199
Views
84
CrossRef citations to date
0
Altmetric
Research Article

Analytical Studies on Tobacco-Specific N-Nitrosamines in Tobacco and Tobacco Smoke

&
Pages 235-240 | Published online: 25 Sep 2008

References

  • Druckrey H., Preussmann R. Zur Eotstehung carcinogener Nitrosamine am Beispiel des Tabakrauchs. Naturwissenschaften 1962; 49: 498
  • Roe F. J. C., Boyland E., Gorrod J. W. The importance of looking for further carcinogens in tobacco smoke, and the possible role of nitrosoanabasine. Alkylierend wirkende Verbindungen. 1st Conf. on N-Nitroso Compounds and Lactones, HamburgGermany, 1963, 85
  • Boyland E., Roe F. J. C., Gorrod J. W. Induction of pulmonary tumors in mice by nitrosonomicotine, a possible constituent of tobacco smoke. Nature 1964; 202: 1136
  • Boyland E., Roe F. J. C., Gorrod J. W., Mitchley B. C. V. The carcinogenicity of nitrosoanabasine, a possible constituent of tobacco smoke. Br. J. Cancer 1964; 18: 265
  • Preussmann R., Daiber D., Hengy H. A sensitive colour reaction for nitrosamines on thin-layer chromatograms. Nature 1974; 201: 502
  • Neurath G., Pirmann B., Wichern H. Zur Frage der N-Nitrosoverbindungen im Tabakrauch. Beitr. Tabakforsch. 1964; 2: 311
  • Klus H., Kuhn H. Die Bestimmung des Nomikotinnitrosamins im Rauchkondensat nornikotinreicher Zigaretten. Fachliche Mitt. Oesterr. Tabakregie 1973; 14: 251
  • Hoffmann D., Hecht S. S., Ornaf R. M., Wynder E. L. N'-Nitrosonornicotine in tobacco. Science 1974; 186: 265
  • Hoffmann D., Rathkamp G., Liu Y. Y. Chemical studies on tobacco smoke. XXVI. On the isolation and identification of volatile and non-volatileN′-nitrosamines and hydrazines in cigarette smoke, inN-Nitroso Compounds in the Environment. IARC Sci. Publ. 1974; 9: 159, Bogovski, P., Walker, E. A., and Davis, W.
  • Klus H., Kuhn H. Reaktionschromatographischer Nachweis einiger N-Nitrosamine der Tabakalkaloide. J. Chromatogr. 1975; 109: 425
  • Klus H., Kuhn H. Untersuehungen über die nichtflüchtigen N-Nitrosamine der Tabakalkaloide. Fachliche Mitt. Oesterr. Tabakregie 1975; 16: 307
  • Hecht S. S., Ornaf R. M., Hoffmann D. Determination ofN′-nitrosonomicotine in tobacco by high speed liquid chromatography. Anal. Chem. 1975; 47: 2046
  • Bharadwaj V. P., Takayama S., Yamada T., Tanhnura S. N'-Nitrosonornicotine in Japanese tobacco products. Gann 1975; 66: 585
  • Munson J. W., Abdine H. Determination ofN′-nitrosonornicotine in tobacco by gas chromatography/mass spectroscopy. Anal. Lett. 1977; 10: 777
  • Castonguay A., Van Vunakis H. Radioimmunoassay of N'-nitrosonornicotine. Anal. Biochem. 1979; 95: 387
  • Hecht S. S., Chen C. B., Ornaf R. M., Hoffmann D. Chemical studies on tobacco smoke. LVI. Tobacco-specific nitrosamines: origins, carcinogemcity and metabolism, in Environmental Aspects of N-Nitroso Compounds, Walker, E. W., Castegnaro, M., Griciute, L., Lyle, R. E., and Davis, W., Eds. IARC Sci. Publ. 1978; 19: 395
  • Fine D. H., Rufeh F., Lieb D., Rounbehler D. P. Description of the thermal energy analyzer (TEA) for trace determination of volatile and non-volatile N-nitroso compounds. Anal. Chem. 1975; 47: 1188
  • Hoffmann D., Adams J. D., Brunnemann K. D., Hecht S. S. Assessment of tobacco-specific N-nitrosamines in tobacco products. Cancer Res. 1979; 39: 2505
  • Brunnemann K. D., Hoffmann D. Assessment of the carcinogenic N-nitrosodiethanolamine in tobacco products and tobacco smoke. Carcinogenesis 1981; 2: 1123
  • Adams J. D., Brunnemann K. D., Hoffmann D. Chemical studies on tobacco smoke. LXXV. Rapid method for the analysis of tobacco-specific N-nitrosamines by gas-liquid chromatography with a thermal energy analyzer. J. Chromatogr. 1983; 256: 347
  • Brunnemann K. D., Genoble L., Hoffmann D. Identification and analysis of a new tobacco-specific N-nitrosarnine, 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol. Carcinogenesis 1987; 8: 465
  • Djordjevic M. V., Brunnemann K. D., Hoffmann D. Identification and analysis of a nicotine-derivedN-nitrosamino acid and other nitrosamino acids in tobacco. Carcinogenesis 1989; 10: 1725
  • Hoffmann D., Rivenson A., Chung F.-L., Hecbt S. S. Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco Carcinogenesis. Crit. Rev. Toxicol. 1991; 21(4)305
  • Mirvish S. S., Wallcave L., Eagan M., Shubik P. Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds. Science 1972; 177: 65
  • Spiegelhalder B., Kubacki S. J., Fischer S. A method for the determination of tobacco-specific nitrosamines (TSNA), nitrate and nitrite in tobacco leaves and processed tobacco. Beitr. Tabakforsch. Int. 1989; 14: 135
  • Fischer S., Spiegelhalder B. Improved method for the determination of tobacco-specific nitrosamines (TSNA) in tobacco smoke. Beitr. Tabalrforsch. Int. 1990; 14: 145
  • National Research Council. The Health Effect of Nitrate, Nitrite, and N-Nitroso Compounds. Washington, DC 1981, chap. 7
  • Hoffmann D., Djordjevic M. V., Brunnemann K. D. New brands of oral snuff. Food Chem. Toxicol., in press
  • Fischer S., Spiegelhalder B., Preussmann R. Tobacco-specific nitrosamine in European and USA cigarettes. Arch. Geschwulstforsch. 1990; 60: 169
  • Fischer S., Spiegelhalder B., Eisenbarth J., Preussmann R. Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis 1990; 11: 723
  • Hoffmann D., Dong M., Hecht S. S. Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen, brief communication. JNCI 1977; 58: 1841
  • Roberts D. L. Natural tobacco flavor. Rec. Adv. Tobacco Sci. 1988; 14: 49

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.