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Research Article

Too fast for catalysis

, &
Pages 269-271 | Published online: 30 Sep 2013

References

  • Bandaria JN, Dutta S, Nydegger MW, Rock W, Kohen A, Cheatum CM. 2010. Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase. Proc Natl Acad Sci USA 107:17974–17979.
  • Bhabha G, Lee J, Ekiert D, Gam J, Wilson IA, Dyson HJ, Benkovic SJ, Wright PE. 2011. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science 332:234–238.
  • Cui QA, Karplus M. 2002. Promoting modes and demoting modes in enzyme-catalyzed proton transfer reactions: a study of models and realistic systems. J Phys Chem B 106: 7927–7947.
  • Doshi U, McGowan LC, Ladani ST, Hamelberg D. 2012. Resolving the complex role of enzyme conformational dynamics in catalytic function. Proc Natl Acad Sci USA 109:5699–5704.
  • Hammes GG, Benkovic SJ, Hammes-Schiffer S. 2011. Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Biochemistry 50:10422–10430.
  • Henzler-Wildman K, Kern D. 2007. Dynamic personalities of proteins. Nature 450:964–972.
  • Kamerlin SCL, Warshel A. 2010. At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?. Proteins 78:1339–1375.
  • Kosugi T, Hayashi S. 2012. Crucial role of protein flexibility in formation of a stable reaction transition state in an α-Amylase catalysis. J Am Chem Soc 136:7045–7055.
  • Lee GM, Craik, CS. 2009. Trapping moving targets with small molecules. Science 324:213–215.
  • Nagel ZD, Klinman JP. 2009. A 21st century revisionist's view at a turning point in enzymology. Nat Chem Biol 5:543–550.
  • Nunez S, Antioniou D, Schramm VL, Schwartz SD. 2004. Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study. J Am Chem Soc 126: 15720–15729.
  • Peng JW. 2009. Communication breakdown: protein dynamics and drug design. Structure 17:319–320.
  • Peters B. 2010. Transition-State theory, dynamics, and narrow time scale separation in the rate-promoting vibrations model of enzyme catalysis. J Chem Theory Comput 6:1447–1454.
  • Russell HJ, Jones, AR, Hay S, Greetham GM, Towrie M, Scrutton NS. 2012. Protein motions are coupled to the reaction chemistry in coenzyme B12-dependent ethanolamine ammonia lyase. Angew Chem Int Ed 51:9306–9310.
  • Schwartz SD, Schramm VL. 2009. Enzymatic transition states and dynamic motion in barrier crossing. Nat Chem Biol 8: 551–558.
  • Suydam IT, Snow CD, Pande VS, Boxer SG. 2006. Electric fields at the active site of an enzyme: direct comparison of experiment with theory. Science 313:200–204.
  • Wolfenden R, Snider MJ. 2001. The depth of chemical time and the power of enzymes as catalysts. Acc Chem Res 34: 938–945.

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