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PAPERS

Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?

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Pages 14-29 | Received 12 Feb 2010, Published online: 11 Nov 2010

References

  • Almaça J, Ousingsawat J, Hieke B, Viollet B, Schreiber R, Amaral MD, Kunzelmann K. 2009. AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflügers Arch 458:713–721.
  • Alvi F, Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. 2007. Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci 64:263–270.
  • Bachhuber T, Almaça J, AlDehni F, Mehta A, Amaral MD, Schreiber R, Kunzelmann K. 2008. Regulation of the epithelial Na+ channel by protein kinase CK2. J Biol Chem 283:13225–13232.
  • Barwise JL, Walker JH. 1996. Annexins II, IV, V and VI relocate in response to rises in intracellular calcium in human foreskin fibroblasts. J Cell Sci 109:247–255.
  • Benharouga M, Sharma M, So J, Haardt M, Drzymala L, Popov M, Schwapach B, Grinstein S, Du K, Lukacs GL. 2003. The role of the C terminus and na+/h+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. J Biol Chem 278:22079–22089.
  • Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L, Muimo R. 2007. The formation of the cAMP/PKA-dependent Annexin 2-S100A10 complex with CFTR regulates CFTR channel function. Mol Biol Cell 18:3388–3397.
  • Boucherot A, Schreiber R, Kunzelmann K. 2001. Role of CFTR's PDZ- binding domain, NBF1 and Cl- conductance in inhibition of epithelial Na+ channels in Xenopus oocytes. BBA 1515:64–71.
  • Broughman JR, Sun L, Umar S, Sellin JH, Morris AP. 2006. Chronic PKC-beta2 activation in HT-29 Cl.19a colonocytes prevents cAMP-mediated ion secretion by inhibiting apical membrane CFTR targeting. Am J Physiol Gastrointest Liver Physiol 291:G331–G344.
  • Cantiello HF. 2001. Role of actin filament organization in CFTR activation. Pflügers Arch 443(Suppl. 1):S75–S80.
  • Cholon DM, O'Neal WK, Randell SH, Riordan JR, Gentzsch M. 2010. Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol 98:L304–L314.
  • Cunningham SA, Worrell RT, Benos DJ, Frizzell RA. 1992. cAMP-stimulated ion currents in xenopus oocytes expressing CFTR cRNA. Am J Physiol 262:C783–C788.
  • Della GB, Weinman S, Huber C, Lemnaouar M, Paul A, Picard J, Gruenert DC. 1995. Overexpression of annexin V in cystic fibrosis epithelial cells from fetal trachea. Exp Cell Res 219:379–383.
  • Doherty GJ, McMahon HT. 2009. Mechanisms of endocytosis. Annu Rev Biochem 78:857–902.
  • Faria D, Schreiber R, Kunzelmann K. 2009. CFTR is activated through stimulation of purinergic P2Y2 receptors. Pflügers Arch 457:1373–1380.
  • Farinha CM, Amaral MD. 2005. Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin. Mol Cell Biol 25:5242–5252.
  • Farinha CM, Penque D, Roxo-Rosa M, Lukacs GL, Dormer R, McPherson M, Pereira M, Bot AG, Jorna H, Willemsen R, DeJonge H, Heda GD, Marino CR, Fanen P, Hinzpeter A, Lipecka J, Fritsch J, Gentzsch M, Edelman A, Amaral MD. 2004. Biochemical methods to assess CFTR expression and membrane localization. J Cyst Fibros 3(Suppl. 2):73–77.
  • Futter CE, White IJ. 2007. Annexins and endocytosis. Traffic 8:951–958.
  • Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR. 2004. Endocytic trafficking routes of wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator. Mol Biol Cell 15:2684–2696.
  • Gentzsch M, Choudhury A, Chang XB, Pagano RE, Riordan JR. 2007. Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking. J Cell Sci 120:447–455.
  • Gentzsch M, Riordan JR. 2001. Localization of sequences within the C-terminal domain of the cystic fibrosis transmembrane conductance regulator which impact maturation and stability. J Biol Chem 276:1291–1298.
  • Gerke V, Creutz CE, Moss SE. 2005. Annexins: linking Ca2+ signalling to membrane dynamics. Nat Rev Mol Cell Biol 6:449–461.
  • Gerke V, Moss SE. 2002. Annexins: from structure to function. Physiol Rev 82:331–371.
  • Guerra L, Fanelli T, Favia M, Riccardi SM, Busco G, Cardone RA, Carrabino S, Weinman EJ, Reshkin SJ, Conese M, Casavola V. 2005. Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues ΔF508 CFTR functional expression in cystic fibrosis cells. J Biol Chem 280:40925–40933.
  • Guggino WB, Stanton BA. 2006. New insights into cystic fibrosis: molecular switches that regulate CFTR. Nat Rev Mol Cell Biol 7:426–436.
  • Hayes MJ, Rescher U, Gerke V, Moss SE. 2004. Annexin-actin interactions. Traffic 5:571–576.
  • Hug T, Koslowsky T, Ecke D, Greger R, Kunzelmann K. 1995. Actin-dependent activation of ion conductances in bronchial epithelial cells. Pflügers Arch 429:682–690.
  • Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. 2006. Protein kinase C delta (ΔPKC)-annexin V interaction: a required step in ΔPKC translocation and function. J Biol Chem 281:23218–23226.
  • King JD, Jr., Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. 2009. AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol 297:C94–C101.
  • Kongsuphol P, Cassidy D, Hieke B, Treharne KJ, Schreiber R, Mehta A, Kunzelmann K. 2009. Mechanistic insight into control of CFTR by AMPK. J Biol Chem 284:5645–5653.
  • Lajoie P, Nabi IR. 2007. Regulation of raft-dependent endocytosis. J Cell Mol Med 11:644–653.
  • Le Drevo MA, Benz N, Kerbiriou M, Giroux-Metges MA, Pennec JP, Trouvé P, Ferec C. 2008. Annexin A5 increases the cell surface expression and the chloride channel function of the ΔF508-cystic fibrosis transmembrane regulator. Biochim Biophys Acta 1782:605–614.
  • Mendes F, Doucet L, Hinzpeter A, Ferec C, Lipecka J, Fritsch J, Edelman A, Jorna H, Willemsen R, Bot AG, De Jonge HR, Hinnrasky J, Castillon N, Taouil K, Puchelle E, Penque D, Amaral MD. 2004. Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures. J Cyst Fibros 3(Suppl. 2):37–41.
  • Penmatsa H, Zhang W, Yarlagadda S, Li C, Conoley VG, Yue J, Bahouth SW, Buddington RK, Zhang G, Nelson DJ, Sonecha MD, Manganiello V, Wine JJ, Naren AP. 2010. Compartmentalized cAMP at the plasma membrane clusters PDE3A and CFTR into microdomains. Mol Biol Cell 21:1097–1110.
  • Peter K, Varga K, Bebok Z, McNicholas-Bevensee CM, Schwiebert L, Sorscher EJ, Schwiebert EM, Collawn JF. 2002. Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression. J Biol Chem 277:49952–49957.
  • Prince LS, Peter K, Hatton SR, Zaliauskiene L, Cotlin LF, Clancy JP, Marchase RB, Collawn JF. 1999. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J Biol Chem 274:3602–3609.
  • Prince LS, Workman RB, Marchase RB. 1994. Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci USA 91:5192–5196.
  • Qu BH, Thomas PJ. 1996. Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway. J Biol Chem 271:7261–7264.
  • Ramalho AS, Lewandowska M, Farinha CM, Mendes F, Goncalves J, Barreto C, Harris A, Amaral MD. 2009. Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients. Cell Physiol Biochem 24:335–346.
  • Roxo-Rosa M, da Costa G, Luider TM, Scholte BJ, Coelho AV, Amaral MD, Penque D. 2006. Proteomic analysis of nasal cells from cystic fibrosis patients and non-cystic fibrosis control individuals: search for novel biomarkers of cystic fibrosis lung disease. Proteomics 6:2314–2325.
  • Roxo-Rosa M, Xu Z, Schmidt A, Neto M, Cai Z, Soares CM, Sheppard DN, Amaral MD. 2006. Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms. Proc Natl Acad Sci USA 103:17891–17896.
  • Schlaepfer DD, Jones J, Haigler HT. 1992. Inhibition of protein kinase C by annexin V. Biochemistry 31:1886–1891.
  • Schreiber R, Boucherot A, Mürle B, Sun J, Kunzelmann K. 2004. Control of epithelial ion transport by Cl- and PDZ proteins. J Membr Biol 199:89–98.
  • Scott-Ward TS, Amaral MD. 2009. Deletion of F508 in the first nucleotide binding domain of CFTR increases its affinity to bind the HSC70 chaperone. FEBS J 276:7097–7109.
  • Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, Boucher RC, Stutts MJ, Milgram SL. 1998. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeletonr. J Biol Chem 273:19797–19801.
  • Skrahina T, Piljic A, Schultz C. 2008. Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins. Exp Cell Res 314:1039–1047.
  • Spitzner M, Martins JR, Barro Soria R, Ousingsawat J, Scheidt K, Schreiber R, Kunzelmann K. 2008. Eag1 and bestrophin 1 are upregulated in fast growing colonic cancer cells. J Biol Chem 283:7421–7428.
  • Stossel TP, Chaponnier C, Ezzell RM, Hartwig JH, Janmey PA, Kwiatkowski DJ, Lind SE, Smith DB, Southwick FS, Yin HL. 1985. Nonmuscle actin-binding proteins. Annu Rev Cell Biol 1:353–402.
  • Sun F, Hug MJ, Lewarchik CM, Yun C, Bradbury NA, Frizzell RA. 2000. E3KARP mediates the association of ezrin and PKA with CFTR in airway cells. J Biol Chem 275:29539–29546.
  • Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, Cutting GR, Guggino WB, Langford G, Stanton BA. 2002. PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 277:40099–40105.
  • Takahashi A, Watkins SC, Howard M, Frizzell RA. 1996. CFTR-dependent membrane insertion is linked to stimulation of the CFTR Cl- channel. Am J Physiol 271:C1887–C1894.
  • Thelin WR, Chen Y, Gentzsch M, Kreda SM, Sallee JL, Scarlett CO, Borchers CH, Jacobson K, Stutts MJ, Milgram SL. 2007. Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest 117:364–374.
  • Trouvé P, Le Drevo MA, Kerbiriou M, Friocourt G, Fichou Y, Gillet D, Ferec C. 2007. Annexin V is directly involved in cystic fibrosis transmembrane conductance regulator's chloride channel function. Biochim Biophys Acta 1772:1121–1133.
  • Tzima E, Trotter PJ, Orchard MA, Walker JH. 2000. Annexin V relocates to the platelet cytoskeleton upon activation and binds to a specific isoform of actin. Eur J Biochem 267:4720–4730.
  • Wang W, Kirsch T. 2006. Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes. J Biol Chem 281:30848–30856.
  • Weber WM, Cuppens H, Cassiman JJ, Clauss W, Van Driessche W. 1999. Capacitance measurements reveal different pathways for the activation of CFTR. Pflügers Arch 438:561–569.
  • Weber WM, Segal A, Simaels J, Vankeerberghen A, Cassiman JJ, Van Driessche W. 2001. Functional integrity of the vesicle transporting machinery is required for complete activation of CFTR expressed in Xenopus laevis oocytes. Pflügers Arch 441:850–859.
  • Young A, Gentzsch M, Abban CY, Jia Y, Meneses PI, Bridges RJ, Bradbury NA. 2009. Dynasore inhibits removal of wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane. Biochem J 421:377–385.

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