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Review Article

Risks and benefits of dietary isoflavones for cancer

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Pages 463-506 | Received 11 Aug 2010, Accepted 17 Nov 2010, Published online: 26 Mar 2011

References

  • Adams KF, Lampe PD, Newton KM, Ylvisaker JT, Feld A, Myerson D, Emerson SS, White E, Potter JD, Lampe JW. (2005). Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial. Am J Clin Nutr 82:620–626.
  • Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK, Markkanen MH, Makela TH, Wahala KT, Adlercreutz T. (1995). Soybean phytoestrogen intake and cancer risk. J Nutr 125:757S–770S.
  • Adlercreutz H, Mazur W. (1997). Phyto-oestrogens and Western diseases. Ann Med 29:95–120.
  • Agostoni C, Axelsson I, Goulet O, Koletzko B, Michaelsen KF, Puntis J, Rieu D, Rigo J, Shamir R, Szajewska H, Turck D. (2006). Soy protein infant formulae and follow-on formulae: A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 42:352–361.
  • Ahn YO. (1997). Diet and stomach cancer in Korea. Int J Cancer Suppl 10:7–9.
  • Akaza H, Miyanaga N, Takashima N, Naito S, Hirao Y, Tsukamoto T, Mori M. (2002). Is daidzein non-metabolizer a high risk for prostate cancer? A case-controlled study of serum soybean isoflavone concentration. Jpn J Clin Oncol 32:296–300.
  • Akaza H, Miyanaga N, Takashima N, Naito S, Hirao Y, Tsukamoto T, Fujioka T, Mori M, Kim WJ, Song JM, Pantuck AJ. (2004). Comparisons of percent equol producers between prostate cancer patients and controls: Case-controlled studies of isoflavones in Japanese, Korean and American residents. Jpn J Clin Oncol 34:86–89.
  • Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. (2008). Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. Cancer Epidemiol Biomarkers Prev 17:2128–2135.
  • Akimoto T, Nonaka T, Ishikawa H, Sakurai H, Saitoh JI, Takahashi T, Mitsuhashi N. (2001). Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: Possible involvement of inhibition of survival signal transduction pathways. Int J Radiat Oncol Biol Phys 50:195–201.
  • Alhasan SA, Pietrasczkiwicz H, Alonso MD, Ensley J, Sarkar FH. (1999). Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line. Nutr Cancer 34:12–19.
  • Alhasan SA, Aranha O, Sarkar FH. (2001). Genistein elicits pleiotropic molecular effects on head and neck cancer cells. Clin Cancer Res 7:4174–4181.
  • Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. (2001a). Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res 61:5045–5050.
  • Allred CD, Ju YH, Allred KF, Chang J, Helferich WG. (2001b). Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22:1667–1673.
  • Allred CD, Allred KF, Ju YH, Clausen LM, Doerge DR, Schantz SL, Korol DL, Wallig MA, Helferich WG. (2004a). Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats. Carcinogenesis 25:211–218.
  • Allred CD, Allred KF, Ju YH, Goeppinger TS, Doerge DR, Helferich WG. (2004b). Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25:1649–1657.
  • Allred CD, Twaddle NC, Allred KF, Goeppinger TS, Churchwell MI, Ju YH, Helferich WG, Doerge DR. (2005). Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice. J Agric Food Chem 53:8542–8550.
  • Amin AR, Kucuk O, Khuri FR, Shin DM. (2009). Perspectives for cancer prevention with natural compounds. J Clin Oncol 27:2712–2725.
  • An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. (2001). Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem 276:17808–17814.
  • Anderson GL, Judd HL, Kaunitz AM, Barad DH, Beresford SA, Pettinger M, Liu J, McNeeley SG, Lopez AM. (2003). Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: The Women’s Health Initiative randomized trial. JAMA 290:1739–1748.
  • Arai N, Strom A, Rafter JJ, Gustafsson JA. (2000a). Estrogen receptor beta mRNA in colon cancer cells: Growth effects of estrogen and genistein. Biochem Biophys Res Commun 270:425–431.
  • Arai Y, Uehara M, Sato Y, Kimira M, Eboshida A, Adlercreutz H, Watanabe S. (2000b). Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol 10:127–135.
  • Arbeit JM, Howley PM, Hanahan D. (1996). Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci U S A 93:2930–2935.
  • Atkinson C, Lampe JW, Scholes D, Chen C, Wahala K, Schwartz SM. (2006). Lignan and isoflavone excretion in relation to uterine fibroids: A case-control study of young to middle-aged women in the United States. Am J Clin Nutr 84:587–593.
  • Badger TM, Ronis MJ, Simmen RC, Simmen FA. (2005). Soy protein isolate and protection against cancer. J Am Coll Nutr 24:146S–149S.
  • Badger TM, Gilchrist JM, Pivik RT, Andres A, Shankar K, Chen JR, Ronis MJ. (2009). The health implications of soy infant formula. Am J Clin Nutr 89:1668S–1672S.
  • Bae EA, Han MJ, Kim DH. (2001). In vitro anti-Helicobacter pylori activity of irisolidone isolated from the flowers and rhizomes of Pueraria thunbergiana. Planta Med 67:161–163.
  • Bahr JM, Nakai M, Rivera A, Walsh J, Evans GL, Lotinun S, Turner RT, Black M, Jeffery EH. (2005). Dietary soy protein and isoflavones: Minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Menopause 12:165–173.
  • Baird DD, Umbach DM, Lansdell L, Hughes CL, Setchell KD, Weinberg CR, Haney AF, Wilcox AJ, McLachlan JA. (1995). Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 80:1685–1690.
  • Balakrishnan B, Thorstensen EB, Ponnampalam AP, Mitchell MD. (2010). Transplacental transfer and biotransformation of genistein in human placenta. Placenta. 31:506–511.
  • Bandele OJ, Osheroff N. (2007). Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry 46:6097–6108.
  • Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH. (2005). Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65:9064–9072.
  • Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, Abbruzzese JL, Sarkar FH. (2007). In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. Int J Cancer 120:906–917.
  • Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. (2004). Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 11:537–551.
  • Barjesteh van Waalwijk van Doorn-Khosrovani, Janssen J, Maas LM, Godschalk RW, Nijhuis JG, van Schooten FJ. (2007). Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis 28:1703–1709.
  • Basly JP, Lavier MC. (2005). Dietary phytoestrogens: Potential selective estrogen enzyme modulators? Planta Med 71:287–294.
  • Baxa DM, Luo X, Yoshimura FK. (2005). Genistein induces apoptosis in T lymphoma cells via mitochondrial damage. Nutr Cancer 51:93–101.
  • Bektic J, Berger AP, Pfeil K, Dobler G, Bartsch G, Klocker H. (2004). Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta. Eur Urol 45:245–251.
  • Bektic J, Guggenberger R, Eder IE, Pelzer AE, Berger AP, Bartsch G, Klocker H. (2005). Molecular effects of the isoflavonoid genistein in prostate cancer. Clin Prostate Cancer 4:124–129.
  • Bemis DL, Capodice JL, Desai M, Buttyan R, Katz AE. (2004). A concentrated aglycone isoflavone preparation (GCP) that demonstrates potent anti-prostate cancer activity in vitro and in vivo. Clin Cancer Res 10:5282–5292.
  • Bennink MR. (2001). Dietary soy reduces colon carcinogenesis in human and rats. Soy and colon cancer. Adv Exp Med Biol 492:11–17.
  • Bernstein L, Ross RK. (1993). Endogenous hormones and breast cancer risk. Epidemiol Rev 15:48–65.
  • Berstein LM, Tchernobrovkina AE, Gamajunova VB, Kovalevskij AJ, Vasilyev DA, Chepik OF, Turkevitch EA, Tsyrlina EV, Maximov SJ, Ashrafian LA, Thijssen JH. (2003). Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer. J Cancer Res Clin Oncol 129:245–249.
  • BfR. (2007). Isolated isoflavones are not without risk. BfR (Federal Institute for Risk Assessment) Expert Opinion No. 039/2007. Berlin, Germany.
  • Bischoff J. (1997). Cell adhesion and angiogenesis. J Clin Invest 99:373–376.
  • Bitto A, Polito F, Atteritano M, Altavilla D, Mazzaferro S, Marini H, Adamo EB, D’Anna R, Granese R, Corrado F, Russo S, Minutoli L, Squadrito F. (2010). Genistein aglycone does not affect thyroid function: Results from a three-year, randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 95:3067–3072.
  • Blair RM, Appt SE, Franke AA, Clarkson TB. (2003). Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr 133:2262–2267.
  • Bobe G, Sansbury LB, Albert PS, Cross AJ, Kahle L, Ashby J, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Lance P, Daston C, Marshall JR, Schatzkin A, Lanza E. (2008). Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidemiol Biomarkers Prev 17:1344–1353.
  • Bocchinfuso WP, Hively WP, Couse JF, Varmus HE, Korach KS. (1999). A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res 59:1869–1876.
  • Bocchinfuso WP, Lindzey JK, Hewitt SC, Clark JA, Myers PH, Cooper R, Korach KS. (2000). Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology 141:2982–2994.
  • Bodger K, Wyatt JI, Heatley RV. (1997). Gastric mucosal secretion of interleukin-10: Relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut 40:739–744.
  • Bolca S, Urpi-Sarda M, Blondeel P, Roche N, Vanhaecke L, Possemiers S, Al-Maharik N, Botting N, De KD, Bracke M, Heyerick A, Manach C, Depypere H. (2010). Disposition of soy isoflavones in normal human breast tissue. Am J Clin Nutr 91:976–984.
  • Bosetti C, Rossi M, McLaughlin JK, Negri E, Talamini R, Lagiou P, Montella M, Ramazzotti V, Franceschi S, LaVecchia C. (2007). Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 16:98–101.
  • Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE. (2003). Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem 51:2193–2199.
  • Bouker KB, Hilakivi-Clarke L. (2000). Genistein: Does it prevent or promote breast cancer? Environ Health Perspect 108:701–708.
  • Boyapati SM, Shu XO, Ruan ZX, Dai Q, Cai Q, Gao YT, Zheng W. (2005). Soyfood intake and breast cancer survival: A followup of the Shanghai Breast Cancer Study. Breast Cancer Res Treat 92:11–17.
  • Brandenberger AW, Tee MK, Jaffe RB. (1998). Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: Down-regulation of ER-beta in neoplastic tissues. J Clin Endocrinol Metab 83:1025–1028.
  • Brandt L. (1985). Environmental factors and leukaemia. Med Oncol Tumor Pharmacother 2:7–10.
  • Brown A, Jolly P, Wei H. (1998). Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression. Carcinogenesis 19:991–997.
  • Browning AM, Walle UK, Walle T. (2005). Flavonoid glycosides inhibit oral cancer cell proliferation—Role of cellular uptake and hydrolysis to the aglycones. J Pharm Pharmacol 57:1037–1042.
  • Brownson RC, Alavanja MC, Caporaso N, Simoes EJ, Chang JC. (1998). Epidemiology and prevention of lung cancer in nonsmokers. Epidemiol Rev 20:218–236.
  • Bruce B, Messina M, Spiller GA. (2003). Isoflavone supplements do not affect thyroid function in iodine-replete postmenopausal women. J Med Food 6:309–316.
  • Buchler P, Gukovskaya AS, Mouria M, Buchler MC, Buchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. (2003). Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas 26:264–273.
  • Buchler P, Reber HA, Buchler MW, Friess H, Lavey RS, Hines OJ. (2004). Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer 100:201–210.
  • Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G, Hilakivi-Clarke L. (2004). Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis 25:741–748.
  • Campbell-Thompson M, Lynch IJ, Bhardwaj B. (2001). Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res 61:632–640.
  • Canderelli R, Leccesse LA, Miller NL, Unruh DJ. (2007). Benefits of hormone replacement therapy in postmenopausal women. J Am Acad Nurse Pract 19:635–641.
  • Cao Y, Calafat AM, Doerge DR, Umbach DM, Bernbaum JC, Twaddle NC, Ye X, Rogan WJ. (2009). Isoflavones in urine, saliva, and blood of infants: Data from a pilot study on the estrogenic activity of soy formula. J Expo Sci Environ Epidemiol 19:223–234.
  • Cappelletti V, Miodini P, Di Fronzo G, Daidone MG. (2006). Modulation of estrogen receptor-beta isoforms by phytoestrogens in breast cancer cells. Int J Oncol 28:1185–1191.
  • Carreau C, Flouriot G, Bennetau-Pelissero C, Potier M. (2009). Respective contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation. Mol Nutr Food Res. 53:652–658.
  • Cassidy A, Brown JE, Hawdon A, Faughnan MS, King LJ, Millward J, Zimmer-Nechemias L, Wolfe B, Setchell KD. (2006). Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 136:45–51.
  • Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, Lacroix AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, Pettinger M, Stefanick ML, Wactawski-Wende J, Watts NB. (2003). Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women’s Health Initiative randomized trial. JAMA 290:1729–1738.
  • Chandrareddy A, Muneyyirci-Delale O, McFarlane SI, Murad OM. (2008). Adverse effects of phytoestrogens on reproductive health: A report of three cases. Complement Ther Clin Pract 14:132–135.
  • Chang HC, Churchwell MI, Delclos KB, Newbold RR, Doerge DR. (2000). Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats. J Nutr 130:1963–1970.
  • Chang HC, Doerge DR. (2000). Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 168:244–252.
  • Chang EC, Frasor J, Komm B, Katzenellenbogen BS. (2006). Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 147:4831–4842.
  • Chang ET, Lee VS, Canchola AJ, Clarke CA, Purdie DM, Reynolds P, Anton-Culver H, Bernstein L, Deapen D, Peel D, Pinder R, Ross RK, Stram DO, West DW, Wright W, Ziogas A, Horn-Ross PL. (2007). Diet and risk of ovarian cancer in the California Teachers Study cohort. Am J Epidemiol 165:802–813.
  • Chang KL, Cheng HL, Huang LW, Hsieh BS, Hu YC, Chih TT, Shyu HW, Su SJ. (2009). Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line. Cancer Lett 276:14–20.
  • Chen A, Rogan WJ. (2004). Isoflavones in soy infant formula: A review of evidence for endocrine and other activity in infants. Annu Rev Nutr 24:33–54.
  • Chen WF, Wong MS. (2004). Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells. J Clin Endocrinol Metab 89:2351–2359.
  • Chen KY, Hsiao CF, Chang GC, Tsai YH, Su WC, Perng RP, Huang MS, Hsiung CA, Chen CJ, Yang PC. (2007). Hormone replacement therapy and lung cancer risk in Chinese. Cancer 110:1768–1775.
  • Chen GG, Vlantis AC, Zeng Q, van Hasselt CA. (2008a). Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer. Curr Cancer Drug Targets 8:367–377.
  • Chen N, Scarpa R, Zhang L, Seiberg M, Lin CB. (2008b). Nondenatured soy extracts reduce UVB-induced skin damage via multiple mechanisms. Photochem Photobiol 84:1551–1559.
  • Chen Y, Huang C, Zhou T, Chen G. (2008c). Genistein induction of human sulfotransferases in HepG2 and Caco-2 cells. Basic Clin Pharmacol Toxicol 103:553–559.
  • Cheng G, Wilczek B, Warner M, Gustafsson JA, Landgren BM. (2007). Isoflavone treatment for acute menopausal symptoms. Menopause 14:468–473.
  • Chiechi LM, Putignano G, Guerra V, Schiavelli MP, Cisternino AM, Carriero C. (2003). The effect of a soy rich diet on the vaginal epithelium in postmenopause: A randomized double blind trial. Maturitas 45:241–246.
  • Chinni SR, Alhasan SA, Multani AS, Pathak S, Sarkar FH. (2003). Pleotropic effects of genistein on MCF-7 breast cancer cells. Int J Mol Med 12:29–34.
  • Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, Hubbell FA, Ascensao J, Rodabough RJ, Rosenberg CA, Taylor VM, Harris R, Chen C, Adams-Campbell LL, White E. (2004). Estrogen plus progestin and colorectal cancer in postmenopausal women. N Engl J Med 350:991–1004.
  • Chodon D, Banu SM, Padmavathi R, Sakthisekaran D. (2007). Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma. Mol Cell Biochem 297:73–80.
  • Ciana P, Di Luccio G, Belcredito S, Pollio G, Vegeto E, Tatangelo L, Tiveron C, Maggi A. (2001). Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol Endocrinol 15:1104–1113.
  • Cohen LA, Zhao Z, Pittman B, Scimeca JA. (2000). Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis. Carcinogenesis 21:929–935.
  • Cohen MS, Hussain HB, Moley JF. (2002). Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors. Surgery 132:960–966.
  • Cohen LA, Zhao Z, Pittman B, Scimeca J. (2003). Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. Prostate 54:169–180.
  • Conrad SC, Chiu H, Silverman BL. (2004). Soy formula complicates management of congenital hypothyroidism. Arch Dis Child 89:37–40.
  • Constantinou AI, Lantvit D, Hawthorne M, Xu X, Van Breemen RB, Pezzuto JM. (2001). Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr Cancer 41:75–81.
  • Constantinou AI, White BE, Tonetti D, Yang Y, Liang W, Li W, Van Breemen RB. (2005). The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur J Cancer 41:647–654.
  • Coon JT, Pittler MH, Ernst E. (2007). Trifolium pratense isoflavones in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine 14:153–159.
  • Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey A, Harper P. (2006). Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. J Nutr 136:3046–3053.
  • Coughlin SS, Giustozzi A, Smith SJ, Lee NC. (2000). A meta-analysis of estrogen replacement therapy and risk of epithelial ovarian cancer. J Clin Epidemiol 53:367–375.
  • Couse JF, Korach KS. (1999). Estrogen receptor null mice: What have we learned and where will they lead us? Endocr Rev 20:358–417.
  • Couse JF, Korach KS. (2001). Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice. Ann N Y Acad Sci 948:1–8.
  • Craig WJ. (1997). Phytochemicals: Guardians of our health. J Am Diet Assoc 97:S199–S204.
  • Craig W, Beck L. (1999). Phytochemicals: Health protective effects. Can J Diet Pract Res 60:78–84.
  • Crowell JA, Steele VE, Fay JR. (2007). Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther 6:2139–2148.
  • Cui HB, Na XL, Song DF, Liu Y. (2005). Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma. World J Gastroenterol 11:69–72.
  • D’Anna R, Cannata ML, Marini H, Atteritano M, Cancellieri F, Corrado F, Triolo O, Rizzo P, Russo S, Gaudio A, Frisina N, Bitto A, Polito F, Minutoli L, Altavilla D, Adamo EB, Squadrito F. (2009). Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: A 2-year randomized, double-blind, placebo-controlled study. Menopause 16:301–306.
  • D’Avanzo B, La Vecchia C, Franceschi S, Negri E, Talamini R. (1995). History of thyroid diseases and subsequent thyroid cancer risk. Cancer Epidemiol Biomarkers Prev 4:193–199.
  • D’Errico M, Teson M, Calcagnile A, Nardo T, De Luca N, Lazzari C, Soddu S, Zambruno G, Stefanini M, Dogliotti E. (2005). Differential role of transcription-coupled repair in UVB-induced response of human fibroblasts and keratinocytes. Cancer Res 65:432–438.
  • Dai Q, Shu XO, Jin F, Potter JD, Kushi LH, Teas J, Gao YT, Zheng W. (2001). Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. Br J Cancer 85:372–378.
  • Dai Q, Xu WH, Long JR, Courtney R, Xiang YB, Cai Q, Cheng J, Zheng W, Shu XO. (2007). Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancer. Pharmacogenet Genomics 17:161–167.
  • Dalais FS, Rice GE, Wahlqvist ML, Grehan M, Murkies AL, Medley G, Ayton R, Strauss BJ. (1998). Effects of dietary phytoestrogens in postmenopausal women. Climacteric 1:124–129.
  • Daly KT, Tracy AC, Malik M, Wang T, Francke-Carroll S, Magnuson BA. (2007). Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats. Food Chem Toxicol 45:628–637.
  • Davies MJ, Bowey EA, Adlercreutz H, Rowland IR, Rumsby PC. (1999). Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats. Carcinogenesis 20:927–931.
  • Day JK, Besch-Williford C, McMann TR, Hufford MG, Lubahn DB, MacDonald RS. (2001). Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Cancer 39:226–232.
  • De Assis S, Hilakivi-Clarke L. (2006). Timing of dietary estrogenic exposures and breast cancer risk. Ann N Y Acad Sci 1089:14–35.
  • De Stefani E, Ronco A, Mendilaharsu M, Deneo-Pellegrini H. (1999). Diet and risk of cancer of the upper aerodigestive tract—II. Nutrients. Oral Oncol 35:22–26.
  • De Wilde A, Maria RC, Cournot G, Colin C, Lacroix HC, Chaumaz G, Coxam V, Bennetau-Pelissero C, Pointillart A, Lieberherr M. (2007). Dietary isoflavones act on bone marrow osteoprogenitor cells and stimulate ovary development before influencing bone mass in pre-pubertal piglets. J Cell Physiol 212:51–59.
  • Degen GH, Janning P, Diel P, Michna H, Bolt HM. (2002). Transplacental transfer of the phytoestrogen daidzein in DA/Han rats. Arch Toxicol 76:23–29.
  • Deming SL, Zheng W, Xu WH, Cai Q, Ruan Z, Xiang YB, Shu XO. (2008). UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev 17:563–570.
  • den Boer ML, Pieters R, Kazemier KM, Janka-Schaub GE, Henze G, Veerman AJ. (1998). The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia. Leukemia 12:912–920.
  • Di X, Yu L, Moore AB, Castro L, Zheng X, Hermon T, Dixon D. (2008). A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells. Hum Reprod 23:1873–1883.
  • Diel P, Smolnikar K, Schulz T, Laudenbach-Leschowski U, Michna H, Vollmer G. (2001). Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium. Hum Reprod 16:997–1006.
  • Diel P, Hertrampf T, Seibel J, Laudenbach-Leschowsky U, Kolba S, Vollmer G. (2006). Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats. J Steroid Biochem Mol Biol 102:60–70.
  • Dillingham BL, McVeigh BL, Lampe JW, Duncan AM. (2007). Soy protein isolates of varied isoflavone content do not influence serum thyroid hormones in healthy young men. Thyroid 17:131–137.
  • Divi RL, Chang HC, Doerge DR. (1997). Anti-thyroid isoflavones from soybean: Isolation, characterization, and mechanisms of action. Biochem Pharmacol 54:1087–1096.
  • Doerge DR, Churchwell MI, Chang HC, Newbold RR, Delclos KB. (2001). Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Sprague-Dawley rats. Reprod Toxicol 15:105–110.
  • Doerge DR, Chang HC. (2002). Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo. J Chromatogr B Analyt Technol Biomed Life Sci 777:269–279.
  • Doerge DR, Sheehan DM. (2002). Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect 110 (Suppl 3):349–353.
  • Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. (2006). Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 114:567–572.
  • Dornstauder E, Jisa E, Unterrieder I, Krenn L, Kubelka W, Jungbauer A. (2001). Estrogenic activity of two standardized red clover extracts (Menoflavon) intended for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol 78:67–75.
  • Dorward AM, Shultz KL, Beamer WG. (2007). LH analog and dietary isoflavones support ovarian granulosa cell tumor development in a spontaneous mouse model. Endocr Relat Cancer 14:369–379.
  • Dulaimi E, Ibanez dC, I Uzzo, RG, Al Saleem T, Greenberg RE, Polascik TJ, Babb JS, Grizzle WE, Cairns P. (2004a). Promoter hypermethylation profile of kidney cancer. Clin Cancer Res 10:3972–3979.
  • Dulaimi E, Uzzo RG, Greenberg RE, Al Saleem T, Cairns P. (2004b). Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clin Cancer Res 10:1887–1893.
  • Duncan AM, Merz-Demlow BE, Xu X, Phipps WR, Kurzer MS. (2000). Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol Biomarkers Prev 9:581–586.
  • Durai R, Davies M, Yang W, Yang SY, Seifalian A, Goldspink G, Winslet M. (2006). Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). Int J Oncol 28:1317–1325.
  • Eisenbrand G. (2007). Isoflavones as phytoestrogens in food supplements and dietary foods for special medical purposes. Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG)-(shortened version). Mol Nutr Food Res 51:1305–1312.
  • El Touny LH, Banerjee PP. (2009). Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis. Cancer Res 69:3695–3703.
  • Elson DA, Riley RR, Lacey A, Thordarson G, Talamantes FJ, Arbeit JM. (2000). Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Cancer Res 60:1267–1275.
  • Emons G, Fleckenstein G, Hinney B, Huschmand A, Heyl W. (2000). Hormonal interactions in endometrial cancer. Endocr Relat Cancer 7:227–242.
  • Emons G, Huschmand-Nia A, Krauss T, Hinney B. (2004). Hormone replacement therapy and endometrial cancer. Onkologie 27:207–210.
  • Engelhardt PF, Riedl CR. (2008). Effects of one-year treatment with isoflavone extract from red clover on prostate, liver function, sexual function, and quality of life in men with elevated PSA levels and negative prostate biopsy findings. Urology 71:185–190.
  • Ernster VL. (1996). Female lung cancer. Annu Rev Public Health 17:97–114.
  • Evans BA, Griffiths K, Morton MS. (1995). Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol 147:295–302.
  • Fan S, Meng Q, Auborn K, Carter T, Rosen EM. (2006). BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer 94:407–426.
  • Farhan H, Wahala K, Adlercreutz H, Cross HS. (2002). Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells. J Chromatogr B Analyt Technol Biomed Life Sci 777:261–268.
  • Farina HG, Pomies M, Alonso DF, Gomez DE. (2006). Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncol Rep 16:885–891.
  • Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V. (2001). Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 63:202–207.
  • Ferrara A, Karter AJ, Ackerson LM, Liu JY, Selby JV. (2001). Hormone replacement therapy is associated with better glycemic control in women with type 2 diabetes: The Northern California Kaiser Permanente Diabetes Registry. Diabetes Care 24:1144–1150.
  • Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N. (1998). Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90:1371–1388.
  • Folkman J. (1992). The role of angiogenesis in tumor growth. Semin Cancer Biol 3:65–71.
  • Fort P, Moses N, Fasano M, Goldberg T, Lifshitz F. (1990). Breast and soy-formula feedings in early infancy and the prevalence of autoimmune thyroid disease in children. J Am Coll Nutr 9:164–167.
  • Foth D, Cline JM. (1998). Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. Am J Clin Nutr 68:1413S–1417S.
  • Foth D, Nawroth F. (2005). Effect of phytoestrogens on the endometrium? Fertil Steril 83:256–257.
  • Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R, Schweigerer L. (1995). Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 125:790S–797S.
  • Franco EL, Rohan TE, Villa LL. (1999). Epidemiologic evidence and human papillomavirus infection as a necessary cause of cervical cancer. J Natl Cancer Inst 91:506–511.
  • Franke AA, Custer LJ, Tanaka Y. (1998). Isoflavones in human breast milk and other biological fluids. Am J Clin Nutr 68:1466S–1473S.
  • Frankenfeld CL, McTiernan A, Aiello EJ, Thomas WK, LaCroix K, Schramm J, Schwartz SM, Holt VL, Lampe JW. (2004). Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women. Cancer Epidemiol Biomarkers Prev 13:1156–1162.
  • Fritz WA, Wang J, Eltoum IE, Lamartiniere CA. (2002). Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol Cell Endocrinol 186:89–99.
  • Fritz WA, Cotroneo MS, Wang J, Eltoum IE, Lamartiniere CA. (2003). Dietary diethylstilbestrol but not genistein adversely affects rat testicular development. J Nutr 133:2287–2293.
  • Fuhrman BJ, Teter BE, Barba M, Byrne C, Cavalleri A, Grant BJ, Horvath PJ, Morelli D, Venturelli E, Muti PC. (2008). Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. Cancer Epidemiol Biomarkers Prev 17:33–42.
  • Fujimoto N, Honda H. (2003). Effects of environmental estrogenic compounds on growth of a transplanted estrogen responsive pituitary tumor cell line in rats. Food Chem Toxicol 41:1711–1717.
  • Fukutake M, Takahashi M, Ishida K, Kawamura H, Sugimura T, Wakabayashi K. (1996). Quantification of genistein and genistin in soybeans and soybean products. Food Chem Toxicol 34:457–461.
  • Gadgeel SM, Ali S, Philip PA, Wozniak A, Sarkar FH. (2009). Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines. Cancer 115:2165–2176.
  • Galanis DJ, Kolonel LN, Lee J, Nomura A. (1998). Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: A prospective study. Int J Epidemiol 27:173–180.
  • Gallo D, Ferlini C, Fabrizi M, Prislei S, Scambia G. (2006). Lack of stimulatory activity of a phytoestrogen-containing soy extract on the growth of breast cancer tumors in mice. Carcinogenesis 27:1404–1409.
  • Gallo D, Zannoni GF, De S, I Mosca, M, Ferlini C, Mantuano E, Scambia G. (2008). Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. J Nutr 138:1360–1364.
  • Gann PH, Kazer R, Chatterton R, Gapstur S, Thedford K, Helenowski I, Giovanazzi S, Van Horn L. (2005). Sequential, randomized trial of a low-fat, high-fiber diet and soy supplementation: Effects on circulating IGF-I and its binding proteins in premenopausal women. Int J Cancer 116:297–303.
  • Gao Z, Matsuo H, Wang Y, Nakago S, Maruo T. (2001). Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells. J Clin Endocrinol Metab 86:5593–5599.
  • Garavello W, Rossi M, McLaughlin JK, Bosetti C, Negri E, Lagiou P, Talamini R, Franceschi S, Parpinel M, Dal Maso L, La Vecchia C. (2007). Flavonoids and laryngeal cancer risk in Italy. Ann Oncol 18:1104–1109.
  • Gardner CD, Oelrich B, Liu JP, Feldman D, Franke AA, Brooks JD. (2009). Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69:719–726.
  • Gee JM, Noteborn HP, Polley AC, Johnson IT. (2000). Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya protein. Carcinogenesis 21:2255–2259.
  • Geller J, Sionit L, Partido C, Li L, Tan X, Youngkin T, Nachtsheim D, Hoffman RM. (1998). Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 34:75–79.
  • Genovese MI, Barbosa AC, Pinto MS, Lajolo FM. (2007). Commercial soy protein ingredients as isoflavone sources for functional foods. Plant Foods Hum Nutr 62:53–58.
  • Giannitrapani L, Soresi M, La SE, Cervello M, D’Alessandro N, Montalto G. (2006). Sex hormones and risk of liver tumor. Ann N Y Acad Sci 1089:228–236.
  • Giovannucci E. (1999). Insulin-like growth factor-I and binding protein-3 and risk of cancer. Horm Res 51 (Suppl 3):34–41.
  • Giovannucci E. (2007). Metabolic syndrome, hyperinsulinemia, and colon cancer: A review. Am J Clin Nutr 86:s836–s842.
  • Goodman MT, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN. (1997). Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiol 146:294–306.
  • Goodman MT, Shvetsov YB, Wilkens LR, Franke AA, Le ML, Kakazu KK, Nomura AM, Henderson BE, Kolonel LN. (2009). Urinary phytoestrogen excretion and postmenopausal breast cancer risk: The multiethnic cohort study. Cancer Prev Res (Phila Pa) 2:887–894.
  • Gorodeski GI, Pal D. (2000). Involvement of estrogen receptors alpha and beta in the regulation of cervical permeability. Am J Physiol Cell Physiol 278:C689–C696.
  • Gossner G, Choi M, Tan L, Fogoros S, Griffith KA, Kuenker M, Liu JR. (2007). Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. Gynecol Oncol 105:23–30.
  • Gotoh T, Yamada K, Ito A, Yin H, Kataoka T, Dohi K. (1998a). Chemoprevention of N-nitroso-N-methylurea-induced rat mammary cancer by miso and tamoxifen, alone and in combination. Jpn J Cancer Res 89:487–495.
  • Gotoh T, Yamada K, Yin H, Ito A, Kataoka T, Dohi K. (1998b). Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Jpn J Cancer Res 89:137–142.
  • Govers MJ, Lapre JA, De Vries HT, Van der MR. (1993). Dietary soybean protein compared with casein damages colonic epithelium and stimulates colonic epithelial proliferation in rats. J Nutr 123:1709–1713.
  • Grace PB, Taylor JI, Low YL, Luben RN, Mulligan AA, Botting NP, Dowsett M, Welch AA, Khaw KT, Wareham NJ, Day NE, Bingham SA. (2004). Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk. Cancer Epidemiol Biomarkers Prev 13:698–708.
  • Griffiths K, Morton MS, Nicholson RI. (1997). Androgens, androgen receptors, antiandrogens and the treatment of prostate cancer. Eur Urol 32 (Suppl 3):24–40.
  • Gu Y, Zhu CF, Iwamoto H, Chen JS. (2005). Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World J Gastroenterol 11:6512–6517.
  • Gu L, House SE, Prior RL, Fang N, Ronis MJ, Clarkson TB, Wilson ME, Badger TM. (2006). Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J Nutr 136:1215–1221.
  • Gu Y, Zhu CF, Dai YL, Zhong Q, Sun B. (2009). Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma. World J Gastroenterol 15:4952–4957.
  • Guha N, Kwan ML, Quesenberry CP, Jr., Weltzien EK, Castillo AL, Caan BJ. (2009). Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: The Life After Cancer Epidemiology study. Breast Cancer Res Treat.
  • Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL, Jr. (2001). Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice. J Nutr 131:3251–3258.
  • Guo JM, Kang GZ, Xiao BX, Liu DH, Zhang S. (2004a). Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro. Int J Gynecol Cancer 14:882–888.
  • Guo JM, Xiao BX, Dai DJ, Liu Q, Ma HH. (2004b). Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro. World J Gastroenterol 10:860–863.
  • Guo JM, Xiao BX, Liu DH, Grant M, Zhang S, Lai YF, Guo YB, Liu Q. (2004c). Biphasic effect of daidzein on cell growth of human colon cancer cells. Food Chem Toxicol 42:1641–1646.
  • Guo JY, Li X, Browning JD, Jr., Rottinghaus GE, Lubahn DB, Constantinou A, Bennink M, MacDonald RS. (2004d). Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer. J Nutr 134:179–182.
  • Gurney JG, Ross JA, Wall DA, Bleyer WA, Severson RK, Robison LL. (1997). Infant cancer in the U.S.: Histology-specific incidence and trends, 1973 to 1992. J Pediatr Hematol Oncol 19:428–432.
  • Haines CJ, Fan S, Tang GW, Tang LC. (1999). Guidelines for the administration of hormone replacement therapy. The Hong Kong College of Obstetricians and Gynaecologists. Hong Kong Med J 5:195–199.
  • Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJ, Badger TM. (2000). Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev 9:113–117.
  • Hakkak R, Korourian S, Ronis MJ, Johnston JM, Badger TM. (2001). Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats. Cancer Lett 166:27–32.
  • Hall JM, McDonnell DP. (1999). The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140:5566–5578.
  • Hamilton-Reeves JM, Rebello SA, Thomas W, Slaton JW, Kurzer MS. (2007). Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer. J Nutr 137:1769–1775.
  • Hamilton-Reeves JM, Rebello SA, Thomas W, Kurzer MS, Slaton JW. (2008). Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer. Nutr Cancer 60:7–13.
  • Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100:57–70.
  • Hargreaves DF, Potten CS, Harding C, Shaw LE, Morton MS, Roberts SA, Howell A, Bundred NJ. (1999). Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metab 84:4017–4024.
  • Harris PF, Remington PL, Trentham-Dietz A, Allen CI, Newcomb PA. (2002). Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manage 23:501–509.
  • Harris DM, Besselink E, Henning SM, Go VL, Heber D. (2005). Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells. Exp Biol Med (Maywood) 230:558–568.
  • Haselkorn T, Stewart SL, Horn-Ross PL. (2003). Why are thyroid cancer rates so high in southeast asian women living in the United States? The bay area thyroid cancer study. Cancer Epidemiol Biomarkers Prev 12:144–150.
  • Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, Chen H. (2008). Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage. J Clin Endocrinol Metab 93:809–814.
  • He H, Chen L, Zhai M, Chen JZ. (2009). Genistein down-regulates the constitutive activation of nuclear factor-kappaB in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Phytother Res 23:868–873.
  • Heald CL, Ritchie MR, Bolton-Smith C, Morton MS, Alexander FE. (2007). Phyto-oestrogens and risk of prostate cancer in Scottish men. Br J Nutr 98:388–396.
  • Hearnshaw H, Brown JM, Cumming IA, Goding JR, Nairn M. (1972). Endocrinological and histopathological aspects of the infertility in the ewe caused by oetrogenic clover. J Reprod Fertil 28:160–161.
  • Hedelin M, Balter KA, Chang ET, Bellocco R, Klint A, Johansson JE, Wiklund F, Thellenberg-Karlsson C, Adami HO, Gronberg H. (2006). Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer. Prostate 66:1512–1520.
  • Hedlund TE, van Bokhoven A, Johannes WU, Nordeen SK, Ogden LG. (2006). Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. Prostate 66:557–566.
  • Helferich WG, Andrade JE, Hoagland MS. (2008). Phytoestrogens and breast cancer: A complex story. Inflammopharmacology 16:219–226.
  • Hempstock J, Kavanagh JP, George NJ. (1998). Growth inhibition of prostate cell lines in vitro by phyto-oestrogens. Br J Urol 82:560–563.
  • Hernandez BY, McDuffie K, Franke AA, Killeen J, Goodman MT. (2004). Reports: Plasma and dietary phytoestrogens and risk of premalignant lesions of the cervix. Nutr Cancer 49:109–124.
  • Hernandez J, Thompson IM. (2004). Prostate-specific antigen: A review of the validation of the most commonly used cancer biomarker. Cancer 101:894–904.
  • Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel G. (2005). The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: A randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 21:257–264.
  • Hikosaka A, Asamoto M, Hokaiwado N, Kato K, Kuzutani K, Kohri K, Shirai T. (2004). Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 25:381–387.
  • Hilakivi-Clarke L, Cabanes A, Olivo S, Kerr L, Bouker KB, Clarke R. (2002a). Do estrogens always increase breast cancer risk? J Steroid Biochem Mol Biol 80:163–174.
  • Hilakivi-Clarke L, Cho E, Cabanes A, DeAssis S, Olivo S, Helferich W, Lippman ME, Clarke R. (2002b). Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring. Clin Cancer Res 8:3601–3610.
  • Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, Clarke R. (1999a). Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep 6:1089–1095.
  • Hilakivi-Clarke L, De Assis S. (2006). Fetal origins of breast cancer. Trends Endocrinol Metab 17:340–348.
  • Hilakivi-Clarke L, Onojafe I, Raygada M, Cho E, Skaar T, Russo I, Clarke R. (1999b). Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br J Cancer 80:1682–1688.
  • Hilakivi-Clarke L, Shajahan A, Yu B, de AS. (2006). Differentiation of mammary gland as a mechanism to reduce breast cancer risk. J Nutr 136:2697S–2699S.
  • Hilakivi-Clarke L. (2007). Nutritional modulation of terminal end buds: Its relevance to breast cancer prevention. Curr Cancer Drug Targets 7:465–474.
  • Hillman GG, Forman JD, Kucuk O, Yudelev M, Maughan RL, Rubio J, Layer A, Tekyi-Mensah S, Abrams J, Sarkar FH. (2001). Genistein potentiates the radiation effect on prostate carcinoma cells. Clin Cancer Res 7:382–390.
  • Hillman GG, Wang Y, Kucuk O, Che M, Doerge DR, Yudelev M, Joiner MC, Marples B, Forman JD, Sarkar FH. (2004). Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Mol Cancer Ther 3:1271–1279.
  • Hillman GG, Wang Y, Che M, Raffoul JJ, Yudelev M, Kucuk O, Sarkar FH. (2007). Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 7:4.
  • Ho SM. (2004). Estrogens and anti-estrogens: Key mediators of prostate carcinogenesis and new therapeutic candidates. J Cell Biochem 91:491–503.
  • Hoey L, Rowland IR, Lloyd AS, Clarke DB, Wiseman H. (2004). Influence of soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children. Br J Nutr 91:607–616.
  • Holzbeierlein JM, McIntosh J, Thrasher JB. (2005). The role of soy phytoestrogens in prostate cancer. Curr Opin Urol 15:17–22.
  • Hong SJ, Kim SI, Kwon SM, Lee JR, Chung BC. (2002). Comparative study of concentration of isoflavones and lignans in plasma and prostatic tissues of normal control and benign prostatic hyperplasia. Yonsei Med J 43:236–241.
  • Hooper L, Ryder JJ, Kurzer MS, Lampe JW, Messina MJ, Phipps WR, Cassidy A. (2009). Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: A systematic review and meta-analysis. Hum Reprod Update 15:423–440.
  • Horn-Ross PL, Lee M, John EM, Koo J. (2000). Sources of phytoestrogen exposure among non-Asian women in California, USA. Cancer Causes Control 11:299–302.
  • Horn-Ross PL, Hoggatt KJ, Lee MM. (2002). Phytoestrogens and thyroid cancer risk: The San Francisco Bay Area thyroid cancer study. Cancer Epidemiol Biomarkers Prev 11:43–49.
  • Horvath LG, Henshall SM, Lee CS, Head DR, Quinn DI, Makela S, Delprado W, Golovsky D, Brenner PC, O’Neill G, Kooner R, Stricker PD, Grygiel JJ, Gustafsson JA, Sutherland RL. (2001). Frequent loss of estrogen receptor-beta expression in prostate cancer. Cancer Res 61:5331–5335.
  • Howes JB, Howes LG. (2002). Content of isoflavone-containing preparations. Med J Aust 176:135–136.
  • Hsieh CY, Santell RC, Haslam SZ, Helferich WG. (1998). Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58:3833–3838.
  • Hu J, Johnson KC, Mao Y, Xu T, Lin Q, Wang C, Zhao F, Wang G, Chen Y, Yang Y. (1997). A case-control study of diet and lung cancer in northeast China. Int J Cancer 71:924–931.
  • Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC, Bergan RC. (2005). Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res 65:3470–3478.
  • Huber MH, Hong WK. (1994). Biology and chemoprevention of head and neck cancer. Curr Probl Cancer 18:81–140.
  • Hwang CS, Kwak HS, Lim HJ, Lee SH, Kang YS, Choe TB, Hur HG, Han KO. (2006). Isoflavone metabolites and their in vitro dual functions: They can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem Mol Biol 101:246–253.
  • Hwang YW, Kim SY, Jee SH, Kim YN, Nam CM. (2009). Soy food consumption and risk of prostate cancer: A meta-analysis of observational studies. Nutr Cancer 61:598–606.
  • Iavarone M, Lampertico P, Seletti C, Francesca DM, Ronchi G, del Ninno E, Colombo M. (2003). The clinical and pathogenetic significance of estrogen receptor-beta expression in chronic liver diseases and liver carcinoma. Cancer 98:529–534.
  • Iishi H, Tatsuta M, Baba M, Yano H, Sakai N, Akedo H. (2000). Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar rats. Int J Cancer 86:416–420.
  • Ikeda T, Nishikawa A, Son HY, Nakamura H, Miyauchi M, Imazawa T, Kimura S, Hirose M. (2001). Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation. Jpn J Cancer Res 92:390–395.
  • Imamov O, Morani A, Shim GJ, Omoto Y, Thulin-Andersson C, Warner M, Gustafsson JA. (2004). Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A 101:9375–9380.
  • Imhof M, Gocan A, Reithmayr F, Lipovac M, Schimitzek C, Chedraui P, Huber J. (2006). Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Maturitas 55:76–81.
  • Imhof M, Molzer S, Imhof M. (2008). Effects of soy isoflavones on 17beta-estradiol-induced proliferation of MCF-7 breast cancer cells. Toxicol In Vitro 22:1452–1460.
  • Ingram D, Sanders K, Kolybaba M, Lopez D. (1997). Case-control study of phyto-oestrogens and breast cancer. Lancet 350:990–994.
  • Isaacs JT. (1994). Role of androgens in prostatic cancer. Vitam Horm 49:433–502.
  • Ito C, Itoigawa M, Tan HT, Tokuda H, Yang M, X Mukainaka, T, Ishikawa T, Nishino H, Furukawa H. (2000). Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Lett 152:187–192.
  • Ito K, Utsunomiya H, Yaegashi N, Sasano H. (2007). Biological roles of estrogen and progesterone in human endometrial carcinoma—New developments in potential endocrine therapy for endometrial cancer. Endocr J 54:667–679.
  • Iwasaki M, Inoue M, Otani T, Sasazuki S, Kurahashi N, Miura T, Yamamoto S, Tsugane S. (2008). Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: A nested case-control study from the Japan Public Health Center-based prospective study group. J Clin Oncol 26:1677–1683.
  • Iwasaki M, Shigeaki HG, Nobuko N, I Mourao, NM, Motola J, Jr., Martins LF, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S. (2009). Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Cancer Sci 100:927–933.
  • Jabbar MA, Larrea J, Shaw RA. (1997). Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formula. J Am Coll Nutr 16:280–282.
  • Jacobs A, Wegewitz U, Sommerfeld C, Grossklaus R, Lampen A. (2009). Efficacy of isoflavones in relieving vasomotor menopausal symptoms - —A systematic review. Mol Nutr Food Res.
  • Janning P, Schuhmacher US, Upmeier A, Diel P, Michna H, Degen GH, Bolt HM. (2000). Toxicokinetics of the phytoestrogen daidzein in female DA/Han rats. Arch Toxicol 74:421–430.
  • Jarred RA, Keikha M, Dowling C, McPherson SJ, Clare AM, Husband AJ, Pedersen JS, Frydenberg M, Risbridger GP. (2002). Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Cancer Epidemiol Biomarkers Prev 11:1689–1696.
  • Jefferson WN, Padilla-Banks E, Newbold RR. (2007). Disruption of the developing female reproductive system by phytoestrogens: Genistein as an example. Mol Nutr Food Res 51:832–844.
  • Jemal A, Clegg LX, Ward E, Ries LA, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN, Edwards BK. (2004). Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival. Cancer 101:3–27.
  • Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. (2008). Cancer statistics, 2008. CA Cancer J Clin 58:71–96.
  • Ji ZN, Zhao WY, Liao GR, Choi RC, Lo CK, Dong TT, Tsim KW. (2006). In vitro estrogenic activity of formononetin by two bioassay systems. Gynecol Endocrinol 22:578–584.
  • Jian L. (2009). Soy, isoflavones, and prostate cancer. Mol Nutr Food Res 53:217–226.
  • Joannou GE, Kelly GE, Reeder AY, Waring M, Nelson C. (1995). A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. J Steroid Biochem Mol Biol 54:167–184.
  • Johnson TL, Lai MB, Lai JC, Bhushan A. (2008). Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A. Evid Based Complement Alternat Med.
  • Jones JL, Daley BJ, Enderson BL, Zhou JR, Karlstad MD. (2002). Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 68:575–577.
  • Jou HJ, Wu SC, Chang FW, Ling PY, Chu KS, Wu WH. (2008). Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones. Int J Gynaecol Obstet 102:44–49.
  • Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG. (2001). Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 131:2957–2962.
  • Ju YH, Doerge DR, Allred KF, Allred CD, Helferich WG. (2002). Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 62:2474–2477.
  • Ju YH, Allred KF, Allred CD, Helferich WG. (2006a). Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations. Carcinogenesis 27:1292–1299.
  • Ju YH, Fultz J, Allred KF, Doerge DR, Helferich WG. (2006b). Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis 27:856–863.
  • Ju YH, Fultz J, Allred KF, Doerge DR, Helferich WG. (2006c). Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis 27:856–863.
  • Ju YH, Doerge DR, Woodling KA, Hartman JA, Kwak J, Helferich WG. (2008). Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis 29:2162–2168.
  • Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. (2007). Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1:324–337.
  • Kang JL, Lee HW, Lee HS, Pack IS, Chong Y, Castranova V, Koh Y. (2001a). Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am J Respir Crit Care Med 164:2206–2212.
  • Kang LP, Qi LH, Zhang JP, Shi N, Zhang M, Wu TM, Chen J. (2001b). Effect of genistein and quercetin on proliferation, collagen synthesis, and type I procollagen mRNA levels of rat hepatic stellate cells. Acta Pharmacol Sin 22:793–796.
  • Kang JL, Lee HW, Lee HS, Pack IS, Castranova V, Koh Y. (2003). Time course for inhibition of lipopolysaccharide-induced lung injury by genistein: Relationship to alteration in nuclear factor-kappaB activity and inflammatory agents. Crit Care Med 31:517–524.
  • Kang X, Jin S, Zhang Q. (2009). Antitumor and antiangiogenic activity of soy phytoestrogen on 7,12-dimethylbenz[alpha]anthracene-induced mammary tumors following ovariectomy in Sprague-Dawley rats. J Food Sci 74:H237–H242.
  • Kato I, Nomura AM, Stemmermann GN, Chyou PH. (1992). A prospective study of gastric and duodenal ulcer and its relation to smoking, alcohol, and diet. Am J Epidemiol 135:521–530.
  • Kawai H, Ishii A, Washiya K, Konno T, Kon H, Yamaya C, Ono I, Minamiya Y, Ogawa J. (2005). Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer. Clin Cancer Res 11:5084–5089.
  • Kayisli UA, Aksu CA, Berkkanoglu M, Arici A. (2002). Estrogenicity of isoflavones on human endometrial stromal and glandular cells. J Clin Endocrinol Metab 87:5539–5544.
  • Kelly GE, Nelson C, Waring MA, Joannou GE, Reeder AY. (1993). Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 223:9–22.
  • Kennedy AR, Billings PC, Wan XS, Newberne PM. (2002). Effects of Bowman-Birk inhibitor on rat colon carcinogenesis. Nutr Cancer 43:174–186.
  • Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL. (2000). Synergistic action of genistein and cisplatin on growth inhibition and cytotoxicity of human medulloblastoma cells. Pediatr Neurosurg 33:123–131.
  • Khoshyomn S, Nathan D, Manske GC, Osler TM, Penar PL. (2002). Synergistic effect of genistein and BCNU on growth inhibition and cytotoxicity of glioblastoma cells. J Neurooncol 57:193–200.
  • Kilfoy BA, Zheng T, Holford TR, Han X, Ward MH, Sjodin A, Zhang Y, Bai Y, Zhu C, Guo GL, Rothman N, Zhang Y. (2009). International patterns and trends in thyroid cancer incidence, 1973–2002. Cancer Causes Control 20:525–531.
  • Kim EJ, Shin HK, Park JH. (2005). Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: A possible mechanism of the growth inhibitory effect of Genistein. J Med Food 8:431–438.
  • Kim YS, Milner JA. (2007). Dietary modulation of colon cancer risk. J Nutr 137:2576S–2579S.
  • Kimura S, Suwa J, Ito M, Sato H. (1976). Development of malignant goiter by defatted soybean with iodine-free diet in rats. Gann 67:763–765.
  • King RA, Bursill DB. (1998). Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 67:867–872.
  • Klein CB, King AA. (2007). Genistein genotoxicity: Critical considerations of in vitro exposure dose. Toxicol Appl Pharmacol 224:1–11.
  • Klein MA, Nahin RL, Messina MJ, Rader JI, Thompson LU, Badger TM, Dwyer JT, Kim YS, Pontzer CH, Starke-Reed PE, Weaver CM. (2010). Guidance from an NIH Workshop on Designing, Implementing, and Reporting Clinical Studies of Soy Interventions. J Nutr 140:1192s–1204s.
  • Klotz DM, Hewitt SC, Korach KS, DiAugustine RP. (2000). Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: Requirement of estrogen receptor-alpha. Endocrinology 141:3430–3439.
  • Ko KP, Park SK, Cho LY, Gwack J, Yang JJ, Shin A, Kim CS, Kim Y, Kang D, Chang SH, Shin HR, Yoo KY. (2009). Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk. J Nutr 139:1008–1012.
  • Konduri S, Schwarz RE. (2007). Estrogen receptor beta/alpha ratio predicts response of pancreatic cancer cells to estrogens and phytoestrogens. J Surg Res 140:55–66.
  • Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I, Sotiropoulou-Bonikou G, Papavassiliou AG. (2003). Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour’s dedifferentiation. Eur J Cancer 39:1251–1258.
  • Koratkar R, Rao AV. (1997). Effect of soya bean saponins on azoxymethane-induced preneoplastic lesions in the colon of mice. Nutr Cancer 27:206–209.
  • Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover RN, Ziegler RG. (2009). Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev 18:1050–1059.
  • Kramer F, Johnson IT, Doleman JF, Lund EK. (2009). A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors alpha and beta in the mammary gland and colon of the rat. Br J Nutr 102:29–36.
  • Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O. (1998). Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A 95:15677–15682.
  • Kreimer AR, Randi G, Herrero R, Castellsague X, La Vecchia C, Franceschi S. (2006). Diet and body mass, and oral and oropharyngeal squamous cell carcinomas: Analysis from the IARC multinational case-control study. Int J Cancer 118:2293–2297.
  • Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252–4263.
  • Kumar NB, Cantor A, Allen K, Riccardi D, Besterman-Dahan K, Seigne J, Helal M, Salup R, Pow-Sang J. (2004). The specific role of isoflavones in reducing prostate cancer risk. Prostate 59:141–147.
  • Kumi-Diaka JK, Hassanhi M, Merchant K, Horman V. (2006). Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells. J Med Food 9:491–497.
  • Kurahashi N, Iwasaki M, Inoue M, Sasazuki S, Tsugane S. (2008). Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: The Japan Public Health Center. J Clin Oncol 26:5923–5929.
  • Kurahashi N, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S. (2007). Soy product and isoflavone consumption in relation to prostate cancer in Japanese men. Cancer Epidemiol Biomarkers Prev 16:538–545.
  • Kurahashi N, Inoue M, Iwasaki M, Tanaka Y, Mizokami M, Tsugane S. (2009). Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women. Int J Cancer 124:1644–1649.
  • Kurozawa Y, Ogimoto I, Shibata A, Nose T, Yoshimura T, Suzuki H, Sakata R, Fujita Y, Ichikawa S, Iwai N, Fukuda K, Tamakoshi A. (2004). Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Univariate analysis of JACC study data. Kurume Med J 51:141–149.
  • Kuzu N, Metin K, Dagli AF, Akdemir F, Orhan C, Yalniz M, Ozercan IH, Sahin K, Bahcecioglu IH. (2007). Protective role of genistein in acute liver damage induced by carbon tetrachloride. Mediators Inflamm 2007:36381.
  • Kwan ML, Jensen CD, Block G, Hudes ML, Chu LW, Buffler PA. (2009). Maternal diet and risk of childhood acute lymphoblastic leukemia. Public Health Rep 124:503–514.
  • Kyle E, Neckers L, Takimoto C, Curt G, Bergan R. (1997). Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 51:193–200.
  • Lacey JV, Jr., Mink PJ, Lubin JH, Sherman ME, Troisi R, Hartge P, Schatzkin A, Schairer C. (2002). Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA 288:334–341.
  • Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, Pelling JC, Bergan RC. (2008). Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Res 68:2024–2032.
  • Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R, Elgavish A. (2002a). Genistein chemoprevention: Timing and mechanisms of action in murine mammary and prostate. J Nutr 132:552S–558S.
  • Lamartiniere CA, Wang J, Smith-Johnson M, Eltoum IE. (2002b). Daidzein: Bioavailability, potential for reproductive toxicity, and breast cancer chemoprevention in female rats. Toxicol Sci 65:228–238.
  • Lampe JW, Nishino Y, Ray RM, Wu C, Li W, Lin MG, Gao DL, Hu Y, Shannon J, Stalsberg H, Porter PL, Frankenfeld CL, Wahala K, Thomas DB. (2007). Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China. Cancer Epidemiol Biomarkers Prev 16:2579–2586.
  • Larkin T, Price WE, Astheimer L. (2008). The key importance of soy isoflavone bioavailability to understanding health benefits. Crit Rev Food Sci Nutr 48:538–552.
  • Le Marchand L, Murphy SP, Hankin JH, Wilkens LR, Kolonel LN. (2000). Intake of flavonoids and lung cancer. J Natl Cancer Inst 92:154–160.
  • Leav I, Lau KM, Adams JY, McNeal JE, Taplin ME, Wang J, Singh H, Ho SM. (2001). Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am J Pathol 159:79–92.
  • Lechner D, Bajna E, Adlercreutz H, Cross HS. (2006). Genistein and 17beta-estradiol, but not equol, regulate vitamin D synthesis in human colon and breast cancer cells. Anticancer Res 26:2597–2603.
  • Lee YS, Kim TH, Cho KJ, Jang JJ. (1992). Inhibitory effects of biochanin A on benzo(a)pyrene induced carcinogenesis in mice. In Vivo 6:283–286.
  • Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. (1994). Preserved foods and nasopharyngeal carcinoma: A case-control study among Singapore Chinese. Int J Cancer 59:585–590.
  • Lee WY, Huang SC, Tzeng CC, Chang TL, Hsu KF. (2007). Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated HCC1395 breast cancer cells. Nutr Cancer 58:239–246.
  • Lee SA, Shu XO, Li H, Yang G, Cai H, Wen W, Ji BT, Gao J, Gao YT, Zheng W. (2009). Adolescent and adult soy food intake and breast cancer risk: Results from the Shanghai Women’s Health Study. Am J Clin Nutr 89:1920–1926.
  • Lei W, Mayotte JE, Levitt ML. (1999). Enhancement of chemosensitivity and programmed cell death by tyrosine kinase inhibitors correlates with EGFR expression in non-small cell lung cancer cells. Anticancer Res 19:221–228.
  • Lei B, Roncaglia V, Vigano R, Cremonini C, De Maria N, Del Buono MG, Manenti F, Villa E. (2002). Phytoestrogens and liver disease. Mol Cell Endocrinol 193:81–84.
  • Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. (2007). Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev (4):CD001395.
  • Leung YK, Mak P, Hassan S, Ho SM. (2006). Estrogen receptor (ER)-beta isoforms: A key to understanding ER-beta signaling. Proc Natl Acad Sci U S A 103:13162–13167.
  • Lewandowski S, Kalita K, Kaczmarek L. (2002). Estrogen receptor beta. Potential functional significance of a variety of mRNA isoforms. FEBS Lett 524:1–5.
  • Leygue E, Dotzlaw H, Watson PH, Murphy LC. (1998). Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Res 58:3197–3201.
  • Leygue E, Dotzlaw H, Watson PH, Murphy LC. (1999). Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissue. Cancer Res 59:1175–1179.
  • Li D, Yee JA, McGuire MH, Murphy PA, Yan L. (1999). Soybean isoflavones reduce experimental metastasis in mice. J Nutr 129:1075–1078.
  • Li Y, Che M, Bhagat S, Ellis KL, Kucuk O, Doerge DR, Abrams J, Cher ML, Sarkar FH. (2004a). Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein. Neoplasia 6:354–363.
  • Li Y, Ellis KL, Ali S, El Rayes BF, Nedeljkovic-Kurepa A, Kucuk O, Philip PA, Sarkar FH. (2004b). Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line. Pancreas 28:e90–e95.
  • Li M, Zhang Z, Hill DL, Chen X, Wang H, Zhang R. (2005a). Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res 65:8200–8208.
  • Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. (2005b). Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 65:6934–6942.
  • Li Y, Kucuk O, Hussain M, Abrams J, Cher ML, Sarkar FH. (2006). Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer. Cancer Res 66:4816–4825.
  • Li Z, Li J, Mo B, Hu C, Liu H, Qi H, Wang X, Xu J. (2008). Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway. Toxicol In Vitro 22:1749–1753.
  • Lian F, Li Y, Bhuiyan M, Sarkar FH. (1999). p53-independent apoptosis induced by genistein in lung cancer cells. Nutr Cancer 33:125–131.
  • Lian Z, Niwa K, Tagami K, Hashimoto M, Gao J, Yokoyama Y, Mori H, Tamaya T. (2001). Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice. Jpn J Cancer Res 92:726–734.
  • Lieberman ME, Maurer RA, Claude P, Wiklund J, Wertz N, Gorski J. (1981). Regulation of pituitary growth and prolactin gene expression by estrogen. Adv Exp Med Biol 138:151–163.
  • Lieberman R. (2004). Evidence-based medical perspectives: The evolving role of PSA for early detection, monitoring of treatment response, and as a surrogate end point of efficacy for interventions in men with different clinical risk states for the prevention and progression of prostate cancer. Am J Ther 11:501–506.
  • Lien TF, Hsu YL, Lo DY, Chiou RY. (2009). Supplementary health benefits of soy aglycons of isoflavone by improvement of serum biochemical attributes, enhancement of liver antioxidative capacities and protection of vaginal epithelium of ovariectomized rats. Nutr Metab (Lond) 6:15.
  • Lin CY, Strom A, Li KS, Kietz S, Thomsen JS, Tee JB, Vega VB, Miller LD, Smeds J, Bergh J, Gustafsson JA, Liu ET. (2007). Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer. Breast Cancer Res 9:R25.
  • Lin CT. (2009). Relationship between Epstein-Barr virus infection and nasopharyngeal carcinoma pathogenesis. Chin J Cancer 28:791–804.
  • Lindberg MK, Moverare S, Skrtic S, Gao H, Dahlman-Wright K, Gustafsson JA, Ohlsson C. (2003). Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a “ying yang” relationship between ERalpha and ERbeta in mice. Mol Endocrinol 17:203–208.
  • Linsalata M, Russo F, Notarnicola M, Guerra V, Cavallini A, Clemente C, Messa C. (2005). Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. Nutr Cancer 52:84–93.
  • Linseisen J, Piller R, Hermann S, Chang-Claude J. (2004). Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Int J Cancer 110:284–290.
  • Liu J, Burdette JE, Xu H, Gu C, Van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. (2001). Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 49:2472–2479.
  • Liu B, Edgerton S, Yang X, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Liu N, Thor A. (2005). Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res 65:879–886.
  • Lo FH, Mak NK, Leung KN. (2007). Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells. Biomed Pharmacother 61:591–595.
  • Los M, Maddika S, Erb B, Schulze-Osthoff K. (2009). Switching Akt: From survival signaling to deadly response. Bioessays 31:492–495.
  • Low YL, Taylor JI, Grace PB, Mulligan AA, Welch AA, Scollen S, Dunning AM, Luben RN, Khaw KT, Day NE, Wareham NJ, Bingham SA. (2006). Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutr Cancer 56:31–39.
  • Lu CM, Lan SJ, Lee YH, Huang JK, Huang CH, Hsieh CC. (1999). Tea consumption: Fluid intake and bladder cancer risk in Southern Taiwan. Urology 54:823–828.
  • Lyn-Cook BD, Stottman HL, Yan Y, Blann E, Kadlubar FF, Hammons GJ. (1999). The effects of phytoestrogens on human pancreatic tumor cells in vitro. Cancer Lett 142:111–119.
  • MacDonald RS, Guo J, Copeland J, Browning JD, Jr., Sleper D, Rottinghaus GE, Berhow MA. (2005). Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer. J Nutr 135:1239–1242.
  • Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S. (2004). Association of Helicobacter pylori infection and environmental factors in non-cardia gastric cancer in Japan. Gastric Cancer 7:46–53.
  • Mahady GB, Parrot J, Lee C, Yun GS, Dan A. (2003). Botanical dietary supplement use in peri- and postmenopausal women. Menopause 10:65–72.
  • Mahady GB. (2005). Do soy isoflavones cause endometrial hyperplasia? Nutr Rev 63:392–397.
  • Mai Z, Blackburn GL, Zhou JR. (2007a). Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells. Mol Carcinog 46:534–542.
  • Mai Z, Blackburn GL, Zhou JR. (2007b). Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis 28:1217–1223.
  • Majid S, Dar AA, Ahmad AE, Hirata H, Kawakami K, Shahryari V, Saini S, Tanaka Y, Dahiya AV, Khatri G, Dahiya R. (2009). BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30:662–670.
  • Marini H, Bitto A, Altavilla D, Burnett BP, Polito F, Di S, V Minutoli, L, Atteritano M, Levy RM, D’Anna R, Frisina N, Mazzaferro S, Cancellieri F, Cannata ML, Corrado F, Frisina A, Adamo V, Lubrano C, Sansotta C, Marini R, Adamo EB, Squadrito F. (2008). Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: A follow-up study. J Clin Endocrinol Metab 93:4787–4796.
  • Maruyama T, Yoshimura Y. (2008). Molecular and cellular mechanisms for differentiation and regeneration of the uterine endometrium. Endocr J 55:795–810.
  • Marverti G, Andrews PA. (1996). Stimulation of cis-diamminedichloroplatinum(II) accumulation by modulation of passive permeability with genistein: An altered response in accumulation-defective resistant cells. Clin Cancer Res 2:991–999.
  • Maskarinec G, Verheus M, Steinberg FM, Amato P, Cramer MK, Lewis RD, Murray MJ, Young RL, Wong WW. (2009). Various doses of soy isoflavones do not modify mammographic density in postmenopausal women. J Nutr 139:981–986.
  • Mateos-Aparicio I, Redondo CA, Villanueva-Suarez MJ, Zapata-Revilla MA. (2008). Soybean, a promising health source. Nutr Hosp 23:305–312.
  • Matousek M, Mikuni M, Mitsube K, Yoshida M, Brannstrom M. (1999). Inhibition of ovulation by tyrosine kinase inhibitors in the in vitro perfused rat ovary. J Reprod Fertil 117:379–385.
  • Matsuo K, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K. (2008). Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese. Cancer Sci 99:1202–1208.
  • Maubach J, Bracke ME, Heyerick A, Depypere HT, Serreyn RF, Mareel MM, De Keukeleire D. (2003). Quantitation of soy-derived phytoestrogens in human breast tissue and biological fluids by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 784:137–144.
  • Mazer NA. (2004). Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women. Thyroid 14 (Suppl 1):S27–S34.
  • Mazur W. (1998). Phytoestrogen content in foods. Baillieres Clin Endocrinol Metab 12:729–742.
  • McClain RM, Wolz E, Davidovich A, Pfannkuch F, Bausch J. (2005). Subchronic and chronic safety studies with genistein in dogs. Food Chem Toxicol 43:1461–1482.
  • McClain RM, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J. (2006). Acute, subchronic and chronic safety studies with genistein in rats. Food Chem Toxicol 44:56–80.
  • McMichael-Phillips DF, Harding C, Morton M, Roberts SA, Howell A, Potten CS, Bundred NJ. (1998). Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr 68:1431S–1435S.
  • McTiernan AM, Weiss NS, Daling JR. (1984). Incidence of thyroid cancer in women in relation to previous exposure to radiation therapy and history of thyroid disease. J Natl Cancer Inst 73:575–581.
  • Menon LG, Kuttan R, Nair MG, Chang YC, Kuttan G. (1998). Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells. Nutr Cancer 30:74–77.
  • Mense SM, Hei TK, Ganju RK, Bhat HK. (2008). Phytoestrogens and breast cancer prevention: Possible mechanisms of action. Environ Health Perspect 116:426–433.
  • Mentor-Marcel R, Lamartiniere CA, Eltoum IA, Greenberg NM, Elgavish A. (2005). Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP). J Nutr 135:989–995.
  • Messina M, Kucuk O, Lampe JW. (2006). An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 89:1121–1134.
  • Messina M, Redmond G. (2006a). Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: A review of the relevant literature. Thyroid 16:249–258.
  • Messina M, Redmond G. (2006b). Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: A review of the relevant literature. Thyroid 16:249–258.
  • Messina MJ. (1999). Legumes and soybeans: Overview of their nutritional profiles and health effects. Am J Clin Nutr 70:439S–450S.
  • Messina MJ. (2003). Emerging evidence on the role of soy in reducing prostate cancer risk. Nutr Rev 61:117–131.
  • Messina MJ, Loprinzi CL. (2001). Soy for breast cancer survivors: A critical review of the literature. J Nutr 131:3095S–3108S.
  • Milne TA, Dou Y, Martin ME, Brock HW, Roeder RG, Hess JL. (2005). MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A 102:14765–14770.
  • Messina M. (2008). Conclusion that isoflavones exert estrogenic effects on breast tissue and may raise breast cancer risk unfounded. Mol Nutr Food Res 52:299–300.
  • Miltyk W, Craciunescu CN, Fischer L, Jeffcoat RA, Koch MA, Lopaczynski W, Mahoney C, Jeffcoat RA, Crowell J, Paglieri J, Zeisel SH. (2003). Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer. Am J Clin Nutr 77:875–882.
  • Mitchell JH, Duthie SJ, Collins AR. (2000). Effects of phytoestrogens on growth and DNA integrity in human prostate tumor cell lines: PC-3 and LNCaP. Nutr Cancer 38:223–228.
  • Mohammad RM, Al Katib A, Aboukameel A, Doerge DR, Sarkar F, Kucuk O. (2003). Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Mol Cancer Ther 2:1361–1368.
  • Mohammad RM, Banerjee S, Li Y, Aboukameel A, Kucuk O, Sarkar FH. (2006). Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer 106:1260–1268.
  • Molinie B, Georgel P. (2009). Genetic and epigenetic regulations of prostate cancer by genistein. Drug News Perspect 22:247–254.
  • Mollerup S, Jorgensen K, Berge G, Haugen A. (2002). Expression of estrogen receptors alpha and beta in human lung tissue and cell lines. Lung Cancer 37:153–159.
  • Moon YJ, Wang X, Morris ME. (2006). Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 20:187–210.
  • Moon YJ, Zhang S, Brazeau DA, Morris ME. (2007). Effects of the flavonoid biochanin A on gene expression in primary human hepatocytes and human intestinal cells. Mol Nutr Food Res 51:317–323.
  • Moon YJ, Shin BS, An G, Morris ME. (2008). Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res 25:2158–2163.
  • Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM, Willson TM. (1998). Cloning and characterization of human estrogen receptor beta isoforms. Biochem Biophys Res Commun 247:75–78.
  • Moore JO, Wang Y, Stebbins WG, Gao D, Zhou X, Phelps R, Lebwohl M, Wei H. (2006). Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis 27:1627–1635.
  • Moore AB, Castro L, Yu L, Zheng X, Di X, Sifre MI, Kissling GE, Newbold RR, Bortner CD, Dixon D. (2007). Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration. Hum Reprod 22:2623–2631.
  • Morton MS, Chan PS, Cheng C, Blacklock N, Matos-Ferreira A, Abranches-Monteiro L, Correia R, Lloyd S, Griffiths K. (1997). Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom. Prostate 32:122–128.
  • Morton MS, Arisaka O, Miyake N, Morgan LD, Evans BA. (2002). Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J Nutr 132:3168–3171.
  • Mousavi Y, Adlercreutz H. (1993). Genistein is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma human liver cancer cells and suppresses proliferation of these cells in culture. Steroids 58:301–304.
  • Muir CS, Nectoux J, Staszewski J. (1991). The epidemiology of prostatic cancer. Geographical distribution and time-trends. Acta Oncol 30:133–140.
  • Munro IC, Harwood M, Hlywka JJ, Stephen AM, Doull J, Flamm WG, Adlercreutz H. (2003). Soy isoflavones: A safety review. Nutr Rev 61:1–33.
  • Murillo G, Choi JK, Pan O, Constantinou AI, Mehta RG. (2004). Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice. Anticancer Res 24:3049–3055.
  • Murota K, Terao J. (2003). Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism. Arch Biochem Biophys 417:12–17.
  • Murray MJ, Meyer WR, Lessey BA, Oi RH, DeWire RE, Fritz MA. (2003). Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: A pilot trial. Menopause 10:456–464.
  • Myoung H, Hong SP, Yun PY, Lee JH, Kim MJ. (2003). Anti-cancer effect of genistein in oral squamous cell carcinoma with respect to angiogenesis and in vitro invasion. Cancer Sci 94:215–220.
  • Myung SK, Ju W, Choi HJ, Kim SC. (2009). Soy intake and risk of endocrine-related gynaecological cancer: A meta-analysis. BJOG 116:1697–1705.
  • Nagata C. (2000). Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. Int J Epidemiol 29:832–836.
  • Nagata C, Takatsuka N, Kawakami N, Shimizu H. (2002). A prospective cohort study of soy product intake and stomach cancer death. Br J Cancer 87:31–36.
  • Nagel G, Mack U, von Fournier D, Linseisen J. (2005). Dietary phytoestrogen intake and mammographic density—Results of a pilot study. Eur J Med Res 10:389–394.
  • Naik HR, Lehr JE, Pienta KJ. (1994). An in vitro and in vivo study of antitumor effects of genistein on hormone refractory prostate cancer. Anticancer Res 14:2617–2619.
  • Nakai M, Black M, Jeffery EH, Bahr JM. (2005a). Dietary soy protein and isoflavones: No effect on the reproductive tract and minimal positive effect on bone resorption in the intact female Fischer 344 rat. Food Chem Toxicol 43:945–949.
  • Nakai M, Cook L, Pyter LM, Black M, Sibona J, Turner RT, Jeffery EH, Bahr JM. (2005b). Dietary soy protein and isoflavones have no significant effect on bone and a potentially negative effect on the uterus of sexually mature intact Sprague-Dawley female rats. Menopause 12:291–298.
  • Nan HM, Park JW, Song YJ, Yun HY, Park JS, Hyun T, Youn SJ, Kim YD, Kang JW, Kim H. (2005). Kimchi and soybean pastes are risk factors of gastric cancer. World J Gastroenterol 11:3175–3181.
  • Negri E, Tzonou A, Beral V, Lagiou P, Trichopoulos D, Parazzini F, Franceschi S, Booth M, La Vecchia C. (1999). Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies. Int J Cancer 80:848–851.
  • Ness RB, Grisso JA, Klapper J, Vergona R. (2000). Racial differences in ovarian cancer risk. J Natl Med Assoc 92:176–182.
  • Newbold RR, Banks EP, Bullock B, Jefferson WN. (2001). Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61:4325–4328.
  • Nielsen IL, Williamson G. (2007). Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr Cancer 57:1–10.
  • Nishida N, Yano H, Nishida T, Kamura T, Kojiro M. (2006). Angiogenesis in cancer. Vasc Health Risk Manag 2:213–219.
  • Nishikawa A, Ikeda T, Son HY, Okazaki K, Imazawa T, Umemura T, Kimura S, Hirose M. (2005). Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets. Toxicol Sci 86:258–263.
  • Nojima D, Li LC, Dharia A, Perinchery G, Ribeiro-Filho L, Yen TS, Dahiya R. (2001). CpG hypermethylation of the promoter region inactivates the estrogen receptor-beta gene in patients with prostate carcinoma. Cancer 92:2076–2083.
  • NTP. (2008). NTP Toxicology and Carcinogenesis Studies of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study). Natl Toxicol Program Tech Rep Ser 1–240.
  • Oba S, Nagata C, Shimizu N, Shimizu H, Kametani M, Takeyama N, Ohnuma T, Matsushita S. (2007). Soy product consumption and the risk of colon cancer: A prospective study in Takayama, Japan. Nutr Cancer 57:151–157.
  • Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK, Lee AV. (2001). Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Res 61:5771–5777.
  • Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M. (1998). Molecular cloning and characterization of human estrogen receptor betacx: A potential inhibitor ofestrogen action in human. Nucleic Acids Res 26:3505–3512.
  • Ohuchi Y, Myojin Y, Shimamoto F, Kashimoto N, Kamiya K, Watanabe H. (2005). Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso. Oncol Rep 14:1559–1564.
  • Oliveira PA, Colaco A, Chaves R, Guedes-Pinto H, De La Cruz PL, Lopes C. (2007). Chemical carcinogenesis. An Acad Bras Cienc 79:593–616.
  • Omoto Y, Kobayashi Y, Nishida K, Tsuchiya E, Eguchi H, Nakagawa K, Ishikawa Y, Yamori T, Iwase H, Fujii Y, Warner M, Gustafsson JA, Hayashi SI. (2001). Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers. Biochem Biophys Res Commun 285:340–347.
  • Onozawa M, Fukuda K, Ohtani M, Akaza H, Sugimura T, Wakabayashi K. (1998). Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Jpn J Clin Oncol 28:360–363.
  • Palacios S, Pornel B, Vazquez F, Aubert L, Chantre P, Mares P. (2010). Long-term endometrial and breast safety of a specific, standardized soy extract. Climacteric 13:368–375.
  • Park SY, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN. (2008). Legume and isoflavone intake and prostate cancer risk: The Multiethnic Cohort Study. Int J Cancer 123:927–932.
  • Park SY, Wilkens LR, Franke AA, Le ML, Kakazu KK, Goodman MT, Murphy SP, Henderson BE, Kolonel LN. (2009). Urinary phytoestrogen excretion and prostate cancer risk: A nested case-control study in the Multiethnic Cohort. Br J Cancer 101:185–191.
  • Parkin DM, Pisani P, Ferlay J. (1999). Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80:827–841.
  • Parkin DM, Bray F, Ferlay J, Pisani P. (2005). Global cancer statistics, 2002. CA Cancer J Clin 55:74–108.
  • Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. (2004). Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 64:423–428.
  • Patel JD, Bach PB, Kris MG. (2004). Lung cancer in US women: A contemporary epidemic. JAMA 291:1763–1768.
  • Pelletier G, El Alfy M. (2000). Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 85:4835–4840.
  • Pendleton JM, Tan WW, Anai S, Chang M, Hou W, Shiverick KT, Rosser CJ. (2008). Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy. BMC Cancer 8:132.
  • Perabo FG, von Low EC, Ellinger J, von Rucker A, Muller SC, Bastian PJ. (2008). Soy isoflavone genistein in prevention and treatment of prostate cancer. Prostate Cancer Prostatic Dis 11:6–12.
  • Perez EA. (2007). Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant therapy of hormone-responsive early breast cancer. Ann Oncol 18(Suppl 8):viii26–viii35.
  • Perez-Farinos N, Lopez-Abente G, Pastor-Barriuso R. (2006). Time trend and age-period-cohort effect on kidney cancer mortality in Europe, 1981–2000. BMC Public Health 6:119.
  • Persky VW, Turyk ME, Wang L, Freels S, Chatterton R, Jr., Barnes S, Erdman J, Jr., Sepkovic DW, Bradlow HL, Potter S. (2002). Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 75:145–153.
  • Peterson G, Barnes S. (1993). Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22:335–345.
  • Petrakis NL, Barnes S, King EB, Lowenstein J, Wiencke J, Lee MM, Miike R, Kirk M, Coward L. (1996). Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiol Biomarkers Prev 5:785–794.
  • Phrakonkham P, Chevalier J, Desmetz C, Pinnert MF, Berges R, Jover E, Davicco MJ, Bennetau-Pelissero C, Coxam V, Artur Y, Canivenc-Lavier MC. (2007). Isoflavonoid-based bone-sparing treatments exert a low activity on reproductive organs and on hepatic metabolism of estradiol in ovariectomized rats. Toxicol Appl Pharmacol 224:105–115.
  • Pitot HC, Dragan YP. (1991). Facts and theories concerning the mechanisms of carcinogenesis. FASEB J 5:2280–2286.
  • Pollard M, Luckert PH. (1997). Influence of isoflavones in soy protein isolates on development of induced prostate-related cancers in L-W rats. Nutr Cancer 28:41–45.
  • Pollard M, Wolter W. (2000). Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet. Prostate 45:101–105.
  • Power KA, Saarinen NM, Chen JM, Thompson LU. (2006). Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. Int J Cancer 118:1316–1320.
  • Powles TJ, Howell A, Evans DG, McCloskey EV, Ashley S, Greenhalgh R, Affen J, Flook LA, Tidy A. (2008). Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. Menopause Int 14:6–12.
  • Probst-Hensch NM, Wang H, Goh VH, Seow A, Lee HP, Yu MC. (2003). Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women. Cancer Epidemiol Biomarkers Prev 12:739–746.
  • Pugazhendhi D, Watson KA, Mills S, Botting N, Pope GS, Darbre PD. (2008). Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells. J Endocrinol 197:503–515.
  • Puli S, Lai JC, Bhushan A. (2006). Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones. J Neurooncol 79:135–142.
  • Qin LQ, Xu JY, Wang PY, Hoshi K. (2006). Soyfood intake in the prevention of breast cancer risk in women: A meta-analysis of observational epidemiological studies. J Nutr Sci Vitaminol (Tokyo) 52:428–436.
  • Qin W, Zhu W, Shi H, Hewett JE, Ruhlen RL, MacDonald RS, Rottinghaus GE, Chen YC, Sauter ER. (2009). Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr Cancer 61:238–244.
  • Rachon D, Vortherms T, Seidlova-Wuttke D, Menche A, Wuttke W. (2007a). Uterotropic effects of dietary equol administration in ovariectomized Sprague-Dawley rats. Climacteric 10:416–426.
  • Rachon D, Vortherms T, Seidlova-Wuttke D, Wuttke W. (2007b). Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 57:161–170.
  • Radovic B, Mentrup B, Kohrle J. (2006). Genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid. Br J Nutr 95:1171–1176.
  • Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG. (2006). Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 6:107.
  • Raffoul JJ, Banerjee S, Che M, Knoll ZE, Doerge DR, Abrams J, Kucuk O, Sarkar FH, Hillman GG. (2007). Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model. Int J Cancer 120:2491–2498.
  • Ragin CC, Modugno F, Gollin SM. (2007). The epidemiology and risk factors of head and neck cancer: A focus on human papillomavirus. J Dent Res 86:104–114.
  • Rajah TT, Du N, Drews N, Cohn R. (2009). Genistein in the presence of 17beta-estradiol inhibits proliferation of ERbeta breast cancer cells. Pharmacology 84:68–73.
  • Raju J, Bielecki A, Caldwell D, Lok E, Taylor M, Kapal K, Curran I, Cooke GM, Bird RP, Mehta R. (2009). Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. J Nutr 139:474–481.
  • Ramnath N, Menezes RJ, Loewen G, Dua P, Eid F, Alkhaddo J, Paganelli G, Natarajan N, Reid ME. (2007). Hormone replacement therapy as a risk factor for non-small cell lung cancer: Results of a case-control study. Oncology 73:305–310.
  • Rao CV, Wang CX, Simi B, Lubet R, Kelloff G, Steele V, Reddy BS. (1997). Enhancement of experimental colon cancer by genistein. Cancer Res 57:3717–3722.
  • Rauth S, Kichina J, Green A. (1997). Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: Chemosensitivity is regulated by cellular p53. Br J Cancer 75:1559–1566.
  • Raynal NJ, Charbonneau M, Momparler LF, Momparler RL. (2008a). Synergistic effect of 5-aza-2’-deoxycytidine and genistein in combination against leukemia. Oncol Res 17:223–230.
  • Raynal NJ, Momparler L, Charbonneau M, Momparler RL. (2008b). Antileukemic activity of genistein, a major isoflavone present in soy products. J Nat Prod 71:3–7.
  • Record IR, Broadbent JL, King RA, Dreosti IE, Head RJ, Tonkin AL. (1997). Genistein inhibits growth of B16 melanoma cells in vivo and in vitro and promotes differentiation in vitro. Int J Cancer 72:860–864.
  • Reeve VE, Widyarini S, Domanski D, Chew E, Barnes K. (2005). Protection against photoaging in the hairless mouse by the isoflavone equol. Photochem Photobiol 81:1548–1553.
  • Regenbrecht CR, Jung M, Lehrach H, Adjaye J. (2008). The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics 1:49.
  • Reiter E, Beck V, Medjakovic S, Mueller M, Jungbauer A. (2009). Comparison of hormonal activity of isoflavone-containing supplements used to treat menopausal complaints. Menopause 16:1049–1060.
  • Rimoldi G, Christoffel J, Seidlova-Wuttke D, Jarry H, Wuttke W. (2007). Effects of chronic genistein treatment in mammary gland, uterus, and vagina. Environ Health Perspect 115 (Suppl 1):62–68.
  • Roberts DW, Doerge DR, Churchwell MI, Gamboa dC, Marques MM, Tolleson WH. (2004). Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover). J Agric Food Chem 52:6623–6632.
  • Rodriguez C, Patel AV, Calle EE, Jacob EJ, Thun MJ. (2001). Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women. JAMA 285:1460–1465.
  • Ross JA, Potter JD, Robison LL. (1994). Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 86:1678–1680.
  • Ross JA, Potter JD, Reaman GH, Pendergrass TW, Robison LL. (1996). Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children’s Cancer Group. Cancer Causes Control 7:581–590.
  • Rossi M, Negri E, Talamini R, Bosetti C, Parpinel M, Gnagnarella P, Franceschi S, Dal Maso L, Montella M, Giacosa A, La Vecchia C. (2006). Flavonoids and colorectal cancer in Italy. Cancer Epidemiol Biomarkers Prev 15:1555–1558.
  • Ross RK, Pike MC, Coetzee GA, Reichardt JK, Yu MC, Feigelson H, Stanczyk FZ, Kolonel LN, Henderson BE. (1998). Androgen metabolism and prostate cancer: Establishing a model of genetic susceptibility. Cancer Res 58:4497–4504.
  • Rossi M, Garavello W, Talamini R, Negri E, Bosetti C, Dal Maso L, Lagiou P, Tavani A, Polesel J, Barzan L, Ramazzotti V, Franceschi S, La Vecchia C. (2007). Flavonoids and the risk of oral and pharyngeal cancer: A case-control study from Italy. Cancer Epidemiol Biomarkers Prev 16:1621–1625.
  • Rossouw JE, Anderson GL, Prentice RL, Lacroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333.
  • Rowell C, Carpenter DM, Lamartiniere CA. (2005). Chemoprevention of breast cancer, proteomic discovery of genistein action in the rat mammary gland. J Nutr 135:2953S–2959S.
  • Rowlands JC, He L, Hakkak R, Ronis MJ, Badger TM. (2001). Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J Nutr 131:3281–3287.
  • Rowley JD. (1998). The critical role of chromosome translocations in human leukemias. Annu Rev Genet 32:495–519.
  • Rucinska A, Kirko S, Gabryelak T. (2007). Effect of the phytoestrogen, genistein-8-C-glucoside, on Chinese hamster ovary cells in vitro. Cell Biol Int 31:1371–1378.
  • Runnebaum IB, Stickeler E. (2001). Epidemiological and molecular aspects of ovarian cancer risk. J Cancer Res Clin Oncol 127:73–79.
  • Russo J, Ao X, Grill C, Russo IH. (1999). Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat 53:217–227.
  • Russo J, Hu YF, Yang X, Russo IH. (2000). Developmental, cellular, and molecular basis of human breast cancer. J Natl Cancer Inst Monogr 27:17–37.
  • Russo A, Cardile V, Lombardo L, Vanella L, Acquaviva R. (2006). Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. J Nutr Biochem 17:103–108.
  • Russo J, Tahin Q, Lareef MH, Hu YF, Russo IH. (2002). Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens. Environ Mol Mutagen 39:254–263.
  • Russo J, Russo IH. (2006). The role of estrogen in the initiation of breast cancer. J Steroid Biochem Mol Biol 102:89–96.
  • Ryan-Borchers T, Chew B, Park JS, McGuire M, Fournier L, Beerman K. (2008). Effects of dietary and supplemental forms of isoflavones on thyroid function in healthy postmenopausal women. Clinical Nutrition 23:13–22.
  • Saarinen NM, Power K, Chen J, Thompson LU. (2006). Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int J Cancer 119:925–931.
  • Sakauchi F, Khan MM, Mori M, Kubo T, Fujino Y, Suzuki S, Tokudome S, Tamakoshi A. (2007). Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan. Nutr Cancer 57:138–145.
  • Salas AL, Ocampo G, Farina GG, Reyes-Esparza J, Rodriguez-Fragoso L. (2007). Genistein decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat. Ann Hepatol 6:41–47.
  • Salas AL, Montezuma TD, Farina GG, Reyes-Esparza J, Rodriguez-Fragoso L. (2008). Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats. Pharmacology 81:41–49.
  • Santell RC, Chang YC, Nair MG, Helferich WG. (1997). Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr 127:263–269.
  • Sartippour MR, Rao JY, Apple S, Wu D, Henning S, Wang H, Elashoff R, Rubio R, Heber D, Brooks MN. (2004). A pilot clinical study of short-term isoflavone supplements in breast cancer patients. Nutr Cancer 49:59–65.
  • Sasamura H, Takahashi A, Miyao N, Yanase M, Masumori N, Kitamura H, Itoh N, Tsukamoto T. (2002). Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma. Br J Cancer 86:768–773.
  • Sasamura H, Takahashi A, Yuan J, Kitamura H, Masumori N, Miyao N, Itoh N, Tsukamoto T. (2004). Antiproliferative and antiangiogenic activities of genistein in human renal cell carcinoma. Urology 64:389–393.
  • Schmidt F, Knobbe CB, Frank B, Wolburg H, Weller M. (2008). The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol Rep 19:1061–1066.
  • Schwartz AG, Prysak GM, Murphy V, Lonardo F, Pass H, Schwartz J, Brooks S. (2005). Nuclear estrogen receptor beta in lung cancer: Expression and survival differences by sex. Clin Cancer Res 11:7280–7287.
  • Schwartz AG, Wenzlaff AS, Prysak GM, Murphy V, Cote ML, Brooks SC, Skafar DF, Lonardo F. (2007). Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women. J Clin Oncol 25:5785–5792.
  • Seike N, Wanibuchi H, Morimura K, Wei M, Nishikawa T, Hirata K, Yoshikawa J, Fukushima S. (2003). Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat multiorgan carcinogenesis model. Cancer Lett 192:25–36.
  • Seow A, Poh WT, Teh M, Eng P, Wang YT, Tan WC, Chia KS, Yu MC, Lee HP. (2002). Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers. Int J Cancer 97:365–371.
  • Seow A, Koh WP, Wang R, Lee HP, Yu MC. (2009). Reproductive variables, soy intake, and lung cancer risk among nonsmoking women in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev 18:821–827.
  • Setchell KD, Gosselin SJ, Welsh MB, Johnston JO, Balistreri WF, Kramer LW, Dresser BL, Tarr MJ. (1987). Dietary estrogens–a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93:225–233.
  • Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. (1997). Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350:23–27.
  • Setchell KD. (1998). Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68:1333S–1346S.
  • Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. (1998). Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. Am J Clin Nutr 68:1453–S1461S
  • Setchell KD, Brown NM, Desai P, Zimmer-Nechemias L, Wolfe BE, Brashear WT, Kirschner AS, Cassidy A, Heubi JE. (2001). Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131:1362S–1375S.
  • Setchell KD, Brown NM, Lydeking-Olsen E. (2002). The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577–3584.
  • Setchell KD, Cole SJ. (2003). Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling. J Agric Food Chem 51:4146–4155.
  • Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, Wolfe BE, Brashear WT, Desai P, Oldfield MF, Botting NP, Cassidy A. (2003). Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr 77:411–419.
  • Setchell KD, Cole SJ. (2006). Method of defining equol-producer status and its frequency among vegetarians. J Nutr 136:2188–2193.
  • Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, Wolfe BE, Brashear WT, Desai P, Oldfield MF, Botting NP, Cassidy A. (2003). Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr 77:411–419.
  • Setchell KD, Gosselin SJ, Welsh MB, Johnston JO, Balistreri WF, Kramer LW, Dresser BL, Tarr MJ. (1987). Dietary estrogens—A probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93:225–233.
  • Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. (1997). Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350:23–27.
  • Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. (1998). Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. Am J Clin Nutr 68:1453S–1461S.
  • Sharp GB, Lagarde F, Mizuno T, Sauvaget C, Fukuhara T, Allen N, Suzuki G, Tokuoka S. (2005). Relationship of hepatocellular carcinoma to soya food consumption: A cohort-based, case-control study in Japan. Int J Cancer 115:290–295.
  • Shen F, Xue X, Weber G. (1999). Tamoxifen and genistein synergistically down-regulate signal transduction and proliferation in estrogen receptor-negative human breast carcinoma MDA-MB-435 cells. Anticancer Res 19:1657–1662.
  • Shimazu T, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S. (2010). Isoflavone intake and risk of lung cancer: A prospective cohort study in Japan. Am J Clin Nutr 91:722–728.
  • Shimizu H, Ross RK, Bernstein L. (1991). Possible underestimation of the incidence rate of prostate cancer in Japan. Jpn J Cancer Res 82:483–485.
  • Shinchi K, Ishii H, Imanishi K, Kono S. (1997). Relationship of cigarette smoking, alcohol use, and dietary habits with Helicobacter pylori infection in Japanese men. Scand J Gastroenterol 32:651–655.
  • Shu XO, Jin F, Dai Q, Wen W, Potter JD, Kushi LH, Ruan Z, Gao YT, Zheng W. (2001). Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 10:483–488.
  • Shu XO, Zheng Y, Cai H, Gu K, Chen Z, Zheng W, Lu W. (2009). Soy food intake and breast cancer survival. JAMA 302:2437–2443.
  • Siegelin MD, Gaiser T, Habel A, Siegelin Y. (2009a). Daidzein overcomes TRAIL-resistance in malignant glioma cells by modulating the expression of the intrinsic apoptotic inhibitor, bcl-2. Neurosci Lett 454:223–228.
  • Siegelin MD, Siegelin Y, Habel A, Gaiser T. (2009b). Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis. Neurosci Lett 453:92–97.
  • Simmen RC, Eason RR, Till SR, Chatman L, Jr., Velarde MC, Geng Y, Korourian S, Badger TM. (2005). Inhibition of NMU-induced mammary tumorigenesis by dietary soy. Cancer Lett 224:45–52.
  • Singh AV, Franke AA, Blackburn GL, Zhou JR. (2006). Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res 66:1851–1858.
  • Singh-Gupta V, Zhang H, Yunker CK, Ahmad Z, Zwier D, Sarkar FH, Hillman GG. (2010). Daidzein Effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: Potentiation of radiotherapy. Pharm Res 27:1115–1127.
  • Eisenbrand G.. (2007). Isoflavones as phytoestrogens in food supplements and dietary foods for special medical purposes. Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG)-(shortened version). Mol Nutr Food Res 51:1305–1312.
  • Slater M, Brown D, Husband A. (2002). In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor beta and E-cadherin expression but decrease transforming growth factor beta1. Prostate Cancer Prostatic Dis 5:16–21.
  • Smith HO, Kammerer-Doak DN, Barbo DM, Sarto GE. (1996). Hormone replacement therapy in the menopause: A pro opinion. CA Cancer J Clin 46:343–363.
  • Smith S, Sepkovic D, Bradlow HL, Auborn KJ. (2008). 3,3’-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells. J Nutr 138:2379–2385.
  • Snyder RD, Gillies PJ. (2002). Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. Environ Mol Mutagen 40:266–276.
  • Son HY, Nishikawa A, Ikeda T, Furukawa F, Hirose M. (2000a). Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Jpn J Cancer Res 91:966–972.
  • Son HY, Nishikawa A, Ikeda T, Nakamura H, Miyauchi M, Imazawa T, Furukawa F, Hirose M. (2000b). Lack of modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Jpn J Cancer Res 91:899–905.
  • Son HY, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M. (2001). Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet. Jpn J Cancer Res 92:103–108.
  • Sorensen IK, Kristiansen E, Mortensen A, Nicolaisen GM, Wijnands JA, van Kranen HJ, van Kreijl CF. (1998). The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse. Cancer Lett 130:217–225.
  • Sotoca AM, Ratman D, van der Saag P, Strom A, Gustafsson JA, Vervoort J, Rietjens IM, Murk AJ. (2008). Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERalpha/ERbeta ratio. J Steroid Biochem Mol Biol 112:171–178.
  • Spector D, Anthony M, Alexander D, Arab L. (2003). Soy consumption and colorectal cancer. Nutr Cancer 47:1–12.
  • Spector LG, Xie Y, Robison LL, Heerema NA, Hilden JM, Lange B, Felix CA, Davies SM, Slavin J, Potter JD, Blair CK, Reaman GH, Ross JA. (2005). Maternal diet and infant leukemia: The DNA topoisomerase II inhibitor hypothesis: A report from the children’s oncology group. Cancer Epidemiol Biomarkers Prev 14:651–655.
  • Stabile LP, Davis AL, Gubish CT, Hopkins TM, Luketich JD, Christie N, Finkelstein S, Siegfried JM. (2002). Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res 62:2141–2150.
  • Stabile LP, Lyker JS, Gubish CT, Zhang W, Grandis JR, Siegfried JM. (2005). Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects. Cancer Res 65:1459–1470.
  • Stahl S, Chun TY, Gray WG. (1998). Phytoestrogens act as estrogen agonists in an estrogen-responsive pituitary cell line. Toxicol Appl Pharmacol 152:41–48.
  • Strick R, Strissel PL, Borgers S, Smith SL, Rowley JD. (2000). Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci U S A 97:4790–4795.
  • Strom A, Hartman J, Foster JS, Kietz S, Wimalasena J, Gustafsson JA. (2004). Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A 101:1566–1571.
  • Su SJ, Yeh TM, Lei HY, Chow NH. (2000). The potential of soybean foods as a chemoprevention approach for human urinary tract cancer. Clin Cancer Res 6:230–236.
  • Su SJ, Chow NH, Kung ML, Hung TC, Chang KL. (2003). Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity. Nutr Cancer 45:113–123.
  • Su SJ, Yeh TM, Chuang WJ, Ho CL, Chang KL, Cheng HL, Liu HS, Cheng HL, Hsu PY, Chow NH. (2005). The novel targets for anti-angiogenesis of genistein on human cancer cells. Biochem Pharmacol 69:307–318.
  • Su SJ, Yeh TM, Lei HY, Chow NH. (2000). The potential of soybean foods as a chemoprevention approach for human urinary tract cancer. Clin Cancer Res 6:230–236.
  • Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, Hishida A. (2007). Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol 22:1443–1449.
  • Sun CL, Yuan JM, Arakawa K, Low SH, Lee HP, Yu MC. (2002). Dietary soy and increased risk of bladder cancer: The Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev 11:1674–1677.
  • Sun CL, Yuan JM, Wang XL, Gao YT, Ross RK, Yu MC. (2004). Dietary soy and increased risk of bladder cancer: A prospective cohort study of men in Shanghai, China. Int J Cancer 112:319–323.
  • Suzuki H, Ueda T, Ichikawa T, Ito H. (2003a). Androgen receptor involvement in the progression of prostate cancer. Endocr Relat Cancer 10:209–216.
  • Suzuki K, Nakazato H, Matsui H, Koike H, Okugi H, Kashiwagi B, Nishii M, Ohtake N, Nakata S, Ito K, Yamanaka H. (2003b). Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population. Cancer 98:1411–1416.
  • Suzuki T, Matsuo K, Tsunoda N, Hirose K, Hiraki A, Kawase T, Yamashita T, Iwata H, Tanaka H, Tajima K. (2008). Effect of soybean on breast cancer according to receptor status: A case-control study in Japan. Int J Cancer 123:1674–1680.
  • Takahashi Y, Hursting SD, Perkins SN, Wang TC, Wang TT. (2006). Genistein affects androgen-responsive genes through both androgen- and estrogen-induced signaling pathways. Mol Carcinog 45:18–25.
  • Takezaki T, Hirose K, Inoue M, Hamajima N, Kuroishi T, Nakamura S, Koshikawa T, Matsuura H, Tajima K. (1996). Risk factors of thyroid cancer among women in Tokai, Japan. J Epidemiol 6:140–147.
  • Tamura S, Bito T, Ichihashi M, Ueda M. (2003). Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells. Pigment Cell Res 16:470–476.
  • Tanaka T, Kohno H, Tanino M, Yanaida Y. (2002). Inhibitory effects of estrogenic compounds, 4-nonylphenol and genistein, on 7,12-dimethylbenz[a]anthracene-induced ovarian carcinogenesis in rats. Ecotoxicol Environ Saf 52:38–45.
  • Tatsuta M, Iishi H, Baba M, Yano H, Uehara H, Nakaizumi A. (1999). Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Int J Cancer 80:396–399.
  • Taylor CK, Levy RM, Elliott JC, Burnett BP. (2009). The effect of genistein aglycone on cancer and cancer risk: A review of in vitro, preclinical, and clinical studies. Nutr Rev 67:398–415.
  • Teas J, Braverman LE, Kurzer MS, Pino S, Hurley TG, Hebert JR. (2007). Seaweed and soy: Companion foods in Asian cuisine and their effects on thyroid function in American women. J Med Food 10:90–100.
  • Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. (2006). Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: A case-control study. BMC Cancer 6:148.
  • Tempfer CB, Froese G, Heinze G, Bentz EK, Hefler LA, Huber JC. (2009). Side effects of phytoestrogens: A meta-analysis of randomized trials. Am J Med 122:939–946.
  • Theodorescu D, Laderoute KR, Calaoagan JM, Guilding KM. (1998). Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression. Int J Cancer 78:775–782.
  • Thiagarajan DG, Bennink MR, Bourquin LD, Kavas FA. (1998). Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium. Am J Clin Nutr 68:1394S–1399S.
  • Thigpen JE, Locklear J, Haseman JK, Saunders H, Grant MF, Forsythe DB. (2001). Effects of the dietary phytoestrogens daidzein and genistein on the incidence of vulvar carcinomas in 129/J mice. Cancer Detect Prev 25:527–532.
  • Thomas T, Thomas TJ. (2001). Polyamines in cell growth and cell death: Molecular mechanisms and therapeutic applications. Cell Mol Life Sci 58:244–258.
  • Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N. (2006). Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 54:184–201.
  • Traganos F, Ardelt B, Halko N, Bruno S, Darzynkiewicz Z. (1992). Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 52:6200–6208.
  • Travis RC, Allen NE, Appleby PN, Spencer EA, Roddam AW, Key TJ. (2008). A prospective study of vegetarianism and isoflavone intake in relation to breast cancer risk in British women. Int J Cancer 122:705–710.
  • Travis RC, Spencer EA, Allen NE, Appleby PN, Roddam AW, Overvad K, Johnsen NF, Olsen A, Kaaks R, Linseisen J, Boeing H, Nothlings U, Bueno-de-Mesquita HB, Ros MM, Sacerdote C, Palli D, Tumino R, Berrino F, Trichopoulou A, Dilis V, Trichopoulos D, Chirlaque MD, Ardanaz E, Larranaga N, Gonzalez C, Suarez LR, Sanchez MJ, Bingham S, Khaw KT, Hallmans G, Stattin P, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ. (2009). Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 100:1817–1823.
  • Treeck O, Pfeiler G, Mitter D, Lattrich C, Piendl G, Ortmann O. (2007). Estrogen receptor {beta}1 exerts antitumoral effects on SK-OV-3 ovarian cancer cells. J Endocrinol 193:421–433.
  • Trichopoulos D, Adami HO, Ekbom A, Hsieh CC, Lagiou P. (2008). Early life events and conditions and breast cancer risk: From epidemiology to etiology. Int J Cancer 122:481–485.
  • Trock BJ, Hilakivi-Clarke L, Clarke R. (2006). Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst 98:459–471.
  • Trosko JE, Chang CC, Upham BL, Tai MH. (2004). Ignored hallmarks of carcinogenesis: Stem cells and cell-cell communication. Ann N Y Acad Sci 1028:192–201.
  • Trosko JE. (2006). From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. Ann N Y Acad Sci 1089:36–58.
  • Tsugane S, Kabuto M, Imai H, Gey F, Tei Y, Hanaoka T, Sugano K, Watanabe S. (1993). Helicobacter pylori, dietary factors, and atrophic gastritis in five Japanese populations with different gastric cancer mortality. Cancer Causes Control 4:297–305.
  • Tsugane S, Tei Y, Takahashi T, Watanabe S, Sugano K. (1994). Salty food intake and risk of Helicobacter pylori infection. Jpn J Cancer Res 85:474–478.
  • Tsugane S, Sasazuki S. (2007). Diet and the risk of gastric cancer: Review of epidemiological evidence. Gastric Cancer 10:75–83.
  • Ueda M, Niho N, Imai T, Shibutani M, Mitsumori K, Matsui T, Hirose M. (2003). Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats. Nutr Cancer 47:141–147.
  • Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ. (2001). Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345:784–789.
  • Uesugi T, Toda T, Okuhira T, Chen JT. (2003). Evidence of estrogenic effect by the three-month-intervention of isoflavone on vaginal maturation and bone metabolism in early postmenopausal women. Endocr J 50:613–619.
  • Umetani N, Mori T, Koyanagi K, Shinozaki M, Kim J, Giuliano AE, Hoon DS. (2005). Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer. Oncogene 24:4721–4727.
  • Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, Di Renzo GC. (2004). Endometrial effects of long-term treatment with phytoestrogens: A randomized, double-blind, placebo-controlled study. Fertil Steril 82:145–1458, quiz.
  • Ursin G, Sun CL, Koh WP, Khoo KS, Gao F, Wu AH, Yu MC. (2006). Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Nutr Cancer 56:128–135.
  • Utsunomiya H, Suzuki T, Harada N, Ito K, Matsuzaki S, Konno R, Sato S, Yajima A, Sasano H. (2000). Analysis of estrogen receptor alpha and beta in endometrial carcinomas: Correlation with ER beta and clinicopathologic findings in 45 cases. Int J Gynecol Pathol 19:335–341.
  • Valimaa H, Savolainen S, Soukka T, Silvoniemi P, Makela S, Kujari H, Gustafsson JA, Laine M. (2004). Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. J Endocrinol 180:55–62.
  • Verdrengh M, Collins LV, Bergin P, Tarkowski A. (2004). Phytoestrogen genistein as an anti-staphylococcal agent. Microbes Infect 6:86–92.
  • Verheus M, van Gils CH, Keinan-Boker L, Grace PB, Bingham SA, Peeters PH. (2007). Plasma phytoestrogens and subsequent breast cancer risk. J Clin Oncol 25:648–655.
  • Verheus M, van Gils CH, Kreijkamp-Kaspers S, Kok L, Peeters PH, Grobbee DE, van der Schouw YT. (2008). Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women. Cancer Epidemiol Biomarkers Prev 17:2632–2638.
  • Villa E. (2008). Role of estrogen in liver cancer. Womens Health (Lond Engl) 4:41–50.
  • Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Ando S, Maggiolini M. (2006). 17beta-Estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30. Mol Pharmacol 70:1414–1423.
  • Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lakins J, Lupu R. (2000). Expression and regulation of estrogen receptor beta in human breast tumors and cell lines. Oncol Rep 7:157–167.
  • Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Bosma A, Cats A, van Doorn J, Korse CM, Witteman BJ, van Leeuwen FE, van’t Veer LJ, Voskuil DW. (2008). No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 17:2585–2593.
  • Wada-Hiraike O, Imamov O, Hiraike H, Hultenby K, Schwend T, Omoto Y, Warner M, Gustafsson JA. (2006). Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci U S A 103:2959–2964.
  • Wakai K, Ohno Y, Genka K, Ohmine K, Kawamura T, Tamakoshi A, Lin Y, Nakayama T, Aoki K, Fukuma S. (1999). Risk modification in lung cancer by a dietary intake of preserved foods and soyfoods: Findings from a case-control study in Okinawa, Japan. Lung Cancer 25:147–159.
  • Wang YP, Han XY, Su W, Wang YL, Zhu YW, Sasaba T, Nakachi K, Hoshiyama Y, Tagashira Y. (1992). Esophageal cancer in Shanxi Province, People’s Republic of China: a case-control study in high and moderate risk areas. Cancer Causes Control 3:107–113.
  • Wang SY, Yang KW, Hsu YT, Chang CL, Yang YC. (2001). The differential inhibitory effects of genistein on the growth of cervical cancer cells in vitro. Neoplasma 48:227–233.
  • Wang HZ, Zhang Y, Xie LP, Yu XY, Zhang RQ. (2002a). Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells(1). J Nutr Biochem 13:421–426.
  • Wang J, Eltoum IE, Lamartiniere CA. (2002b). Dietary genistein suppresses chemically induced prostate cancer in Lobund-Wistar rats. Cancer Lett 186:11–18.
  • Wang X, Clubbs EA, Bomser JA. (2006a). Genistein modulates prostate epithelial cell proliferation via estrogen- and extracellular signal-regulated kinase-dependent pathways. J Nutr Biochem 17:204–210.
  • Wang Y, Raffoul JJ, Che M, Doerge DR, Joiner MC, Kucuk O, Sarkar FH, Hillman GG. (2006b). Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model. Radiat Res 166:73–80.
  • Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. (2006c). Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int J Cancer 118:1930–1936.
  • Wang J, Eltoum IE, Lamartiniere CA. (2007). Genistein chemoprevention of prostate cancer in TRAMP mice. J Carcinog 6:3.
  • Wang Z, Desmoulin S, Banerjee S, Kong D, Li Y, Deraniyagala RL, Abbruzzese J, Sarkar FH. (2008). Synergistic effects of multiple natural products in pancreatic cancer cells. Life Sci 83:293–300.
  • Wang J, Eltoum IE, Carpenter M, Lamartiniere CA. (2009). Genistein mechanisms and timing of prostate cancer chemoprevention in lobund-wistar rats. Asian Pac J Cancer Prev 10:143–150.
  • Ward MH, Pan WH, Cheng YJ, Li FH, Brinton LA, Chen CJ, Hsu MM, Chen IH, Levine PH, Yang CS, Hildesheim A. (2000). Dietary exposure to nitrite and nitrosamines and risk of nasopharyngeal carcinoma in Taiwan. Int J Cancer 86:603–609.
  • Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw KT, Bingham S. (2008a). Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study. Breast Cancer Res 10:R32.
  • Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw KT, Bingham S. (2008b). Lack of prospective associations between plasma and urinary phytoestrogens and risk of prostate or colorectal cancer in the European Prospective into Cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev 17:2891–2894.
  • Warri A, Saarinen NM, Makela S, Hilakivi-Clarke L. (2008). The role of early life genistein exposures in modifying breast cancer risk. Br J Cancer 98:1485–1493.
  • Watanabe H, Uesaka T, Kido S, Ishimura Y, Shiraki K, Kuramoto K, Hirata S, Shoji S, Katoh O, Fujimoto N. (1999). Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N’-nitro-N-nitrosoguanidine in rats. Oncol Rep 6:989–993.
  • Wei H, Bowen R, Zhang X, Lebwohl M. (1998). Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis 19:1509–1514.
  • Wei H, Saladi R, Lu Y, Wang Y, Palep SR, Moore J, Phelps R, Shyong E, Lebwohl MG. (2003). Isoflavone genistein: Photoprotection and clinical implications in dermatology. J Nutr 133:3811S–3819S.
  • Weinstein IB, Gattoni-Celli S, Kirschmeier P, Lambert M, Hsiao W, Backer J, Jeffrey A. (1984). Multistage carcinogenesis involves multiple genes and multiple mechanisms. J Cell Physiol Suppl 3:127–137.
  • Widyarini S, Spinks N, Husband AJ, Reeve VE. (2001). Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Photochem Photobiol 74:465–470.
  • Widyarini S, Husband AJ, Reeve VE. (2005). Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen. Photochem Photobiol 81:32–37.
  • Wijnhoven BP, Dinjens WN, Pignatelli M. (2000). E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg 87:992–1005.
  • Williams C, Edvardsson K, Lewandowski SA, Strom A, Gustafsson JA. (2008). A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells. Oncogene 27:1019–1032.
  • Wong MC, Portmann B, Sherwood R, Niemela O, Koivisto H, Parkkila S, Trick K, L’abbe MR, Wilson J, Dash PR, Srirajaskanthan R, Preedy VR, Wiseman H. (2007). The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver. Metabolism 56:865–875.
  • Wood CE, Register TC, Franke AA, Anthony MS, Cline JM. (2006). Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast. Cancer Res 66:1241–1249.
  • Wu AH, Yang D, Pike MC. (2000). A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders. Cancer Epidemiol Biomarkers Prev 9:1051–1058.
  • Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. (2002). Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 23:1491–1496.
  • Wu AH, Pike MC, Williams LD, Spicer D, Tseng CC, Churchwell MI, Doerge DR. (2007). Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer. J Clin Oncol 25:3024–3030.
  • Wu AH, Koh WP, Wang R, Lee HP, Yu MC. (2008a). Soy intake and breast cancer risk in Singapore Chinese Health Study. Br J Cancer 99:196–200.
  • Wu AH, Yu MC, Tseng CC, Pike MC. (2008b). Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98:9–14.
  • Wu-Williams AH, Dai XD, Blot W, Xu ZY, Sun XW, Xiao HP, Stone BJ, Yu SF, Feng YP, Ershow AG. (1990). Lung cancer among women in north-east China. Br J Cancer 62:982–987.
  • Wuttke W, Jarry H, Seidlova-Wuttke D. (2007). Isoflavones—Safe food additives or dangerous drugs? Ageing Res Rev 6:150–188.
  • Xia C, Meng Q, Cao Z, Shi X, Jiang BH. (2006). Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. J Cell Physiol 209:56–66.
  • Xu X, Duncan AM, Wangen KE, Kurzer MS. (2000). Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 9:781–786.
  • Xu WH, Zheng W, Xiang YB, Ruan ZX, Cheng JR, Dai Q, Gao YT, Shu XO. (2004). Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. BMJ 328:1285.
  • Xu WH, Dai Q, Xiang YB, Long JR, Ruan ZX, Cheng JR, Zheng W, Shu XO. (2007). Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer. Am J Epidemiol 166:1420–1430.
  • Xu WH, Zheng W, Cai Q, Cheng JR, Cai H, Xiang YB, Shu XO. (2008). The Asp(327)Asn polymorphism in the sex hormone-binding globulin gene modifies the association of soy food and tea intake with endometrial cancer risk. Nutr Cancer 60:736–743.
  • Yamasaki M, Fujita S, Ishiyama E, Mukai A, Madhyastha H, Sakakibara Y, Suiko M, Hatakeyama K, Nemoto T, Morishita K, Kataoka H, Tsubouchi H, Nishiyama K. (2007). Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo. Cancer Sci 98:1740–1746.
  • Yamazaki F, Okamoto H, Miyauchi-Hashimoto H, Matsumura Y, Itoh T, Tanaka K, Kunisada T, Horio T. (2004). XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesis. J Invest Dermatol 123:220–228.
  • Yan CH, Chen XG, Li Y, Han R. (1999). Effects of genistein, a soybean-derived isoflavone, on proliferation and differentiation of B16-BL6 mouse melanoma cells. J Asian Nat Prod Res 1:285–299.
  • Yan L, Spitznagel EL. (2009). Soy consumption and prostate cancer risk in men: A revisit of a meta-analysis. Am J Clin Nutr 89:1155–1163.
  • Yan L, Spitznagel EL, Bosland MC. (2010). Soy consumption and colorectal cancer risk in humans: A meta-analysis. Cancer Epidemiol Biomarkers Prev 19:148–158.
  • Yanagihara K, Ito A, Toge T, Numoto M. (1993). Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res 53:5815–5821.
  • Yang Y, Zhou ZT, Ge JP. (2006). Effect of genistein on DMBA-induced oral carcinogenesis in hamster. Carcinogenesis 27:578–583.
  • Yeh S, Miyamoto H, Shima H, Chang C. (1998). From estrogen to androgen receptor: A new pathway for sex hormones in prostate. Proc Natl Acad Sci U S A 95:5527–5532.
  • Yin F, Giuliano AE, Van Herle AJ. (1999). Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid 9:369–376.
  • Yu MC, Mo CC, Chong WX, Yeh FS, Henderson BE. (1988). Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China. Cancer Res 48:1954–1959.
  • Yu H, Rohan T. (2000). Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 92:1472–1489.
  • Yu MC, Yuan JM. (2004). Environmental factors and risk for hepatocellular carcinoma. Gastroenterology 127:S72–S78.
  • Yu Z, Li W, Liu F. (2004). Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215:159–166.
  • Zandvliet DW, Hanby AM, Austin CA, Marsh KL, Clark IB, Wright NA, Poulsom R. (1996). Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. Biochim Biophys Acta 1307:239–247.
  • Zhang Y, Song TT, Cunnick JE, Murphy PA, Hendrich S. (1999). Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. J Nutr 129:399–405.
  • Zhang Y, Hendrich S, Murphy PA. (2003). Glucuronides are the main isoflavone metabolites in women. J Nutr 133:399–404.
  • Zhang M, Xie X, Lee AH, Binns CW. (2004). Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china. Nutr Cancer 49:125–130.
  • Zeeb H, Blettner M. (1998). Adult leukaemia: What is the role of currently known risk factors? Radiat Environ Biophys 36:217–228.
  • Zhang C, Ho SC, Lin F, Cheng S, Fu J, Chen Y. (2010). Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status. Cancer Sci 101:501–507.
  • Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. (2003). Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 22:7600–7606.
  • Zhao C, Dahlman-Wright K, Gustafsson JA. (2008). Estrogen receptor beta: An overview and update. Nucl Recept Signal 6:e003.
  • Zhi H, Yamada Y, Hirose Y, Kato K, Sheng H, Zheng Q, Oyama T, Asano N, Kuno T, Hara A, Mori H. (2007). Effect of 2-(carboxyphenyl) retinamide and genistein on the formation of early lesions in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Asian Pac J Cancer Prev 8:33–38.
  • Zhou JR, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL, Clinton SK. (1998). Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res 58:5231–5238.
  • Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. (1999). Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 129:1628–1635.
  • Zhou JR, Yu L, Zhong Y, Blackburn GL. (2003). Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr 133:516–521.
  • Zhou JR, Yu L, Mai Z, Blackburn GL. (2004). Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer 108:8–14.
  • Zhou HB, Chen JM, Cai JT, Du Q, Wu CN. (2008). Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice. World J Gastroenterol 14:627–631.
  • Zhu Q, Meisinger J, Van Thiel DH, Zhang Y, Mobarhan S. (2002). Effects of soybean extract on morphology and survival of Caco-2, SW620, and HT-29 cells. Nutr Cancer 42:131–140.
  • Ziegler RG, Hoover RN, Pike MC, Hildesheim A, Nomura AM, West DW, Wu-Williams AH, Kolonel LN, Horn-Ross PL, Rosenthal JF, Hyer MB. (1993). Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 85:1819–1827.
  • Zielinski SL. (2005). Diversity in cancer rates, control programs matches diversity of European Union. J Natl Cancer Inst 97:1398–1399.
  • Zimmermann MB. (2009). Iodine deficiency. Endocr Rev 30:376–408.
  • Zou J, Sun Q, Akiba S, Yuan Y, Zha Y, Tao Z, Wei L, Sugahara T. (2000). A case-control study of nasopharyngeal carcinoma in the high background radiation areas of Yangjiang, China. J Radiat Res (Tokyo) 41 Suppl:53–62.
  • Zou H, Zhan S, Cao K. (2008). Apoptotic activity of genistein on human lung adenocarcinoma SPC-A-1 cells and preliminary exploration of its mechanisms using microarray. Biomed Pharmacother 62:583–589.
  • Zubik L, Meydani M. (2003). Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am J Clin Nutr 77:1459–1465.

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