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Research Article

The Concept of Critical Levels of Toxic Heavy Metals in Target Tissues

Pages 327-339 | Published online: 25 Sep 2008

References

  • U.S. National Academy of Sciences (1975) . Committee for the working conference on principles of protocols for evaluating chemicals in the environment. 1975. U.S. National Academy of Sciences, Washington, D.C.
  • Friberg L., Elinder C-G., Kjellström T., Nordberg G. F. Cadmium and Health: A Toxicological and Epidemiological Appraisal. CRC Press, Boca Raton, FL 1986
  • Kjellstrom T., Elinder C-G., Friberg L. Conceptual problems in establishing the critical concentration of cadmium in human kidney cortex. Environ. Res. 1984; 33: 284
  • Nordberg G. F. Factors influencing metabolism and toxicity of metals: a consensus report. Environ. Health Persp. 1978; 25: 3
  • Permanent Commission and International Association on Occupational Health. Effects and Dose-Response Relationships of Toxic Metals, G. F. Nordberg. Elsevier/North-Holland, Amsterdam 1976
  • Foulkes E. C. Factors determining target doses: extrapolation from a shifting basis. Hazard Assessment of Chemicals, J. Saxena. Hemisphere Publishing, New York 1989; Vol. 6: 31
  • Lehman L. D., Klaassen C. D. Dosage-dependent disposition of cadmium administered orally to rats. Toxicol. Appl. Pharmacol. 1986; 84: 159
  • Scheuhammer A. M. A dose-dependent deposition of cadmium into organs of Japanese quail following oral administration. Toxicol. Appl. Pharmacol. 1988; 95: 153
  • Tannenbaum A., Silverstone H., Koziol J. Tracer studies of the distribution and excretion of uranium in mice, rats and dogs. Toxicology of Uranium, A. Tannenbaum. McGraw-Hill, New York 1951; 128
  • Aungst B. J., Doke J. A., Fung H.-L. The effect of dose on the disposition of lead in rats after intravenous and oral administration. Toxicol. Appl. Pharmacol. 1981; 61: 48
  • Parizek J., Zahor Z. Effect of cadmium salt on testicular tissue. Nature 1956; 177: 1036
  • Gunn S. A., Gould T. C., Anderson W. A. D. Protective effect of thiol compounds against cadmium-induced vascular damage to testis. Proc. Soc. Exp. Biol. Med. 1966; 122: 1036
  • Friberg L. Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning. Acta Med. Scand. 1950; 138: 1, (Suppl. 240)
  • Kopp J. Cadmium and the cardiovascular system. Cadmium; Handbook of Experimental Pharmacology, E. C. Foulkes. Springer-Verlag, Berlin 1986; Vol. 80: 195
  • Jamall I. S., Smith J. C. The effect of dietary selenium on cadmium cardiotoxicity. Cadmium; Handbook of Experimental Pharmacology, E. C. Foulkes. Springer-Verlag, Berlin 1986; Vol. 80: 351
  • Kjellström T. Critical organs, critical concentrations, and whole body dose-response relationships. Cadmium and Health: A Toxicological and Epidemiological Appraisal, L. Friberg, C.-G. Elinder, T. Kjellström, G. F. Nordberg. CRC Press, Boca Raton, FL 1986; Vol. 2: 231
  • Bernard A., Lauwerys R. Effects of cadmium exposure in humans. Cadmium; Handbook of Experimental Pharmacology, E. C. Foulkes. Springer-Verlag, Berlin 1986; Vol. 80: 135
  • Foulkes E. C. Route, rate and nature of exposure as determinants of effects of heavy metals and other toxicants. Trace Substances in Environmental Health, D. D. Hemphill. University of Missouri, Columbia, MO 1986; Vol. 20: 154
  • Piscator M., Pettersson B. Chronic cadmium poisoning — diagnosis and prevention. Clinical Chemistry and Chemical Toxicology of Metals, S. S. Brown. Elsevier/North-Holland, Amsterdam 1977; 143
  • Chisolm J. J., Leahy N. B. Aminoaciduria in lead intoxication. J. Pediatr. 1962; 60: 1
  • Goyer R. A. Lead and the kidney. Curr. Top. Pathol. 1971; 55: 147
  • Dietrich K. N., Krafft K. M., Bornschein R. L., Hammond P. B., Berger O., Succop P. A., Bier M. Low level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics 1987; 80: 721
  • Foulkes E. C. Effects of heavy metals on renal aspartate transport and the nature of solute movement in kidney cortex slices. Biochim. Biophys. Acta 1971; 241: 815
  • Foulkes E. C. The critical level of cadmium in renal cortex: the concept and its limitations. Environ. Geochem. Health 1986; 8: 91
  • Nomiyama K., Nomiyama H. Tissue metallothionein in rabbits chronically exposed to cadmium, with special reference to the critical concentration of cadmium in the renal cortex. Biological Roles of Metallothionein, E. C. Foulkes. Elsevier/North-Holland, Amsterdam 1982; 47
  • Nomiyama K., Nomiyama H. Critical concentration of “unbound” cadmium in rabbit renal cortex. Experientia 1986; 42: 149
  • Maitani T., Saito Y., Suzuki K. Cadmium found in non-soluble fraction of kidney homogenate and its relation to renal dysfunction after cadmium-cysteine administration. Toxicology 1985; 37: 27
  • Kudo N., Yamashina S., Waku K. Protection against cadmium toxicity by zinc: decrease in the Cd-high molecular weight protein fraction in rat liver and kidney on Zn pretreatment. Toxicology 1986; 40: 267
  • Foulkes E. C., Blanck S. Acute cadmium uptake by rabbit kidneys: mechanism and effects. Toxicol. Appl. Pharmacol. 1990, in press
  • Gieske T. H., Foulkes E. C. Acute effects of cadmium on proximal tubular function in rabbits. Toxicol. Appl. Pharmacol. 1974; 27: 292
  • Wang X. P., Foulkes E. C. Specificity of acute effects of cadmium on renal function. Toxicology 1984; 30: 243
  • Linder G., Foulkes E. C. Kinetics of renal aspartate reabsorption and its inhibition by metals in the intact rat kidney. Environ. Res. 1985; 36: 241
  • Maitani T., Watahiki A., Suzuki K. Acute renal dysfunction by cadmium injected with cysteine in relation to renal critical concentration of cadmium. Arch. Toxicol. 1986; 58: 136
  • Jennings M. B., Reidenberg M. M. Adaptation to nephrotoxic chemicals. Proc. Soc. Exp. Biol. Med. 1988; 189: 338
  • Goyer R. A., Leonard D. L., Moore J. F., Rhyne B., Krigman M. R. Lead dosage and the role of the intranuclear inclusion body. Arch. Environ. Health. 1970; 20: 705
  • Nomiyama K., Nomiyama H. Factors modifying critical concentration and biological half-time of cadmium. Arch. Hig. Rada Tok-sikol 1979; 30: 191, (Suppl.)
  • Singhal R. K., Anderson M. E., Meister A. Glutathione, a first line of defense against cadmium toxicity. FASEB J. 1987; 1: 220
  • Lemberg R., Foulkes E. C. Reaction between catalase and hydrogen peroxide. Nature 1948; 161: 131
  • Nomiyama K., Foulkes E. C. Some effects of uranyl acetate on proximal tubular functions in rabbit kidney. Toxicol. Appl. Pharmacol. 1968; 13: 89
  • Cadmium; Handbook of Experimental Pharmacology, E. C. Foulkes. Springer-Verlag, Berlin 1986; Vol. 80
  • Kazantsis G., Flynn F. V., Spowage J. S., Trott D. G. Renal tubular malfunction and pulmonary emphysema in cadmium pigment workers. Q. J. Med. 1963; 32: 165
  • Axelsson B., Piscator M. Renal damage after prolonged exposure to Cd. An experimental study. Arch. Environ. Health 1966; 12: 360
  • Cain K., Griffiths B. L. Transfer of liver cadmium to the kidney after aflatoxin induced liver damage. Biochem. Pharmacol. 1980; 29: 1852
  • Dudley R. E., Gammal L. M., Klaassen C. D. Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol. Appl. Pharmacol. 1985; 77: 414
  • World Health Organization. Recommended health-based limits in occupational exposure to heavy metals. Report of a study group. WHO Tech. Rep. Ser. 1980; 647
  • Nomiyama K. Does a critical concentration of cadmium in human renal cortex exist. J. Toxicol. Environ. Health 1977; 3: 607
  • Kjellström T. Exposure and accumulation of cadmium in populations from Japan, the United States and Sweden. Environ. Health Persp. 1979; 28: 169
  • Nomiyama K., Nomiyama H., Taguchi T. Effects of environmental temperatures on the chronic toxicity of cadmium in mice. Kankyo Hoken Rep. 1977; 41: 29
  • Wormster U., Nir I. Effect of age on cadmium-induced metallothionein synthesis in the rat. Arch. Toxicol. 1988; 62: 392
  • Foulkes E. C. Absorption of cadmium. Cadmium; Handbook of Experimental Pharmacology, E. C. Foulkes. Springer-Verlag, Berlin 1986; Vol. 80: 75
  • Nomiyama K., Nomiyama H., Akahori F., Masaoka T. Cadmium health effects in monkeys with special reference to the critical concentration of cadmium in the renal cortex. Cadmium 81, Proc. 3rd Int. Cadmium Conf. Cadmium Council and International Lead and Zinc Research Organization, 1982; 151
  • McLellan J. S., Thomas B. J., Kremlin H. H., Harvey T. C. Cadmium — its in vivo detection in man. Phys. Med. Biol. 1975; 20: 88
  • Ellis K. J., Morgan W. D., Zanzi I., Yasamura S., Vartsky D., Cohn S. H. Critical concentrations of cadmium in human renal cortex: dose effect studies in cadmium smelter workers. J. Toxicol. Environ. Health 1981; 7: 691
  • Roels H., Lauwerys R., Dardenne A. N. The critical level of cadmium in human renal cortex: a reevaluation. Toxicol. Lett. 1983; 15: 357
  • Marquis J. K., Siek G. C. Sensitive populations and risk assessment in environmental policy making. Hazard Assessment of Chemicals, J. Saxena. Hemisphere Publishing, New York 1989; Vol. 6: 1
  • Lauwerys R., Roels H., Reguiers M., Buchet J. P., Bernard A., Goret A. Significance of cadmium concentration in blood and in urine in workers exposed to cadmium. Environ. Res. 1979; 20: 375
  • Yuile C. L. Animal experiments. Handbook of Experimental Pharmacology, H. C. Hodge. Springer-Verlag, Berlin 1973; Vol. 36: 165
  • Morrow P. E., Leach L. J., Smith F. A., Gelein R. M., Scott J. B., Beiter H. D., Amato F. J., Picano J. J., Yuile C. L., Consler T. G. Metabolic fate and evaluation of injury in rats and dogs following exposure to the hydrolysis products of uranium hexafluoride. U.S. Nuclear Regulatory Commission, Washington, D.C. 1982, NUREG/CR-2283
  • Diamond G. L., Gelein R. M., Morrow P. E., Panner B. J., Baggs R. B. Nephrotoxicity of uranyl fluoride and reversibility of renal injury in the rat. U.S. Nuclear Regulatory Commission, Washington, D.C. 1987, NUREG/CR-4951
  • Hursh J. B., Spoor N. L. Data on man. Handbook of Experimental Pharmacology, H. C. Hodge. Springer-Verlag, Berlin 1973; 197
  • Bowman F. J., Foulkes E. C. Effects of uranium on rabbit renal tubules. Toxicol. Appl. Pharmacol. 1970; 16: 391
  • Adams N., Spoor N. L. Kidney and bone retention functions in the human metabolism of uranium. Phys. Med. Biol. 1974; 19: 460
  • Durbin P. W. Metabolic models for uranium. Biokinetics and Analysis of Uranium in Man. U.S. Dept. of Energy, Richland, WA 1984, USUR-05, HEHF-47, Proc. Colloquium, Fl
  • Spoor N. L., Hursh J. N. Protection criteria. Handbook of Experimental Pharmacology, H. C. Hodge, J. N. Stannard, J. B. Hursh. Springer-Verlag, Berlin 1973; Vol. 36: 241
  • Leggett R. W. The behavior and chemical toxicity of uranium in the kidney: a reassessment. Health Physics, in press
  • Eidson A. F., Griffith W. C., Jr., Hahn F. F., Pickrell J. A. A model for scaling the results of uranium excretion rate studies in beagle dogs to man. Health Physics, in press
  • Burr W. W. Human experience and epidemiology. Biokinetics and Analysis of Uranium in Man. U.S. Dept. of Energy, Richland, WA 1984, USUR-05 HEHF-47, Proc. Colloquium, H1
  • Magos L. Factors affecting the uptake and retention of mercury by kidneys in rats. Mercury, Mercurials and Mercaptans, M. W. Miller, T. W. Clarkson. Charles C. Thomas, Springfield, IL 1973; 167
  • Hammond P. B., O'Flaherty E. J., Gartside P. S. The impact of air-lead on blood-lead in man — a critique of the recent literature. Food Cosmet. Toxicol. 1981; 19: 631
  • Rhagavan S. R. V., Culver B. D., Gonick H. C. Erythrocyte lead-binding protein after occupational exposure. II. Influence on lead inhibition of membrane Na,K-ATPase. J. Toxicol. Environ. Health 1981; 7: 561

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