The Pathogenesis of Organophosphate Polyneuropathy

References

• Johnson M. K. The delayed neuropathy caused by some organophosphorus esters: mechanism and challenge. Crit. Rev. Toxicol. 1975; 3: 289
   Google Scholar
• Johnson M. K. The target for initiation of delayed neurotoxicity by organophosphorus esters: biochemical studies and toxicological applications. Rev. Biochem. Toxicol. 1982; 4: 141
   Google Scholar
• Lotti M., Becker C. E., Aminoff M. J. Organophosphate polyneuropathy: pathogenesis and prevention. Neurology 1984; 34: 658
   PubMed Web of Science ®Google Scholar
• Richardson R. J. Neurotoxic esterase: normal and pathogenic roles. Cellular and Molecular Neurotoxicology, T. Narahashi. Raven Press, New York 1984; 285
   Google Scholar
• Johnson M. K. Receptor or enzyme: the puzzle of NTE and organophosphate-induced delayed polyneuropathy. Trends Pharmacol. Sci. 1987; 8: 174
   Web of Science ®Google Scholar
• Zech R., Chemnitius J. M. Neurotoxicant sensitive esterase. Enzymology and pathophysiology of organophosphorus ester-induced delayed neuropathy. Progr. Neurobiol. 1987; 29: 193
   PubMed Web of Science ®Google Scholar
• Carrington C. D. Prophylaxis and the mechanism for the initiation of organophosphorus compound-induced delayed neurotoxicity. Arch. Toxicol. 1989; 63: 165
   PubMed Web of Science ®Google Scholar
• Johnson M. K. Organophosphates and delayed neuropathy — is NTE alive and well. Toxicol. Appl. Pharmacol. 1990; 102: 385
   PubMed Web of Science ®Google Scholar
• Richardson R. J. Interactions of organophosphorus compounds with neurotoxic esterase. Organophosphates: Chemistry, Fate and Effects, J. E. Chambers, P. E. Levi. Academic Press, Orlando, in press
   Google Scholar
• Johnson M. K. Molecular events in delayed neuropathy: experimental aspects of neuropathy target esterase. Basic and Clinical Toxicology of Organophosphates and Carbamates, B. Ballantyne, T. C. Mars. Butterworth, London 1991; 90
   Google Scholar
• World Health Organization. Organophosphorus Insecticides: A General Introduction. Environmental Health Criteria, Geneva 1986; 63
   Google Scholar
• Abou-Donia M. B., Lapadula D. M. mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II. Annu. Rev. Pharmacol. Toxicol. 1990; 30: 405
   PubMed Web of Science ®Google Scholar
• Lotti M. Discerning selectivities of organophosphate induced delayed polyneuropathy: a proposed approach to understanding its pathogenesis. Comments Toxicol. 1990; 4: 3
   Google Scholar
• Lotti M. Biological monitoring for organophosphate-induced delayed polyneuropathy. Toxicol. Lett. 1986; 33: 167
   PubMed Web of Science ®Google Scholar
• Lotti M. Organophosphate-induced delayed polyneuropathy in humans: perspectives for biomonitoring. Trends Pharmacol. Sci. 1987; 8: 175
   Google Scholar
• Johnson M. K. Delayed neurotoxicity tests of organophosphorus esters: a proposed protocol integrating neuropathy target esterase (NTE) assays with behaviour and histopathology tests to obtain more information more quickly from fewer animals. Int. Conf. on Environmental Hazards of Agrochemicals in Developing Countries, AlexandriaEgypt, November 8 to 12, 1983, A. H. El-Sebae. Vol. 1: 474
   Google Scholar
• Johnson M. K. A benefit from mechanistic research in toxicology. Br. J. Ind. Med. 1987; 44: 217
   PubMedGoogle Scholar
• Cherniak M. G. Toxicological screening for organophosphorus-induced delayed neurotoxicity: complications in toxicity testing. Neurotoxicology 1988; 9: 249
   PubMedGoogle Scholar
• Lotti M. (1990) Scientific basis of risk assessment and biological monitoring for organophosphorus induced delayed polyneuropathy. Basic Science in Toxicology, Proceedings of the V International Congress of Toxicology. 1990, G. N. Volans, J. Sims, F. M. Sullivan, P. Turner. Taylor & Francis, London, 133
   Google Scholar
• Senanayake N., Karalliedde L. Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome. N. Engl. J. Med. 1987; 316: 761
   PubMed Web of Science ®Google Scholar
• Karademir M., Ertürk F., Koçak R. Two cases of organophosphate poisoning with development of intermediate syndrome. Hum. Exp. Toxicol. 1990; 9: 187
   PubMed Web of Science ®Google Scholar
• Wecker L., Laskowski M. B., Dettbarn W. D. Neuromuscular dysfunction induced by acetylcholinesterase inhibition. Fed. Proc. 1978; 37: 2818
   PubMedGoogle Scholar
• Lotti M., Moretto A., Zoppellari R., Dainese R., Rizzuto N., Barusco G. Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy. Arch. Toxicol. 1986; 59: 176
   PubMed Web of Science ®Google Scholar
• Wadia R. S., Shinde S. N., Vaidya S. Delayed neurotoxicity after an episode of poisoning with dichlorvos. Neurology (India) 1985; 33: 247
   Google Scholar
• Vasilescu C., Florescu A. Clinical and electrophysiological study of neuropathy after organophosphorus compounds poisoning. Arch. Toxicol. 1980; 43: 305
   PubMedGoogle Scholar
• Xintaras C., Burg J. R. Screening and prevention of human neurotoxic outbreaks: issues and problems. Experimental and Clinical Neurotoxicology, P. S. Spencer, H. H. Schaumburg. Williams & Wilkins, Baltimore 1980; 663
   Google Scholar
• Xintaras C., Burg J. R., Tanaka S., Lee S. T., Johnson B. L., Cottrili C. A., Bender J. Occupational exposure to leptophos and other chemicals. U.S. Department of Health and Welfare, National Institute of Occupational Safety and Health, Cincinnati 1978, U.S. DHEW NIOSH Publication No. 78–136
   Google Scholar
• Spencer P. S., Schaumburg H. H., Sabri M. I., Veronesi B. The enlarging view of hexacarbon neurotoxicity. Crit. Rev. Toxicol. 1980; 7: 279
   PubMed Web of Science ®Google Scholar
• Senanayake N., Johnson M. K. Acute polyneuropathy after poisoning by a new organophosphate insecticide. N. Engl. J. Med. 1982; 306: 155
   PubMed Web of Science ®Google Scholar
• Senanayake N. Polyneuropathy following insecticide poisoning: a clinical and electrophysiological study. Neurology 1985; 232: 203, (Suppl.)
   Google Scholar
• Lotti M. Unpublished results
   Google Scholar
• Flucke W., Machemer L. H. Personal communication
   Google Scholar
• Bertolazzi M., Caroldi S., Moretto A., Lotti M. Interaction of methamidophos with hen and human acetylcholinesterase and neuropathy target esterase. Arch. Toxicol. 1991; 65: 580
   PubMedGoogle Scholar
• Bidstrup P. L., Bonnel J. A., Beckett A. G. Paralysis following poisoning by a new organic phosphorus insecticide (mipafox). Br. Med. J. 1953; 1: 1068
   PubMed Web of Science ®Google Scholar
• Curtes J. P., Develay P., Hubert J. P. Late peripheral neuropathy due to an acute voluntary intoxication by organophosphorus compounds. Clin. Toxicol. 1981; 18: 1453
   PubMed Web of Science ®Google Scholar
• Lotti M., Ferrara S. D., Caroldi S., Sinigaglia F. Enzyme studies with human and hen autopsy tissue suggest omethoate does not cause delayed neuropathy in man. Arch. Toxicol. 1981; 48: 265
   PubMed Web of Science ®Google Scholar
• De Jager A. E. J., Van Weerden T. W., Houthhoff H. J., De Monchy J. G. R. Polyneuropathy after massive exposure to parathion. Neurology 1981; 31: 603
   PubMed Web of Science ®Google Scholar
• Lotti M., Becker C. E. Polyneuropathy and exposure to parathion. Neurology 1982; 32: 217
   PubMedGoogle Scholar
• Johnson M. K., Richardson R. J. Biochemical endpoints: neurotoxic esterase assay. Neurotoxicology 1983; 4: 311
   PubMedGoogle Scholar
• Johnson M. K. Check your paraoxon and parathion for neurotoxic impurities. Proc. Delayed Neurotoxicity Workship, J. M. Crammer, J. E. Hixson. IUTOX Press, Little Rock, AK 1984
   Google Scholar
• Inoue N., Fujishiro K., Mori K., Matsuoka M. Triorthocresyl phosphate poisoning. A review of human cases. J. UOEH 1988; 10: 433
   PubMedGoogle Scholar
• Smith M. I., Elvove E., Valaer P. J., Frazier W. H., Mallory E. E. Pharmacological and chemical studies of the cause of so called ginger paralysis. U. S. Public Health Rep. 1930; 45: 1703
   PubMedGoogle Scholar
• Smith H. V., Spalding J. M. K. Outbreak of paralysis in Marocco due to orthocresylphosphate poisoning. Lancet 1959; 2: 1019
   PubMed Web of Science ®Google Scholar
• Senanayake N., Jeyaratnam J. Toxic polyneuropathy due to gingili oil contaminated with tricresyl phosphate affecting adolescent girls in Sri Lanka. Lancet 1981; 1: 88
   PubMed Web of Science ®Google Scholar
• Johnson M. K. Delayed neurotoxicity — do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals. Acta Pharmacol. Toxicol. 1981; 49(Suppl. 5)87
   PubMedGoogle Scholar
• Shiraishi S., Inoue N., Murai Y., Onishi A., Noda S. Dipterex (trichlorfon) poisoning. Clinical and pathological studies in human and monkeys. J. UOEH 1983; 5: 125, (Suppl.)
   PubMedGoogle Scholar
• Vasilescu C., Alexianu M., Dan A. Delayed neuropathy after organophosphorus insecticide (Dipterex) poisoning: a clinical, electrophysiological and nerve biopsy study. J. Neurol. Neurosurg. Psychiatry 1984; 47: 543
   PubMed Web of Science ®Google Scholar
• Csik V., Motika A., Marosi G. Y. Delayed neuropathy after trichlorfon intoxication. J. Neurol. Neurosurg. Psychiatry 1986; 49: 222
   PubMedGoogle Scholar
• Jedrzejowska H., Rowińska-Marcińska K., Hoppe B. Neuropathy due to phytosol (agritox). Report of a case. Acta Neuropathol. 1980; 49: 163
   PubMed Web of Science ®Google Scholar
• Willems J. M. Poisoning by organophosphate insecticide: analysis of 53 human cases with regard to management and drug treatment. Acta Med. Milit. 1981; 134: 7
   Google Scholar
• Johnson M. K. Organophosphorus esters causing delayed neurotoxic effects. Mechanism of action and structure/activity studies. Arch. Toxicol. 1975; 34: 259
   PubMed Web of Science ®Google Scholar
• Capodicasa E., Scapellato M. L., Moretto A., Caroldi S., Lotti M. Chlorpyrifos-induced delayed polyneuropathy. Arch. Toxicol. 1991; 65: 150
   PubMed Web of Science ®Google Scholar
• Abou-Donla M. B., Makkawy H. A., Graham D. G. Coumaphos: delayed neurotoxic effect following dermal administration in hens. J. Toxicol. Environ. Health 1982; 10: 87
   PubMedGoogle Scholar
• Wilson B. W., Hooper M., Chow E., Higgins R. J., Knaak J. B. Antidotes and neuropathic potential of isofenphos. Bull. Environ. Contam. Toxicol. 1984; 33: 386
   PubMed Web of Science ®Google Scholar
• Johnson M. K., Vilanova E., Read D. J. Anomalous biochemical responses in tests of the delayed neuropathic potential of methamidophos (O,S-dimethyl phosphorothioamidate), its resolved isomers and of some higher O-alkyl homologues. Arch. Toxicol, in press
   Google Scholar
• Lock E. A., Johnson M. K. Delayed neuropathy and acute toxicity studies with pirimiphos-methyl in the hen. J. Appl. Toxicol. 1990; 10: 17
   PubMed Web of Science ®Google Scholar
• Ohkawa H., Oshita H., Miyamoto J. Comparison of inhibitory activity of various organophosphorus compounds against acetylcholinesterase and neurotoxic esterase of hens with respect to delayed neurotoxicity. Biochem. Pharmacol. 1980; 29: 2721
   PubMedGoogle Scholar
• El-Sebae A. H., Soliman S. A., Ahmed N. S., Curley A. Biochemical interaction of six OP delayed neurotoxicants with several neurotargets. J. Environ. Sci. Health 1981; B16(4)465
   Google Scholar
• Gordon J. J., Inns R. H., Johnson M. K., Leadbeater L., Maidment M. P., Upshall D. G., Cooper G. H., Rickard R. L. The delayed neuropathic effects of nerve agents and some other organophosphorus compounds. Arch. Toxicol. 1983; 52: 71
   PubMed Web of Science ®Google Scholar
• Johnson M. K., Willems J. L., De Bisschop H. C., Read D. J., Benschop H. P. High doses of soman protect against organo-phosphorus-induced delayed polyneuropathy but tabuon does not. Toxicol. Appl. Pharmacol. 1988; 92: 34
   PubMed Web of Science ®Google Scholar
• Wilson B. W., Henderson J. D., Chow E., Schreider J., Goldman M., Culbertson R., Dacre J. C. Toxicity of an acute dose agent VX and other organophosphorus esters in the chicken. J. Toxicol. Environ. Health 1988; 23: 103
   PubMed Web of Science ®Google Scholar
• Olajos E. J., Bergmann J., Weimer J. T., Wall H. Neurotoxicity assessment of O-ethyl-O′-(2-diisopropylaminoefhyl) methylphosphonite (QL) in hens. J. Appl. Toxicol. 1986; 6: 135
   PubMedGoogle Scholar
• Johnson M. K., Vilanova E., Read D. J. Biochemical and clinical tests of the delayed neuropathic potential of some O-alkyl O-dichlorophenyl phosphoroamidate analogues of methamidophos (O,S-dimethyl phosphorothioamidate). Toxicology 1989; 54: 89
   PubMedGoogle Scholar
• Moretto A., Lotti M., Spencer P. S. In vivo andin vitro regional differential sensitivity of neuropathy target esterase to Di-n-butyl-2,2 dichlorovinyl phosphate. Arch. Toxicol. 1989; 63: 469
   PubMedGoogle Scholar
• Metcalf R. L., Magnus Francis B., Metcalf R. A., Farage-Elawar M., Hansen L. G. Structure-activity relationships in the acute and delayed neurotoxicity of methyl- and ethylphosphonothionates. Pestic. Biochem. Physiol. 1988; 30: 46
   Google Scholar
• Soliman S. A. Delayed neuropathy in hen by the insecticide synergist O-n-propyl O-(2-propynyl) phenylphosphonate (NIA-16388) and other phenylphosphonate esters. J. Toxicol. Environ. Health 1982; 10: 907
   PubMed Web of Science ®Google Scholar
• Johnson M. K., Barnes J. M. Age and the sensitivity of chicks to the delayed neurotoxic effects on some organophosphorus compounds. Biochem. Pharmacol. 1970; 19: 3045
   PubMed Web of Science ®Google Scholar
• Sprague G. L., Sandvik L. L., Bickford A. A., Castles T. R. Evaluation of a sensitive grading system for assessing acute and subchronic delayed neurotoxicity in hens. Life Sci. 1980; 27: 2523
   PubMed Web of Science ®Google Scholar
• Roberts N. L., Fairley C., Phillips C. Screening, acute delayed and subchronic neurotoxicity studies in the hen: measurements and evaluations of clinical signs following administration of TOCP. Neurotoxicology 1983; 4: 263
   PubMedGoogle Scholar
• Lotti M., Caroldi S., Moretto A., Johnson M. K., Fish C. J., Gopinath C., Roberts N. L. Central-peripheral delayed neuropathy caused by diisopropyl phosphorofluoridate (DFP): segregation of peripheral nerve and spinal cord effects using biochemical, clinical and morphological criteria. Toxicol. Appl. Pharmacol. 1987; 88: 87
   PubMedGoogle Scholar
• Lotti M., Caroldi S., Capodicasa E., Moretto A. Promotion of organophosphate induced delayed polyneuropathy by phenylmethanesulfonyl fluoride. Toxicol. Appl. Pharmacol. 1991; 108: 234
   PubMed Web of Science ®Google Scholar
• Abou-Donia M. B., Jensen D. N., Lapadula D. M. Neurologic manifestations of tri-o-cresyl phosphate delayed neurotoxicity in cats. Neurobehav. Toxicol. Teraiol. 1983; 5: 431
   PubMedGoogle Scholar
• Experimental and Clinical Neurotoxicology, P. S. Spencer, H. H. Schaumburg. Williams & Wilkins, Baltimore 1980
   Google Scholar
• Bouldin T. W., Cavanagh J. B. Organophosphorusneuropathy. I. A teased-fiber study of the spatiotemporal spread of axonal degeneration. Am. J. Pathol. 1979; 94: 241
   PubMedGoogle Scholar
• Bouldin T. W., Cavanagh J. B. Organophosphorus neuropathy. II. A fine-structural study of the early stages of axonal degeneration. Am. J. Pathol. 1979; 94: 253
   PubMed Web of Science ®Google Scholar
• Cavanagh J. B. Peripheral neuropathy caused by toxic agents. Crit. Rev. Toxicol. 1973; 2: 365
   Google Scholar
• Prentice D. E., Roberts N. L. Acute delayed neurotoxicity in hens dosed with tri-ortho-cresyl phosphate (TOCP): correlation between clinical ataxia and neuropathological findings. Neurotoxicology 1983; 4: 271
   PubMedGoogle Scholar
• Bickford A. A., Sprague G. L. The significance of background neurologic lesions in acute delayed neurotoxicity studies: a comparison of neurohistopathologic lesions induced in commercial hens by tri-o-tolyl phosphate (TOCP) with those observed in negative control hens. Neurotoxicology 1983; 4: 283
   PubMedGoogle Scholar
• Itoh H., Kishida H., Tadokoro M., Oikawa K. Studies on the delayed neurotoxicity of organophosphorus compounds. II. J. Toxicol. Sci. 1984; 9: 37
   PubMedGoogle Scholar
• Itoh H., Kishida H., Takeuchi E., Tadokoro M., Uchikoshi T., Oikawa K. Studies on the delayed neurotoxicity of organophosphorus compounds. III. J. Toxicol. Sci. 1985; 10: 67
   PubMedGoogle Scholar
• Jortner B. S., Enrich M. Neuropathological effects of phenyl saligenin phosphate in chickens. Neurotoxicology 1987; 8: 303
   PubMedGoogle Scholar
• Tanaka D., Jr., Bursian S. J. Degeneration patterns in the chicken central nervous system induced by ingestion of the organophosphorus delayed neurotoxin tri-ortho-tolyl phosphate. A silver impregnation study. Brain Res. 1989; 484: 240
   PubMedGoogle Scholar
• Abou-Donia M. B., Graham D. G., Kinnes C. G. Sensitivity of the cat to delayed neurotoxicity induced by O-ethyl O-4-nitrophenyl phenylphosphonothioate. Toxicol. Appl. Pharmacol. 1983; 68: 54
   PubMedGoogle Scholar
• Abou-Donia M. B., Trofatter L. P., Graham D. G., Lapaduia D. M. Electromyographic., neuropathologic, and functional correlates in the cat as the result of tri-o-cresyl phosphate delayed neurotoxicity. Toxicol. Apppl. Pharmacol. 1986; 83: 126
   PubMedGoogle Scholar
• Veronesi B. A rodent model of organophosphorus-induced delayed neuropathy: distribution of central (spinal cord) and peripheral nerve damage. Neuropathol. Appl. Neurobiol. 1984; 10: 357
   PubMed Web of Science ®Google Scholar
• Lapaduia D. M., Patton S. E., Campbell G. A., Abou-Donia M. B. Characterization of delayed neurotoxicity in the mouse following chronic oral administration of tri-o-cresyl phosphate. Toxicol. Appl. Pharmacol. 1985; 79: 83
   PubMedGoogle Scholar
• Soliman S. A., Farmer J. D. Delayed neuropathy in adult peking ducks induced by some organophosphorus esters. J. Toxicol. Environ. Health 1984; 14: 789
   PubMed Web of Science ®Google Scholar
• Larsen C., Jortner B. S., Enrich M. Effect of neurotoxic organophosphorus compounds in turkeys. J. Toxicol. Environ. Health 1986; 17: 365
   PubMed Web of Science ®Google Scholar
• Stumpf A. M., Tanaka D., Jr., Aulerich R. J., Bursian S. J. Delayed neurotoxic effects of tri-o-tolyl phosphate in the european ferret. J. Toxicol. Environ. Health 1989; 26: 61
   PubMed Web of Science ®Google Scholar
• Soliman S. A., Svendsgaard D., Farmer J. D., Curley A., Durham W. F. Six-month daily treatment of sheep with neurotoxic organophosphorus compounds. Toxicol Appl. Pharmacol. 1983; 69: 417
   PubMedGoogle Scholar
• Durham H. D., Ecobichon D. J. The function of motor nerves innervating slow tonic skeletal muscle in hens with delayed neuropathy induced by tri-o-tolyl phosphate. Can. J. Physiol. Pharmacol. 1984; 62: 1268
   PubMed Web of Science ®Google Scholar
• Lowndes H. E., Baker T., Riker W. F., Jr. Motor nerve dysfunction in delayed DFP neuropathy. Eur. J. Pharmacol. 1974; 29: 66
   PubMed Web of Science ®Google Scholar
• Baker T., Lowndes H. E., Johnson M. K., Sandborg I. C. The effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy. Arch. Toxicol. 1980; 46: 305
   PubMed Web of Science ®Google Scholar
• Drakontides A. B., Baker T. An electrophysiologic and ultrastructural study of the phenylmethanesulfonyl fluoride protection against a delayed organophosphorus neuropathy. Toxicol. Appl. Pharmacol. 1983; 70: 411
   PubMedGoogle Scholar
• Shell L., Jortner B. S., Ehrich M. Assessment of organophosphorus-induced delayed neuropathy in chickens using needle electromyography. J. Toxicol. Environ. Health 1988; 24: 21
   Google Scholar
• Robertson D. G., Schwab B. W., Sills R. D., Richardson R. J., Anderson R. J. Electrophysiologic changes following treatment with organophosphorus-induced delayed neuropathy-producing agents in the adult hen. Toxicol. Appl. Pharmacol. 1987; 87: 420
   PubMed Web of Science ®Google Scholar
• Robertson D. G., Mattson A. M., Bestervelt L. L., Richardson R. J., Anderson R. J. Time course of electrophysiologic effects induced by Di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) in the adult hen. J. Toxicol. Environ. Health 1988; 23: 283
   PubMed Web of Science ®Google Scholar
• Baker T., Lowndes H. E. Muscle spindle function in organophosphorus neuropathy. Brain Res. 1980; 185: 77
   PubMedGoogle Scholar
• Le Quesne P. M. Clinical expression of neurotoxic injury and diagnostic use of electromyography. Environ. Health Perspect. 1978; 26: 89
   PubMedGoogle Scholar
• El-Fawal H. A. N., Jortner B. S., Eyre P., Ehrich M. The biventer cervicis nerve-muscle preparation of adult hens: effects of phenyl saligenin phosphate administration. Neurotoxicology 1988; 9: 625
   PubMedGoogle Scholar
• Aldridge W. N., Reiner E. Enzyme Inhibitors as Substrates. North Holland, Amsterdam 1972
   Google Scholar
• Johnson M. K. Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential. Arch. Toxicol. 1977; 37: 113
   PubMed Web of Science ®Google Scholar
• Soliman S. A., Curley A., El-Sebae A. K. A direct method to assay neurotoxic esterase activity. Toxicol. Lett. 1981; 9: 283
   PubMedGoogle Scholar
• Soliman S. A., Curley A. Assay of chicken brain neurotoxic esterase activity using leptophosoxon as the selective neurotoxic inhibitor. J. Anal. Toxicol. 1981; 5: 183
   PubMedGoogle Scholar
• Reinders J. H., Hansen L. G., Metcalf R. L. In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors. Toxicol. Lett. 1983; 17: 107
   PubMedGoogle Scholar
• Johnson M. K. Sensitivity and selectivity of compounds interacting with neuropathy target esterase. Further structure-activity studies. Biochem. Pharmacol. 1988; 37: 4095
   PubMed Web of Science ®Google Scholar
• Kayyali U. S., Moore T. B., Randall J. C., Richardson R. J. Neurotoxic esterase (NTE) assay: optimized conditions based on detergent-induced shifts in the phenol/4-aminoantipyrine chromophore spectrum. J. Anal Toxicol. 1991; 15: 86
   PubMed Web of Science ®Google Scholar
• Caroldi S., Lotti M. Neurotoxic esterase in peripheral nerve: assay, inhibition and rate of resynthesis. Toxicol. Appl Pharmacol. 1982; 62: 498
   PubMedGoogle Scholar
• Barril J. B., Vilanova E., Pellin M. C. Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration. Toxicology 1988; 49: 107
   PubMedGoogle Scholar
• Correll L., Ehrich M. A microassay method for neurotoxic esterase determinations. Fund. Appl. Toxicol. 1991; 16: 110
   PubMedGoogle Scholar
• Thomas T. C., Székács A., Rojas S., Hammock B. D., Wilson B. W., McNamee M. G. Characterization of neuropathy target esterase using trifluoromethyl ketones. Biochem. Pharmacol. 1990; 40: 2587
   PubMedGoogle Scholar
• Lotti M. Unpublished results
   Google Scholar
• Chemnitius J. M., Haselmeyer K. H., Zech R. Neurotoxic esterase. Identification of two isoenzymes in hen brain. Arch. Toxicol. 1983; 53: 235
   PubMedGoogle Scholar
• Carrington C. D., Abou-Donia M. B. Paraoxon reversibly inhibits neurotoxic esterase. Toxicol. Appl. Pharmacol. 1985; 79: 175
   PubMedGoogle Scholar
• Carrington C. D., Abou-Donia M. B. Kinetics of substrate hydrolysis and inhibition by mipafox of paraoxon-preinhibited hen brain esterase activity. Biochem. J. 1986; 236: 503
   PubMed Web of Science ®Google Scholar
• Richardson R. J., Davis C. S., Johnson M. K. Subcellular distribution of marker enzymes and of neurotoxic esterase in adult hen brain. J. Neurochem. 1979; 32: 607
   PubMed Web of Science ®Google Scholar
• Vilanova E., Barril J., Carrera V., Pellin M. C. Soluble and particulate forms of the organophosphorus neuropathy target esterase in hen sciatic nerve. J. Neurochem. 1990; 55: 1258
   PubMedGoogle Scholar
• Reiner E., Davis C. S., Schwab B. W., Schopfer L. M., Richardson R. J. Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain. Biochem. Pharmacol. 1987; 36: 3181
   PubMedGoogle Scholar
• De Jong L. P. A., Benschop H. P. Biochemical and toxicological implications of chirality in anticholinesterase organophosphates. Stereoselectivity of Pesticides. Biological and Chemical Problems, E. J. Aliëns, J. J. S. Van Rensen, W. Welling. Elsevier, Amsterdam 1988; 109
   Google Scholar
• Johnson M. K. The importance of chirality in influencing both acute and delayed neuropathic toxicity of organophosphorus esters. Toxicol. Environ. Chem. 1987; 14: 321
   Web of Science ®Google Scholar
• Johnson M. K., Read D. J., Yoshikawa H. The effect of steric factors on the interaction of some phenylphosphonates with acetylcholinesterase and neuropathy target esterase of hen brain. Pestic. Biochem. Physiol. 1986; 25: 133
   Google Scholar
• Lotti M., Moretto A., Traverso R. Serum “A”-esterases and organophosphates toxicity in man. Esterases Hydrolysing Organophosphorus Compounds, E. Reiner, W. N. Aldridge, F. C. G. Hoskin. Ellis Horwood, Chichester 1989; 193
   Google Scholar
• Johnson M. K., Read D. J., Benschop H. P. Interaction of the four stereo-isomers of soman (pinacolyl methylphosphonofluoridate) with acetylcholinesterase and neuropathy target esterase of hen brain. Biochem. Pharmacol. 1985; 34: 1945
   PubMedGoogle Scholar
• Johnson M. K., Read D. J. The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of steroisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase. in vivo, Toxicol. Appl. Pharmacol. 1987; 90: 103
   PubMedGoogle Scholar
• Pope C. N., Padilla S. Modulation of neurotoxic esterase activityin vitro by phospholipids. Toxicol. Appl. Phamacol. 1989; 97: 272
   PubMedGoogle Scholar
• Davis C. S., Richardson R. J. Neurotoxic esterase: characterization of the solubilized enzyme and the conditions for its solubilization from chicken brain microsomal membranes with ionic., switterionic., or nonionic detergents. Biochem. Pharmacol. 1987; 36: 1393
   PubMed Web of Science ®Google Scholar
• Williams D. G., Johnson M. K. Gel-electrophoretic identification of hen brain neurotoxic esterase, labelled with tritiated di-iso-propyl phosphorofluoridate. Biochem. J. 1981; 199: 323
   PubMedGoogle Scholar
• Williams D. G. Intramolecular group transferis a characteristic of neurotoxic esterase and is independent of the tissue source of the enzyme. Biochem. J. 1983; 209: 817
   PubMedGoogle Scholar
• Carrington C. D., Abou-Donia M. B. Characterization of [3H]-di-isopropyl phosphorofluoridate-binding proteins in hen brain. Biochem. J. 1985; 228: 537
   PubMedGoogle Scholar
• Pope C. N., Padilla S. Chromotographic characterization of neurotoxic esterase. Biochem. Pharmacol. 1989; 38: 181
   PubMed Web of Science ®Google Scholar
• Thomas T. C., Ishikawa Y., McNamee M. G., Wilson B. W. Correlation of neuropathy target esterase activity with specific tritiated di-isopropyl phosphorofluoridate-labelled proteins. Biochem. J. 1989; 257: 109
   PubMedGoogle Scholar
• Carrington C. D., Fluke D. J., Abou-Donia M. B. Target size of neurotoxic esterase and acetylcholinesterase as determined by radiation inactivation. Biochem. J. 1985; 231: 789
   PubMedGoogle Scholar
• Chemnitius J. M., Haselmeyer K. H., Zech R. Neurotoxic esterase: gel filtration and isoelectric focusing of carboxylesterases solubilized from hen brain. Life Sci. 1984; 34: 1119
   PubMedGoogle Scholar
• Rüffer-Turner M. E., Read D. E., Johnson M. K. Purification of neuropathy target esterase (NTE) from avian brain after prelabelling with [3H]-di-isopropyl phosphorofluoridate. J. Neurochem., in press
   Google Scholar
• Vilanova E., Johnson M. K., Vicedo J. L. Interaction of some unsubstiruted phosphoroamidate analogs of methamidophos (O,S-dimethyl phosphorothioamidate) with acetylcholinesterase and neuropathy target esterase of hen brain. Pestic. Biochem. Physiol. 1987; 28: 224
   Web of Science ®Google Scholar
• Pope C. N., Padilla S. Potentiation of organophosphorus-induced delayed neurotoxicity by phenylmethylsulfonyl fluoride. J. Toxicol. Environ. Health 1990; 31: 261
   PubMed Web of Science ®Google Scholar
• Peraica M., Capodicasa E., Scapellato M. L., Bertolazzi M., Moretto A., Lotti M. Organophosphate-induced delayed polyneuropathy (OPIDP) in chicks: induction, promotion and recovery. Toxicologist 1991; 11: 306
   Google Scholar
• Pope C. N., Chapman M., Arthun D., Tanaka D., Padilla S. Age sensitivity to organophosphorus-induced delayed nuerotoxicity (OPIDN): effects of phenylmethylsulfonylfluoride (PMSF). Toxicologist 1991; 11: 304
   Google Scholar
• Moretto A., Bertolazzi M., Capodicasa E., Peraica M., Richardson R. J., Scapellato M. L., Lotti M. Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. Arch. Toxicol., in press
   Google Scholar
• Johnson M. K. Personal communication
   Google Scholar
• Ray D. E., Johnson M. K. Evaluation of phenylmethanesulphonyl fluoride as a promoter of peripheral neuropathies in the rat. Hum. Exp. Toxicol., in press
   Google Scholar
• Moretto A., Lotti M., Sabri M. I., Spencer P. S. Progressive deficit of retrograde axonal transport is associated with the pathogenesis of Di-n-butyl dichlorvos axonopathy. J. Neurochem. 1987; 49: 1515
   PubMed Web of Science ®Google Scholar
• Lotti M., Johnson M. K. Neurotoxic esterase in human nervous tissue. J. Neurochem. 1980; 34: 747
   PubMed Web of Science ®Google Scholar
• Hollingsworth P. J., Dudek B. R., Smith C. B., Richardson R. J. Direct comparison of the distribution of neurotoxic esterase and acetylcholinesterase in rat and hen brain. Cholinesterases, M. Brzin, E. A. Barnard, D. Sket. Walter de Gruyter, Berlin 1984; 483
   Google Scholar
• Correll L., Ehrich M. Comparative sensitivities of avian neural esterases toin vitro inhibition of organophosphorus compounds. Toxicol. Lett. 1987; 36: 197
   PubMedGoogle Scholar
• Husain K., Mirza M. A., Matin M. A. Neurotoxic esterase activity in brain, spinal cord and platelets of certain birds and mammals. J. Appl. Toxicol. 1991; 11: 61
   PubMedGoogle Scholar
• Moretto A., Lotti M. Organ distribution of neuropathy target esterase in man. Biochem. Pharmacol. 1988; 37: 3041
   PubMed Web of Science ®Google Scholar
• Novak R., Padilla S. Anin vitro comparison of rat and chicken brain neurotoxic esterase. Fundam. Appl. Toxicol. 1986; 6: 464
   PubMedGoogle Scholar
• Meredith C., Johnson M. K. Species distribution of paraoxonresistant brain polypeptides radiolabelled with diisopropyl phosphorofluoridate ([3H]DiPF): electrophoretic assay for the aged polypeptide of [3H]DiPF-labelled neuropathy target esterase. J. Neurochem. 1989; 52: 1248
   PubMedGoogle Scholar
• Howland R. D., Lowndes H. E., Baker T., Richardson R. J. DFP mononeuropathy: evidence for a peripheral site of initiation. Brain Res. 1980; 184: 248
   PubMedGoogle Scholar
• Caroldi S., Lotti M., Masutti A. Intraarterial injection of diisopropyl fluorophosphate or phenylmethanesulphonyl fluoride produces unilateral neuropathy or protection, respectively, in hens. Biochem. Pharmacol. 1984; 33: 3213
   PubMedGoogle Scholar
• Pleasure D. E., Mishler K. C., Engel W. K. Axonal transport of protein in experimental neuropathies. Science 1969; 166: 524
   PubMed Web of Science ®Google Scholar
• James K. A. C., Austin L. The effect of DFP on axonal transport of protein in chicken sciatic nerve. Brain Res. 1970; 18: 192
   PubMedGoogle Scholar
• Bradley W. G., Williams M. H. Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies. Brain 1973; 96: 235
   PubMed Web of Science ®Google Scholar
• Reichert B. L., Abou-Donia M. B. Inhibition of fast axoplasmic transport by delayed neurotoxic organophosphorus esters: a possible mode of action. Mol. Pharmacol. 1980; 17: 56–60
   PubMed Web of Science ®Google Scholar
• Carrington C. D., Lapadula D. M., Abou-Donia M. B. Acceleration of anterograde axonal transport in cat sciatic nerve by diisopropyl phosphorofluoridate. Brain Res. 1989; 476: 179
   PubMed Web of Science ®Google Scholar
• Lotti M., Moretto A. The pathogenesis of organophosphate induced polyneuropathy. Hum. Toxicol. 1989; 8: 144
   Google Scholar
• Carrington C. D., Abou-Donia M. B. Axoplasmic transport and turnaround of neurotoxic esterase in hen sciatic nerve. J. Neurochem. 1985; 44: 616
   PubMed Web of Science ®Google Scholar
• Johnson M. K. The primary biochemical lesion leading to the delayed neurotoxic effects of some organophosphorus esters. J. Neurochem. 1974; 23: 785
   PubMed Web of Science ®Google Scholar
• Carrington C. D., Abou-Donia M. B. The correlation between the recovery rate of neurotoxic esterase activity and sensitivity to organophosphorus-induced delayed neurotoxicity. Toxicol. Appl. Pharmacol. 1984; 75: 350
   PubMed Web of Science ®Google Scholar
• Moretto A., Capodicasa E., Peraica M., Lotti M. Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicologica) studies in developing chicks. Biochem. Pharmacol. 1991; 41: 1497
   PubMed Web of Science ®Google Scholar
• Meredith C., Johnson M. K. Neuropathy target esterase: rates of turnoverin vivo following covalent inhibition with phenyl di-n-pentylphospinate. J. Neurochem. 1988; 51: 1097
   PubMed Web of Science ®Google Scholar
• Abou-Donia M. B., Lapadula D. M., Suwita E. Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity. Toxicology 1988; 49: 469
   PubMed Web of Science ®Google Scholar
• Suwita E., Lapadula D. M., Abou-Donia M. B. Calcium and calmodulin-enhancedin vitro phosphorylation of hen brain cold-stable microtubules and spinal cord neurofilament triplet proteins after a single dose of tri-o-cresyl phosphate. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 6174
   PubMedGoogle Scholar
• Patton S. E., Lapadula D. M., O'Callaghan J. P., Miller D. B., Abou-Donia M. B. Changes inin vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens. J. Neurochem. 1985; 45: 1567
   PubMed Web of Science ®Google Scholar
• Patton S. E., Lapadula D. M., Abou-Donia M. B. Relationship of tri-o-cresyl phosphate-induced delayed neurotoxicity to enhancement ofin vitro phosphorylation of hen brain and spinal cord proteins. J. Pharmacol. Exp. Ther. 1986; 239: 597
   PubMed Web of Science ®Google Scholar
• Kimmerle G., Löser K. Delayed neurotoxicity of organophosphorus compounds and copper concentration in the serum of hens. Environ. Qual. Safety 1974; 3: 173
   Google Scholar
• Lotti M., Caroldi S., Moretto A. Blood copper in organophosphate-induced delayed polyneuropathy. Toxicol. Lett. 1988; 41: 175
   PubMedGoogle Scholar
• Olajos E. J. Biochemical evaluation of organophosphorus-ester induced delayed neurotoxicity (OPIDN): the role of 2′,3′-cyclic nucleotide 3′-phosphohydrolase. Neurotoxicology 1987; 8: 211
   PubMedGoogle Scholar
• Hernandez A. F., Pla A., Villanueva E. Decreased phosphofructokinase activity during the development of triorthocresyl-phosphate-induced delayed neuropathy. Toxicol. Lett. 1989; 49: 35
   PubMedGoogle Scholar
• Hernandez A. F., Pla A., Villanueva E. Lack of inhibition of glycolytic enzymes by the neurotoxic organophosphorus compounds mipafox and methamidofos. Arch. Toxicol. 1988; 61: 330
   PubMedGoogle Scholar
• Somkuti S. G., Lapadula D. M., Chapin R. E., Lamb J. C., IV, Abou-Donia M. B. Testicular toxicity following oral administration of tri-o-cresyl phosphate (TOCP) in roosters. Toxicol. Lett. 1987; 37: 279
   PubMedGoogle Scholar
• Somkuti S. G., Lapadula D. M., Chapin R. E., Lamb J. C., IV, Abou-Donia M. B. Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats. Toxicol. Appl. Pharmacol. 1987; 89: 49
   PubMed Web of Science ®Google Scholar
• Somkuti S. G., Lapadula D. M., Chapin R. E., Lamb J. C., IV, Abou-Donia M. B. Time course of the tri-o-cresyl phosphate-induced testicular lesion in F-344 rats: enzymatic, hormonal and sperm parameter studies. Toxicol. Appl. Pharmacol. 1987; 89: 64
   PubMedGoogle Scholar
• Lotti M., Wei E. T., Spear R. C., Becker C. E. Neurotoxic esterase in rooster testis. Toxicol. Appl. Pharmacol. 1985; 11: 175
   Google Scholar
• Padilla S., Veronesi B. The relationship between neurological damage and neurotoxic esterase inhibition in rats acutely exposed to tri-ortho-cresyl phosphate. Toxicol. Appl. Pharmacol. 1985; 78: 78
   PubMed Web of Science ®Google Scholar
• Veronesi B., Padilla S. Phenylmethylsulfonyl fluoride protects rats from mipafox-induced delayed neuropathy. Toxicol. Appl. Pharmacol. 1985; 81: 258
   PubMed Web of Science ®Google Scholar
• Somkuti S. G., Tilson H. A., Brown H. R., Campbell G. A., Lapadula D. M., Abou-Donia M. B. Lack of delayed neurotoxic effect after tri-o-cresyl phosphate treatment in male Fischer 344 rats: biochemical, neurobehavioral and neuropathological studies. Fundam. Appl. Toxicol. 1988; 10: 199
   PubMedGoogle Scholar
• Lotti M., Johnson M. K. Repeated small doses of a neurotoxic organophosphate. Monitoring of neurotoxic esterase in brain and spinal cord. Arch. Toxicol. 1980; 45: 263
   PubMed Web of Science ®Google Scholar
• Veronesi B., Padilla S., Blackmon K., Pope C. Murine susceptibility to organophosphorus-induced delayed neuropathy (OPIDN). Toxicol. Appl. Phamracol. 1991; 107: 311
   PubMed Web of Science ®Google Scholar
• Averbook B. J., Anderson R. J. Electrophysiological changes associated with chronic administration of organophosphates. Arch. Toxicol. 1983; 52: 167
   PubMedGoogle Scholar
• Moretto A., Capodicasa E., Lotti M. Unpublished results
   Google Scholar
• Goldstein D. A., McGuigan M. A., Ripley B. D. Acute tricresylphosphate intoxication in childhood. Hum. Toxicol. 1988; 7: 179
   PubMedGoogle Scholar
• Senanayake N. Tri-cresyl phosphate neuropathy in Sri Lanka: a clinical and neurophysiological study with a three year follow up. J. Neurol. Neursurg. Psychiatry 1981; 44: 775
   PubMed Web of Science ®Google Scholar
• Lotti M. Unpublished results
   Google Scholar
• Reveley J. W., Sabourin T. D., Moore M. T., Goss L. B. Distribution of neurotoxic esterase activity in the brain of control and diisopropyl phosphorofluoridate-treated hens:in vivo andin vitro exposure. Toxicol. Lett. 1986; 31: 45
   PubMedGoogle Scholar
• Abou-Donia M. B., Hernandez Y. M., Ahmed N. S., Abou-Donia S. A. Distribution and metabolism of O-ehtyl O-4-nitrophenyl phenylphosphonothioate after a single oral dose in one-week old chicks. Arch. Toxicol. 1983; 54: 83
   PubMedGoogle Scholar
• Abou-Donia M. B. Toxicokinetics and metabolism of delayed neurotoxic organophosphorus esters. Neurotoxicology 1983; 4: 113
   PubMed Web of Science ®Google Scholar
• Abou-Donia M. B., Nomeir A. A. The role of pharmacokinetics and metabolism in species sensitivity to neurotoxic agents. Fundam. Appl. Toxicol. 1986; 6: 190
   PubMedGoogle Scholar
• Olson B. A., Bursian S. J. Effect of route of administration on the development of organophosphate-induced delayed neurotoxicity in 4-week-old chicks. J. Toxicol. Environ. Health 1988; 23: 499
   PubMed Web of Science ®Google Scholar
• Sheets L., Norton S. Peripheral nerve damage in chicks following treatment with organophosphorus compounds. in ovo, Toxicol. Appl. Pharmacol. 1985; 78: 412
   PubMedGoogle Scholar
• Sheets L., Norton S. Morphologic alterations in leg muscles of chicks treated with triorthocresyl phosphate. in ovo, Toxicol. Appl. Pharmacol. 1985; 79: 39
   PubMedGoogle Scholar
• Sheets L., Hassanein R. S., Norton S. Gait analysis of chicks following treatment with tri-ortho-cresyl phosphate. in ovo, J. Toxicol. Environ. Health 1987; 21: 445
   PubMed Web of Science ®Google Scholar
• Bursian S., Flaga C., Ringer R. The injection of the delayed neurotoxin tri-o-tolyl phosphate into embryonating chicken eggs and its effects on subsequent chick development. J. Toxicol. Environ. Health 1982; 10: 101
   PubMed Web of Science ®Google Scholar
• Farage-Elawar M., Magnus Francis B. Effects of fenthion, fenitrothion and desbromoleptophos on gait, acetylcholinesterase and neurotoxic esterase in young chicks afterin ovo exposure. Toxicology 1988; 49: 253
   PubMedGoogle Scholar
• Enrich M., Gross W. B. Modification of triorthotolyl phosphate toxicity in chickens by stress. Toxicol. Appl. Pharmacol. 1983; 70: 249
   PubMedGoogle Scholar
• Ehrich M., Gross W. B. Effect of supplemental corticosterone and social stress on organophosphorus-induced delayed neuropathy in chickens. Toxicol. Lett. 1986; 31: 9
   PubMed Web of Science ®Google Scholar
• Pellin M., Vicedo J. L., Vilanova E. Sensitivity to tri-o-cresylphosphate neurotoxicity onn-hexane exposed hens as a model of simultaneous hexacarbon solvent and organophosphorus occupational intoxication. Arch. Toxicol. 1987; 59: 311
   PubMedGoogle Scholar
• Pellin M. C., Vilanova E., Barril E. Low non-neuropathic tri-o-cresyl phosphate (TOCP) doses inhibit neuropathy target esterase near the neuropathic threshold inn-hexane pretreated hens. Toxicology 1988; 49: 99
   PubMedGoogle Scholar
• Kellner T. P., Henderson J. D., Higgins R. J., Wilson B. W. Atropine and DFP-induced delayed neurotoxicity. Neurotoxicology 1988; 9: 181
   PubMedGoogle Scholar
• Drakontides A. B., Baker T., Riker W. F., Jr. A morphological study of the effect of glucocorticoid treatment on delayed organophosphorus neuropathy. Neurotoxicology 1982; 3: 165
   PubMedGoogle Scholar
• Baker T., Drakontides A. B., Riker W. F., Jr. Prevention of the organophosphorus neuropathy by glucocorticoids. Exp. Neurol. 1982; 78: 397
   PubMed Web of Science ®Google Scholar
• Baker T., Stanec A. Methylprednisolone treatment of an organophosphorus-induced delayed neuropathy. Toxicol. Appl. Pharmacol. 1985; 79: 348
   PubMed Web of Science ®Google Scholar
• Ehrich M., Briles R. W., Briles W. E., Dunnington E. A., Martin A., Siegel P. B., Gross W. B. Neurotoxicity of triorthotolyl phosphate in chickens of different genotypes in the presence and absence of deoxycorticosterone. Poul. Sci. 1986; 65: 375
   PubMed Web of Science ®Google Scholar
• Ehrich M., Jortner B. S., Gross W. B. Absence of a protective effect of corticosterone on O,O-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens. Neurotoxicology 1985; 6: 87
   PubMed Web of Science ®Google Scholar
• Ehrich M., Jortner B. S., Gross W. B. Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens. Toxicol. Appl. Pharmacol. 1986; 83: 250
   PubMed Web of Science ®Google Scholar
• Ehrich M., Jortner B. S., Gross W. B. Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens. Toxicol. Appl. Pharmacol. 1988; 92: 214
   PubMed Web of Science ®Google Scholar
• El-Fawal H. A. N., Jortner B. S., Ehrich M. Effect of verapamil on organophosphorus-induced delayed neuropathy in hens. Toxicol. Appl. Pharmacol. 1989; 97: 500
   PubMed Web of Science ®Google Scholar
• El-Fawal H. A. N., Correll L., Gay L., Ehrich M. Protease activity in brain, nerve, and muscle of hens given neuropathy-inducing organophosphates and a calcium channel blocker. Toxicol. Appl. Pharmacol. 1990; 103: 133
   PubMed Web of Science ®Google Scholar
• Berry M. M., Trosko B. K., Tanaka D., Jr., Bursian S. J. The effect of a ganglioside mixture on the development of tri-o-tolyl phosphate-induced delayed neurotoxicity. Toxicologist 1986; 6: 219
   Google Scholar
• Moretto A., Lotti M. Effects of gangliosides on neuropathy target esterase. Toxicologist 1989; 9: 74
   Google Scholar
• Lotti M. Unpublished results
   Google Scholar
• Lotti M., Johnson M. K. Neurotoxicity of organophosphorus pesticides: predictions can be based onin vitro studies with hen and human enzymes. Arch. Toxicol. 1978; 41: 215
   PubMed Web of Science ®Google Scholar
• 1990 OECD Ad Hoc Meeting on Neurotoxicity Testing, Summary Report. 1990. U.S. Environmental Protection Agency, Eastern Research Group Inc., Arlington, MA September, 1990
   Google Scholar
• Dudek B. R., Richardson R. J. Evidence for the existence of neurotoxic esterase in neural and lymphatic tissue of the adult hen. Biochem. Pharmacol. 1982; 31: 1117
   PubMed Web of Science ®Google Scholar
• Bertoncin D., Russolo A., Caroldi S., Lotti M. Neuropathy target esterase in human lymphocytes. Arch. Environ. Health 1985; 40: 139
   PubMed Web of Science ®Google Scholar
• Maroni M., Bleecker M. L. Neuropathy target esterase in human lymphocytes and platelets. J. Appl. Toxicol. 1986; 6: 1
   PubMedGoogle Scholar
• Schwab B. W., Richardson R. J. Lymphocytic and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters. Toxicol. Appl. Pharmacol. 1986; 83: 1
   PubMed Web of Science ®Google Scholar
• Farage-Elawar M., Magnus-Francis B. The effect of three organophosphorus esters on brain and blood neurotoxic esterase and acetylcholinesterase. Pestic. Biochem. Physiol. 1988; 31: 175
   Google Scholar
• Lotti M. Neuropathy target esterase in blood lymphocytes. Monitoring the interaction of organophosphates with a primary target. Biological Monitoring for Pesticide Exposure: Measurement, Estimation, and Risk Reduction, R. G. M. Wang, C. A. Franklin, R. C. Honeycutt, J. C. Reinert. American Chemical Society Symposium Series No. 382, The Sheridan Press, Hanover, PA 1989; 117
   Google Scholar
• Lotti M., Becker C. E., Aminoff M. J., Woodrow J. E., Seiber J. N., Talcott R. E., Richardson R. J. Occupational exposure to the cotton defoliants DEF and Merphos. A rational approach to monitoring organophosphorus-induced delayed neurotoxicity. J. Occup. Med. 1983; 25: 517
   PubMedGoogle Scholar