Friendly pathogens: prevent or provoke autoimmunity

References

• Alard P, Parnell SA, Manirarora JN, Kosiewicz MM. (2009). Probiotics control lupus progression via induction of regulatory cells and IL-10 production. J Immunol 82:50. 30
   Google Scholar
• Armougom F, Henry M, Vialettes B, et al. (2009). Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS One 4:e7125
   PubMed Web of Science ®Google Scholar
• Artemis P, Simopoulos MD. (2002). Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21:495–505
   PubMed Web of Science ®Google Scholar
• Asseman C, Mauze S, Leach MW, et al. (1999). An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190:995–1004
   PubMed Web of Science ®Google Scholar
• Atarashi K, Nishimura J, Shima T, et al. (2008). ATP drives lamina propria T(H)17 cell differentiation. Nature 455:808–12
   PubMed Web of Science ®Google Scholar
• Atarashi K, Tanoue T, Shima T, et al. (2011). Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331:337–41
   PubMed Web of Science ®Google Scholar
• Bamba T, Matsuda H, Endo M, Fujiyama Y. (1995). The pathogenic role of Bacteroides vulgatus in patients with ulcerative colitis. J Gastroenterol 30:45–7
   PubMed Web of Science ®Google Scholar
• Berer K, Mues M, Koutrolos M, et al. (2011). Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479:538–41
   PubMed Web of Science ®Google Scholar
• Braat H, van den Brande J, van Tol E, et al. (2004). Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am J Clin Nutr 80:1618–25
   PubMed Web of Science ®Google Scholar
• Brown CT, Davis-Richardson AG, Giongo A, et al. (2011). Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One 6:e25792
   PubMed Web of Science ®Google Scholar
• Chassaing B, Michaud AD. (2011). The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1720–8
   PubMed Web of Science ®Google Scholar
• Chervonsky AV. (2010). Influence of microbial environment on autoimmunity. Nat Immunol 11:28–35
   PubMed Web of Science ®Google Scholar
• Cobb BA, Wang Q, Tzianabos AO, Kasper DL. (2004). Polysaccharide processing and presentation by the MHCII pathway. Cell 117:677–87
   PubMed Web of Science ®Google Scholar
• Cormstock LE. (2009). Importance of glycans to the host-bacteroides mutualism in the mammalian intestine. Cell Host Microbe 5:522–6
   PubMed Web of Science ®Google Scholar
• Denic A, Johnson AJ, Bieber AJ, et al. (2010). The relevance of animal models in multiple sclerosis research. Pathophysiology 18:21–9
   Google Scholar
• Dicksved J, Halfvarson J, Rosenquist M, et al. (2008). Molecular analysis of the gut microbiota of identical twins with Crohn’s disease. ISME J 2:716–27
   PubMed Web of Science ®Google Scholar
• Dobber R, Hertogh-Huijbregts A, Rozing J, et al. (1992). The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery. Dev Immunol 2:141–50
   PubMedGoogle Scholar
• Dominguez-Bello MG, Costello EK, Contreras M, et al. (2010). Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 107:11971–5
   PubMed Web of Science ®Google Scholar
• Duerkop BA, Vaishnava S, Hooper LV. (2009). Immune responses to the microbiota at the intestinal mucosal surface. Immunity 31:368–76
   PubMed Web of Science ®Google Scholar
• Fielder M, Pirt SJ, Tarpey I, et al. (1995). Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS Lett 369:243–8
   PubMed Web of Science ®Google Scholar
• Fink LN, Zeuthen LH, Christensen HR, et al. (2007). Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses. Int Immunol 19:1319–27
   PubMed Web of Science ®Google Scholar
• Foligne B, Zoumpopoulou G, Dewulf J, et al. (2007). A key role of dendritic cells in probiotic functionality. PLoS One 2:e313
   PubMed Web of Science ®Google Scholar
• Frank DN, St Amand AL, Feldman RA, et al. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 104:13780–5
   PubMed Web of Science ®Google Scholar
• Fukata M, Breglio K, Chen A, et al. (2008). The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol 180:1886–94
   PubMed Web of Science ®Google Scholar
• G’Routhiau V, Rakotobe S, Lecuyer E, et al. (2009). The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31:677–89
   PubMed Web of Science ®Google Scholar
• Gasbarrini A, Franceschi F, Tartaglione R, et al. (1998). Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet 352:878--78
   PubMed Web of Science ®Google Scholar
• Giongo A, Gano KA, Crabb DB, et al. (2011). Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 5:82–91
   PubMed Web of Science ®Google Scholar
• Green EA, Gorelik L, McGregor CM, et al. (2003). CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 100:10878–83
   PubMed Web of Science ®Google Scholar
• Hacker G, Redecke V, Hacker H. (2002). Activation of the immune system by bacterial CpG-DNA. Immunology 105:245–51
   PubMed Web of Science ®Google Scholar
• Hall JA, Bouladoux N, Sun CM, et al. (2008). Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29:637–49
   PubMed Web of Science ®Google Scholar
• Harmsen HJ, Wildeboer-Veloo AC, Grijpstra J, et al. (2000). Development of 16S rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 66:4523–7
   PubMed Web of Science ®Google Scholar
• Hopkins MJ, Macfarlane GT, Furrie E, et al. (2005). Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses. FEMS Microbiol Ecol 54:77–85
   PubMed Web of Science ®Google Scholar
• Houliston RS, Vinogradov E, Dzieciatkowska M, et al. (2011). Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides. J Biol Chem 286:12361–70
   PubMed Web of Science ®Google Scholar
• Ivanov II, Atarashi K, Manel N, et al. (2009). Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485–98
   PubMed Web of Science ®Google Scholar
• Ivanov, II, Frutos Rde L, Manel N, et al. (2008). Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4:337–49
   PubMed Web of Science ®Google Scholar
• Karvonen M, Tuomilehto J, Libman I, Laporte R. (1993). A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group. Diabetologia 36:883–92
   PubMed Web of Science ®Google Scholar
• Kelly D, Campbell JI, King TP, et al. (2004). Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 5:104–12
   PubMed Web of Science ®Google Scholar
• Koenig JE, Spor A, Scalfone N, et al. (2011). Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA 108:4578–85
   PubMed Web of Science ®Google Scholar
• Konieczna P, Groeger D, Ziegler M, et al. (2012). Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells. Gut 61:354–66
   PubMed Web of Science ®Google Scholar
• Kouskoff V, Korganow AS, Duchatelle V, et al. (1996). Organ-specific disease provoked by systemic autoreactivity. Cell 87:811–22
   PubMed Web of Science ®Google Scholar
• Kranich J, Maslowski KM, Mackay CR. (2011). Commensal flora and the regulation of inflammatory and autoimmune responses. Semin Immunol 23:139–45
   PubMed Web of Science ®Google Scholar
• Kriegel MA, Sefik E, Hill JA, et al. (2011). Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in non obese diabetic mice. Proc Natl Acad Sci USA 108:11548–53
   PubMed Web of Science ®Google Scholar
• Krinos CM, Coyne MJ, Weinacht KG, et al. (2001). Extensive surface diversity of a commensal microorganism by multiple DNA inversions. Nature 414:555–8
   Google Scholar
• Lai Y, Di Nardo A, Nakatsuji T, et al. (2009). Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med 15:1377–82
   PubMed Web of Science ®Google Scholar
• Lathrop SK, Bloom SM, Rao SM, et al. (2011). Peripheral education of the immune system by colonic commensal microbiota. Nature 478:250–4
   PubMed Web of Science ®Google Scholar
• Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. (2011). Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 108:4615–22
   PubMed Web of Science ®Google Scholar
• Ley RE, Turnbaugh PJ, Klein S, Gordon JI. (2006). Microbial ecology: human gut microbes associated with obesity. Nature 444:1022–3
   PubMed Web of Science ®Google Scholar
• Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. (2005). An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107–18
   PubMed Web of Science ®Google Scholar
• Mazmanian SK, Round JL, Kasper DL. (2008). A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453:620–5
   PubMed Web of Science ®Google Scholar
• McClain MT, Heinlen LD, Dennis GJ, et al. (2005). Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 11:85–9
   PubMed Web of Science ®Google Scholar
• Murphy SF, Kwon JH, Boone DL. (2012). Novel players in inflammatory bowel disease pathogenesis. Curr Gastroenterol Rep 14:146–52
   PubMedGoogle Scholar
• Noverr MC, Huffnagle GB. (2004). Does the microbiota regulate immune responses outside the gut? Trends Microbiol 12:562–8
   PubMed Web of Science ®Google Scholar
• O’Reparaz J, Mielcarz DW, Begum-Haque S, Kasper LH. (2011). Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann Neurol 69:240–7
   PubMed Web of Science ®Google Scholar
• O’Repáraz J, Mielcarz DW, Ditrio LE, et al. (2010). Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol 185:4101–8
   PubMed Web of Science ®Google Scholar
• O’Mahony C, Scully P, O’Mahony D, et al. (2008). Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation. PLoS Pathog 4:e1000112
   PubMed Web of Science ®Google Scholar
• Palmer C, Bik EM, Eisen MB, et al. (2006). Rapid quantitative profiling of complex microbial populations. Nucleic Acids Res 34:e5
   PubMed Web of Science ®Google Scholar
• Penders J, Thijs C, Vink C, et al. (2006). Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118:511–21
   PubMed Web of Science ®Google Scholar
• Perdigon G, Maldonado Galdeano C, Valdez JC, Medici M. (2002). Interaction of lactic acid bacteria with the gut immune system. Eur J Clin Nutr 56:21–6
   PubMed Web of Science ®Google Scholar
• Qin J, Li R, Raes J, et al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59–65
   PubMed Web of Science ®Google Scholar
• Rajilic-Stojanovic M, Smidt H, de Vos WM. (2007). Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol 9:2125–36
   PubMed Web of Science ®Google Scholar
• Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. (2004). Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229–41
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. (2009). The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313–23
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. (2010). Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 107:12204–9
   PubMed Web of Science ®Google Scholar
• Salvetti M, Ristori G, Bomprezzi R, et al. (2000). Twins: mirrors of the immune system. Immunol Today 21:342–7
   PubMedGoogle Scholar
• Scher JU, Abramson SB. (2011). The microbiome and rheumatoid arthritis. Nat Rev Rheumatol 7:569–78
   PubMed Web of Science ®Google Scholar
• Silhavy TJ, Kahne D, Walker S. (2010). The bacterial cell envelope. Cold Spring Harb Perspect Biol 2:a000414
   PubMed Web of Science ®Google Scholar
• Sinkorova Z, Capkova J, Niederlova J, et al. (2008). Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2(k)) male mice. Hum Immunol 69:845–50
   PubMed Web of Science ®Google Scholar
• Smits HH, Engering A, van der Kleij D, et al. (2005). Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 115:1260–7
   PubMed Web of Science ®Google Scholar
• Sokol H, Seksik P, Rigottier-Gois L, et al. (2006). Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis 12:106–11
   PubMed Web of Science ®Google Scholar
• Strachan DP. (2000). Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax 55:2–10
   PubMed Web of Science ®Google Scholar
• Swidsinski A, Weber J, Loening-Baucke V, et al. (2005). Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol 43:3380–9
   PubMed Web of Science ®Google Scholar
• Tedelind S, Westberg F, Kjerrulf M, Vidal A. (2007). Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 13:2826–32
   PubMed Web of Science ®Google Scholar
• Tiemessen MM, Jagger AL, Evans HG, et al. (2007). CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 104:19446–51
   PubMed Web of Science ®Google Scholar
• Tlaskalova-Hogenova H, Stepankova R, Hudcovic T, et al. (2004). Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett 93:97–108
   PubMed Web of Science ®Google Scholar
• Vaahtovuo J, Munukka E, Korkeamaki M, et al. (2008). Fecal microbiota in early rheumatoid arthritis. J Rheumatol 35:1500–5
   PubMed Web of Science ®Google Scholar
• Vaarala O. (2008). Leaking gut in type 1 diabetes. Curr Opin Gastroenterol 24:701–6
   PubMed Web of Science ®Google Scholar
• van den Broek MF, van Bruggen MC, Koopman JP, et al. (1992). Gut flora induces and maintains resistance against streptococcal cell wall-induced arthritis in F344 rats. Clin Exp Immunol 88:313–17
   PubMed Web of Science ®Google Scholar
• Vassallo MF, Walker WA. (2008). Neonatal microbial flora and disease outcome. Nestle Nutr Workshop Ser Pediatr Program 61:211–24
   PubMedGoogle Scholar
• Wang Z, MacLeod DT, Di Nardo A. (2012). Commensal bacteria lipoteichoic acid increases skin mast cell antimicrobial activity against vaccinia viruses. J Immunol 189:1551–8
   PubMed Web of Science ®Google Scholar
• Wen L, Ley RE, Volchkov PY, et al. (2008). Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455:1109–13
   PubMed Web of Science ®Google Scholar
• Wilson M, McNab R, Henderson B, eds. (2002). Bacterial disease mechanisms. Cambridge: Cambridge University Press
   Google Scholar
• Wu HJ, Ivanov II, Darce J, et al. (2010). Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32:815–27
   PubMed Web of Science ®Google Scholar
• Yokote H, Miyake S, Croxford JL, et al. (2008). NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 173:1714–23
   PubMed Web of Science ®Google Scholar
• Yuki N, Susuki K, Koga M, et al. (2004). Carbohydrate mimicry between human ganglioside GM 1 and Campylobacter jejuni lipo oligosaccharide causes Guillain–Barre syndrome. Pro Natl Acad Sci 101:11404–9
   PubMed Web of Science ®Google Scholar