The carcinogenicity of dietary acrylamide intake: A comparative discussion of epidemiological and experimental animal research

References

• Abramsson-Zetterberg L, Grawe J, Zetterberg G. (1995). Flow cytometric analysis of micronucleus induction in mice by internal exposure to 137Cs at very low dose rates. Int J Radiat Biol 67:29–36.
   PubMed Web of Science ®Google Scholar
• Abramsson-Zetterberg L. (2003). The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat Res 535:215–222.
   PubMedGoogle Scholar
• Acconcia F, Totta P, Ogawa S, Cardillo I, Inoue S, Leone S, et al. (2005). Survival versus apoptotic 17beta-estradiol effect: Role of ER alpha and ER beta activated non-genomic signaling. J Cell Physiol 203:193–201.
   PubMed Web of Science ®Google Scholar
• Adler ID, Zouh R, Schmid E. (1993). Perturbation of cell division by acrylamide in vitro and in vivo. Mutat Res 301:249–254.
   PubMed Web of Science ®Google Scholar
• Adler ID, Ingwersen I, Kliesch U, el Tarras A. (1988). Clastogenic effects of acrylamide in mouse bone marrow cells. Mutat Res 206:379–385.
   PubMed Web of Science ®Google Scholar
• Agrawal AK, Seth PK, Squibb RE, Tilson HA, Uphouse LL, Bondy SC. (1981). Neurotransmitter receptors in brain regions of acrylamide- treated rats. I: Effects of a single exposure to acrylamide. Pharmacol Biochem Behav 14:527–531.
   PubMed Web of Science ®Google Scholar
• Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. (2001). Role of exogenous and endogenous hormones in endometrial cancer: Review of the evidence and research perspectives. Ann N Y Acad Sci 943:296–315.
   PubMed Web of Science ®Google Scholar
• Aliau S, Mattras H, Richard E, Borgna JL. (1999). Cysteine 530 of the human estrogen receptor alpha is the main covalent attachment site of 11beta-(aziridinylalkoxyphenyl)estradiols. Biochemistry 38:14752–14762.
   PubMedGoogle Scholar
• Ali SF, Hong JS, Wilson WE, Uphouse LL, Bondy SC. (1983). Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones. Arch Toxicol 52:35–43.
   PubMed Web of Science ®Google Scholar
• Allen NE, Key TJ, Dossus L, Rinaldi S, Cust A, Lukanova A, et al. (2008). Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer 15:485–497.
   PubMed Web of Science ®Google Scholar
• Backer LC, Dearfield KL, Erexson GL, Campbell JA, Westbrook-Collins B, Allen JW. (1989). The effects of acrylamide on mouse germ-line and somatic cell chromosomes. Environ Mol Mutagen 13:218–226.
   PubMedGoogle Scholar
• Barrett JC. (1995). Mechanisms for species differences in receptor-mediated carcinogenesis. Mutat Res 333:189–202.
   PubMed Web of Science ®Google Scholar
• Baum M, Fauth E, Fritzen S, Herrmann A, Mertes P, Merz K, et al. (2005). Acrylamide and glycidamide: Genotoxic effects in V79-cells and human blood. Mutat Res 580:61–69.
   PubMed Web of Science ®Google Scholar
• Besaratinia A, Pfeifer GP. (2003). Weak yet distinct mutagenicity of acrylamide in mammalian cells. J Natl Cancer Inst 95:889–896.
   PubMedGoogle Scholar
• Besaratinia A, Pfeifer GP. (2004). Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst 96:1023–1029.
   PubMed Web of Science ®Google Scholar
• Besaratinia A, Pfeifer GP. (2007). A review of mechanisms of acrylamide carcinogenicity. Carcinogenesis 28:519–528.
   PubMed Web of Science ®Google Scholar
• Bjellaas T, Olesen PT, Frandsen H, Haugen M, Stolen LH, Paulsen JE, et al. (2007). Comparison of estimated dietary intake of acrylamide with hemoglobin adducts of acrylamide and glycidamide. Toxicol Sci 98:110–117.
   PubMed Web of Science ®Google Scholar
• Bowyer JF, Latendresse JR, Delongchamp RR, Muskhelishvili L, Warbritton AR, Thomas M, et al. (2008). The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. Toxicol Appl Pharmacol 230:208–215.
   PubMed Web of Science ®Google Scholar
• Bull RJ, Robinson M, Laurie RD, Stoner GD, Greisiger E, Meier JR, et al.. (1984a). Carcinogenic effects of acrylamide in Sencar and A/J mice. Cancer Res 44:107–111.
   PubMed Web of Science ®Google Scholar
• Bull RJ, Robinson M, Stober JA. (1984b). Carcinogenic activity of acrylamide in the skin and lung of Swiss-ICR mice. Cancer Lett 24:209–212.
   PubMed Web of Science ®Google Scholar
• Burek JD, Albee RR, Beyer JE, Bell TJ, Carreon RM, Morden DC, et al. (1980). Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4:157–182.
   PubMedGoogle Scholar
• Butterworth BE, Eldridge SR, Sprankle CS, Working PK, Bentley KS, Hurtt ME. (1992). Tissue-specific genotoxic effects of acrylamide and acrylonitrile. Environ Mol Mutagen 20:148–155.
   PubMed Web of Science ®Google Scholar
• Cao J, Beisker W, Nusse M, Adler ID. (1993). Flow cytometric detection of micronuclei induced by chemicals in poly- and normochromatic erythrocytes of mouse peripheral blood. Mutagenesis 8:533–541.
   PubMedGoogle Scholar
• Cihak R, Vontorkova M. (1988). Cytogenetic effects of acrylamide in the bone marrow of mice. Mutat Res 209:91–94.
   PubMedGoogle Scholar
• Clement FC, Dip R, Naegeli H. (2007). Expression profile of human cells in culture exposed to glycidamide, a reactive metabolite of the heat-induced food carcinogen acrylamide. Toxicology 240:111–124.
   PubMed Web of Science ®Google Scholar
• Collins JJ, Swaen GM, Marsh GM, Utidjian HM, Caporossi JC, Lucas LJ. (1989). Mortality patterns among workers exposed to acrylamide. J Occup Med 31:614–617.
   PubMedGoogle Scholar
• Collins BW, Howard DR, Allen JW. (1992). Kinetochore-staining of spermatid micronuclei: Studies of mice treated with X-radiation or acrylamide. Mutat Res 281:287–294.
   PubMed Web of Science ®Google Scholar
• Doerge DR, Young JF, McDaniel LP, Twaddle NC, Churchwell MI. (2005a). Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice. Toxicol Appl Pharmacol 202:258–267.
   PubMed Web of Science ®Google Scholar
• Doerge DR, Young JF, McDaniel LP, Twaddle NC, Churchwell MI. (2005b). Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats. Toxicol Appl Pharmacol 208:199–209.
   PubMed Web of Science ®Google Scholar
• Doroshyenko O, Fuhr U, Kunz D, Frank D, Kinzig M, Jetter A, et al. (2009). In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans. Cancer Epidemiol Biomarkers Prev 18:433–443.
   PubMed Web of Science ®Google Scholar
• Dourson M, Hertzberg R, Allen B, Haber L, Parker A, Kroner O, et al. (2008). Evidence-based dose-response assessment for thyroid tumorigenesis from acrylamide. Regul Toxicol Pharmacol 52:264–289.
   PubMed Web of Science ®Google Scholar
• Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SP, Muller DJ, et al. (2005). Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 43:365–410.
   PubMed Web of Science ®Google Scholar
• Dybing E, Sanner T. (2003). Risk assessment of acrylamide in foods. Toxicol Sci 75:7–15.
   PubMed Web of Science ®Google Scholar
• EFSA. (2005a). Statement of the Scientific Panel on Contaminants in the Food Chain of the European Food Safety Authority to a summary report on acrylamide in food of the 64th Meeting of the Joint FAO/WHO Expert Committee on Food Additives and Contaminants.
   Google Scholar
• EFSA. (2005b). Opinion of the Scientific Committee of the European Food Safety Authority on a harmonised approach for risk assessment of compounds which are both genotoxic and carcinogenic. EFSA J 282:1–31.
   Google Scholar
• EFSA. (2008). Acrylamide carcinogenicity—New evidence in relation to dietary exposure. Tabiano: European Food Safety Authority. Report No. 11.
   Google Scholar
• Ehling UH, Neuhauser-Klaus A. (1992). Reevaluation of the induction of specific-locus mutations in spermatogonia of the mouse by acrylamide. Mutat Res 283:185–191.
   PubMedGoogle Scholar
• Exon JH. (2006). A review of the toxicology of acrylamide. J Toxicol Environ Health B Crit Rev 9:397–412.
   PubMedGoogle Scholar
• Fennell TR, Friedman MA. (2005). Comparison of acrylamide metabolism in humans and rodents. Adv Exp Med Biol 561:109–116.
   PubMed Web of Science ®Google Scholar
• Fennell TR, Sumner SC, Snyder RW, Burgess J, Spicer R, Bridson WE, et al.. (2005). Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol Sci 85:447–459.
   PubMed Web of Science ®Google Scholar
• Foo LH, Khor GL, Tee ES, Dhanaraj P. (2004). Determinants of iron status in Malaysian adolescents from a rural community. Int J Food Sci Nutr 55:517–525.
   PubMed Web of Science ®Google Scholar
• Friedman MA, Dulak LH, Stedham MA. (1995). A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 27:95–105.
   PubMedGoogle Scholar
• Friedman M. (2003). Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem 51:4504–4526.
   PubMed Web of Science ®Google Scholar
• Fuhr U, Boettcher MI, Kinzig-Schippers M, Weyer A, Jetter A, Lazar A, et al. (2006). Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity. Cancer Epidemiol Biomarkers Prev 15:266–271.
   PubMed Web of Science ®Google Scholar
• Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ. (1996). Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst 88:1118–1126.
   PubMed Web of Science ®Google Scholar
• Hagmar L, Tornqvist M. (2003). Inconclusive results from an epidemiological study on dietary acrylamide and cancer. Br J Cancer 89:774–775; author reply 5–6.
   PubMed Web of Science ®Google Scholar
• Hall JM, McDonnell DP. (1999). The estrogen receptor beta-isoform. (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140:5566–5578.
   PubMed Web of Science ®Google Scholar
• Harris HA, Bapat AR, Gonder DS, Frail DE. (2002). The ligand binding profiles of estrogen receptors alpha and beta are species dependent. Steroids 67:379–384.
   PubMed Web of Science ®Google Scholar
• Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, et al. (2003). Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology 144:4241–4249.
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Aldridge WN. (1970). Biochemical studies on acrylamide, a neurotoxic agent. Biochem Pharmacol 19:2591–2604.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. (2007). A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Cancer Epidemiol Biomarkers Prev 16:2304–2313.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. (2008a). Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr 87:1428–1438.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. (2008b). Dietary acrylamide intake is not associated with gastrointestinal cancer risk. J Nutr 138:2229–2236.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. (2009a). Lung cancer risk in relation to dietary acrylamide intake. J Natl Cancer Inst 101:651–662.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. (2009b). Dietary acrylamide intake and brain cancer risk. Cancer Epidemiol Biomarkers Prev 18:1663–1666.
   PubMed Web of Science ®Google Scholar
• Husoy T, Haugen M, Murkovic M, Jobstl D, Stolen LH, Bjellaas T, et al.. (2008). Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure. Food Chem Toxicol 46:3697–3702.
   PubMed Web of Science ®Google Scholar
• IARC. (International Agency for Research on Cancer). (1994 ). Acrylamide. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 60. Lyon, France: IARC.
   Google Scholar
• Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, et al. (2005). Progesterone receptor in non-small cell lung cancer—A potent prognostic factor and possible target for endocrine therapy. Cancer Res 65:6450–6458.
   PubMedGoogle Scholar
• JECFA. (2006). Summary and conclusions of the sixty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva: JECFA. Report No. 930.
   Google Scholar
• Jiang L, Cao J, An Y, Geng C, Qu S, Zhong L. (2007). Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol In Vitro 21:1486–492.
   PubMed Web of Science ®Google Scholar
• Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, et al.. (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 85:154–168.
   PubMed Web of Science ®Google Scholar
• Kaaks R, Lukanova A, Kurzer MS. (2002). Obesity, endogenous hormones, and endometrial cancer risk: A synthetic review. Cancer Epidemiol Biomarkers Prev 11:1531–1543.
   PubMed Web of Science ®Google Scholar
• Kabat GC, Miller AB, Rohan TE. (2007). Reproductive and hormonal factors and risk of lung cancer in women: A prospective cohort study. Int J Cancer 120:2214–2220.
   PubMedGoogle Scholar
• Kemplay S, Cavanagh JB. (1984). Effects of acrylamide and some other sulfhydryl reagents on spontaneous and pathologically induced terminal sprouting from motor end-plates. Muscle Nerve 7:101–109.
   PubMedGoogle Scholar
• Khan MA, Davis CA, Foley GL, Friedman MA, Hansen LG. (1999). Changes in thyroid gland morphology after acute acrylamide exposure. Toxicol Sci 47:151–157.
   PubMed Web of Science ®Google Scholar
• Kjuus H, Hansteen IL, Ryberg D, Goffeng LO, Ovrebo S, Skaug V. (2005). Chromosome aberrations in tunnel workers exposed to acrylamide and N-methylolacrylamide. Scand J Work Environ Health 31:300–306.
   PubMed Web of Science ®Google Scholar
• Klaunig JE, Kamendulis LM. (2005). Mechanisms of acrylamide induced rodent carcinogenesis. Adv Exp Med Biol 561:49–62.
   PubMed Web of Science ®Google Scholar
• Knaap AG, Kramers PG, Voogd CE, Bergkamp WG, Groot MG, Langebroek PG, et al. (1988). Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria. Mutagenesis 3:263–268.
   PubMed Web of Science ®Google Scholar
• Konings EJ, Baars AJ, van Klaveren JD, Spanjer MC, Rensen PM, Hiemstra M, et al. (2003). Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 41:1569–1579.
   PubMed Web of Science ®Google Scholar
• Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. (1997). Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863–870.
   PubMed Web of Science ®Google Scholar
• Kutting B, Schettgen T, Beckmann MW, Angerer J, Drexler H. (2005). Influence of diet on exposure to acrylamide—Reflections on the validity of a questionnaire. Ann Nutr Metab 49:173–177.
   PubMed Web of Science ®Google Scholar
• Kutting B, Uter W, Drexler H. (2008). The association between self-reported acrylamide intake and hemoglobin adducts as biomarkers of exposure. Cancer Causes Control 19:273–281.
   PubMed Web of Science ®Google Scholar
• Lapadula DM, Bowe M, Carrington CD, Dulak L, Friedman M, Abou-Donia MB. (1989). In vitro binding of [14C]acrylamide to neurofilament and microtubule proteins of rats. Brain Res 481:157–161.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Hakansson N, Akesson A, Wolk A. (2008). Long-term dietary acrylamide intake and risk of endometrial cancer in a prospective cohort of Swedish women. Int J Cancer 124:1196–1199.
   Google Scholar
• Larsson SC, Akesson A, Wolk A. (2009a). Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women. Am J Epidemiol 169:376–381.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Akesson A, Wolk A. (2009b). Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. Cancer Epidemiol Biomarkers Prev 18:994–997.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Kesson A, Bergkvist L, Wolk A. (2009c). Dietary acrylamide intake and risk of colorectal cancer in a prospective cohort of men. Eur J Cancer 45:513–516.
   PubMed Web of Science ®Google Scholar
• Lau KM, Mok SC, Ho SM. (1999). Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci U S A 96:5722–5727.
   PubMed Web of Science ®Google Scholar
• Legator MS. (1997). Underestimating risk for three important human carcinogens: Vinyl chloride, benzene, and butadiene. Ann N Y Acad Sci 837:170–175.
   PubMedGoogle Scholar
• Lin P, Chang YC, Chen CH, Yang WJ, Cheng YH, Chang LW. (2004). A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells. Toxicol Appl Pharmacol 195:83–91.
   PubMed Web of Science ®Google Scholar
• LoPachin RM. (2005). Acrylamide neurotoxicity: Neurological, morphological and molecular endpoints in animal models. Adv Exp Med Biol 561:21–37.
   PubMed Web of Science ®Google Scholar
• Lopachin RM, Gavin T. (2008). Acrylamide-induced nerve terminal damage: Relevance to neurotoxic and neurodegenerative mechanisms. J Agric Food Chem 56:5994–6003.
   PubMed Web of Science ®Google Scholar
• Lukanova A, Kaaks R. (2005). Endogenous hormones and ovarian cancer: Epidemiology and current hypotheses. Cancer Epidemiol Biomarkers Prev 14:98–107.
   PubMed Web of Science ®Google Scholar
• Manjanatha MG, Aidoo A, Shelton SD, Bishop ME, McDaniel LP, Lyn-Cook LE, et al. (2006). Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice. Environ Mol Mutagen 47:6–17.
   PubMed Web of Science ®Google Scholar
• Mannaa F, Abdel-Wahhab MA, Ahmed HH, Park MH. (2006). Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. J Appl Toxicol 26:198–206.
   PubMed Web of Science ®Google Scholar
• Marsh GM, Lucas LJ, Youk AO, Schall LC. (1999). Mortality patterns among workers exposed to acrylamide: 1994 follow up. Occup Environ Med 56:181–190.
   PubMed Web of Science ®Google Scholar
• Marsh GM, Youk AO, Buchanich JM, Kant IJ, Swaen G. (2007). Mortality patterns among workers exposed to acrylamide: Updated follow up. J Occup Environ Med 49:82–95.
   PubMed Web of Science ®Google Scholar
• Matthews J, Celius T, Halgren R, Zacharewski T. (2000). Differential estrogen receptor binding of estrogenic substances: A species comparison. J Steroid Biochem Mol Biol 74:223–234.
   PubMed Web of Science ®Google Scholar
• Matthews J, Gustafsson JA. (2003). Estrogen signaling: A subtle balance between ER alpha and ER beta. Mol Interv 3:281–292.
   PubMedGoogle Scholar
• Matthys C, Bilau M, Govaert Y, Moons E, De Henauw S, Willems JL. (2005). Risk assessment of dietary acrylamide intake in Flemish adolescents. Food Chem Toxicol 43:271–278.
   PubMed Web of Science ®Google Scholar
• McGrath M, Michaud DS, De Vivo I. (2006). Hormonal and reproductive factors and the risk of bladder cancer in women. Am J Epidemiol 163:236–244.
   PubMed Web of Science ®Google Scholar
• Mei N, Guo L, Tseng J, Dial SL, Liao W, Manjanatha MG. (2008). Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. Environ Mol Mutagen 49:741–745.
   PubMed Web of Science ®Google Scholar
• Milman N, Pedersen AN. (2008). Blood haemoglobin concentrations are higher in smokers and heavy alcohol consumers than in non-smokers and abstainers-should we adjust the reference range? Ann Hematol xx:xx–xx.
   Google Scholar
• Moore MM, Amtower A, Doerr C, Brock KH, Dearfield KL. (1987). Mutagenicity and clastogenicity of acrylamide in L5178Y mouse lymphoma cells. Environ Mutagen 9:261–267.
   PubMedGoogle Scholar
• Moorman PG, Calingaert B, Palmieri RT, Iversen ES, Bentley RC, Halabi S, et al. (2008). Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. Am J Epidemiol 167:1059–1069.
   PubMed Web of Science ®Google Scholar
• Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K. (2003). Dietary acrylamide and cancer of the large bowel, kidney, and bladder: Absence of an association in a population-based study in Sweden. Br J Cancer 88:84–89.
   PubMed Web of Science ®Google Scholar
• Mucci LA, Lindblad P, Steineck G, Adami HO. (2004). Dietary acrylamide and risk of renal cell cancer. Int J Cancer 109:774–776.
   PubMed Web of Science ®Google Scholar
• Mucci LA, Sandin S, Balter K, Adami HO, Magnusson C, Weiderpass E. (2005). Acrylamide intake and breast cancer risk in Swedish women. JAMA 293:1326–1327.
   PubMed Web of Science ®Google Scholar
• Mucci LA, Adami HO, Wolk A. (2006). Prospective study of dietary acrylamide and risk of colorectal cancer among women. Int J Cancer 118:169–173.
   PubMed Web of Science ®Google Scholar
• Nicodemus KK, Sweeney C, Folsom AR. (2004). Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women. Int J Cancer 108:115–121.
   PubMed Web of Science ®Google Scholar
• Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, et al. (2001). Mechanisms of estrogen action. Physiol Rev 81:1535–1565.
   PubMed Web of Science ®Google Scholar
• O’Donnell AJ, Macleod KG, Burns DJ, Smyth JF, Langdon SP. (2005). Estrogen receptor-alpha mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen. Endocr Relat Cancer 12:851–866.
   PubMed Web of Science ®Google Scholar
• Olesen PT, Olsen A, Frandsen H, Frederiksen K, Overvad K, Tjonneland A. (2008). Acrylamide exposure and incidence of breast cancer among postmenopausal women in the Danish Diet, Cancer and Health Study. Int J Cancer 122:2094–2100.
   PubMed Web of Science ®Google Scholar
• Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, et al. (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 32:56–67.
   PubMed Web of Science ®Google Scholar
• Omoto Y, Kobayashi Y, Nishida K, Tsuchiya E, Eguchi H, Nakagawa K, et al. (2001). Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers. Biochem Biophys Res Commun 285:340–347.
   PubMed Web of Science ®Google Scholar
• Ortega RM, Lopez-Sobaler AM, Requejo AM, Quintas ME, Gaspar MJ, Andres P, et al. (1998). The influence of meat consumption on dietary data, iron status and serum lipid parameters in young women. Int J Vitam Nutr Res 68:255–262.
   PubMed Web of Science ®Google Scholar
• Park J, Kamendulis LM, Friedman MA, Klaunig JE. (2002). Acrylamide-induced cellular transformation. Toxicol Sci 65:177–183.
   PubMed Web of Science ®Google Scholar
• Paulsson B, Kotova N, Grawe J, Henderson A, Granath F, Golding B, et al. (2003). Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide. Mutat Res 535:15–24.
   PubMed Web of Science ®Google Scholar
• Pedersen GS, Hogervorst JGF, Schouten LJ, Konings EJMG, R., ?Alexandra, van den Brandt PA. In press. Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk.
   Google Scholar
• Pelucchi C, Galeone C, Levi F, Negri E, Franceschi S, Talamini R, et al. (2006). Dietary acrylamide and human cancer. Int J Cancer 118:467–471.
   PubMed Web of Science ®Google Scholar
• Pelucchi C, Galeone C, Dal Maso L, Talamini R, Montella M, Ramazzotti V, et al. (2007). Dietary acrylamide and renal cell cancer. Int J Cancer 120:1376–1377.
   PubMed Web of Science ®Google Scholar
• Reventos J, Sullivan PM, Joseph DR, Gordon JW. (1993). Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice. Mol Cell Endocrinol 96:69–73.
   PubMedGoogle Scholar
• Reynolds T. (2002). Acrylamide and cancer: Tunnel leak in Sweden prompted studies. J Natl Cancer Inst 94:876–878.
   PubMedGoogle Scholar
• Robinson M, Bull RJ, Knutsen GL, Shields RP, Stober J. (1986). A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. Environ Health Perspect 68:141–145.
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Spencer Feigelson H, Deka A, Patel AV, Jacobs EJ, Thun MJ, et al. (2008). Postmenopausal hormone therapy and lung cancer risk in the cancer prevention study II nutrition cohort. Cancer Epidemiol Biomarkers Prev 17:655–660.
   PubMed Web of Science ®Google Scholar
• Russell LB, Hunsicker PR, Cacheiro NL, Generoso WM. (1991). Induction of specific-locus mutations in male germ cells of the mouse by acrylamide monomer. Mutat Res 262:101–107.
   PubMed Web of Science ®Google Scholar
• Salehi F, Dunfield L, Phillips KP, Krewski D, Vanderhyden BC. (2008). Risk factors for ovarian cancer: An overview with emphasis on hormonal factors. J Toxicol Environ Health B Crit Rev 11:301–321.
   PubMed Web of Science ®Google Scholar
• Sanner T, Dybing E. (2005). Comparison of carcinogen hazard characterisation based on animal studies and epidemiology. Basic Clin Pharmacol Toxicol 96:66–70.
   PubMed Web of Science ®Google Scholar
• SCF. (2002). Opinion of the Scientific Committee on Food of the European Commission on new findings regarding the presence of acrylamide in food.
   Google Scholar
• Schabacker J, Schwend T, Wink M. (2004). Reduction of acrylamide uptake by dietary proteins in a caco-2 gut model. J Agric Food Chem 52:4021–4025.
   PubMedGoogle Scholar
• Schettgen T, Weiss T, Drexler H, Angerer J. (2003). A first approach to estimate the internal exposure to acrylamide in smoking and non-smoking adults from Germany. Int J Hyg Environ Health 206:9–14.
   PubMed Web of Science ®Google Scholar
• Schettgen T, Rossbach B, Kutting B, Letzel S, Drexler H, Angerer J. (2004). Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and non-smoking persons of the general population. Int J Hyg Environ Health 207:531–539.
   PubMed Web of Science ®Google Scholar
• Schouten LJ, Hogervorst JG, Konings EJ, Goldbohm RA, van den Brandt PA. (2009). Dietary acrylamide intake and the risk of head-neck and thyroid cancers: Results from the Netherlands Cohort Study. Am J Epidemiol 170:873–884.
   PubMed Web of Science ®Google Scholar
• Schwend T, Moller M, Schabacker J, Ruppert T, Wink M. (2009). Alkylation of adenosine deaminase and thioredoxin by acrylamide in human cell cultures. Z Naturforsch C 64:447–453.
   PubMedGoogle Scholar
• Sega GA, Generoso EE. (1990). Measurement of DNA breakage in specific germ-cell stages of male mice exposed to acrylamide, using an alkaline-elution procedure. Mutat Res 242:79–87.
   PubMedGoogle Scholar
• Segerback D, Calleman CJ, Schroeder JL, Costa LG, Faustman EM. (1995). Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Carcinogenesis 16:1161–1165.
   PubMed Web of Science ®Google Scholar
• Shelby MD, Cain KT, Hughes LA, Braden PW, Generoso WM. (1986). Dominant lethal effects of acrylamide in male mice. Mutat Res 173:35–40.
   PubMedGoogle Scholar
• Shipp A, Lawrence G, Gentry R, McDonald T, Bartow H, Bounds J, et al. (2006). Acrylamide: Review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit Rev Toxicol 36:481–608.
   PubMed Web of Science ®Google Scholar
• Shiraishi Y. (1978). Chromosome aberrations induced by monomeric acrylamide in bone marrow and germ cells of mice. Mutat Res 57:313–324.
   PubMed Web of Science ®Google Scholar
• Sickles DW, Sperry AO, Testino A, Friedman M. (2007). Acrylamide effects on kinesin-related proteins of the mitotic/meiotic spindle. Toxicol Appl Pharmacol 222:111–121.
   PubMed Web of Science ®Google Scholar
• Silva Lima B, Van der Laan JW. (2000). Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard. Regul Toxicol Pharmacol 32:135–143.
   PubMed Web of Science ®Google Scholar
• Smith MK, Zenick H, Preston RJ, George EL, Long RE. (1986). Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans rat. Mutat Res 173:273–277.
   PubMed Web of Science ®Google Scholar
• Sobel W, Bond GG, Parsons TW, Brenner FE. (1986). Acrylamide cohort mortality study. Br J Ind Med 43:785–788.
   PubMedGoogle Scholar
• Sorgel F, Weissenbacher R, Kinzig-Schippers M, Hofmann A, Illauer M, Skott A, et al.. (2002). Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy 48:267–274.
   PubMed Web of Science ®Google Scholar
• Swaen GM. (2006). A framework for using epidemiological data for risk assessment. Hum Exp Toxicol 25:147–155.
   PubMed Web of Science ®Google Scholar
• Swaen GM, Haidar S, Burns CJ, Bodner K, Parsons T, Collins JJ, et al. (2007). Mortality study update of acrylamide workers. Occup Environ Med 64:396–401.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Sasaki M, Kaneuchi M, Fujimoto S, Dahiya R. (2003). Estrogen receptor alpha polymorphisms and renal cell carcinoma—A possible risk. Mol Cell Endocrinol 202:109–116.
   PubMedGoogle Scholar
• Tanaka Y, Hirata H, Chen Z, Kikuno N, Kawamoto K, Majid S, et al. (2007). Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer. Cancer Epidemiol Biomarkers Prev 16:92–97.
   PubMed Web of Science ®Google Scholar
• Tareke E, Rydberg P, Karlsson P, Eriksson S, Tornqvist M. (2000). Acrylamide: A cooking carcinogen? Chem Res Toxicol 13:517–522.
   PubMed Web of Science ®Google Scholar
• Taylor AH, Al-Azzawi F. (2000). Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol 24:145–155.
   PubMed Web of Science ®Google Scholar
• Tomatis L, Melnick RL, Haseman J, Barrett JC, Huff J. (2001). Alleged misconceptions distort perceptions of environmental cancer risks. FASEB J 15:195–203.
   PubMed Web of Science ®Google Scholar
• Tsuda H, Shimizu CS, Taketomi MK, Hasegawa MM, Hamada A, Kawata KM, et al. (1993). Acrylamide; induction of DNA damage, chromosomal aberrations and cell transformation without gene mutations. Mutagenesis 8:23–29.
   PubMed Web of Science ®Google Scholar
• Tyl RW, Friedman MA. (2003). Effects of acrylamide on rodent reproductive performance. Reprod Toxicol 17:1–13.
   PubMed Web of Science ®Google Scholar
• Uphouse LL. (1981). Interactions between handling and acrylamide on the striatal dopamine receptor. Brain Res 221:421–424.
   PubMed Web of Science ®Google Scholar
• Uphouse LL, Nemeroff CB, Mason G, Prange AJ, Bondy SC. (1982). Interactions between “handling” and acrylamide on endocrine responses in rats. Neurotoxicology 3:121–125.
   PubMed Web of Science ®Google Scholar
• van den Brandt P, Voorrips L, Hertz-Picciotto I, Shuker D, Boeing H, Speijers G, et al. (2002). The contribution of epidemiology. Food Chem Toxicol 40:387–424.
   PubMedGoogle Scholar
• WHO. (1999). Assessing human health risks of chemicals: Principles for the assessment of risk to human health from exposure to chemicals. Geneva: WHO. Report No. 210.
   Google Scholar
• Wilson KM, Balter K, Adami HO, Gronberg H, Vikstrom AC, Paulsson B, et al. (2009a). Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study. Int J Cancer 124:2384–2390.
   PubMed Web of Science ®Google Scholar
• Wilson KM, Mucci LA, Cho E, Hunter DJ, Chen WY, Willett WC. (2009b). Dietary acrylamide intake and risk of premenopausal breast cancer. Am J Epidemiol 169:954–961.
   PubMed Web of Science ®Google Scholar
• Wilson KM, Vesper HW, Tocco P, Sampson L, Rosen J, Hellenas KE, et al. (2009c). Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide. Cancer Causes Control 20:269–278.
   PubMed Web of Science ®Google Scholar
• Wirfält E, Paulsson B, Tornqvist M, Axmon A, Hagmar L. (2008). Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmo Diet and Cancer cohort. Eur J Clin Nutr 62:314–323.
   PubMed Web of Science ®Google Scholar
• Wong AS, Lui WY, Hui IT, Lee WM. (2001). Rabbit sex hormone-binding globulin: Expression in the liver and testis during postnatal development and structural characterization by truncated proteins. Int J Androl 24:165–174.
   PubMedGoogle Scholar
• Yousef MI, El-Demerdash FM. (2006). Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology 219:133–141.
   PubMed Web of Science ®Google Scholar
• Zhao C, Dahlman-Wright K, Gustafsson JA. (2008). Estrogen receptor beta: An overview and update. Nucl Recept Signal 6:e003.
   PubMedGoogle Scholar