Stressful life events, perceived stress, and 12-month course of geriatric depression: Direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms

References

• Alexopoulos GS, Young RC, Abrams RC, Meyers B, Shamoian CA. 1989. Chronicity and relapse in geriatric depression. Biol Psychiatry. 26 6: 551–564.
   PubMed Web of Science ®Google Scholar
• Andrew B, Hawton K, Fagg J, Westbrook D. 1993. Do psychosocial factors influence outcome in severely depressed female psychiatric in-patients?. Br J Psychiatry. 163:747–754.
   PubMed Web of Science ®Google Scholar
• Baldwin RC, Jolley DJ. 1986. The prognosis of depression in old age. Br J Psychiatry. 149:574–583.
   PubMed Web of Science ®Google Scholar
• Belsher G, Costello CG. 1988. Relapse after recovery from unipolar depression: A critical review. Psychol Bull. 104 1: 84–96.
   PubMed Web of Science ®Google Scholar
• Belsky J, Jonassaint C, Pluess M, Stanton M, Brummett B, Williams R. 2009. Vulnerability genes or susceptibility genes?. Mol Psychiatry. 14 8: 746–754.
   PubMed Web of Science ®Google Scholar
• Billings AG, Moos RH. 1985. Life stressors and social resources affect posttreatment outcomes among depressed patients. J Abnorm Psychol. 94 2: 140–153.
   PubMed Web of Science ®Google Scholar
• Blazer DG, Hybels CF. 2005. Origins of depression in later life. Psychol Med. 35 9: 1241–1252.
   PubMed Web of Science ®Google Scholar
• Bukh JD, Bock C, Vinberg M, Werge Y, Gether U, Kessing LV. 2010. No association between genetic polymorphisms and stressful life events on outcomes of antidepressant treatment. Eur Neuropsychopharmacol. 20 5: 327–335.
   PubMed Web of Science ®Google Scholar
• Bulmash E, Harkness KL, Stewart JG, Bagby RM. 2009. Personality, stressful life events, and treatment response in major depression. J Consult Clin Psychol. 77 6: 1067–1077.
   PubMed Web of Science ®Google Scholar
• Burvill PW, Hall WD, Stampfer HG, Emmerson JP. 1991. The prognosis of depression in old age. Br J Psychiatry. 158:64–71.
   PubMed Web of Science ®Google Scholar
• Candrian M, Farabaugh A, Pizzagalli DA, Baer L, Fava M. 2007. Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome on major depression: A path analysis. J Nerv Ment Dis. 195 9: 729–737.
   PubMed Web of Science ®Google Scholar
• Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. 2003. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science. 301 5631: 386–389.
   PubMed Web of Science ®Google Scholar
• Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR. 2004. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Human Genetics. 75 5: 807–821.
   PubMed Web of Science ®Google Scholar
• Chrousos GP. 2009. Stress and disorders of the stress system. Nat Rev Endocrinol. 5 7: 374–381.
   PubMed Web of Science ®Google Scholar
• Cronkite RC, Moos RH, Twohey J, Cohen C, Swindle RJr. 1998. Life circumstances and personal resources as predictors of the ten-year course of depression. Am J Community Psychol. 26 2: 255–280.
   PubMed Web of Science ®Google Scholar
• Drabant EM, Hariri AR, Meyer-Lindenberg A, Munoz KE, Mattay VS, Kolachana BS, Egan MF, Weinberger DR. 2006. Catechol O-methyltransferase Val158Met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry. 63 12: 1396–1406.
   PubMed Web of Science ®Google Scholar
• Drury SS, Theall KP, Smyke AT, Keats BJB, Egger HL, Nelson CA, Fox NA, Marshall PJ, Zeanah CH. 2010. Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation. Child Abuse Negl. 34 6: 387–395.
   PubMed Web of Science ®Google Scholar
• Farabaugh AH, Mischoulon D, Fava M, Green C, Guyker W, Alpert J. 2004. The potential relationship between levels of perceived stress and subtypes of major depressive disorder (MDD). Acta Psychiatr Scand. 110 6: 465–470.
   PubMed Web of Science ®Google Scholar
• Faravelli C, Ambonetti A, Pallanti S, Pazzagli A. 1986. Depressive relapses and incomplete recovery from index episode. Am J Psychiatry. 143 7: 888–891.
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. 1975. Mini-mental state a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12 3: 189–198.
   PubMed Web of Science ®Google Scholar
• George IK. 1994. Social factors and depression in late life. In: Schneider LS, Reynolds CF, Lebowitz BD, Friedhoff AJ. editors. Diagnosis and treatment of depression in late life. Washington DC: American Psychiatric Press131–153.
   Google Scholar
• Gonzales LR, Lewinsohn PM, Clarke GN. 1985. Longitudinal follow-up of unipolar depressives: An investigator of predictors of relapse. J Consult Clin Psychol. 53 4: 461–469.
   PubMed Web of Science ®Google Scholar
• Hammen C. 1991. Generation of stress in the course of unipolar depression. J Abnorm Psychol. 100 4: 555–561.
   PubMed Web of Science ®Google Scholar
• Hammen C. 2005. Stress and depression. Annu Rev Clin Psychol. 1:293–319.
   PubMed Web of Science ®Google Scholar
• Harkness KL, Monroe SM. 2006. Severe melancholic depression is more vulnerable than non-melancholic depression to minor precipitating life events. J Affect Disord. 91 2–3: 257–263.
   PubMed Web of Science ®Google Scholar
• Hays JC, Krishnan KRR, George LK, Pieper CF, Flint EP, Blazer DG. 1997. Psychosocial and physical correlates of chronic depression. Psychiatry Res. 72 3: 149–159.
   PubMed Web of Science ®Google Scholar
• Jabbi M, Kema IP, van der Pompe G, te Meermann GJ, Ormel J, den Boer JA. 2007. Catechol-O-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response. Psychiatr Genetics. 17 3: 183–193.
   PubMed Web of Science ®Google Scholar
• Kaufman J, Gelernter J, Kaffman A, Caspi A, Moffitt T. 2010. Arguable assumptions, debatable conclusions. Biol Psychiatry. 67 4: e19–e20.
   PubMedGoogle Scholar
• Karel MJ. 1997. Aging and depression: Vulnerability and stress across adulthood. Clin Psychol Rev. 17 8: 847–879.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Karkowski LM, Prescott CA. 1998. Stressful life events and major depression: Risk period, long-term contextual threat, and diagnostic specificity. J Nerv Ment dis. 186 11: 661–669.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Karkowski LM, Prescott CA. 1999. Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry. 156 6: 837–841.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Thornton LM, Gardner CO. 2000. Stressful life events and previous episodes in the etiology of major depression in women: An evaluation of the “kindling” hypothesis. Am J Psychiatry. 157 8: 1243–1251.
   PubMed Web of Science ®Google Scholar
• Kennedy GJ, Kelman HR, Thomas C. 1991. Persistence and remission of depressive symptoms in late life. Am J Psychiatry. 148 2: 174–178.
   PubMed Web of Science ®Google Scholar
• Kessler RC. 1997. The effects of stressful life events on depression. Ann Rev Psychol. 48:191–214.
   PubMed Web of Science ®Google Scholar
• Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Kim YH, Yoon JS. 2007. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry. 62 5: 423–428.
   PubMed Web of Science ®Google Scholar
• Kivela SL, Viramo P, Pahkala K. Factors predicting the relapse of depression in old age. Int J Geriatr Psychiatry. 2000a; 15 2: 112–119.
   PubMed Web of Science ®Google Scholar
• Kivela SL, Viramo P, Pahkala K. Factors predicting chronicity of depression in elderly primary care patients. Int Psychogeriatr. 2000b; 12 2: 183–194.
   PubMed Web of Science ®Google Scholar
• Koenen KC, Galea S. 2009. Gene–environment interactions and depression. JAMA. 302 17: 1859.
   PubMed Web of Science ®Google Scholar
• Kraaij V, de Wilde EJ. 2001. Negative life events and depressive symptoms in the elderly: A life span perspective. Aging Ment Health. 5 1: 84–91.
   PubMed Web of Science ®Google Scholar
• Kraaij V, Arensman E, Spinhoven P. 2002. Negative life events and depression in elderly persons: A meta-analysis. J Gerontol Psychol Sci. 57B 1: 87–94.
   Google Scholar
• Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. 1996. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 6 3: 243–250.
   PubMedGoogle Scholar
• Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, Rogers JC, Quear T, Houck P, Reynolds CF. 2005. Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry. 13 5: 428–432 3rd.
   PubMed Web of Science ®Google Scholar
• Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274 5292: 1527–1531.
   PubMed Web of Science ®Google Scholar
• Lethbridge R, Allen NB. 2008. Mood induced cognitive and emotional reactivity, life stress, and the prediction of depressive relapse. Behav Res Ther. 46 10: 1142–1150.
   PubMed Web of Science ®Google Scholar
• Lotrich FE, Lenze E. 2009. Gene–environment interactions and depression. JAMA. 302 17: 1859–1860.
   PubMed Web of Science ®Google Scholar
• Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I, Taskinen J. 1995. Kinetics of human soluble and membrane-bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry. 34 13: 4202–4210.
   PubMed Web of Science ®Google Scholar
• Lloyd C, Zisook S, Click MJr, Jaffe KE. 1981. Life events and response to antidepressants. J Human Stress. 7 1: 2–15.
   PubMed Web of Science ®Google Scholar
• Mandelli L, Marino E, Pirovano A, Calati R, Zanardi R, Colombo C, Serretti A. 2009. Interaction between SERTPR and stressful life events on response to antidepressant treatment. Eur Neuropsychopharmacol. 19 1: 64–67.
   PubMed Web of Science ®Google Scholar
• Mazure CM, Bruce ML, Maciejewski PK, Jacobs SC. 2000. Adverse life events and cognitive-personality characteristics in the prediction of major depression and antidepressant response. Am J Psychiatry. 157 6: 896–903.
   PubMed Web of Science ®Google Scholar
• McGonagle KA, Kessler RC. 1990. Chronic stress, acute stress, and depressive symptoms. Am J Community Psychol. 18 5: 681–706.
   PubMed Web of Science ®Google Scholar
• Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B, Reynolds CF. 1992. Rating chronic medical illness burden in geropsychiatric practice and research: Application of the cumulative illness rating scale. Psychiatry Res. 41 3: 237–248 3rd.
   PubMed Web of Science ®Google Scholar
• Monroe SM, Bellack AS, Hersen M, Himmelhoch JM. 1983. Life events, symptom course, and treatment outcome in unipolar depressed women. J Consult Clin Psychol. 51 4: 604–615.
   PubMed Web of Science ®Google Scholar
• Monroe SM, Kupfer DJ, Frank E. 1992. Life stress and treatment course of recurrent depression: 1. Response during index episode. J Consult Clin Psychol. 60 5: 718–724.
   PubMed Web of Science ®Google Scholar
• Montgomery SA, Asberg M. 1979. A new depression scale designed to be sensitive to change. Br J Psychiatry. 134:382–389.
   PubMed Web of Science ®Google Scholar
• Munafo MR, Durrant C, Lewis G, Flint J. 2009. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry. 65 3: 211–219.
   PubMed Web of Science ®Google Scholar
• Mundt C, Reck C, Backenstrass M, Kronmuller K, Fiedler P. 2000. Reconfirming the role of life events for the timing of depressive episodes. A two-year prospective follow-up study. J Affect Disord. 59 1: 23–30.
   PubMed Web of Science ®Google Scholar
• Murphy E. 1982. Social origins of depression in old age. Br J Psychiatry. 141:135–142.
   PubMed Web of Science ®Google Scholar
• Murphy E. 1983. The prognosis of depression in old age. Br J Psychiatry. 142:111–119.
   PubMed Web of Science ®Google Scholar
• Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. 2002. Neurobiology of depression. Neuron. 34 1: 13–25.
   PubMed Web of Science ®Google Scholar
• Pedrelli P, Feldman GC, Vorono S, Fava M, Petersen T. 2008. Dysfunctional attitudes and perceived stress predict depressive symptoms severity following antidepressant treatment in patients with chronic depression. Psychiatry Res. 161 3: 302–308.
   PubMed Web of Science ®Google Scholar
• Potter GG, Taylor WD, McQuoid DR, Steffens DC, Welsh-Bohmer KA, Krishnan KR. 2009. The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults. Int J Geriatr Psychiatry. 24 10: 1127–1133.
   PubMed Web of Science ®Google Scholar
• Ravindran AV, Matheson K, Griffiths J, Merali Z, Anisman H. 2002. Stress, coping, uplifts, and quality of life in subtypes of depression: A conceptual frame and emerging data. J Affect Disord. 71 1–3: 121–130.
   PubMed Web of Science ®Google Scholar
• Reno RM, Halaris AE. 1990. The relationship between life stress and depression in an endogenous sample. Compr Psychiatry. 31 1: 25–33.
   PubMed Web of Science ®Google Scholar
• Rieckmann N, Rapp MA, Muller-Nordhorn J. 2009. Gene–environment interactions and depression. JAMA. 302 17: 1861.
   PubMed Web of Science ®Google Scholar
• Rimmler J, McDowell JG, Slotterback BD, Haynes CS, Menold MM, Rogala A, Speer MC, Gilbert JR, Hauser ER, Vance JM, Pericak-Vance MA. 1998. Development of a data coordinating center (DCC): Data quality control for complex disease studies. Am J Hum Genet Suppl. 62:A240.
   Google Scholar
• Risch N, Herrell R, Lehner T, Liang K, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR. 2009. Interaction between the berotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA. 301 23: 2462–2471.
   PubMed Web of Science ®Google Scholar
• Robins LN, Helzer JE, Croughan J, Ratcliff KS. 1981. National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Arch Gen Psychiatry. 38 4: 381–389.
   PubMed Web of Science ®Google Scholar
• Savitz J, Solms M, Ramesar R. 2006. The molecular genetics of cognition: Dopamine, COMT, and BDNF. Genes Brain Behav. 5 4: 311–328.
   PubMed Web of Science ®Google Scholar
• Schoevers RA, Beekman ATF, Deeg DJH, Hooijer C, Jonker C, van Tilburg W. 2003. The natural history of late-life depression: Results from the Amsterdam study of the elderly (AMSTEL). J Affect Disord. 76 1–3: 5–14.
   PubMed Web of Science ®Google Scholar
• Smolka MN, Schumann G, Wrase J, Grusser SM, Flor H, Mann K, Braus DF, Goldman D, Büchel C, Heinz A. 2005. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci. 25 4: 836–842.
   PubMed Web of Science ®Google Scholar
• Steffens DC, McQuoid DR, Krishnan KRR. The Duke somatic treatment algorithm for geriatric depression (STAGED) approach. Psychopharmacol Bull. 2002a; 36 2: 58–68.
   PubMedGoogle Scholar
• Steffens DC, Svenson I, Marchuk DA, Levy RM, Hays JC, Flint EP, Krishnan KR, Siegler IC. Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. Am J Geriatr Psychiatry. 2002b; 10 2: 185–191.
   PubMed Web of Science ®Google Scholar
• Surtees PG, Miller PM, Ingham JG, Kreitman NB, Rennie D, Sashidharan SP. 1986. Life events and the onset of affective disorder: A longitudinal general population study. J Affect Disord. 10 1: 37–50.
   PubMed Web of Science ®Google Scholar
• Swindle RWJr, Cronkite RC, Moos RH. 1989. Life stressors, social resources, coping, and the 4-year course of unipolar depression. J Abnorm Psychol. 98 4: 468–477.
   PubMed Web of Science ®Google Scholar
• Taylor WD, Steffens DC, Payne ME, MacFall JR, Marchuk DA, Svenson IK, Krishnan KR. 2005. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry. 62 5: 537–544.
   PubMed Web of Science ®Google Scholar
• Taylor SE, Way BM, Welch WT, Hilmert CJ, Lehman BJ, Eisenberger NI. 2006. Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol Psychiatry. 60 7: 671–676.
   PubMed Web of Science ®Google Scholar
• Taylor WD, Zuchner S, Payne ME, Messer DF, Doty TJ, MacFall JR, Beyer JL, Krishnan KR. 2007. The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. Psychiatry Res. 155 2: 173–177.
   PubMed Web of Science ®Google Scholar
• Tennant C. 2002. Life events, stress and depression: A review of recent findings. Aust N Z J Psychiatry. 36 2: 173–182.
   PubMed Web of Science ®Google Scholar
• Vieland VJ. 2001. The replication requirement. Nat Genet. 29 3: 244–245.
   PubMed Web of Science ®Google Scholar
• Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D. 2003. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 299 5610: 1240–1243.
   PubMed Web of Science ®Google Scholar