Indoor fungal contamination: Health risks and measurement methods in hospitals, homes and workplaces

References

• Adhikari A, Gupta J, Wilkins JR, et al. (2011). Airborne microorganisms, endotoxin, and (1→3)-β-D-glucan exposure in greenhouses and assessment of respiratory symptoms among workers. Ann Occup Hyg 552:72–85
   Google Scholar
• Adhikari A, Reponen T, Lee S-A, Grinshpun SA. (2004a). Assessment of human exposure to airborne fungi in agricultural confinements: personal inhalable sampling versus stationary sampling. Ann Agric Environ Med 112:69–277
   Google Scholar
• Adhikari A, Sen MM, Gupta-Bhattacharya S, Chanda S. (2004b). Volumetric assessment of airborne fungi in two sections of a rural indoor dairy cattle shed. Environ Int 29:1071–8
   PubMed Web of Science ®Google Scholar
• Alberti C, Bouakline A, Ribaud P, et al. (2001). Relationship between environmental fungal contamination and the incidence of invasive aspergillosis in haematology patients. J Hosp Infect 48:198–206
   PubMed Web of Science ®Google Scholar
• Allermann L, Wilkins CK, Madsen AM. (2006). Inflammatory potency of dust from the indoor environment and correlation to content of NAGase and fungi. Toxicol In Vitro 20:1522–31
   PubMed Web of Science ®Google Scholar
• An HR, Mainelis G, Yao M. (2004). Evaluation of a high-volume portable bioaerosol sampler in laboratory and field environments. Indoor Air 14:385–93
   PubMed Web of Science ®Google Scholar
• De Ana SG, Torres-Rodríguez JM, Ramírez EA, et al. (2006). Seasonal distribution of Alternaria, Aspergillus, Cladosporium and Penicillium species isolated in homes of fungal allergic patients. J Invest Allerg Clin 16:357–63
   PubMed Web of Science ®Google Scholar
• Anaissie EJ, Stratton SL, Dignani MC, et al. (2002). Cleaning patient shower facilities: a novel approach to reducing patient exposure to aerosolized Aspergillus species and other opportunistic molds. Clin Infect Dis 35:e86–8
   Web of Science ®Google Scholar
• Araujo R, Cabral JP, Rodrigues AG. (2008). Air filtration systems and restrictive access conditions improve indoor air quality in clinical units: Penicillium as a general indicator of hospital indoor fungal levels. Am J Infect Control 36:129–34
   PubMed Web of Science ®Google Scholar
• Aríngoli EE, de la Basílico MLZ, Altahus RL, Basílico JC. (2008). Multivariate analysis of fungal associations in the indoor air of Argentinean houses. Int Biodeter Biodegr 62:281–6
   Google Scholar
• Awad AHA. (2007). Airborne dust, bacteria, actinomycetes and fungi at a flourmill. Aerobiologia 23:59–69
   Web of Science ®Google Scholar
• Barnes CS, Amado M, Portnoy JM. (2010). Reduced clinic, emergency room, and hospital utilization after home environmental assessment and case management. Allergy Asthma Proc 31:317–23
   PubMed Web of Science ®Google Scholar
• Begerow D, Nilsson H, Unterseher M, Maier W. (2010). Current state and perspectives of fungal DNA barcoding and rapid identification procedures. Appl Microbiol Biot 87:99–108
   PubMed Web of Science ®Google Scholar
• Bellanger A-P, Reboux G, Murat J-B, et al. (2010). Detection of Aspergillus fumigatus by quantitative polymerase chain reaction in air samples impacted on low-melt agar. Am J Infect Control 38:195–8
   PubMed Web of Science ®Google Scholar
• Bellanger A-P, Reboux G, Roussel S, et al. (2009). Indoor fungal contamination of moisture-damaged and allergic patient housing analysed using real-time PCR. Lett Appl Microbiol 49:260–6
   PubMed Web of Science ®Google Scholar
• Bellanger A-P, Reboux G, Scherer E, et al. (2012). Contribution of a cyclonic-based liquid air collector for detecting Aspergillus fumigatus by QPCR in air samples. J Occup Environ Hyg 9:D7–11
   PubMed Web of Science ®Google Scholar
• Bernstein JA, Alexis N, Bacchus H, et al. (2008). The health effects of nonindustrial indoor air pollution. J Allergy Clin Immun 121:585–91
   PubMed Web of Science ®Google Scholar
• Bex V, Squinazi F. (2006). Mise en évidence de moisissures des ambiances intérieures par la mesure des (1→3)-[β]-d-glucanes. Rev Fr Allergol Immunol Clin 46:184–7
   Google Scholar
• Bloom E, Nyman E, Must A, et al. (2009). Molds and mycotoxins in indoor environments – a survey in water-damaged buildings. J Occup Environ Hyg 6:671–8
   PubMed Web of Science ®Google Scholar
• Bornehag C-G, Sundell J, Sigsgaard T. (2004). Dampness in buildings and health (DBH): report from an ongoing epidemiological investigation on the association between indoor environmental factors and health effects among children in Sweden. Indoor Air 14:59–66
   PubMed Web of Science ®Google Scholar
• Boutin-Forzano S, Charpin-Kadouch C, Chabbi S, et al. (2004). Wall relative humidity: a simple and reliable index for predicting Stachybotrys chartarum infestation in dwellings. Indoor Air 14:196–9
   PubMed Web of Science ®Google Scholar
• Brasel TL, Douglas DR, Wilson SC, Straus DC. (2005a). Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. Appl Environ Microbiol 71:114–22
   PubMed Web of Science ®Google Scholar
• Brasel TL, Martin JM, Carriker CG, et al. (2005b). Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment. Appl Environ Microbiol 71:7376–88
   PubMed Web of Science ®Google Scholar
• Bünger J, Schappler-Scheele B, Hilgers R, Hallier E. (2007). A 5-year follow-up study on respiratory disorders and lung function in workers exposed to organic dust from composting plants. Int Arch Occup Environ Health 80:306–12
   PubMed Web of Science ®Google Scholar
• Burge HA. (2001). Fungi: toxic killers or unavoidable nuisances? Ann Allergy Asthma Immunol 87:52–6
   PubMedGoogle Scholar
• Burr ML. (2001). Health effects of indoor molds. Rev Environ Health 16:97–103
   PubMedGoogle Scholar
• Cai G-H, Bröms K, Mälarstig B, et al. (2009). Quantitative PCR analysis of fungal DNA in Swedish day care centers and comparison with building characteristics and allergen levels. Indoor Air 19:392–400
   PubMedGoogle Scholar
• Chang CC, Cheng AC, Devitt B, et al. (2008). Successful control of an outbreak of invasive aspergillosis in a regional haematology unit during hospital construction works. J Hosp Infect 69:33–8
   PubMed Web of Science ®Google Scholar
• Chao H, Milton D, Schwartz J, Burge HA. (2002a). Dustborne fungi in large office buildings. Mycopathologia 154:93–106
   PubMedGoogle Scholar
• Chao H, Schwartz J, Milton DK, Burge HA. (2002b). Populations and determinants of airborne fungi in large office buildings. Environ Health Perspect 110:777–82
   PubMed Web of Science ®Google Scholar
• Charpin-Kadouch C, Maurel G, Felipo R, et al. (2006). Mycotoxin identification in moldy dwellings. J Appl Toxicol 26:475–79
   PubMed Web of Science ®Google Scholar
• Chen Q, Hildemann LM. (2009). The effects of human activities on exposure to particulate matter and bioaerosols in residential homes. Environ Sci Technol 43:4641–6
   PubMed Web of Science ®Google Scholar
• Chew GL, Rogers C, Burge HA, et al. (2003). Dustborne and airborne fungal propagules represent a different spectrum of fungi with differing relations to home characteristics. Allergy 58:13–20
   PubMed Web of Science ®Google Scholar
• Cho S-H, Seo S-C, Schmechel D, et al. (2005). Aerodynamic characteristics and respiratory deposition of fungal fragments. Atmos Environ 39:5454–65
   Web of Science ®Google Scholar
• Claeson A-S, Sandström M, Sunesson A-L. (2007). Volatile organic compounds (VOCs) emitted from materials collected from buildings affected by microorganisms. J Environ Monitor 9:240–5
   PubMedGoogle Scholar
• Codispoti CD, Levin L, LeMasters GK, et al. (2010). Breast-feeding, aeroallergen sensitization, and environmental exposures during infancy are determinants of childhood allergic rhinitis. J Allergy Clin Immunol 125:1054–60
   PubMed Web of Science ®Google Scholar
• Cormier Y, Israel-Assayag E, Racine G, Duchaine C. (2000). Farming practices and the respiratory health risks of swine confinement buildings. Eur Respir J 15:560–5
   PubMed Web of Science ®Google Scholar
• Crawford C, Reponen T, Lee T, et al. (2009). Temporal and spatial variation of indoor and outdoor airborne fungal spores, pollen, and (1→3)-β-d-glucan. Aerobiologia 25:147–58
   Web of Science ®Google Scholar
• Crook B, Burton NC. (2010). Indoor moulds, sick building syndrome and building related illness. Fungal Biol Rev 24:106–13
   Google Scholar
• Dales R, Ruest K, Guay M, et al. (2010). Residential fungal growth and incidence of acute respiratory illness during the first two years of life. Environ Res 110:692–8
   PubMedGoogle Scholar
• Danuser B, Weber C, Künzli N, et al. (2001). Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors. Am J Ind Med 39:410–18
   PubMed Web of Science ®Google Scholar
• Dassonville C, Demattei C, Detaint B, et al. (2008). Assessment and predictors determination of indoor airborne fungal concentrations in Paris newborn babies’ homes. Environ Res 108:80–5
   PubMed Web of Science ®Google Scholar
• De Vos MM, Nelis HJ. (2006). An improved method for the selective detection of fungi in hospital waters by solid phase cytometry. J Microbiol Meth 67:557–65
   PubMedGoogle Scholar
• Douwes J. (2005). (1→3)-β-d-Glucans and respiratory health: a review of the scientific evidence. Indoor Air 15:160–9
   PubMed Web of Science ®Google Scholar
• Douwes J, Thorne P, Pearce N, Heederik D. (2003). Bioaerosol health effects and exposure assessment: progress and prospects. Ann Occup Hyg 47:187–200
   PubMed Web of Science ®Google Scholar
• Duchaine C, Mériaux A. (2000). Airborne microfungi from eastern Canadian sawmills. Can J Microbiol 46:612–16
   PubMed Web of Science ®Google Scholar
• Duquenne P, Simon X, Koehler V, et al. (2012). Documentation of bioaerosol concentrations in an indoor composting facility in France. J Environ Monit 14:409–19
   PubMed Web of Science ®Google Scholar
• Eduard W. (2009). Fungal spores: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting. Crit Rev Toxicol 39:799–864
   PubMed Web of Science ®Google Scholar
• Fabian MP, Miller SL, Reponen T, Hernandez MT. (2005). Ambient bioaerosol indices for indoor air quality assessments of flood reclamation. J Aerosol Sci 36:763–83
   Web of Science ®Google Scholar
• Fairs A, Agbetile J, Bourne M, et al. (2013). Isolation of Aspergillus fumigatus from sputum is associated with elevated airborne levels in homes of patients with asthma. Indoor Air: In press. DOI: 10.1111/ina.12020
   Google Scholar
• Fairs A, Wardlaw AJ, Thompson J, Pashley CH. (2010). Guidelines on ambient intramural airborne fungal spores. J Invest Allergy Clin 20:490–8
   PubMed Web of Science ®Google Scholar
• Falvey DG, Streifel AJ. (2007). Ten-year air sample analysis of Aspergillus prevalence in a university hospital. J Hosp Infect 67:35–41
   PubMed Web of Science ®Google Scholar
• Faure O, Fricker-Hidalgo H, Lebeau B, et al. (2002). Eight-year surveillance of environmental fungal contamination in hospital operating rooms and haematological units. J Hosp Infect 50:155–60
   PubMed Web of Science ®Google Scholar
• Fischer G, Dott W. (2003). Relevance of airborne fungi and their secondary metabolites for environmental, occupational and indoor hygiene. Arch Microbiol 179:75–82
   PubMed Web of Science ®Google Scholar
• Fisk WJ, Lei-Gomez Q, Mendell MJ. (2007). Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air 17:284–96
   PubMed Web of Science ®Google Scholar
• Fleming RV, Walsh TJ, Anaissie EJ. (2002). Emerging and less common fungal pathogens. Infect Dis Clin North Am 16:915–33
   PubMed Web of Science ®Google Scholar
• Foto M, Plett J, Berghout J, Miller JD. (2004). Modification of the Limulus amebocyte lysate assay for the analysis of glucan in indoor environments. Anal Bioanal Chem 379:156–62
   PubMed Web of Science ®Google Scholar
• Foto M, Vrijmoed LLP, Miller JD, et al. (2005). A comparison of airborne ergosterol, glucan and Air-O-Cell data in relation to physical assessments of mold damage and some other parameters. Indoor Air 15:257–66
   PubMed Web of Science ®Google Scholar
• Fournel I, Sautour M, Lafon I, et al. (2010). Airborne Aspergillus contamination during hospital construction works: efficacy of protective measures. Am J Infect Control 38:189–94
   PubMed Web of Science ®Google Scholar
• Frankel M, Timm M, Hansen EW, Madsen AM. (2012). Comparison of sampling methods for the assessment of indoor microbial exposure. Indoor Air 22:405–14
   PubMed Web of Science ®Google Scholar
• Gangneux J-P, Adjidé C-C, Bernard L, et al. (2012). Appréciation quantitative du risque fongique en cas de travaux en établissements de santé: propositions d’indicateurs d’impact des mesures de gestion du risque infectieux fongique. J Mycol Med 22:64–71
   PubMedGoogle Scholar
• Gangneux J-P, Bousseau A, Cornillet A, Kauffmann-Lacroix C. (2006a). Maîtrise du risque fongique environnemental dans les établissements de santé. J Mycol Med 16:204–11
   Web of Science ®Google Scholar
• Gangneux J-P, Bretagne S, Cordonnier C, et al. (2002). Prevention of nosocomial fungal infection: the French approach. Clin Infect Dis 35:343–6
   PubMedGoogle Scholar
• Gangneux J-P, Robert-Gangneux F, Gicquel G, et al. (2006b). Bacterial and fungal counts in hospital air: comparative yields for 4 sieve impactor air samplers with 2 culture media. Infect Control Hosp Epidemiol 27:1405–8
   PubMed Web of Science ®Google Scholar
• Garcia-Vidal C, Upton A, Kirby KA, Marr KA. (2008). Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation. Clin Infect Dis 47:1041–50
   PubMed Web of Science ®Google Scholar
• Godish DR, Godish TJ. (2007). Relationship between sampling duration and concentration of culturable airborne mould and bacteria on selected culture media. J Appl Microbiol 102:1479–84
   PubMedGoogle Scholar
• Goebes MD, Hildemann LM, Kujundzic E, Hernandez M. (2007). Real-time PCR for detection of the Aspergillus genus. J Environ Monitor 9:599–609
   PubMed Web of Science ®Google Scholar
• Górny RL. (2004). Filamentous microorganisms and their fragments in indoor air – a review. Ann Agr Env Med 11:185–97
   PubMed Web of Science ®Google Scholar
• Gorny RL, Reponen T, Willeke K, et al. (2002). Fungal fragments as indoor air biocontaminants. Appl Environ Microbiol 68:3522–31
   PubMed Web of Science ®Google Scholar
• Green BJ, Tovey ER, Beezhold DH, et al. (2009). Surveillance of fungal allergic sensitization using the fluorescent halogen immunoassay. J Mycol Med 19:253–61
   PubMedGoogle Scholar
• Green BJ, Tovey ER, Sercombe JK, et al. (2006). Airborne fungal fragments and allergenicity. Med Mycol 44:S245–55
   PubMed Web of Science ®Google Scholar
• Haatainen S, Laitinen J, Linnainmaa M, et al. (2010). The suitability of the IOM – foam sampler for bioaerosol sampling in occupational environments. J Occup Environ Hyg 7:1–6
   PubMedGoogle Scholar
• Hansen VM, Meyling NV, Winding A, et al. (2012). Factors affecting vegetable growers’ exposure to fungal bioaerosols and airborne dust. Ann Occup Hyg 56:170–81
   PubMed Web of Science ®Google Scholar
• Herbarth O, Schlink U, Müller A, Richter M. (2003). Spatiotemporal distribution of airborne mould spores in apartments. Mycol Res 107:1361–71
   PubMedGoogle Scholar
• Hulin M, Moularat S, Kirchner S, et al. (2013). Positive associations between respiratory outcomes and fungal index in rural inhabitants of a representative sample of French dwellings. Int J Hyg Environ Health 216:155–62
   PubMed Web of Science ®Google Scholar
• Hyvärinen A, Vahteristo M, Meklin T, et al. (2001). Temporal and spatial variation of fungal concentrations in indoor air. Aerosol Sci Technol 35:688–95
   Web of Science ®Google Scholar
• Iossifova Y, Reponen T, Sucharew H, et al. (2008). Use of (1-3)-β-d-glucan concentrations in dust as a surrogate method for estimating specific fungal exposures. Indoor Air 18:225–32
   PubMed Web of Science ®Google Scholar
• Jarvis BB, Miller JD. (2005). Mycotoxins as harmful indoor air contaminants. Appl Microbiol Biot 66:367–72
   PubMed Web of Science ®Google Scholar
• Joblin Y, Moularat S, Anton R, et al. (2010). Detection of moulds by volatile organic compounds: application to heritage conservation. Int Biodeter Biodegr 64:210–17
   Google Scholar
• Jovanovic S, Felder-Kennel A, Gabrio T, et al. (2004). Indoor fungi levels in homes of children with and without allergy history. Int J Hyg Environ Health 207:369–78
   PubMedGoogle Scholar
• Kanaani H, Hargreaves M, Ristovski Z, Morawska L. (2008). Deposition rates of fungal spores in indoor environments, factors effecting them and comparison with non-biological aerosols. Atmos Environ 42:7141–54
   Web of Science ®Google Scholar
• Karvala K, Nordman H, Luukkonen R, et al. (2008). Occupational rhinitis in damp and moldy workplaces. Am J Rhinol 22:457–62
   PubMedGoogle Scholar
• Karvala K, Toskala E, Luukkonen R, et al. (2011). Prolonged exposure to damp and moldy workplaces and new-onset asthma. Int Arch Occup Environ Health 84:713–21
   PubMedGoogle Scholar
• Ko G, Simmons I, Likirdopulos CA, et al. (2010). Endotoxin levels at Swine farms using different waste treatment and management technologies. Environ Sci Technol 44:3442–8
   PubMed Web of Science ®Google Scholar
• Ko G, Simmons OD III, Likirdopulos CA, et al. (2008). Investigation of bioaerosols released from Swine farms using conventional and alternative waste treatment and management technologies. Environ Sci Technol 42:8849–57
   PubMed Web of Science ®Google Scholar
• Koch A, Heilemann K-J, Bischof W, et al. (2000). Indoor viable mold spores – a comparison between two cities, Erfurt (eastern Germany) and Hamburg (western Germany). Allergy 55:176–80
   PubMed Web of Science ®Google Scholar
• Krysińska-Traczyk E, Pande BN, Skórska C, et al. (2005). Exposure of Indian agricultural workers to airborne microorganisms, dust and endotoxin during handling of various plant products. Ann Agr Env Med 12:269–75
   PubMed Web of Science ®Google Scholar
• Kuhn DM, Ghannoum MA. (2003). Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. Clin Microbiol Rev 16:144–72
   PubMed Web of Science ®Google Scholar
• Lanier C, Richard E, Heutte N, et al. (2010). Airborne molds and mycotoxins associated with handling of corn silage and oilseed cakes in agricultural environment. Atmos Environ 44:1980–6
   Web of Science ®Google Scholar
• Lanternier F, Sun H-Y, Ribaud P, et al. (2012). Mucormycosis in organ and stem cell transplant recipients. Clin Infect Dis 54:1–8
   PubMed Web of Science ®Google Scholar
• Lee J-H, Jo W-K. (2006). Characteristics of indoor and outdoor bioaerosols at Korean high-rise apartment buildings. Environ Res 101:11–17
   PubMed Web of Science ®Google Scholar
• Le Goff O, Bru-Adan V, Bacheley H, et al. (2010). The microbial signature of aerosols produced during the thermophilic phase of composting. J Appl Microbiol 108:325–40
   PubMed Web of Science ®Google Scholar
• Li C-S, Hou P-A. (2003). Bioaerosol characteristics in hospital clean rooms. Sci Total Environ 305:169–76
   PubMed Web of Science ®Google Scholar
• Lignell U, Meklin T, Rintala H, et al. (2008). Evaluation of quantitative PCR and culture methods for detection of house dust fungi and streptomycetes in relation to moisture damage of the house. Lett Appl Microbiol 47:303–8
   PubMed Web of Science ®Google Scholar
• Lortholary O, Gangneux J-P, Sitbon K, et al. (2011). Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005–2007). Clin Microbiol Infect 17:1882–9
   PubMed Web of Science ®Google Scholar
• Lugauskas A, Krikstaponis A, Sveistyte L. (2004). Airborne fungi in industrial environments – potential agents of respiratory diseases. Ann Agric Environ Med 11:19–25
   PubMed Web of Science ®Google Scholar
• Macher JM. (2001). Evaluation of a procedure to isolate culturable microorganisms from carpet dust. Indoor Air 11:134–40
   PubMed Web of Science ®Google Scholar
• Madsen AM, Matthiesen CB, Frederiksen MW, et al. (2012). Sampling, extraction and measurement of bacteria, endotoxin, fungi and inflammatory potential of settling indoor dust. J Environ Monit 14:3230–9
   PubMed Web of Science ®Google Scholar
• McGinnis MR. (2004). Pathogenesis of indoor fungal diseases. Med Mycol 42:107–17
   PubMed Web of Science ®Google Scholar
• Méheust D, Le Cann P, Gangneux J-P. (2013). Rapid quantification of viable fungi in hospital environments: analysis of air and surface samples using solid-phase cytometry. J Hosp Infect 83:122–6
   PubMedGoogle Scholar
• Méheust D, Le Cann P, Reponen T, et al. (2012a). Possible application of the Environmental Relative Moldiness Index in France: a pilot study in Brittany. Int J Hyg Environ Health 216:333--40
   Google Scholar
• Méheust D, Gangneux J-P, Reponen T, et al. (2012b). Correlation between Environmental Relative Moldiness Index (ERMI) values in French dwellings and other measures of fungal contamination. Sci Total Environ 438:319–24
   PubMedGoogle Scholar
• Meklin T, Haugland RA, Reponen T, et al. (2004). Quantitative PCR analysis of house dust can reveal abnormal mold conditions. J Environ Monit 6:615–20
   PubMed Web of Science ®Google Scholar
• Meklin T, Reponen T, McKinstry C, et al. (2007). Comparison of mold concentrations quantified by MSQPCR in indoor and outdoor air sampled simultaneously. Sci Total Environ 382:130–4
   PubMed Web of Science ®Google Scholar
• Mendell MJ, Mirer AG, Cheung K, et al. (2011). Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ Health Perspect 119:748–56
   PubMed Web of Science ®Google Scholar
• Metzker ML. (2010). Sequencing technologies – the next generation. Nat Rev Gen 11:31–46
   PubMed Web of Science ®Google Scholar
• Morrison J, Yang C, Lin K-T, et al. (2004). Monitoring Aspergillus species by quantitative PCR during construction of a multi-storey hospital building. J Hosp Infect 57:85–7
   PubMed Web of Science ®Google Scholar
• Moularat S, Robine E, Ramalho O, Oturan MA. (2008). Detection of fungal development in closed spaces through the determination of specific chemical targets. Chemosphere 72:224–32
   PubMedGoogle Scholar
• Neely AN, Gallardo V, Barth E, et al. (2004). Rapid monitoring by quantitative polymerase chain reaction for pathogenic Aspergillus during carpet removal from a hospital. Infect Control Hosp Epidemiol 25:350–2
   PubMed Web of Science ®Google Scholar
• Nesa D, Lortholary O, Bouakline A, et al. (2001). Comparative performance of impactor air samplers for quantification of fungal contamination. J Hosp Infect 47:149–55
   PubMed Web of Science ®Google Scholar
• Nieguitsila A, Arné P, Durand B, et al. (2011). Relative efficiencies of two air sampling methods and three culture conditions for the assessment of airborne culturable fungi in a poultry farmhouse in France. Environ Res 111:248–53
   PubMedGoogle Scholar
• Nieguitsila A, Goldenberg O, Deville M, et al. (2010). Molecular monitoring of fungal communities in air samples by denaturing high-performance liquid chromatography (D-HPLC). J Appl Microbiol 109:910–17
   PubMedGoogle Scholar
• Nielsen KF. (2003). Mycotoxin production by indoor molds. Fungal Genet Biol 39:103–17
   PubMed Web of Science ®Google Scholar
• Niemeier RT, Sivasubramani SK, Reponen T, Grinshpun SA. (2006). Assessment of fungal contamination in moldy homes: comparison of different methods. J Occup Environ Hyg 3:262–73
   PubMed Web of Science ®Google Scholar
• Norbäck D, Cai G-H. (2011). Fungal DNA in hotel rooms in Europe and Asia – associations with latitude, precipitation, building data, room characteristics and hotel ranking. J Environ Monit 13:2895–903
   PubMedGoogle Scholar
• Normand A-C, Sudre B, Vacheyrou M, et al. (2011). Airborne cultivable microflora and microbial transfer in farm buildings and rural dwellings. Occup Environ Med 68:849–55
   PubMed Web of Science ®Google Scholar
• Normand A-C, Vacheyrou M, Sudre B, et al. (2009). Assessment of dust sampling methods for the study of cultivable-microorganism exposure in stables. Appl Env Microbiol 75:7617–23
   PubMed Web of Science ®Google Scholar
• Noss I, Wouters IM, Visser M, et al. (2008). Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment. Appl Env Microbiol 74:5621–7
   PubMed Web of Science ®Google Scholar
• O’Connor GT, Walter M, Mitchell H, et al. (2004). Airborne fungi in the homes of children with asthma in low-income urban communities: the inner-city asthma study. J Allergy Clin Immunol 114:599–606
   PubMed Web of Science ®Google Scholar
• O’Gorman C. (2011). Airborne Aspergillus fumigatus conidia: a risk factor for aspergillosis. Fungal Biol Rev 25:151–7
   Google Scholar
• Omland O. (2002). Exposure and respiratory health in farming in temperate zones – a review of the literature. Ann Agr Environ Med 9:119–36
   PubMed Web of Science ®Google Scholar
• Park J-H, Cox-Ganser JM, Kreiss K, et al. (2007). Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged building. Environ Health Perspect 116:45–50
   Google Scholar
• Pastuszka JS, Kyaw Tha Paw U, Lis DO, et al. (2000). Bacterial and fungal aerosol in indoor environment in Upper Silesia, Poland. Atmos Environ 34:3833–42
   Web of Science ®Google Scholar
• Peccia J, Hernandez M. (2006). Incorporating polymerase chain reaction-based identification, population characterization, and quantification of microorganisms into aerosol science: a review. Atmos Environ 40:3941–61
   Web of Science ®Google Scholar
• Peccia J, Hospodsky D, Bibby K. (2011). New Directions: a revolution in DNA sequencing now allows for the meaningful integration of biology with aerosol science. Atmos Environ 45:1896–7
   Web of Science ®Google Scholar
• Peláez T, Muñoz P, Guinea J, et al. (2012). Outbreak of invasive aspergillosis after major heart surgery caused by spores in the air of the intensive care unit. Clin Infect Dis 54:e24–31
   Google Scholar
• Perfect JR, Cox GM, Lee JY, Kauffman CA, et al. (2001). The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis 33:1824–33
   PubMed Web of Science ®Google Scholar
• Pitkäranta M, Meklin T, Hyvarinen A, et al. (2008). Analysis of fungal flora in indoor dust by ribosomal DNA sequence analysis, quantitative PCR, and culture. Appl Environ Microbiol 74:233–44
   PubMed Web of Science ®Google Scholar
• Polizzi V, Delmulle B, Adams A, et al. (2009). JEM Spotlight: fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings. J Environ Monit 11:1849–58
   PubMedGoogle Scholar
• Pongracic JA, O’Connor GT, Muilenberg ML, et al. (2010). Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol 125:593–9
   PubMed Web of Science ®Google Scholar
• Portnoy JM, Barnes CS, Kennedy K. (2004). Sampling for indoor fungi. J Allergy Clin Immunol 113:189–98
   PubMedGoogle Scholar
• Prigione V, Lingua G, Marchisio VF. (2004). Development and use of flow cytometry for detection of airborne fungi. Appl Environ Microbiol 70:1360–5
   PubMedGoogle Scholar
• Quansah R, Jaakkola MS, Hugg TT, et al. (2012). Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis. PLoS ONE 7:e47526
   PubMed Web of Science ®Google Scholar
• Radon K, Danuser B, Iversen M, et al. (2002). Air contaminants in different European farming environments. Ann Agric Environ Med 9:41–8
   PubMed Web of Science ®Google Scholar
• Reboux G. (2006). Mycotoxines: effets sur la santé et interactions avec d’autres composants organiques. Rev Fr Allergol Immunol Clin 46:208–12
   Google Scholar
• Reboux G, Bellanger A-P, Dalphin JC. (2011). Contre: les composés organiques volatils d’origine fongique ont un impact sur la santé. Rev Fr Allergol 51:350–3
   Google Scholar
• Reboux G, Bellanger A-P, Roussel S, et al. (2010). Moisissures et habitat: risques pour la santé et espèces impliquées. Rev Mal Respir 27:169–79
   PubMedGoogle Scholar
• Reboux G, Bellanger A-P, Roussel S, et al. (2009). Indoor mold concentration in Eastern France. Indoor Air 19:446–53
   PubMed Web of Science ®Google Scholar
• Reboux G, Piarroux R, Mauny F, et al. (2001). Role of molds in farmer’s lung disease in Eastern France. Am J Resp Crit Car Med 163:1534–9
   PubMed Web of Science ®Google Scholar
• Reboux G, Roussel S, Grenouillet F. (2006). Moisissures de l’environnement agricole. J Mycol Med 16:248–62
   Web of Science ®Google Scholar
• Ren P, Jankun TM, Belanger K, et al. (2001). The relation between fungal propagules in indoor air and home characteristics. Allergy 56:419–24
   PubMed Web of Science ®Google Scholar
• Reponen T, Lockey J, Bernstein DI, et al. (2012). Infant origins of childhood asthma associated with specific molds. J Allergy Clin Immunol 130:639–44
   PubMed Web of Science ®Google Scholar
• Reponen T, Seo S-C, Grimsley F, et al. (2007). Fungal fragments in moldy houses: a field study in homes in New Orleans and Southern Ohio. Atmos Environ 41:8140–9
   PubMed Web of Science ®Google Scholar
• Reponen T, Vesper SJ, Levin L, et al. (2011). High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age. Ann Allerg Asthma Im 107:120–6
   PubMed Web of Science ®Google Scholar
• Richard E, Heutte N, Sage L, et al. (2007). Toxigenic fungi and mycotoxins in mature corn silage. Food Chem Toxicol 45:2420–5
   PubMed Web of Science ®Google Scholar
• Robine E, Lacaze I, Moularat S, et al. (2005). Characterisation of exposure to airborne fungi: measurement of ergosterol. J Microbiol Meth 63:185–92
   PubMedGoogle Scholar
• Roussel S, Reboux G, Millon L, et al. (2006). Hypersensitivity pneumonitis and exposure to moulds and actinomycetes in the environment. J Mycol Med 16:239–47
   Google Scholar
• Roussel S, Reboux G, Bellanger A-P, et al. (2008). Characteristics of dwellings contaminated by moulds. J Environ Monit 10:724–9
   PubMed Web of Science ®Google Scholar
• Rupp ME, Iwen PC, Tyner LK, et al. (2008). Routine sampling of air for fungi does not predict risk of invasive aspergillosis in immunocompromised patients. J Hosp Infect 68:270–1
   PubMed Web of Science ®Google Scholar
• Sautour M, Sixt N, Dalle F, et al. (2009). Profiles and seasonal distribution of airborne fungi in indoor and outdoor environments at a French hospital. Sci Total Environ 407:3766–71
   PubMed Web of Science ®Google Scholar
• Schleibinger H, Laussmann D, Bornehag C-G, et al. (2008). Microbial volatile organic compounds in the air of moldy and mold-free indoor environments. Indoor Air 18:113–24
   PubMed Web of Science ®Google Scholar
• Schmechel D, Górny RL, Simpson JP, et al. (2003). Limitations of monoclonal antibodies for monitoring of fungal aerosols using Penicillium brevicompactum as a model fungus. J Immunol Meth 283:235–45
   PubMed Web of Science ®Google Scholar
• Schmechel D, Simpson JP, Lewis DM. (2005). The production and characterization of monoclonal antibodies to the fungus Aspergillus versicolor. Indoor Air 15:11–19
   PubMedGoogle Scholar
• Schuchardt S, Kruse H. (2009). Quantitative volatile metabolite profiling of common indoor fungi: relevancy for indoor air analysis. J Basic Microb 49:350–62
   PubMedGoogle Scholar
• Seo S-C, Grinshpun Sergey A, Iossifova Y, et al. (2007). A new field-compatible methodology for the collection and analysis of fungal fragments. Aerosol Sci Tech 41:794–803
   Web of Science ®Google Scholar
• Sherif R, Segal BH. (2010). Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications. Curr Opin Pulm Med 16:242–50
   PubMed Web of Science ®Google Scholar
• Singh J. (2001). Review: occupational exposure to moulds in buildings. Indoor Built Environ 10:172–8
   Google Scholar
• Sixt N, Dalle F, Lafon I, et al. (2007). Reduced fungal contamination of the indoor environment with the Plasmair™ system (Airinspace). J Hosp Infect 65:156–62
   PubMed Web of Science ®Google Scholar
• Skorska C, Sitkowska J, Krysinska-Traczyk E. (2005). Exposure to airborne microorganisms, dust and endotoxin during processing of peppermint and chamomile herbs on farms. Ann Agric Environ Med 12:281–8
   PubMed Web of Science ®Google Scholar
• Stetzenbach LD, Buttner MP, Cruz P. (2004). Detection and enumeration of airborne biocontaminants. Curr Opin Biotech 15:170–4
   PubMed Web of Science ®Google Scholar
• Su H-J, Wu P-C, Chen H-L, et al. (2001). Exposure assessment of indoor allergens, endotoxin, and airborne fungi for homes in Southern Taiwan. Environ Res 85:135–44
   PubMed Web of Science ®Google Scholar
• Takigawa T, Wang B-L, Sakano N, et al. (2009). A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. Sci Total Environ 407:5223–8
   PubMed Web of Science ®Google Scholar
• Tedersoo L, Nilsson RH, Abarenkov K, et al. (2010). 454 Pyrosequencing and Sanger sequencing of tropical mycorrhizal fungi provide similar results but reveal substantial methodological biases. New Phytologist 188:291–301
   PubMed Web of Science ®Google Scholar
• Teixeira JV, Miranda S, Monteiro RAR, et al. (2013). Assessment of indoor airborne contamination in a wastewater treatment plant. Environ Monit Assess 185:59–72
   PubMed Web of Science ®Google Scholar
• Thornton CR. (2010). Detection of invasive aspergillosis. Adv Appl Microbiol 70:187–216
   PubMed Web of Science ®Google Scholar
• Tolvanen OK, Hänninen KI. (2005). Occupational hygiene in a waste incineration plant. Waste Manage 25:519–29
   PubMed Web of Science ®Google Scholar
• Tovey ER, Taylor DJM, Graham AH, et al. (2000). New immunodiagnostic system. Aerobiologia 16:113–18
   Google Scholar
• Trout DB, Seltzer JM, Page EH, et al. (2004). Clinical use of immunoassays in assessing exposure to fungi and potential health effects related to fungal exposure. Ann Allergy Asthma Im 92:483–92
   PubMed Web of Science ®Google Scholar
• Tuomi T, Reijula K, Johnsson T, et al. (2000). Mycotoxins in crude building materials from water-damaged buildings. Appl Environ Microbiol 66:1899–904
   PubMed Web of Science ®Google Scholar
• Vanhee LME, Nelis HJ, Coenye T. (2009a). Detection and quantification of viable airborne bacteria and fungi using solid-phase cytometry. Nat Protoc 4:224–31
   PubMedGoogle Scholar
• Vanhee LME, Nelis HJ, Coenye T. (2009b). Rapid detection and quantification of Aspergillus fumigatus in environmental air samples using solid-phase cytometry. Environ Sci Technol 43:3233–9
   PubMed Web of Science ®Google Scholar
• Van Lancker F, Adams A, Delmulle B, et al. (2008). Use of headspace SPME-GC-MS for the analysis of the volatiles produced by indoor molds grown on different substrates. J Environ Monitor 10:1127--33
   PubMed Web of Science ®Google Scholar
• Vesper SJ. (2011). Traditional mould analysis compared to a DNA-based method of mould analysis. Crit Rev Microbiol 37:15–24
   PubMed Web of Science ®Google Scholar
• Vesper SJ, McKinstry C, Hartmann C, et al. (2008a). Quantifying fungal viability in air and water samples using quantitative PCR after treatment with propidium monoazide (PMA). J Microbiol Meth 72:180–4
   PubMed Web of Science ®Google Scholar
• Vesper SJ, McKinstry C, Haugland RA, et al. (2007a). Relative moldiness index as predictor of childhood respiratory illness. J Expo Sci Env Epid 17:88–94
   PubMed Web of Science ®Google Scholar
• Vesper SJ, McKinstry C, Haugland RA, et al. (2008b). Higher Environmental Relative Moldiness Index (ERMIsm) values measured in Detroit homes of severely asthmatic children. Sci Total Environ 394:192–6
   PubMed Web of Science ®Google Scholar
• Vesper SJ, McKinstry C, Haugland RA, et al. (2007b). Development of an environmental relative moldiness index for US homes. J Occup Environ Med 49:829–33
   PubMed Web of Science ®Google Scholar
• Wålinder R, Ernstgård L, Johanson G, et al. (2005). Acute effects of a fungal volatile compound. Environ Health Perspect 113:1775–8
   PubMedGoogle Scholar
• Warris A, Verweij PE. (2005). Clinical implications of environmental sources for Aspergillus. Med Mycol 43:S59–65
   Web of Science ®Google Scholar
• World Health Organization (WHO) Europe. (2009). WHO Guidelines for indoor air quality, dampness and mould. Copenhagen, Denmark: WHO. Available from: www.who.int/indoorair/publications/7989289041683/en/index.html [last accessed 12 Mar 2013]
   Google Scholar
• Wu P-C, Su H-JJ, Ho H-M. (2000). A comparison of sampling media for environmental viable fungi collected in a hospital environment. Environ Res 82:253–7
   PubMed Web of Science ®Google Scholar
• Wu Z, Blomquist G, Westermark S-O, Wang X-R. (2002). Application of PCR and probe hybridization techniques in detection of airborne fungal spores in environmental samples. J Environ Monitor 4:673–8
   PubMed Web of Science ®Google Scholar
• Yamamoto N, Kimura M, Matsuki H, Yanagisawa Y. (2010). Optimization of a real-time PCR assay to quantitate airborne fungi collected on a gelatin filter. J Biosci Bioeng 109:83–8
   PubMed Web of Science ®Google Scholar
• Yao M, Mainelis G. (2007). Use of portable microbial samplers for estimating inhalation exposure to viable biological agents. J Expos Sci Environ Epidemiol 17:31–8
   PubMed Web of Science ®Google Scholar
• Yap J, Toh ZA, Goh V, et al. (2009). Assessment of mold concentrations in Singapore shopping centers using mold-specific quantitative PCR (MSQPCR) analysis. Ind J Microbiol 49:290–3
   Google Scholar
• Zeng Q-Y, Westermark S-O, Rasmuson-Lestander A, Wang X-R. (2004). Detection and quantification of Wallemia sebi in aerosols by real-time PCR, conventional PCR, and cultivation. Appl Environ Microbiol 70:7295–302
   PubMed Web of Science ®Google Scholar
• Zeng Q-Y, Westermark S-O, Rasmuson-Lestander Å, Wang X-R. (2006). Detection and quantification of Cladosporium in aerosols by real-time PCR. J Environ Monit 8:153–60
   PubMedGoogle Scholar