Drugs and drug intermediates from fungi: Striving for greener processes

References

• Ahmed F, Williams RA, Smith KE. (1996). Microbial transformations of steroids-X Cytochromes P-450 11 alpha-hydroxylase and C17-C20 lyase and a 1-ene dehydrogenase transform steroids in Nectria haematococca. J Steroid Biochem Mol Biol 58:337–49
   PubMed Web of Science ®Google Scholar
• Alberts AW, Chen J, Kuron G, et al. (1980). Mevinolin: a high potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci USA 77:3957–61
   PubMed Web of Science ®Google Scholar
• Alberts AW. (1990). Lovastatin and simvastatin- Inhibitors of HMG CoA reductase and cholesterol Biosynthesis. Cardiology 77:14–21
   PubMed Web of Science ®Google Scholar
• Alvarado-Vasquez, N Santiago J, Alcazar-Leyva S, et al. (2005). A fungal tRNA of Aspergillus niger induces IFN-β synthesis in HEp-2 cells. Life Sci 77:578–88
   PubMed Web of Science ®Google Scholar
• Bentley R. (1997). Microbial secondary metabolites play important roles in medicine; prospects for discovery of new drugs. Perspect Biol Med 40:364–94
   PubMed Web of Science ®Google Scholar
• Borel JF. (2003). Xenotransplantation in the cyclosporine era. Xenotransplantation 10:383–4
   PubMed Web of Science ®Google Scholar
• Bortolini O, Medici A, Poli S. (1997). Biotransformations of the steroid nucleus of bile acids. Steroids 62:564–77
   PubMed Web of Science ®Google Scholar
• Brandhorst T, Kenealy WR. (1995). Effects of leader sequences upon the heterologous expression of restrictocin in A. nidulans and A. niger. Can J Microbiol 41:601−11
   PubMed Web of Science ®Google Scholar
• Broekhuijsen MP, Mattern IE, Contreras R, et al. (1993). Secretion of heterologous proteins by A. niger. Production of active human interleukin-6 in a protease deficient mutant by KEX-2 processing of a glucoamylase-HIL-6 fusion protein. J Biotechnol 31:135–45
   PubMed Web of Science ®Google Scholar
• Brown MS, Faust JR, Goldstein JL, et al. (1978). Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J Biol Chem 253:1121–8
   PubMed Web of Science ®Google Scholar
• Bugni TS, Ireland CM. (2004). Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep 21:143–63
   PubMed Web of Science ®Google Scholar
• Butler MS. (2008). Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 25:475–516
   PubMed Web of Science ®Google Scholar
• Chartrain M, Salmon PM, Robinson DK, Buckland BC. (2000). Metabolic engineering and directed evolution for the production of pharmaceuticals. Curr Opin Biotechnol 11:209–14
   PubMed Web of Science ®Google Scholar
• Chen X, Shi Q, Lin G, et al. (2009). Spirobisnaphthalene analogues from the endophytic Fungus preussia sp. J Nat Prod 72:1712–15
   PubMed Web of Science ®Google Scholar
• Cisse M, Mucke L. (2009). Alzheimer's disease: A prion protein connection. Nature 457:1090–1
   PubMed Web of Science ®Google Scholar
• Cousins RPC, Mahmoudian M, Youds PM. (1995). Enzymatic resolution of oxathiolane intermediates: an alternative approach to the anti-viral agent lamivudine(3TCTM). Tetrahedron Asymmetry 6:393–6
   Web of Science ®Google Scholar
• Cragg GM, Kingston DGI, Newman DJ. (2005). Anticancer agents from natural products. Boca Raton, FL: CRC Press
   Google Scholar
• Croom EM. (1995). Taxus for Taxol and Toxoids. Boca Raton, FL: CRC Press, 37–70
   Google Scholar
• Cui CM, Li XM, Li CS, et al. (2010). Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod 73:729–33
   PubMed Web of Science ®Google Scholar
• Cullen D, Gray GL, Wilson LJ, et al. (1987). Controlled expression and secretion of bovine chymosin in A. nidulans. Biotechnology 5:369−76
   Google Scholar
• Daisy BG, Strobel Ezra D, Castillo U, et al. (2002a). Muscodor vitigenus anam. sp. nov., an endophyte from Paullinia paullinioides. Mycotaxon 84:39–50
   Web of Science ®Google Scholar
• Daisy BH, Strobel GA, Castillo U, et al. (2002b). Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus. Microbiology 148:3737–41
   PubMed Web of Science ®Google Scholar
• Dana MDLM, Limon MC, Mejias R, et al. (2001). Regulation of chitinase 33 (chit33) gene expression in T. harzianum. Curr Genet 38:335–42
   PubMed Web of Science ®Google Scholar
• Davies RW. (1990). Molecular biology of a high-level recombinant protein production system in Aspergillus. In: Leong SA, Berka RM, eds. Molecular industrial mycology. New York: Marcel Dekker, 45–81
   Google Scholar
• Demain AL. (1999). Pharmaceutically active secondary metabolites of microorganisms. Appl Microbiol Biotechnol 52:455–63
   PubMed Web of Science ®Google Scholar
• Dunn-Coleman NS, Bloebaum P, Berka RM, et al. (1991). Commercial levels of chymosin production by Aspergillus. Biotechnology 9:976−81
   PubMedGoogle Scholar
• Elander RP. (2003). Industrial production of β-lactam antibiotics. Appl Microbiol Biotechnol 61:385–92
   PubMed Web of Science ®Google Scholar
• Endo A, Kuroda M, Tanazawa K. (1976a). Competitive inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase by ML-236 A and ML-236 B fungal metabolites having hypocholesterolemic activity. FEBS Lett 72:323–6
   PubMed Web of Science ®Google Scholar
• Endo A, Kuroda M, Tanazawa K. (1976b). ML-236 A, ML-236 B and ML-236 C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J Antibiotics 29:1346–8
   PubMed Web of Science ®Google Scholar
• Endo A, Kuroda M, Terahara A, et al. (1977). Physiologically active substances and fermentative process for producing the same. US Patent 4,049,495
   Google Scholar
• Endo A, Kuroda M, Terahara A, et al. (1976c). Physiologically active substances. US Patent 3,983,140
   Google Scholar
• Engel B, Erkel G, Anke T, Sterner O. (1998). Sesquicillin, an inhibitor of glucocorticoid mediated signal transduction. J Antibiot 51:518–21
   PubMed Web of Science ®Google Scholar
• Ezra D, Hess WH, Strobel GA. (2004). New endophytic isolates of M. albus, a volatile antibiotic-producing fungus. Microbiology 150:4023–31
   PubMed Web of Science ®Google Scholar
• Fernandes P, Cruz A, Angelova B, et al. (2003). Microbial conversion of steroid compounds: recent developments. Enzyme Microb Technol 32:688–705
   Web of Science ®Google Scholar
• Flores A, Chet I, Herrera Estrella A. (1997). Improved biocontrol activity of the proteinase encoding gene prb1. Curr Genet 31:30–7
   PubMed Web of Science ®Google Scholar
• Ge HM, Yu ZG, Zhang J, et al. (2009). Bioactive alkaloids from endophytic Aspergillus fumigates. J Nat Prod 72:753–75
   PubMed Web of Science ®Google Scholar
• Goodhue CT, Schaeffer JR. (1971). Preparation of L-(+)-β-hydroxyisobutyric acid by bacterial oxidation of isobutyric acid. Biotechnol Bioeng 13:203
   PubMed Web of Science ®Google Scholar
• Gouka RJ, Hessing JG, Punt PJ, et al. (1996). An expression system based on the promoter region of the A. awamori 1,4-beta-endoxylanase A gene. Appl Microbiol Biotechnol 46:28–35
   PubMed Web of Science ®Google Scholar
• Gouka RJ, Punt PJ, van den Hondel CAMJJ. (1997). Efficient production of secreted proteins by Aspergillus. progress, limitations and prospects. Appl Microbiol Biotechnol 47:1–11
   PubMed Web of Science ®Google Scholar
• Grabley S, Thiericke R. (1999). Drug discovery from nature. Springer-Verlag: Heidelberg, 51–5
   Google Scholar
• Grove JF, MacMillan J, Mulholland TPC, Rogers MAT. (1952). Griseofulvin. Part IV. Structure. J Chem Soc 3977–87
   Web of Science ®Google Scholar
• Gunde-Cimerman N, Plemenitas A, Cimerman A. (1993). Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase. FEMS Microbiol Lett 113:333–7
   PubMed Web of Science ®Google Scholar
• Haggag Wafaa M, Mohamed HAA. (2007). Biotechnological aspects of microorganisms used in plant biological control. World J Agric Sci 3:771–6
   Google Scholar
• Hajjaj H, Niederberger P, Duboc P. (2001). Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl Environ Microbiol 67:2596–602
   PubMed Web of Science ®Google Scholar
• Hanson RL, Parker WL, Brzozowski DB, et al. (2005). Preparation of (R)- and (S)-hydroxybuspirone by enzymatic resolution and hydroxylation. Tetrahedron Asymmetry 16:2711
   Web of Science ®Google Scholar
• Harkki A, Mantyla A, Penttila M, et al. (1991). Genetic engineering of Trichoderma to produce strains with novel cellulase profiles. Enzyme Microb Technol 3:227–33
   Google Scholar
• Harkki A, Uusitalo J, Bailey M, et al. (1989). A novel expression system. secretion of active calf chymosin from the filamentous fungus T. reesei. Biotechnology 7:596–603
   Google Scholar
• Hensens OD, Ondeyka JG, Dombrowski AW, et al. (1999). Isolation and structure of nodulisporic acid A1 and A2, novel insecticides from a Nodulisporium sp. Tetrahedron Lett 40:5455–8
   Web of Science ®Google Scholar
• Hwang HJ, Kim SW, Lim JM, et al. (2005). Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci 76:3069–80
   PubMed Web of Science ®Google Scholar
• Irrgang S, Schlosser D, Fritsche W. (1997). Involvement of cytochrome P-450 in the 15alpha-hydroxylation of 13-ethyl-gon-4-ene-3,17-dione by Penicillium raistrickii. J Steroid Biochem Mol Biol 60:339–46
   PubMed Web of Science ®Google Scholar
• Isoai A, Kimura HA, Reichert K, et al. (2002). Production of D-amino acid oxidase (DAO) of Trigonopsis variabilis in Schizosaccharomyces pombe and the characterization of biocatalysts prepared with recombinant cells. Biotechnol Bioeng 80:22–32
   PubMed Web of Science ®Google Scholar
• Jajoo HK, Mayol RF, LaBudde JA, Blair IA. (1989). Metabolism of the antianxiety drug buspirone in human subjects. Drug Metab Dispos 17:634–40
   PubMed Web of Science ®Google Scholar
• Jayasuriya H, Guan Z, Polishook JD, et al. (2003). Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp. J Nat Prod 66:551–3
   PubMed Web of Science ®Google Scholar
• Jeenes DJ, Marczinke B, MacKenzie DA, Archer DB. (1993). A truncated glucoamylase gene fusion for heterologous protein secretion from A. niger. FEMS Microbiol Lett 107:267–71
   PubMed Web of Science ®Google Scholar
• Jeong HW, Lee HJ, Kho YH, et al. (2002). Biological effects of G1 phase arrest compound, sesquicillin in human breast cancer cell lines. Bioorg Med Chem 10:3129–34
   PubMed Web of Science ®Google Scholar
• Karhunen T, Mantyla A, Nevalainen H, Suominen P. (1993). High frequency one-step replacement in T. reesei. I. Endoglucanase I overproduction. Mol Gen Genet 241:515–22
   PubMedGoogle Scholar
• Karwowski JP, Jackson M, Rasmussen RR, et al. (1993). 5-N-Acetylardeemin, A novel heterocyclic compound which reverses multiple drug resistance in tumor cells. J Antibiot 46:374–9
   PubMed Web of Science ®Google Scholar
• Keiner MJ, McMorris TC, Rojas RK, et al. (2008). Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil. Invest New Drugs 26:407
   PubMed Web of Science ®Google Scholar
• Kharwar RN, Mishra A, Gond SK, et al. (2011). Anticancer compounds derived from fungal endophytes: their importance and future challenges. Nat Prod Rep 28:1208–28
   PubMed Web of Science ®Google Scholar
• Kiho T, Itahashi S, Sakushima M, et al. (1997). Polysaccharides in fungi. XXXVIII. Anti-diabetic activity and structural feature of a galactomannan elaborated by Pestalotiopsis species. Biol Pharm Bull 20:118–21
   PubMed Web of Science ®Google Scholar
• Kirby TJ. (1967). Cataracts produced by triparanol (MER-29). Trans Am Ophthalmol Soc 65:494–543
   PubMedGoogle Scholar
• Kovalenko OH, Barkalova AO, Nahorrna SS. (2005). Antiphytoviral activity of capsule substances of Cryptococcus albidus yeast. Mikrobiol Z 67:81–4
   PubMedGoogle Scholar
• Kuwabara A, Fujita S, Kobayashi S, Nishigori T. (1996). (Nippon Kayaku KK). Sesquicillin isomer manufacture with Acremonium. JP 8,092,119
   Google Scholar
• Larsen TO, Smedsgaard J, Nielsen KF, et al. (2005). Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat Prod Rep 22:672–95
   PubMed Web of Science ®Google Scholar
• Lehrer RI, Ganz T. (2002). Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol 9:18–22
   PubMed Web of Science ®Google Scholar
• Ligon BL. (2004). Penicillin: its discovery and early development. Semin Pediatr Infect Dis 15:52–7
   PubMedGoogle Scholar
• Limon MC, Pintor-Toro JA, Benitez T. (1999). Increased antifungal activity of T. harzianum transformants that overexpress a 33-kDa chitinase. Phytopathology 89:254–61
   PubMed Web of Science ®Google Scholar
• Liu JY, Huang LL, Ye YH, et al. (2006). Antifungal and new metabolites of Myrothecium sp. Z16, a fungus associated with white croaker Argyrosomus argentatus. J Appl Microbiol 100:195–202
   PubMed Web of Science ®Google Scholar
• Mach RL, Zeilinger S. (2003). Regulation of gene expression in industrial fungi Trichoderma. Appl Microbiol Biotechnol 60:515–22
   PubMed Web of Science ®Google Scholar
• Mahato SB, Garai S. (1997). Advances in microbial steroid biotransformation. Steroids 62:332–45
   PubMed Web of Science ®Google Scholar
• Mahato SB, Mukherjee A. (1984). Steroid transformations by microorganisms. Phytochemistry 23:2131–54
   Web of Science ®Google Scholar
• Mahmoudian M, Baines BS, Drake CS. (1993). Enzymatic production of optically pure 3TCTM (Lamivudine): a potent anti-HIV agent. Enzyme Microb Technol 15:749–55
   PubMed Web of Science ®Google Scholar
• Malaviya A, Gomes J. (2008). Androstenedione production by biotransformation of phytosterols. Bioresour Technol 99:6725–37
   PubMed Web of Science ®Google Scholar
• Manosroia J, Saowakhonb S, Manosroia A. (2007). A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a. Enzyme Microb Technol 41:322–5
   Web of Science ®Google Scholar
• Manzoni M, Bergomi S, Rollini M, Cavazzoni V. (1999). Production of statins by filamentous fungi. Biotechnol Lett 21:253–7
   Web of Science ®Google Scholar
• Manzoni M, Rollini M, Bergomi S, Cavazzoni V. (1998). Production and purification of statins from Aspergillus terreus strains. Biotechnol Tech 12:529–32
   Google Scholar
• Manzoni M, Rollini M. (2002). Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58:555–64
   PubMed Web of Science ®Google Scholar
• Margolles-Clark E, Hayes CK, Harman GE, Penttila M. (1996). Improved production of T. harzianum endochitinase by expression in T. reesei. Appl Environ Microbiol 62:2145–51
   PubMed Web of Science ®Google Scholar
• Mayol RF. (2000). Busiprone metabolite for the alleviation of anxiety, Cont.-in-part of U.S. Ser. No. 484,161 US 6150365 A 20001121 CAN 133:359250 AN 2000:819478
   Google Scholar
• Meinke PT, Colletti SL, Fisher MH, et al. (2009). Discovery of the development candidate Ntert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals. J Med Chem 52:3505–15
   PubMed Web of Science ®Google Scholar
• Mercier J, Jimenez JI. (2004). Control of fungal decay of apples and paches by the biofumigant fungus Muscodor albus. Postharvest Biol Technol 31:1–8
   Web of Science ®Google Scholar
• Ming H, Lara Pizarro AV, Park EY. (2003). Application of waste activated bleaching earth containing rapeseed oil on riboflavin production in the culture of Ashbya gossypii. Biotechnol Prog 19:410–17
   PubMed Web of Science ®Google Scholar
• Moebius N, Hertweck C. (2009). Mycotoxins as mediators of plant virulence. Curr Opin Plant Biol 12:1–9
   PubMedGoogle Scholar
• Mostafa ME, Zohri AA. (2000). Progesterone side-chain degradation by some species of Aspergillus flavus group. Folia Microbiol 45:243–7
   PubMed Web of Science ®Google Scholar
• Mygind PH, Fischer RL, Schnorr KM, et al. (2005). Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437:975–80
   PubMed Web of Science ®Google Scholar
• Nanduri V. (2000). Purification of astereospecific 2-ketoreductase from Gluconobacter oxydan. J Ind Microbial Biotechnol 25:171
   Web of Science ®Google Scholar
• Nanduri VB, Hanson RL, Goswami A, et al. (2001). Biochemical approaches to the synthesis of ethyl 5-(S)-hydroxyl hexanoate and 5-(S)-hydroxyhexanitrile. Enzyme Microb Technol 28:632–6
   PubMed Web of Science ®Google Scholar
• Negishi S, Cai-Huang Z, Hasumi K, et al. (1986). Productivity of monacolin K (mevinolin) in the genus Monascus. J Ferment Eng, 64:509–12
   Web of Science ®Google Scholar
• Nevalainen H. (2001). Improvement in filamentous fungi. In: Kchachatourians G, Arora D, eds. Applied mycology and biotechnology, agriculture and food production. Amsterdam: Elsevier, 289–304
   Google Scholar
• Newton GGF, Abraham EP. (1955). Cephalosporin C, a new antibiotic containing sulphur and D-α-aminoadipic acid. Nature 175:548
   PubMed Web of Science ®Google Scholar
• Nijland JG, Ebbendorf B, Woszczynska M, et al. (2010). Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum. Appl Environ Microbiol 76:7109–71
   PubMed Web of Science ®Google Scholar
• Nishikawa M, Ogawa K. (2004). Antimicrobial activity of a chelatable poly(arginyl-histidine) produced by the ergot fungus Verticillium kibiense. Antimicrob Agents Chemother 48:229–35
   PubMed Web of Science ®Google Scholar
• Nyyssonen E, Keranen S. (1995). Multiple roles of the cellulase CBHI in enhancing production of fusion antibodies by the filamentous fungus T. reesei. Curr Genet 28:71−9
   PubMed Web of Science ®Google Scholar
• Nyyssonen E, Penttila M, Harkki A, et al. (1993). Efficient production of antibody fragments by the filamentous fungus T. reesei. Biotechnology 11:591−5
   PubMedGoogle Scholar
• Ondetti MA, Cushman DW. (1981). Inhibition of rennin-angiotensin system: a new approach to the theory of hypertension. J Med Chem 24:355
   PubMed Web of Science ®Google Scholar
• Ondetti MA, Rubin B, Cushman DW. (1977). Design of specific inhibitors of angiotensin converting enzyme: new class of orally active antihypertensive agents. Science 196:441
   PubMed Web of Science ®Google Scholar
• Ondeyka JG, Helms GL, Hensens OD, et al. (1997). Nodulisporic acid A, a novel and potent insecticide from a Nodulisporium sp. isolation, structure determination, and chemical transformations. J Am Chem Soc 119:8809–16
   Web of Science ®Google Scholar
• Park EY, Ming H. (2004). Oxidation of rapeseed oil in waste activated bleaching earth and its effect on riboflavin production in culture of Ashbya gossypii. J Biosci Bioeng 97:59–64
   PubMed Web of Science ®Google Scholar
• Patel RN. (2004). Enantioselective microbial reduction of substituted acetophenones. Tetrahedron Asymmetry 15:1247
   Web of Science ®Google Scholar
• Patel RN, Banerjee A, Nanduri V, et al. (2000). Enzymatic resolution of racemic secondary alcohols by lipase B from Candida antarctica. JAm Oil Chem Soc 77:1015
   Web of Science ®Google Scholar
• Patel RN, Banerjee A, Szarka L. (1997). Stereoselective acetylation of [1-(hydroxyl)-4-(3-phenoxy-phenyl)butyl] phosphonic acid diethyl ester. Tetrahedron Asymmetry 8:1055
   Web of Science ®Google Scholar
• Patel RN, Chu L, Nanduri V, et al. (2005). Enantioselective microbial reduction of 6-oxo-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl] butyl]-8-azaspiro [4.5] decane-7,9-dione. Tetrahed Asymmetry 16:2778
   Web of Science ®Google Scholar
• Patel, RN. Howell JM, McNamee CG, et al. (1992a). Stereoselective enzymatic hydrolysis of α [acetylthio)methyl]benzenepropanoic acid and 3-acetylthio-2-methylpropanoic acid. Biotechnol Appl Biochem 16:34–47
   Web of Science ®Google Scholar
• Patel RN, Mcnamee CG, Banerjee A, et al. (1992b). Stereoselective reduction of β-ketoesters by Geotrichum candidum. Enzyme Microb Technol 14:731
   Web of Science ®Google Scholar
• Paz Z, Komon-Zelazowska M, Druzhinina IS, et al. (2010). Diversity and potential antifungal properties of fungi associated with a Mediterranean sponge. Fungal Divers 42:17–26
   Web of Science ®Google Scholar
• Peng Y, Demain AL. (1998). A new hydrolase system in Actinomadura sp cells converting compactin to pravastatin. J Ind Microbiol Biotechnol 20:373–5
   Web of Science ®Google Scholar
• Peng Y, Yashphe J, Demain AL. (1997). Biotransformation of compactin to pravastatin by Actinomadura sp. 2966. J Antibiot (Tokyo) 50:1032–5
   PubMed Web of Science ®Google Scholar
• Petrič S, Hakki T, Bernhardt R, et al. (2010). Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application. J Biotechnol 150:428–37
   PubMed Web of Science ®Google Scholar
• Raap J, Erkelens K, Ogrel A, et al. (2005). Fungal biosynthesis of non-ribosomal peptide antibiotics and a,a-dialkylated amino acid constituents. J Peptide Sci 11:331–8
   PubMed Web of Science ®Google Scholar
• Rateb ME, Ebel R. (2011). Secondary metabolites of fungi from marine habitats. Nat Prod Rep 28:290–344
   PubMed Web of Science ®Google Scholar
• Roberts IN, Jeenes DJ, MacKenzie DA, et al. (1992). Heterologous gene expression in A. niger. a glucoamylase – porcine pancreatic prophospholipase A2 fusion protein is secreted and processed to yield mature enzyme. Gene 122:155−61
   PubMed Web of Science ®Google Scholar
• Romanos MA, Scorer CA, Clare JJ. (1992). Foreign gene expression in yeast. a review. Yeast 8:423−88
   PubMed Web of Science ®Google Scholar
• Rowley DC, Kelly S, Jensen P, Fenical W. (2004). Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus. Bioorg Med Chem 12:4929–36
   PubMed Web of Science ®Google Scholar
• Rowley DC, Kelly S, Kauffman CA, et al. (2003). New antiviral agents from a marine-derived fungus of the genus Scytalidium. Bioorg Med Chem 11:4263–74
   PubMed Web of Science ®Google Scholar
• Ruhlmann A, Nordheim A. (1997). Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. Immunobiology 198:192–206
   PubMed Web of Science ®Google Scholar
• Sallam LAR, El-Refai AM, El-Minofi HA. (2005). Physiological and biochemical improvement of the enzyme side-chain degradation of cholesterol by Fusarium solani. Process Biochem 40:203–6
   Web of Science ®Google Scholar
• Samanta TB, Ghosh DK. (1987). Characterization of progesterone 11 alpha-hydroxylase of Aspergillus ochraceus TS: a cytochrome P-450 linked monooxygenase. J Steroid Biochem 28:327–32
   PubMedGoogle Scholar
• Sasaki S, Hashimoto R, Kiuchi M, et al. (1994). Fungal metabolites part 14+. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia. J Antibiot 47:420–33
   PubMed Web of Science ®Google Scholar
• Schiff Pb, Fant J, Horowitz SB. (1979). Promotion of microtubule assembly in vitro by taxol. Nature 227:665–7
   Web of Science ®Google Scholar
• Schroda M, Blocker D, Beck CF. (2000). The HSP70A promoter as a tool for the improved expression of transgenes in Chlamydomonas. Plant J 21:121–31
   PubMed Web of Science ®Google Scholar
• Schuren FHJ, Wessels JGH. (1998). Expression of heterologous genes in Schizophyllum commune is often hampered by the formation of truncated transcripts. Curr Genet 33:151–6
   PubMed Web of Science ®Google Scholar
• Scorer CA, Buckholz RG, Clare JJ, Romanos MA. (1993). The intracellular production and secretion of HIV-1 envelope protein in the methylotrophic yeast Pichia pastoris. Gene 136:111–19
   PubMed Web of Science ®Google Scholar
• Shkumatov VM, Usova EV, Poljakov YS, et al. (2002). Biotransformation of steroids by a recombinant yeast strain expressing bovine cytochrome P-45017α. Biochemistry 67:456–67
   PubMed Web of Science ®Google Scholar
• Shoop WL, Gregory LM, Zakson-Aiken M, et al. (2001). Systemic efficacy of nodulisporic acid against fleas on dogs. J Parasitol 87:419–23
   PubMed Web of Science ®Google Scholar
• Singh SB, Herath K, Guan Z, et al. (2002). Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase. Org Lett 4:1431–4
   PubMed Web of Science ®Google Scholar
• Singh SB, Ondeyka JG, Jayasuriya H, et al. (2004). Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships. J Nat Prod 67:1496–506
   PubMed Web of Science ®Google Scholar
• Smith D, Ryan MJ. (2009). Fungal sources for new drug discovery. AccessScience, ©McGraw-Hill Companies. Available at: http://www.accessscience.com
   Google Scholar
• Smith TL, Gaskell J, Berka RM, et al. (1990). The promoter of the glucoamylase-encoding gene of A. niger functions in Ustilago maydis. Gene 88:259−62
   PubMed Web of Science ®Google Scholar
• Sonomoto K, Hoq MMD, Tanaka A, Fukui S. (1981). Growth of Curvularia lunata spores into mycelial form with various gels, and steroid 11β-hydroxy1ation by the entrapped mycelia. J Ferment Technol 59:465–9
   Google Scholar
• Sopalun K, Strobel GA, Hess WM, Worapong J. (2003). A record of Muscodor albus, an endophyte from Myristica fragrans, in Thailand. Mycotaxon 88:239–47
   Web of Science ®Google Scholar
• Stasz TE. (1990). Genetic improvement of fungi by protoplast fusion for biological control of plant pathogens. Can J Plant Pathol 12:322–7
   Web of Science ®Google Scholar
• Steiger A, Pyun H, Coates R. (1992). Synthesis and characterization of aza analog inhibitors of squalene and geranylgeranyl diphosphate synthases. J Org Chem 57:3444
   Web of Science ®Google Scholar
• Steinberg D, Avigan J, Feigelson EB. (1961). Effects of triparanol (MER-29) on cholesterol biosynthesis and on blood sterol levels in man. J Clin Invest 40:884–93
   PubMed Web of Science ®Google Scholar
• Stierle A, Strobel G, Stierle D. (1993). Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–16
   PubMed Web of Science ®Google Scholar
• Stinson M, Zidack NK, Strobel GA, Jacobsen B. (2003). Mycofumigation with Muscodor albus and Muscodor roseus for control of seedling diseases of sugar beet and verticillum wilt of eggplant. Plant Dis 87:1349–54
   PubMed Web of Science ®Google Scholar
• Strobel G, Daisy B. (2003). Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502
   PubMed Web of Science ®Google Scholar
• Strobel GA, Dirkse E, Sears J, Markworth C. (2001). Volatile antimicrobials from Muscodor albus, a novel endophytic fungus. Microbiology 147:2943–50
   PubMed Web of Science ®Google Scholar
• Svetina M, Krasevec N, Gaberc-Porekar V, Komel R. (2000). Expression of catalytic subunit of bovine enterokinase in the filamentous fungus A. niger. J Biotechnol 76:245−51
   PubMed Web of Science ®Google Scholar
• Teo VSJ, Cziferszky AE, Bergquist PL, Nevalainen KMH. (2000). Codon optimization of xylanase gene xynB from the thermophilic bacterium Dictyoglomus thermophilum for expression in the filamentous fungus T. reesei. FEMS Microbiol Lett 190:13–19
   PubMed Web of Science ®Google Scholar
• Tobert JA. (1987). New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase. Circulation 76:534–8
   PubMed Web of Science ®Google Scholar
• Tsuchiya K, Tada S, Gomi K, et al. (1992). High level expression of the synthetic human lysozyme gene in A. oryzae. Appl Microbiol Biotechnol 38:109−14
   PubMed Web of Science ®Google Scholar
• Turnbull WH, Ward T. (1995). Mycoprotein reduces glycemia and insulinemia when taken with an oral-glucose-tolerance test. Am J Clin Nutr 61:135–40
   PubMed Web of Science ®Google Scholar
• Uchida R, Imasato R, Yamaguchi Y, et al. (2005). New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778. J Antibiot 58:397–404
   Google Scholar
• Van den Hombergh JPTW, van den Vondervoort PJI, Fraissinet-Tachet L, Visser J. (1997). Aspergillus as a host for heterologous protein production. The problem of proteases. Trends Biotechnol 15:256–63
   PubMed Web of Science ®Google Scholar
• Van den Hondel CAMJJ, Punt PJ, van Gorcom RFM. (1991). Heterologous gene expression in filamentous fungi. In: Bennett JW, Lasure LL, eds. More gene manipulations in fungi. New York: Academic Press, 396–428
   Google Scholar
• van Gemeren IA, Beijersbergen A, Musters W, et al. (1996). The effect of pre- and prosequences and multicopy integration on heterologous expression of the F. solani pisi cutinase gene in A. awamori. Appl Microbiol Biotechnol 45:755−63
   PubMed Web of Science ®Google Scholar
• Verdoes JC, Punt PJ, Schrickx JM, et al. (1993). Glucoamylase overexpression in A. niger. molecular genetic analysis of strains containing multiple copies of the glaA gene. Transgenic Res 2:84–92
   PubMed Web of Science ®Google Scholar
• Viola F, Caputo O, Balliano G, et al. (1983). Side chain degradation and microbial reduction of different steroids by Aspergillus auroefulgens. J Steroid Biochem 19:1451–8
   PubMedGoogle Scholar
• Wang S, Li G, Lu H, et al. (2000). Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei. FEMS Microbiol Lett 193:249–53
   PubMed Web of Science ®Google Scholar
• Wani MC, Taylor HL, Wall ME, et al. (1971). Plant anti-tumor agents. VI. The isolation and structure of taxol, a novel anti-leukemic and anti-tumor agent from Taxus brevifolia. J Am Chem Soc 93:2325–7
   PubMed Web of Science ®Google Scholar
• Ward PP, Piddington CS, Cunningham GA, et al. (1995). A system for production of commercial quantities of human lactoferrin. A broad spectrum natural antibiotic. Biotechnology 13:498−503
   PubMedGoogle Scholar
• Watanabe A, Kamei K, Sekine T, et al. (2003). Immunosuppressive substances in Aspergillus fumigatus culture filtrate. J Infect Chemother 9:114–21
   PubMedGoogle Scholar
• Worapong J, Strobel GA, Ford EJ, et al. (2001). Muscodor albus gen. et sp. nov., an endophyte from Cinnamomum zeylanicum. Mycotaxon 79:67–79
   Web of Science ®Google Scholar
• Xing B, Rao J, Liu R. (2008). Novel beta-zlactam antibiotic derivatives: their new applications as gene reporters, antitumor prodrugs and enzyme inhibitors. Mini Rev Med Chem 8:455–71
   PubMed Web of Science ®Google Scholar
• Xu J, Ebada SS, Proksch P. (2010). Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites. Fungal Divers 44:15–31
   Web of Science ®Google Scholar
• Yanagihara M, Sasaki-Takahashi N, Sugahara T, et al. (2005). Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B. Cancer Sci 96:816–24
   PubMed Web of Science ®Google Scholar
• Yashima Y, Ohgane T. (2001). Pharmacological profiles of mycophenolate mofetil (CellCept), a new immunosuppressive agent. Nippon Yakurigaku Zasshi 117:131–7
   PubMedGoogle Scholar
• Yashphe J, Davis J, Peng Y, et al. (1997). New micro- organisms which convert compactin to pravastatin. Actinomycetologia 11:20–5
   Google Scholar
• Yevich JP, Mayol RF, Li J, Yocca F. (2003). R-6-hydroxybuspirone for the treatment of anxiety, depression, and other psychogenic disorders. PCT Int. Appl., WO 2003009851 A1 20030206 CAN 138:131155 AN 2003:97305
   Google Scholar
• Yuan JI, Jian-Nan BI, Bing Y, Xu-Dong Z. (2006). Taxol producing fungi: a new approach to industrial production of taxol. Chin J Biotechnol 22:1–6
   Google Scholar
• Zafar S, Bibi M, Yousuf S, Choudhary MI. (2013). New metabolites from fungal biotransformation of an oral contraceptive agent: methyloestrenolone. Steroids 78:418–25
   PubMed Web of Science ®Google Scholar
• Zanetti M. (2004). Cathelicidins, multifunctional peptides of the innate immunity. J. Leukoc Biol 75:39–48
   PubMed Web of Science ®Google Scholar
• Zeelen FJ. (1990). Medicinal chemistry of steroids. Amsterdam: Elsevier
   Google Scholar
• Zhang HW, Song YC, Tan RX. (2006). Biology and chemistry of endophytes. Nat Prod Rep 23:753–71
   PubMed Web of Science ®Google Scholar
• Zubrod CG, Schepartz S, Leiter J, et al. (1966). The chemotherapy program of the National Cancer Institute: history, analysis and plans. Cancer Chemother Rep 50:349–540
   PubMedGoogle Scholar