Long-Term side Effects of Newer-Generation Antidepressants: SSRIS, Venlafaxine, Nefazodone, Bupropion, and Mirtazapine

References

• Menting JE, Honig A, Verhey FR, Hartmans M, Rozendaal N, de Vet HC, van Praag HM: Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed pa-tients: A qualitative analysis of the literature on their efficacy and side-effects. Int Clin Psychopharmacol 1996; 11:165–175
   Google Scholar
• Steffens DC, Krishnan KR, Helms MJ: Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta-analysis. De-press Anxiety 1997; 6:10–18
   Google Scholar
• Masand PS, Gupta S: Selective serotonin-reuptake inhibitors: An update. Harvard Rev Psychiatry 1999; 7:69–84
   PubMed Web of Science ®Google Scholar
• Hyttel J: Pharmacological characterization of selective sero-tonin reuptake inhibitors. Int Clin Psychopharmacol 1994; 9\(Suppl. 1):19–26
   Google Scholar
• Leonard BE: Pharmacological differences of serotonin reup-take inhibitors and possible clinical relevance. Drugs 1992; 43\(Suppl. 2):3–9
   Google Scholar
• Hall H, Sällemark M, Wedel I: Acute effects of atypical antide-pressants on various receptors in the rat brain. Acta Pharmacol Toxicol (Copenh) 1984; 54:379–384
   Google Scholar
• Beique JC, de Montigny C, Blier P. Debonnel G: Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: A comparative study with paroxetine and desipramine. Br .1 Pharmacol 1998; 125:526–532
   PubMedGoogle Scholar
• Davis R, Whittington R, Bryson HM. Nefazodone: A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 1997: 53:608–636
   Google Scholar
• Ascher JA, Cole JO, Colin JN, Feighner JP, Ferris RM, Fibiger HC, Golden RN, Martin P, Potter WZ, Richelson E. Bupropion: A review of its mechanism of antidepressant ac-tivity. J Clin Psychiatry 1995; 56:395–401
   PubMed Web of Science ®Google Scholar
• Stimmel GL, Dopheide JA, Stahl SM: Mirtazapine: An antide-pressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 1997; 17:10–21
   PubMed Web of Science ®Google Scholar
• Stahl SM: Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action. J Clin Psychiatry 1998; 59\(Suppl. 4):5–14
   Google Scholar
• Masand PS: Weight gain associated with psychotropic drugs. Exp Opin Pharmacother 2000; 1:377–389
   PubMedGoogle Scholar
• Kawachi I: Physical and psychological consequences of weight gain. J Clin Psychiatry 1999; 60\(Suppl. 21):5–9
   Google Scholar
• Benazzi F: Weight gain in depression remitted with antidepres-sants: Pharmacological or recovery effect? Psychother Psycho-som 1998; 67:271–274
   Google Scholar
• Michelson D, Amsterdam JD, Quitkin FM, Reimherr FW, Rosenbaum JF, Zajecka J, Sundell KL, Kim Y, Beasley CM: Jr. Changes in weight during a 1-year trial of fluoxetine. Am J Psychiatry 1999; 156:1170–1176
   Google Scholar
• Goodnick PI', Kremer C, Wingard P: Weight change during mirtazapine therapy. Prim Psychiatry 1999; 6:103–108
   Google Scholar
• Rosen RC, Lane RM, Menza M: Effects of SSRIs on sex-ual function: A critical review. J Clin Psychopharmacol 1999; 19:67–85
   PubMed Web of Science ®Google Scholar
• Laumann EO, Paik A, Rosen RC: Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999; 281:537–544
   PubMed Web of Science ®Google Scholar
• Finger WW, Lund M, Slagle MA: Medications that contribute to sexual disorders: A guide to assessment and treatment in family practice. J Fam Pract 1997; 44:33–43
   PubMed Web of Science ®Google Scholar
• Angst J: Sexual problems in healthy and depressed persons. Int Clin Psychopharmacol 1998; 13\(Suppl. 6):S1–S4
   Google Scholar
• Montejo-Gonzalez AL, Llorca G, Izquierdo JA, Ledesma A, Bousono M, Calcedo A, Carrasco JL, Ciudad J, Daniel E, De la Gandara J, Derecho J, Franco M, Gomez MJ, Macias JA, Martin T, Perez V, Sanchez JM, Sanchez S, Vicens E: SSRI-induced sexual dysfunction: Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23:176–194
   PubMed Web of Science ®Google Scholar
• Kennedy SH, Eisfeld BS, Dickens SE, Bacchiochi JR, Bagby RM: Antidepressant-induced sexual dysfunction during treat-ment with moclobemide, paroxetine, sertraline, and venlafax-Me. J Clin Psychiatry 2000; 61:276–281
   PubMed Web of Science ®Google Scholar
• Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbet-ter RA, Bolden-Watson C, Bass KI, Donahue RM, Jam erson BD, Metz A: Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 2002; 63:357–366
   PubMed Web of Science ®Google Scholar
• Hirschfeld RM: Management of sexual side effects of antide-pressant therapy. J Clin Psychiatry 1999; 60\(Suppl. 14):27–30
   Google Scholar
• Gelenberg AJ, McGahuey C, Laukes C, Okayli G, Moreno F, Zentner L, Delgado P: Mirtazapine substitution in SSRI-induced sexual dysfunction. J Clin Psychiatry 2000; 61:356–360
   PubMed Web of Science ®Google Scholar
• Segraves RT, Kavoussi R, Hughes AR, Batey SR, Johnston JA, Donahue R, Ascher JA: Evaluation of sexual function-ing in depressed outpatients: A double-blind comparison of sustained-release bupropion and sertraline treatment. J Clin Psychopharmacol 2000; 20:122–128
   PubMed Web of Science ®Google Scholar
• Masand PS, Ashton A, Gupta S, Bradford F: Sustained-release bupropion for SSRI-induced sexual dysfunction: A random-ized double-blind placebo-controlled, parallel group study. Am J Psychiatry 2001; 158:805–807
   PubMed Web of Science ®Google Scholar
• Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, Bass KI, Donahue RM, Jamerson BD, Metz A: Prevalence of sexual dysfunction among newer an-tidepressants. J Clin Psychiatry 2002; 63:357–366.
   PubMed Web of Science ®Google Scholar
• Ashton AK, Ahrens K, Gupta S, Masand PS: Ginkgo biloba: Efficacy in SSRI-induced sexual dysfunction. Am J Psychiatry 2000; 157(5):836–837
   Google Scholar
• Masand PS, Anand V, Tanquary J: Psychostimulant augmen-tation of second generation antidepressants: A case series. De-press Anxiety 1998; 7:89–91
   Google Scholar
• Michelson D, Bancroft J, Targum S, Kim Y, Tepner R: Female sexual dysfunction associated with antidepressant administration: A randomized, placebo-controlled study of pharmacologic intervention. Am J Psychiatry 2000; 157:239–243
   PubMed Web of Science ®Google Scholar
• Lan den M, Eriksson E, A gren H, Fahlen T: Effect of buspirone on sexual dysfunction in depressed patients treated with se-lective serotonin reuptake inhibitors. J Clin Psychopharmacol 1999; 19:268–271
   Google Scholar
• Nelson EB, Shah VN, Welge JA, Keck PE Jr: A placebo-controlled, crossover trial of granisetron in SRI-induced sexual dysfunction. J Clin Psychiatry 2001; 62:469–473
   PubMed Web of Science ®Google Scholar
• Nurnberg HG, Gelenberg A, Hargreave TB, Harrison WM, Siegel RL, Smith MD: Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking sero-tonin reuptake inhibitors. Am J Psychiatry 2001; 158:1926–1928
   PubMed Web of Science ®Google Scholar
• Riche'son E: Pharmacokinetic interactions of antidepressants. J Clin Psychiatry 1998; 59\(Suppl 10):22–26
   Google Scholar
• DeVane CL. Pharmacogenetics and drug metabolism of newer antidepressant agents. J Clin Psychiatry 1994; 55(Suppl 12):38–45
   Google Scholar
• Barbhaiya RH, Shukla UA, Kroboth PD, Greene DS: Coad-ministration of nefazodone and benzodiazepines. II: Pharma-cokinetic interaction study with triazolam. J Clin Psychophar-macol 1995; 15:320–326
   Google Scholar
• Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI: Drug interactions with newer antidepressants: Role of hu-man cytochromes P450. J Clin Psychiatry 1998; 59(Suppl 15): 19–27
   PubMed Web of Science ®Google Scholar
• Greden JF: Antidepressant maintenance medications: When to discontinue and how to stop. J Clin Psychiatry 1993; 54(Suppl 8):39–45
   PubMedGoogle Scholar
• Brown WA, Harrison W: Are patients who are intolerant to one serotonin selective reuptake inhibitor intolerant to an-other? J Clin Psychiatry 1995; 56:30–34
   PubMed Web of Science ®Google Scholar