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Stress
The International Journal on the Biology of Stress
Volume 18, 2015 - Issue 6
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Original Research Report

Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze

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Pages 677-685 | Received 25 Mar 2015, Accepted 12 Aug 2015, Published online: 21 Aug 2015

References

  • Adamec RE, Sayin U, Brown A. (1991). The effects of corticotrophin releasing factor (CRF) and handling stress on behavior in the elevated plus-maze test of anxiety. J Psychopharmacol 5:175–86
  • Alstott J, Timberlake W. (2009). Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls. Behav Brain Res 96:214–19
  • Andrews N, File SE. (1993). Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety. Eur J Pharmacol 235:109–12
  • Andrews N, Zharkovsky A, File SE. (1992). Acute handling stress downregulates benzodiazepine receptors: reversal by diazepam. Eur J Pharmacol 210:247–51
  • Andrews NA, Papakosta M, Barnes NM. (2014). Discovery of novel anxiolytic agents – the trials and tribulations of pre-clinical models of anxiety. Neurobiol Dis 61:72–8
  • Arabo A, Potier C, Ollivier G, Lorivel T, Roy V. (2014). Temporal analysis of free exploration of an elevated plus-maze in mice. J Exp Psychol Anim Learn Cogn 40:457–66
  • Ballenger JC. (2004). Remission rates in patients with anxiety disorders treated with paroxetine. J Clin Psychiatry 65:1696–707
  • Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S, Rowlett JK. (2011). Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice. Pharmacol Biochem Behav 98:544–51
  • Boix F, Fernández Teruel A, Tobeña A. (1988). The anxiolytic action of benzodiazepines is not present in handling-habituated rats. Pharmacol Biochem Behav 31:541–6
  • Brett RR, Pratt JA. (1990). Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze. Eur J Pharmacol 178:135–8
  • Casarrubea M, Roy V, Sorbera, F, Magnusson MS, Santangelo A, Arabo A. (2013). Temporal structure of the rat’s behavior in elevated plus maze test. Behav Brain Res 237:290–9
  • Cloutier S, Newberry RC. (2008). Use of a conditioning technique to reduce stress associated with repeated intra-peritoneal injections in laboratory rats. Appl Anim Behav Sci 112:158–73
  • Cole JM, Pieper WA. (1973). The effects of N,N-dimethyltryptamine on operant behavior in squirrel monkeys. Psychopharmacologia 29:107–12
  • Costa R, Tamascia ML, Nogueira MD, Casarini DE, Marcondes FK. (2012). Handling of adolescent rats improves learning and memory and decreases anxiety. J Am Assoc Lab Anim Sci 51:548–53
  • Cryan JF, Sweeney FF. (2011). The age of anxiety: role of animal models of anxiolytic action in drug discovery. Br J Pharmacol 164:1129–61
  • Dawson GR, Crawford SP, Stanhope KJ, Iversen SD, Tricklebank MD. (1994). One-trial tolerance to the effects of chlordiazepoxide on the elevated plus-maze may be due to locomotor habituation, not repeated drug exposure. Psychopharmacology (Berlin) 113:570–2
  • de Wit H, Phillips TJ. (2012). Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev 36:1565–76
  • Drapier D, Bentué-Ferrer D, Laviolle B, Millet B, Allain H, Bourin M, Reymann JM. (2007). Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behav Brain Res 176:202–9
  • Durand M, Berton O, Aguerre S, Edno L, Combourieu I, Mormède P, Chaouloff F. (1999). Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis in SHR and WKY rats. Neuropharmacology 38:893–907
  • Ennaceur A. (2011). Omission of the habituation procedure in the acquisition of a working memory task – evidence from Balb/c, C57BL/6J, and CD-1 mice. Behav Brain Res 223:203–10
  • Ennaceur A. (2014). Tests of unconditioned anxiety – pitfalls and disappointments. Physiol Behav 135:55–71
  • Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. (2008a). Are benzodiazepines really anxiolytic? Evidence from a 3D maze spatial navigation task. Behav Brain Res 188:136–53
  • Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. (2008b). Detailed analysis of the behavior and memory performance of middle-aged male and female CD-1 mice in a 3D maze. Behav Brain Res 187:312–26
  • Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. (2010). Distinguishing anxiolysis and hyperactivity in a novel open space anxiety test. Behav Brain Res 207:84–98
  • Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. (2011). MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation. Neuropharmacology 61:981–91
  • Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. (2006). Models of anxiety: responses of mice to novelty and open spaces in a 3D maze. Behav Brain Res 174:9–38
  • Escarabajal MD, Torres C, Flaherty CF. (2003). The phenomenon of one-trial tolerance to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze test is abolished by previous administration of chlordiazepoxide or buspirone. Life Sci 73:1063–74
  • Espejo EF. (1997). Effects of weekly or daily exposure to the elevated plus-maze in male mice. Behav Brain Res 87:233–8
  • File SE, Andrews N, Wu PY, Zharkovsky A, Zangrossi H. (1992). Modification of chlordiazepoxide’s behavioural and neurochemical effects by handling and plus-maze experience. Eur J Pharmacol 218:9–14
  • Gelenberg AJ, Chesen CL. (2000). How fast are antidepressants? J Clin Psychiatry 61:712–21
  • Gomes KS, de Carvalho-Netto EF, Monte KC, Acco B, Nogueira PJ, Nunes-de-Souza RL. (2009). Contrasting effects of acute and chronic treatment with imipramine and fluoxetine on inhibitory avoidance and escape responses in mice exposed to the elevated T-maze. Brain Res Bull 78:323–7
  • Gorman JM, Liebowitz MR, Fyer AJ, Goetz D, Campeas RB, Fyer MR, Davies SO, Klein DF. (1987). An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharmacol 7:329–32
  • Griebel G, Cohen C, Perrault G, Sanger DJ. (1999). Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats. Physiol Behav 67:315–20
  • Griebel G, Holmes A. (2013). 50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov 12:667–687
  • Grillon C, Levenson J, Pine DS. (2007). A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology 32:225–31
  • Holmes A, Rodgers RJ. (1998). Responses of Swiss-Webster mice to repeated plus-maze experience: further evidence for a qualitative shift in emotional state? Pharmacol Biochem Behav 60:473–88
  • Holmes A, Rodgers RJ. (2003). Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine. Eur J Pharmacol 459:221–30
  • Huh J, Goebert D, Takeshita J, Lu BY, Kang M. (2011). Treatment of generalized anxiety disorder: a comprehensive review of the literature for psychopharmacologic alternatives to newer antidepressants and benzodiazepines. Prim Care Companion CNS Disord 13:PCC.08r00709
  • Ioannidis JPA. (2008). Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials. Philos Ethics Humanit Med 3:14
  • Izumi J, Washizuka M, Hayashi-Kuwabara Y, Yoshinaga K, Tanaka Y, Ikeda Y, Kiuchi Y, Oguchi K. (1997). Evidence for a depressive-like state induced by repeated saline injections in Fischer 344 rats. Pharmacol Biochem Behav 57:883–8
  • Katzman MA. (2009). Current considerations in the treatment of generalized anxiety disorder. CNS Drugs 23:103–20
  • Khin NA, Chen YF, Yang Y, Yang P, Laughren TP. (2011). Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications. J Clin Psychiatry 72:464–72
  • Knoll AT, Meloni EG, Thomas JB, Carroll FI, Carlezon WA Jr. (2007). Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats. J Pharmacol Exp Ther 323:838–45
  • Kofman O, Einat H, Cohen H, Tenne H, Shoshana C. (2000). The anxiolytic effect of chronic inositol depends on the baseline level of anxiety. J Neural Transm 107:241–53
  • Kõks S, Beljajev S, Koovit I, Abramov U, Bourin M, Vasar E. (2001). 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. Psychopharmacology (Berlin) 153:365–72
  • Kurt M, Arik AC, Celik S. (2000). The effects of sertraline and fluoxetine on anxiety in the elevated plus-maze test in mice. J Basic Clin Physiol Pharmacol 11:173–80
  • McAllister-Williams RH. (2008). Do antidepressants work? A commentary on “Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration” by Kirsch et al. Evid Based Ment Health 11:66–8
  • Michalikova S, van Rensburg R, Chazot PL, Ennaceur A. (2010). Anxiety responses in Balb/c, c57 and CD-1 mice exposed to a novel open space test. Behav Brain Res 207:402–17
  • Miczek KA, de Wit H. (2008). Challenges for translational psychopharmacology research—some basic principles. Psychopharmacology (Berlin) 199:291–301
  • Mitchell AJ. (2006). Two-week delay in onset of action of antidepressants: new evidence. Br J Psychiatry 188:105–6
  • Mòdol L, Darbra S, Vallèe M, Pallarès M. (2013). Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids. Behav Brain Res 241:96–104
  • Nierenberg AA. (2001). Do some antidepressants work faster than others? J Clin Psychiatry 15:22–5
  • Nowakowska E, Kus K, Chodera A, Rybakowski J. (2000). Behavioural effects of fluoxetine and tianeptine, two antidepressants with opposite action mechanisms, in rats. Arzneimittelforschung 50:5–10
  • Nowakowska E, Chodera A, Kus K. (1996). Anxiolytic and memory improving activity of fluoxetine. Pol J Pharmacol 48:255–60
  • Pigott HE Leventhal AM, Alter GS, Boren JJ. (2010). Efficacy and effectiveness of antidepressants: current status of research. Psychother Psychosom 79:267–79
  • Posternak MA, Zimmerman M. (2005). Is there a delay in the antidepressant effect? A meta-analysis. J Clin Psychiatry 66:148–58
  • Rachman S. (1989). The return of fear: review and prospect. Clin Psychol Rev 9:147–68
  • Robert G, Drapier D, Bentué-Ferrer D, Renault A, Reymann JM. (2011). Acute and chronic anxiogenic-like response to fluoxetine in rats in the elevated plus-maze: modulation by stressful handling. Behav Brain Res 220:344–8
  • Rodgers RJ, Cole JC, Aboualfa K, Stephenson LH. (1995). Ethopharmacological analysis of the effects of putative ‘anxiogenic' agents in the mouse elevated plus-maze. Pharmacol Biochem Behav 52:805–13
  • Rodgers RJ, Cutler MG, Jackson JE. (1997). Behavioural effects in mice of subchronic buspirone, ondansetron and tianeptine. II. The elevated plus-maze. Pharmacol Biochem Behav 56:295–303
  • Rodgers RJ, Davies B, Shore R. (2002). Absence of anxiolytic response to chlordiazepoxide in two common background strains exposed to the elevated plus-maze: importance and implications of behavioural baseline. Genes Brain Behav 1:242–51
  • Rodgers RJ, Shepherd JK. (1993). Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice. Psychopharmacology (Berlin) 113:237–42
  • Rogóz Z, Skuza G. (2011). Anxiolytic-like effects of olanzapine, risperidone and fluoxetine in the elevated plus-maze test in rats. Pharmacol Rep 63:1547–52
  • Rosa VP, Vandresen N, Calixto AV, Kovaleski DF, Faria MS. (2000). Temporal analysis of the rat's behavior in the plus-maze: Effect of midazolam. Pharmacol Biochem Behav 67:177–82
  • Schmitt U, Hiemke C. (1998). Strain differences in open-field and elevated plus-maze behavior of rats without and with pretest handling. Pharmacol Biochem Behav 59:807–11
  • Silva MT, Alves CR, Santarem EM. (1999). Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze. Braz J Med Biol Res 32:333–9
  • Silva RC, Brandão ML. (2000). Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacol Biochem Behav 65:209–16
  • Takeuchi T, Owa T, Nishino T, Kamei C. (2010). Assessing anxiolytic-like effects of selective serotonin reuptake inhibitors and serotonin-noradrenaline reuptake inhibitors using the elevated plus maze in mice. Methods Find Exp Clin Pharmacol 32:113–21
  • Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z. (2006). Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 63:1217–23
  • Thompson RF, Spencer WA. (1966). Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol Rev 73:16–43
  • Thompson T, Grabowski-Boase L, Tarantino LM. (2015). Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice. Pharmacol Biochem Behav 133:7–17
  • Treit D, Menard J, Royan C. (1993). Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 44:463–9
  • Whishaw IQ, Gharbawie OA, Clark BJ, Lehmann H. (2006). The exploratory behavior of rats in an open environment optimizes security. Behav Brain Res 171:230–9
  • Yaski O, Eilam D. (2007). The impact of landmark properties in shaping exploration and navigation. Anim Cogn 10:415–28

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