Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice. Radiother Oncol 105:350–357.
   PubMed Web of Science ®Google Scholar
• Poli G, Parola M. 1997. Oxidative damage and fibrogenesis. Free Radic Biol Med 22:287–305.
   PubMed Web of Science ®Google Scholar
• Pouliliou S, Koukourakis MI. 2014. Gamma histone 2AX (γ-H2AX) as a predictive tool in radiation oncology. Biomarkers 19:167–180.
   PubMed Web of Science ®Google Scholar
• Rübe CE, Dong X, Kühne M, Fricke A, Kaestner L, Lipp P, Rübe C. 2008a. DNA double-strand break rejoining in complex normal tissues. Int J Radiat Oncol Biol Phys 72:1180–1187.
   PubMed Web of Science ®Google Scholar
• Rübe CE, Fricke A, Wendorf J, Stützel A, Kühne M, Ong MF, Lipp P, Rübe C. 2010. Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation. Int J Radiat Oncol Biol Phys 76:1206–1213.
   PubMed Web of Science ®Google Scholar
• Rübe CE, Grudzenski S, Kühne M, Dong X, Rief N, Löbrich M, Rübe C. 2008b. DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: Implications for radiosensitivity testing. Clin Cancer Res 14:6546–6555.
   PubMed Web of Science ®Google Scholar
• Sharma A, Singh K, Almasan A. 2012. Histone H2AX phosphorylation: A marker for DNA damage. Methods Molec Bio 920:613–626.
   PubMedGoogle Scholar
• Sharplin J, Franko AJ. 1989a. Quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res 119:1–14.
   PubMed Web of Science ®Google Scholar
• Sharplin J, Franko AJ. 1989b. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat Res 119:15–31.
   PubMed Web of Science ®Google Scholar
• Sprung CN, Ivashkevich A, Forrester HB, Redon CE, Georgakilas A, Martin OA. 2013. Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett pii:S0304–3835(13)00661–7.
   PubMedGoogle Scholar
• Thomas DM, Fox J, Haston CK. 2010. Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse. Int J Radiat Biol 86:436–444.
   PubMed Web of Science ®Google Scholar
• Toyoda T, Akagi J, Cho YM, Mizuta Y, Onami S, Suzuki I, Ogawa K. 2013. Detection of γ-H2AX, a biomarker for DNA double-strand breaks, in urinary bladders of N-butyl-N-(4-Hydroxybutyl)-nitrosamine-treated rats. J Toxicol Pathol 26:215–221.
   PubMedGoogle Scholar
• Wurm R, Burnet NG, Duggal N, Yarnold JR, Peacock JH. 1994. Cellular radiosensitivity and DNA damage in primary human fibroblasts. Int J Radiat Oncol Biol Phys 30:625–633.
   PubMed Web of Science ®Google Scholar