The hidden price of repeated traumatic exposure

References

• Acheson DT, Gresack JE, Risbrough VB. (2012). Hippocampal dysfunction effects on context memory: possible etiology for post-traumatic stress disorder. Neuropharmacology 62:674–85
   PubMed Web of Science ®Google Scholar
• Beck AT, Steer RA, Brown GK. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation
   Google Scholar
• Brown AD, Root JC, Romano TA, Chang LJ, Bryant RA, Hirst W. (2013). Overgeneralized autobiographical memory and future thinking in combat veterans with post-traumatic stress disorder. J Behav Ther Exp Psychiatry 44:129–34
   PubMed Web of Science ®Google Scholar
• Buchel C, Dolan RJ, Armony JL, Friston KJ. (1999). Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related fMRI. J Neurosci 19:10869–76
   PubMed Web of Science ®Google Scholar
• Chang CM, Lee LC, Connor KM, Davidson JR, Lai TJ. (2008). Modification effects of coping on post-traumatic morbidity among earthquake rescuers. Psychiatry Res 158:164–71
   PubMed Web of Science ®Google Scholar
• Davachi L. (2006). Item, context and relational episodic encoding in humans. Curr Opin Neurobiol 16:693–700
   PubMed Web of Science ®Google Scholar
• Del Ben KS, Scotti JR, Chen Y, Fortson BL. (2006). Prevalence of posttraumatic stress disorder symptoms in firefighters. Work Stress 20:37–48
   Web of Science ®Google Scholar
• Diana RA, Yonelinas AP, Ranganath C. (2012). Adaptation to cognitive context and item information in the medial temporal lobes. Neuropsychologia 50:3062–9
   Google Scholar
• Dickerson BC, Eichenbaum H. (2010). The episodic memory system: neurocircuitry and disorders. Neuropsychopharmacology 35:86–104
   PubMed Web of Science ®Google Scholar
• Fani N, Tone EB, Phifer J, Norrholm SD, Bradley B, Ressler KJ, Kamkwalala A, Jovanovic T. (2012). Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSD. Psychol Med 42:533–43
   PubMed Web of Science ®Google Scholar
• Fellows LK, Farah MJ. (2003). Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain 126:1830–7
   PubMed Web of Science ®Google Scholar
• First MB, Gibbon M, Spitzer RL, Williams JBW. (1996). User’s Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders-Research Version. New York: Biometrics Research Department, New York State Psychiatric
   Google Scholar
• Foerde K, Shohamy D. (2011). Feedback timing modulates brain systems for learning in humans. J Neurosci 31:13157–67
   Google Scholar
• Fushimi M. (2012). Posttraumatic stress in professional firefighters in japan: rescue efforts after the Great East Japan Earthquake (higashi nihon dai-shinsai). Prehosp Disaster Med 27:416–18
   PubMed Web of Science ®Google Scholar
• Giachero M, Calfa GD, Molina VA. (2013). Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning. Learn Mem 20:611–16
   Google Scholar
• Goosens KA. (2011). Hippocampal regulation of aversive memories. Curr Opin Neurobiol 21:460–6
   Google Scholar
• Guthrie RM, Bryant RA. (2006). Extinction learning before trauma and subsequent posttraumatic stress. Psychosom Med 68:307–11
   PubMed Web of Science ®Google Scholar
• Hockley WE. (2008). The effects of environmental context on recognition memory and claims of remembering. J Exp Psychol Learn Mem Cogn 34:1412–29
   PubMed Web of Science ®Google Scholar
• Isarida T, Isarin TK. (2007). Environmental context effects of background color in free recall. Mem Cognit 35:1620–9
   PubMed Web of Science ®Google Scholar
• Karl A, Schaefer M, Malta LS, Dorfel D, Rohleder N, Werner A. (2006). A meta analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 30:1004–31
   PubMed Web of Science ®Google Scholar
• Kitayama N, Vaccarino V, Kutner M, Weiss P, Bremner JD. (2005). Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord 88:79–86
   PubMed Web of Science ®Google Scholar
• Kleim B, Ehring T, Ehlers A. (2012). Perceptual processing advantages for trauma-related visual cues in post-traumatic stress disorder. Psychol Med 42:173–81
   Web of Science ®Google Scholar
• LaBar KS, Cabeza R. (2006). Cognitive neuroscience of emotional memory. Nat Rev Neurosci 7:54–64
   PubMed Web of Science ®Google Scholar
• Lang S, Kroll A, Lipinski SJ, Wessa M, Ridder S, Christmann C, Schad LR, Flor H. (2009). Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex. Eur J Neurosci 29:823–32
   PubMed Web of Science ®Google Scholar
• Levy-Gigi E, Kelemen O, Gluck MA, Kéri S. (2011). Impaired context reversal learning, but not cue reversal learning, in patients with amnestic mild cognitive impairment. Neuropsychologia 49:3320–6
   PubMed Web of Science ®Google Scholar
• Levy-Gigi E, Kéri S. (2012). Falling out of time: enhanced memory for scenes presented at behaviorally irrelevant points in time in Posttraumatic Stress Disorder (PTSD). PLoS One 7:e42502
   PubMed Web of Science ®Google Scholar
• Levy-Gigi E, Kéri S, Myers CE, Lencovsky Z, Sharvit-Benbaji H, Orr SP, Gilbertson MW, et al. (2012). Individuals with post-traumatic stress disorder show a selective deficit in generalization of associative learning. Neuropsychology 26:758–67
   PubMed Web of Science ®Google Scholar
• Levy-Gigi E, Szabo C, Richter-Levin G, Kéri S. (2014). Reduced hippocampal volume is associated with impaired generalization of negative context in individuals with PTSD. [Epub ahead of print]
   Google Scholar
• Macken WJ. (2002). Environmental context and recognition: the role of recollection and familiarity. J Exp Psychol Learn Memory Cogn 28:153–61
   PubMed Web of Science ®Google Scholar
• Maren S, Phan KL, Liberzon I. (2013). The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14:417–28
   PubMed Web of Science ®Google Scholar
• Mayes AR, MacDonald C, Donlan L, Pears J, Meudell PR. (1992). Amnesics have a disproportionately severe memory deficit for interactive context. Q J Exp Psychol 45:265–97
   Web of Science ®Google Scholar
• Meyer EC, Zimering R, Daly E, Knight J, Kamholz BW, Gulliver SB. (2012). Predictors of posttraumatic stress disorder and other psychological symptoms in trauma-exposed firefighters. Psychol Serv 9:1–15
   PubMed Web of Science ®Google Scholar
• Moustafa AA, Gilbertson MW, Orr SP, Herzallah MM, Servatius RJ, Myers CE. (2013). A model of amygdala-hippocampal-prefrontal interaction in fear conditioning and extinction in animals. Brain Cogn 81:29–43
   Google Scholar
• Murnane K, Phelps M, Malmberg K. (1999). Context-dependent recognition memory: the ICE theory. J Exp Psychol 128:403–15
   Google Scholar
• Orr SP, Lasko NB, Macklin ML, Pineles SL, Chang Y, Pitman RK. (2012). Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology. Biol Mood Anxiety Disord 2:8. doi: 10.1186/2045-5380-2-8
   PubMedGoogle Scholar
• Phelps EA, O’Connor KJ, Gatenby JC, Gore JC, Grillon C, Davis M. (2001). Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci 4:437–41
   PubMed Web of Science ®Google Scholar
• Pole N, Neylan TC, Otte C, Henn-Hasse C, Metzler TJ, Marmar CR. (2009). Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biol Psychiatry 65:235–40
   PubMed Web of Science ®Google Scholar
• Rogers RD, Andrews TC, Grasby PM, Brooks DJ, Robbins TW. (2000). Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci 12:142–62
   PubMed Web of Science ®Google Scholar
• Rau V, DeCola JP, Fanselow MS. (2005). Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 29:1207–23
   PubMed Web of Science ®Google Scholar
• Rau V, Fanselow MS. (2009). Exposure to a stressor produces a long lasting enhancement of fear learning in rats. Stress 12:125–33
   PubMed Web of Science ®Google Scholar
• Rudy JW. (2009). Context representations, context functions, and the parahippocampale-hippocampal system. Learn Mem 16:573–85
   PubMed Web of Science ®Google Scholar
• Rutherford A. (2004). Environmental context-dependent recognition memory effects: an examination of ICE model and cue-overload hypotheses. Q J Exp Psychol A 57:107–27
   PubMedGoogle Scholar
• Smith AP, Henson RN, Dolan RJ, Rugg MD. (2004). fMRI correlates of the episodic retrieval of emotional contexts. Neuroimage 22:868–78
   PubMed Web of Science ®Google Scholar
• Smith AP, Stephan KE, Rugg MD, Dolan RJ. (2006). Task and content modulate amygdala-hippocampal connectivity in emotional retrieval. Neuron 49:631–8
   PubMed Web of Science ®Google Scholar
• Smith ME. (2005). Bilateral hippocampal volume reduction in adults with posttraumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 15:798–807
   PubMed Web of Science ®Google Scholar
• Soo J, Webber MP, Gustave J, Lee R, Hall CB, Cohen HW, Kelly KJ, Prezant DJ. (2011). Trends in probable PTSD in firefighters exposed to the World Trade Center disaster, 2001–2010. Disaster Med Public Health Prep 2:197–203
   Google Scholar
• Spielberger CD, Gorsuch RL, Lushene RE, Vagg PR. (1983). State-Trait Anxiety Inventory (STAI). Bib 2010:180
   Google Scholar
• Spitzer RL, Williams JB, Gibbon M, First MB. (1990). User’s guide for the structured clinical interview for DSM-III-R: SCID. Washington, DC: American Psychiatric Press
   Google Scholar
• Spreen OA. Compendium of neuropsychological tests: administration, norms, and commentary. NY: Oxford University Press; 1998
   Google Scholar
• Stevens JS, Jovanovic T, Fani N, Ely TD, Glover EM, Bradley B, Ressler KJ. (2013). Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder. J Psychiatr Res 47:1469–78
   Web of Science ®Google Scholar
• Tsoory MM, Guterman A, Richter-Levin G. (2010). “Juvenile stress” alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies. J Neurosci Res 88:369–80
   PubMed Web of Science ®Google Scholar
• Tversky A, Kahneman D, Choice R. (1981). The framing of decisions. Science 211:453–8
   PubMed Web of Science ®Google Scholar
• Vythilingam M, Blair KS, McCaffrey D, Scaramozza M, Jones M, Nakic M, Mondillo K, et al. (2007). Biased emotional attention in post traumatic stress disorder: a help as well as a hindrance? Psychol Med 37:1445–55
   Google Scholar
• Wald I, Degnan KA, Gorodetsky E, Charney DS, Fox NA, Fruchter E, Goldman D, et al. (2013). Attention to threats and combat-related posttraumatic stress symptoms: prospective associations and moderation by the serotonin transporter gene. JAMA Psychiatry 70:401–8
   PubMed Web of Science ®Google Scholar
• Wechsler D. (1997). Wechsler Adult Intelligence Scale – Third addition. San Antonio: The Psychological Corporation
   Google Scholar
• Woon FL, Sood S, Hedges DW. (2010). Hippocampal volume deficits associated with exposure to psychological trauma and post-traumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 34:1181–8
   PubMed Web of Science ®Google Scholar