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Review Article

Structure, mechanism and regulation of an artificial microbial ecosystem for vitamin C production

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Pages 247-255 | Received 29 Feb 2012, Accepted 21 Jun 2012, Published online: 21 Sep 2012

References

  • Anderson S, Marks CB, Lazarus R, Miller J, Stafford K, Seymour J, Light D, Rastetter W, Estell D. (1985). Production of 2-keto-l-gulonate, an intermediate in l-ascorbate synthesis, by a genetically modified Erwinia herbicola. Science, 230, 144–149.
  • Arrigoni O, De Tullio MC. (2002). Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta, 1569, 1–9.
  • Asakura A, Hoshino T. (1999). Isolation and characterization of a new Quinoprotein dehydrogenase, l-sorbose/lsorbosone dehydrogenase. Biosci Biotechnol Biochem, 63, 46–53.
  • Bader J, Mast-Gerlach E, Popovic MK, Bajpai R, Stahl U. (2010). Relevance of microbial coculture fermentations in biotechnology. J Appl Microbiol, 109, 371–387.
  • Biedendieck R, Bunk B, Fürch T, Franco-Lara E, Jahn M, Jahn D. (2010a). Systems biology of recombinant protein production in Bacillus megaterium. Adv Biochem Eng Biotechnol, 120, 133–161.
  • Biedendieck R, Malten M, Barg H, Bunk B, Martens JH, Deery E, Leech H, Warren MJ, Jahn D. (2010b). Metabolic engineering of cobalamin (vitamin B12) production in Bacillus megaterium. Microb Biotechnol, 3, 24–37.
  • Bordbar A, Lewis NE, Schellenberger J, Palsson BØ, Jamshidi N. (2010). Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions. Mol Syst Biol, 6, 422.
  • Bremus C, Herrmann U, Bringer-Meyer S, Sahm H. (2006). The use of microorganisms in L-ascorbic acid production. J Biotechnol, 124, 196–205.
  • Breugelmans P, D’Huys PJ, De Mot R, Springael D. (2007). Characterization of novel linuron-mineralizing bacterial consortia enriched from long-term linuron-treated agricultural soils. FEMS Microbiol Ecol, 62, 374–385.
  • Cai L, Yuan MQ, Li ZJ, Chen JC, Chen GQ. (2012). Genetic engineering of Ketogulonigenium vulgare for enhanced production of 2-keto-L-gulonic acid. J Biotechnol, 157, 320–325.
  • Chen K, Zhou J, Liu L, Liu J, Du G, Chen J. (2010). Enhancing 2-keto-L-gulonic acid production under hyperosmotic stress by adding sucrose. Sheng Wu Gong Cheng Xue Bao, 26, 1507–1513.
  • D’elia J. (2006). Ketogulonigenium shuttle vectors. US Patent, 7033824.
  • Dejonghe W, Berteloot E, Goris J, Boon N, Crul K, Maertens S, Höfte M, De Vos P, Verstraete W, Top EM. (2003). Synergistic degradation of linuron by a bacterial consortium and isolation of a single linuron-degrading variovorax strain. Appl Environ Microbiol, 69, 1532–1541.
  • Du J, Zhou J, Xue J, Song H, Yuan Y. (2011). Metabolomic profiling elucidates community dynamics of the Ketogulonicigenium vulgare-Bacillus megaterium consortium. Metabolomics. In press, doi: 10.1007/s11306-011-0392-2.
  • Eppinger M, Bunk B, Johns MA, Edirisinghe JN, Kutumbaka KK, Koenig SS, Creasy HH, Rosovitz MJ, Riley DR, Daugherty S, Martin M, Elbourne LD, Paulsen I, Biedendieck R, Braun C, Grayburn S, Dhingra S, Lukyanchuk V, Ball B, Ul-Qamar R, Seibel J, Bremer E, Jahn D, Ravel J, Vary PS. (2011). Genome sequences of the biotechnologically important Bacillus megaterium strains QM B1551 and DSM319. J Bacteriol, 193, 4199–4213.
  • Feng S, Sun CB, Zhang ZZ, Zhu KL, Zhang HH, Gao YT. (1998). Effects of Bacillus megaterium on growth and 2KGA synthesizing of Gluconobacter oxydans in vitamin C two-step fermentaion process. J Microbiol, 18, 6–9.
  • Feng S, Zhang Z, Zhang C. (2000). Effect of Bacillus megaterium on Gluconobacter oxydans in mixed culture. Chin J Appl Ecol, 11, 119–122.
  • Fu S, Zhang W, Guo A, Wang J. (2007). Identification of promoters of two dehydrogenase genes in Ketogulonicigenium vulgare DSM 4025 and their strength comparison in K. vulgare and Escherichia coli. Appl Microbiol Biotechnol, 75, 1127–1132.
  • Gao Y, Yuan YJ. (2011). Comprehensive quality evaluation of corn steep liquor in 2-keto-L-gulonic acid fermentation. J Agric Food Chem, 59, 9845–9853.
  • Hancock RD. (2009). Recent patents on vitamin C: opportunities for crop improvement and single-step biological manufacture. Recent Pat Food Nutr Agric, 1, 39–49.
  • Hancock RD, Viola R. (2002). Biotechnological approaches for L-ascorbic acid production. Trends Biotechnol, 20, 299–305.
  • Homann A, Biedendieck R, Götze S, Jahn D, Seibel J. (2007). Insights into polymer versus oligosaccharide synthesis: mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium. Biochem J, 407, 189–198.
  • Hoshino T, Shinjoh M. (2005). Process for producing L-ascorbic acid. US Patent, 20050244940.
  • Kim K, Kim JJ, Masui R, Kuramitsu S, Sung MH. (2011a). A commensal symbiotic interrelationship for the growth of Symbiobacterium toebii with its partner bacterium, Geobacillus toebii. BMC Res Notes, 4, 437.
  • Kim TY, Sohn SB, Kim YB, Kim WJ, Lee SY. (2011b). Recent advances in reconstruction and applications of genome-scale metabolic models. Curr Opin Biotechnol. In press, doi: 10.1016/j.copbio.2011.10.007.
  • Leduc S, de Troostembergh JC, Lebeault JM. (2004). Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium. Appl Microbiol Biotechnol, 65, 163–167.
  • Li GC, Zhang ZZ. (1997). Study on characteristics of mixed fermentation of 2-KLG producing strains and their mixed growth pattern. J Microbiol, 17, 1–4.
  • Liu L, Chen K, Zhang J, Liu J, Chen J. (2011a). Gelatin enhances 2-keto-L-gulonic acid production based on Ketogulonigenium vulgare genome annotation. J Biotechnol, 156, 182–187.
  • Liu L, Li Y, Zhang J, Zhou Z, Liu J, Li X, Zhou J, Du G, Wang L, Chen J. (2011b). Complete genome sequence of the industrial strain Ketogulonicigenium vulgare WSH-001. J Bacteriol, 193, 6108–6109.
  • Liu L, Li Y, Zhang J, Zou W, Zhou Z, Liu J, Li X, Wang L, Chen J. (2011c). Complete genome sequence of the industrial strain Bacillus megaterium WSH-002. J Bacteriol, 193, 6389–6390.
  • Liu L, Agren R, Bordel S, Nielsen J. (2010). Use of genome-scale metabolic models for understanding microbial physiology. FEBS Lett, 584, 2556–2564.
  • Ma Q, Zhang W, Zhang L, Qiao B, Pan C, Yi H, Wang L, Yuan YJ. (2012). Proteomic analysis of Ketogulonicigenium vulgare under glutathione reveals high demand for thiamin transport and antioxidant protection. PLoS ONE, 7, e32156.
  • Ma Q, Zhou J, Zhang W, Meng X, Sun J, Yuan YJ. (2011). Integrated proteomic and metabolomic analysis of an artificial microbial community for two-step production of vitamin C. PLoS ONE, 6, e26108.
  • Macauley S, McNeil B, Harvey LM. (2001). The genus Gluconobacter and its applications in biotechnology. Crit Rev Biotechnol, 21, 1–25.
  • Mandl J, Szarka A, Bánhegyi G. (2009). Vitamin C: update on physiology and pharmacology. Br J Pharmacol, 157, 1097–1110.
  • Miyazaki T, Sugisawa T, Hoshino T. (2006). Pyrroloquinoline quinone-dependent dehydrogenases from Ketogulonicigenium vulgare catalyze the direct conversion of L-sorbosone to L-ascorbic acid. Appl Environ Microbiol, 72, 1487–1495.
  • Müller J, Overmann J. (2011). Close interspecies interactions between prokaryotes from sulfureous environments. Front Microbiol, 2, 146.
  • Oberhardt MA, Palsson BØ, Papin JA. (2009). Applications of genome-scale metabolic reconstructions. Mol Syst Biol, 5, 320.
  • Padh H. (1990). Cellular functions of ascorbic acid. Biochem Cell Biol, 68, 1166–1173.
  • Pueyo MT, Bloch C Jr, Carmona-Ribeiro AM, di Mascio P. (2009). Lipopeptides produced by a soil Bacillus megaterium strain. Microb Ecol, 57, 367–378.
  • Raes J, Bork P. (2008). Molecular eco-systems biology: towards an understanding of community function. Nat Rev Microbiol, 6, 693–699.
  • Reichstein T, Grüssner A. (1934). Eine ergiebige synthese der l-Ascorbinsäure (C-Vitamin). Helv Chim Acta, 17, 311–328.
  • Röling WF, Ferrer M, Golyshin PN. (2010). Systems approaches to microbial communities and their functioning. Curr Opin Biotechnol, 21, 532–538.
  • Rosenthal AZ, Matson EG, Eldar A, Leadbetter JR. (2011). RNA-seq reveals cooperative metabolic interactions between two termite-gut spirochete species in co-culture. ISME J, 5, 1133–1142.
  • Song H, Kim TY, Choi BK, Choi SJ, Nielsen LK, Chang HN, Lee SY. (2008). Development of chemically defined medium for Mannheimia succiniciproducens based on its genome sequence. Appl Microbiol Biotechnol, 79, 263–272.
  • Stammen S, Müller BK, Korneli C, Biedendieck R, Gamer M, Franco-Lara E, Jahn D. (2010). High-yield intra- and extracellular protein production using Bacillus megaterium. Appl Environ Microbiol, 76, 4037–4046.
  • Stolyar S, Van Dien S, Hillesland KL, Pinel N, Lie TJ, Leigh JA, Stahl DA. (2007). Metabolic modeling of a mutualistic microbial community. Mol Syst Biol, 3, 92.
  • Sugisawa T, Miyazaki T, Hoshino T. (2005). Microbial production of L-ascorbic acid from D-sorbitol, L-sorbose, L-gulose, and L-sorbosone by Ketogulonicigenium vulgare DSM 4025. Biosci Biotechnol Biochem, 69, 659–662.
  • Takagi Y, Sugisawa T, Hoshino T. (2010). Continuous 2-Keto-L-gulonic acid fermentation by mixed culture of Ketogulonicigenium vulgare DSM 4025 and Bacillus megaterium or Xanthomonas maltophilia. Appl Microbiol Biotechnol, 86, 469–480.
  • Urbance JW, Bratina BJ, Stoddard SF, Schmidt TM. (2001). Taxonomic characterization of Ketogulonigenium vulgare gen. nov., sp. nov. and Ketogulonigenium robustum sp. nov., which oxidize L-sorbose to 2-keto-L-gulonic acid. Int J Syst Evol Microbiol, 51, 1059–1070.
  • Vary PS. (1994). Prime time for Bacillus megaterium. Microbiology, 140, 1001–1013.
  • Vary PS, Biedendieck R, Fuerch T, Meinhardt F, Rohde M, Deckwer WD, Jahn D. (2007). Bacillus megaterium–from simple soil bacterium to industrial protein production host. Appl Microbiol Biotechnol, 76, 957–967.
  • Wegkamp A, Teusink B, de Vos WM, Smid EJ. (2010). Development of a minimal growth medium for Lactobacillus plantarum. Lett Appl Microbiol, 50, 57–64.
  • Wei DZ, Yuan WK, Yin GL, Yuan ZY, Chen MH. (1992). Studies on kinetic model of vitamin C two-step fermentation process. Chin J Biotechnol, 8, 277–282.
  • Xie L, Zhang D, Dou Y-F, Zhang L-P, Zhao B-H. (2007). Purification of L-sorbose/L-sorbosne dehydrogenase from Ketogulonigenium vulgare and construction and selection of genomic library. Chin J Biotechnol, 23, 891–895.
  • Xiong XH, Han S, Wang JH, Jiang ZH, Chen W, Jia N, Wei HL, Cheng H, Yang YX, Zhu B, You S, He JY, Hou W, Chen MX, Yu CJ, Jiao YH, Zhang WC. (2011). Complete genome sequence of the bacterium Ketogulonicigenium vulgare Y25. J Bacteriol, 193, 315–316.
  • Xu A, Yao J, Yu L, Lv S, Wang J, Yan B, Yu Z. (2004). Mutation of Gluconobacter oxydans and Bacillus megaterium in a two-step process of l-ascorbic acid manufacture by ion beam. J Appl Microbiol, 96, 1317–1323.
  • Yang F, Jia Q, Xiong ZH, Zhang XB, Wu HT, Zhao Y, Yang J, Zhu JP, Dong J, Xue Y, Sun LL, Shen Y, Jin Q. (2006). Complete genome analysis of Ketogulonigenium sp WB0104. Chin Sci Bull, 51, 941–945.
  • Yin GL, He JM, Ren SX, Song Q, Ye Q, Lin HY, Chen CS, Guo XY. (1997). Production of vitamin C precursor—2-keto-L-gulonic acid from L-sorbose by a novel bacterial component system of SCB329-SCB933: I. the biological characteristics of a novel bacterial component system of SCB329-SCB933. Gong Ye Wei Sheng Wu, 27, 1–7.
  • Yin GL, Tao ZX, Yan ZZ, Ning WZ, Wang CH, Wang SD. (1990). Fermentation process. US Patent, 4935359.
  • Yin GL, Tao ZX, Yu LH, Wang DS, Dan JL, Yan ZZ, Ning WZ, Wang CH, Wang SD, Jiang HF, Zhang XD, Feng XY, Zhao Q, Wei WQ. (1980). Studies on the production of vitamin C precursor—2-keto-L-gulonic acid from L-sorbose by fermentation I. isolation, screening and identification of 2-keto-L-gulonic acid producing bacteria. Acta Microbiol Sin, 20, 246–251.
  • Zengler K, Palsson BO. (2012). A road map for the development of community systems (CoSy) biology. Nat Rev Microbiol, 10, 366–372.
  • Zhang J, Liu J, Shi ZP, Liu LM, Chen J. (2010a). Manipulation of B. megaterium growth for efficient 2-KLG production by K. vulgare. Process Biochem, 45, 602–606.
  • Zhang J, Zhou J, Liu J, Chen K, Liu L, Chen J. (2011). Development of chemically defined media supporting high cell density growth of Ketogulonicigenium vulgare and Bacillus megaterium. Bioresour Technol, 102, 4807–4814.
  • Zhang J, Zhou JW, Liu LM, Liu J, Chen KJ, Du GC, Chen J. (2010b). Enhancement of 2-keto-L-gulonic acid production using three-stage pH control strategy. Chin J Biotechnol, 26, 1263–1268.
  • Zhou J, Ma Q, Yi H, Wang L, Song H, Yuan YJ. (2011). Metabolome profiling reveals metabolic cooperation between Bacillus megaterium and Ketogulonicigenium vulgare during induced swarm motility. Appl Environ Microbiol, 77, 7023–7030.
  • Zhu KL, Zhang HH, Sun CB, Zhang ZZ. (1998). Studies on inoculation in the two-step fermentation of vitamin C. J Microbiol, 18, 13–15.
  • Zhu Y, Liu J, Du G, Zhou J, Chen J. (2012). Sporulation and spore stability of Bacillus megaterium enhance Ketogulonigenium vulgare propagation and 2-keto-L-gulonic acid biosynthesis. Bioresour Technol, 107, 399–404.
  • Zhuang K, Izallalen M, Mouser P, Richter H, Risso C, Mahadevan R, Lovley DR. (2011). Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environments. ISME J, 5, 305–316.
  • Zou W, Liu L, Zhang J, Yang H, Zhou M, Hua Q, Chen J. (2012). Reconstruction and analysis of a genome-scale metabolic model of the vitamin C producing industrial strain Ketogulonicigenium vulgare WSH-001. J Biotechnol, 161, 42–48.

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