798
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Ligand binding properties of human galanin receptors

, &
Pages 206-216 | Received 30 May 2012, Accepted 18 Oct 2012, Published online: 13 Dec 2012

References

  • Baldwin JM. 1993. The probable arrangement of the helices in G protein-coupled receptors. EMBO J 12:1693–1703.
  • Baldwin JM. 1994. Structure and function of receptors coupled to G proteins. Curr Opin Cell Biol 6:180–190.
  • Bedecs K, Langel Ü, Bartfai T. 1995. Metabolism of galanin and galanin (1-16) in isolated cerebrospinal fluid and spinal cord membranes from rat. Neuropeptides 29:137–143.
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, 2000. The protein data bank. Nucleic Acids Res 28:235–242.
  • Bernsel A, Viklund H, Hennerdal A, Elofsson A. 2009. TOPCONS: Consensus prediction of membrane protein topology. Nucleic Acids Res 37:W465–W468.
  • Berthold M, Kahl U, Juréus A, Kask K, Nordvall G, Langel U, 1997. Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1. Eur J Biochem/FEBS 249:601–606.
  • Branchek TA, Smith KE, Gerald C, Walker MW. 2000. Galanin receptor subtypes. Trends Pharmacolog Sci 21:109–117.
  • Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SGF, Thian FS, Kobilka TS, 2007. High-resolution crystal structure of an engineered human beta2-adrenergic G protein–coupled receptor. Science (NY) 318:1258–1265.
  • Church WB, Jones KA, Kuiper DA, Shine J, Iismaa TP. 2002. Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity. Protein Engineer 15:313–323.
  • Clément M, Martin SS, Beaulieu M-E, Chamberland C, Lavigne P, Leduc R, 2005. Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay. J Biologic Chem 280:27121–27129.
  • De Lano W. 2002. The Pymol molecular graphics system.
  • Dundas J, Ouyang Z, Tseng J, Binkowski A, Turpaz Y, Liang J. 2006. CASTp: Computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res 34:W116–W118.
  • Ericson E, Ahlenius S. 1999. Suggestive evidence for inhibitory effects of galanin on mesolimbic dopaminergic neurotransmission. Brain Res 822:200–209.
  • Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen M-Y, 2007. Comparative protein structure modeling using MODELLER. Curr Protoc Prot Sci/ edit board Coligan JE, Chapt. 2, Unit 2.9.
  • Evans H, Baumgartner M, Shine J, Herzog H. 1993. Genomic organization and localization of the gene encoding human preprogalanin. Genomics 18:473–477.
  • Fathi Z, Cunningham AM, Iben LG, Battaglino PB, Ward SA, Nichol KA, 1997. Cloning, pharmacological characterization and distribution of a novel galanin receptor. Brain Res Mol Brain Res 51:49–59.
  • Fisone G, Wu CF, Consolo S, Nordström O, Brynne N, Bartfai T, 1987. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: Histochemical, autoradiographic, in vivo, and in vitro studies. Proc Natl Acad Sci USA 84:7339–7343.
  • Florén A, Land T, Langel Ü. 2000. Galanin receptor subtypes and ligand binding. Neuropeptides 34:331–337.
  • Florén A, Sollenberg U, Lundström L, Zorko M, Stojan J, Budihna M, 2005. Multiple interaction sites of galnon trigger its biological effects. Neuropeptides 39:547–558.
  • Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. 2003. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci USA 100:2290–2295.
  • Fuxe K, Jansson A, Diaz-Cabiale Z, Andersson A, Tinner B, Finnman UB, 1998. Galanin modulates 5-hydroxytryptamine functions. Focus on galanin and galanin fragment/5-hydroxytryptamine1A receptor interactions in the brain. Annals NY Acad Sci 863:274–290.
  • Gales C. 2000. Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor. J Biolog Chem 275:17321–17327.
  • Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, 2004. Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Medicinal Chem 47:1750–1759.
  • Hökfelt T, Xu ZQ, Shi TJ, Holmberg K, Zhang X. 1998. Galanin in ascending systems. Focus on coexistence with 5-hydroxytryptamine and noradrenaline. Annals NY Acad Sci 863:252–263.
  • Kask K, Berthold M, Kahl U, Juréus A, Nordvall G, Langel U, 1998. Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding. Annals NY Acad Sci 863:78–85.
  • Kehr J, Yoshitake T, Wang F-H, Razani H, Gimenez-Llort L, Jansson A, 2002. Galanin is a potent in vivo modulator of mesencephalic serotonergic neurotransmission. Neuropsychopharmacology 27:341–356.
  • Konkel MJ, Packiarajan M, Chen H, Topiwala UP, Jimenez H, Talisman IJ, 2006. Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorgan Medicin Chem Lett 16:3950–3954.
  • Krishna AG, Menon ST, Terry TJ, Sakmar TP. 2002. Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch. Biochemistry 41:8298–8309.
  • Krogh A, Larsson B, von Heijne G, Sonnhammer EL. 2001. Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes. J Molec Biol 305:567–580.
  • Kuteeva E, Hökfelt T, Wardi T, Ögren SO. 2008. Galanin, galanin receptor subtypes and depression-like behaviour. Cellular Molec Life Sci 65:1854–1863.
  • Laplante F, Crawley JN, Quirion R. 2004. Selective reduction in ventral hippocampal acetylcholine release in awake galanin-treated rats and galanin-overexpressing transgenic mice. Regulat Peptides 122:91–98.
  • Lassmann T, Sonnhammer ELL. 2005. Kalign – an accurate and fast multiple sequence alignment algorithm. BMC Bioinform 6:298.
  • Lawrence CB, Fraley GS. 2010. Galanin-like peptide: Neural regulator of energy homeostasis and reproduction. EXS 102:263–280.
  • Lengauer T, Rarey M. 1996. Computational methods for biomolecular docking. Current Opin Struct Biol 6:402–406.
  • Liu HX, Brumovsky P, Schmidt R, Brown W, Payza K, Hodzic L, 2001. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors. Proc Natl Acad Sci USA 98:9960–9964.
  • Lu X, Lundström L, Bartfai T. 2005. Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypes. Neuropeptides 39:165–167.
  • Lundström L, Elmquist A, Bartfai T, Langel U. 2005. Galanin and its receptors in neurological disorders. Neuromolec Med 7:157–180.
  • Lundström L, Sollenberg UE, Bartfai T, Langel U. 2007. Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions. J Neurochem 103:1774–1784.
  • Melo F, Sánchez R, Sali A. 2002. Statistical potentials for fold assessment. Protein Sci 11:430–448.
  • Morris MB, Ralston GB, Biden TJ, Browne CL, King GF, Iismaa TP. 1995. Structural and biochemical studies of human galanin: NMR evidence for nascent helical structures in aqueous solution. Biochemistry 34:4538–4545.
  • Murakami M, Kouyama T. 2008. Crystal structure of squid rhodopsin. Nature 453:363–367.
  • Nordström O, Melander T, Hökfelt T, Bartfai T, Goldstein M. 1987. Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence. Neurosci Lett 73:21–26.
  • Ohman A, Lycksell PO, Juréus A, Langel U, Bartfai T, Gräslund A. 1998. NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist. Biochemistry 37:9169–9178.
  • Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, 2000. Crystal structure of rhodopsin: A G protein-coupled receptor. Science (NY) 289:739–745.
  • Parthiban M, Shanmughavel P. 2007. Three dimensional modeling of N-terminal region of galanin and its interaction with the galanin receptor. Bioinformation 2:119–125.
  • Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC. 1992. Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 11:1–20.
  • Rasmussen SGF, Choi H-J, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, 2007. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 450:383–387.
  • Robinson JK. 2004. Galanin and cognition. Behav Cognit Neurosci Rev 3:222–242.
  • Robinson JK, Bartfai T, Langel Ü. 2006. Galanin/GALP receptors and CNS homeostatic processes. CNS Neurolog Disorders Drug Targets 5:327–334.
  • Runesson J, Saar I, Lundström L, Järv J, Langel U. 2009. A novel GalR2-specific peptide agonist. Neuropeptides 43:187–192.
  • Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, 2010. Determining receptor-ligand interaction of human galanin receptor type 3. Neurochem Int 57:804–811.
  • Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, 2002. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci USA 99:7136–7141.
  • Sautel M, Martinez R, Munoz M, Peitsch MC, Beck-Sickinger AG, Walker P. 1995. Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding. Molec Cellular Endocrinol 112:215–222.
  • Schwartz TW. 1994. Locating ligand-binding sites in 7TM receptors by protein engineering. Current Opin Biotechnol 5:434–444.
  • Sjödin P, Holmberg SKS, Akerberg H, Berglund MM, Mohell N, Larhammar D. 2006. Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: A site-directed mutagenesis study. Biochem J 393:161–169.
  • Strnad J, Hadcock JR. 1995. Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2. Biochem Biophys Res Communic 216:913–921.
  • Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu Z-QD, Hökfelt T, 2005. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci USA 102:17489–17494.
  • Teodoro ML, Phillips GN Jr, Kavraki LE. 2001. Molecular docking: A problem with thousands of degrees of freedom. IEEE Int Conf Robotics Automat 960–966.
  • Wang S, Hashemi T, He C, Strader C, Bayne M. 1997. Molecular cloning and pharmacological characterization of a new galanin receptor subtype. Molec Pharmacol 52:337–343.
  • Warne T, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, 2008. Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 454: 486–491.
  • Wiesenfeld-Hallin Z, Xu X-J, Crawley JN, Hökfelt T. 2005. Galanin and spinal nociceptive mechanisms: Recent results from transgenic and knock-out models. Neuropeptides 39:207–210.
  • Wrenn CC, Crawley JN. 2001. Pharmacological evidence supporting a role for galanin in cognition and affect. Progress Neuro-Psychopharmacol Biolog Psychiatry 25:283–299.
  • Zhang L, Robertson CR, Green BR, Pruess TH, White HS, Bulaj G. 2009. Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Medicinal Chem 52:1310–1316.
  • Zini S, Roisin MP, Armengaud C, Ben-Ari Y. 1993. Effect of potassium channel modulators on the release of glutamate induced by ischaemic-like conditions in rat hippocampal slices. Neurosci Lett 153:202–205.
  • von Heijne G. 1989. Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues. Nature 341:456–458.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.