Impact of Knockout Mice in Toxicology

References

• Mosmann T. R., Coffman R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol 1989; 7: 145
   PubMed Web of Science ®Google Scholar
• Grau G. E., Lambert P. H., Vassalli P., Piguet P. F. Tumor necrosis factor/cachectin as an effector of T cell-dependent immunopathology. Int. Rev. Exp. Pathol. 1993; 34: 159
   Google Scholar
• Takahashi T., Tanaka M., Inazawa J., Abe T., Suda T., Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int. Immunol 1994; 6(10)1567
   PubMed Web of Science ®Google Scholar
• Nagata S., Golstein P. The Fas death factor. Science 1995; 267(5203)1449
   PubMed Web of Science ®Google Scholar
• Nagata S. Fas and Fas ligand: a death factor and its receptor. Adv. Immunol 1994; 57(129)129
   Google Scholar
• Miyawaki S., Nakamura Y., Suzuka H., Koba M., Yasumizu R., Ikehara S., Shibata Y. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol 1994; 24(2)429
   Google Scholar
• Yeung R. S., Penninger J., Mak T. W. T-cell development and function in gene-knockout mice. Curr. Opin. Immunol 1994; 6(2)298
   Google Scholar
• Gu H., Marth J. D., Orban P. C., Mossmann H., Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting [see comments]. Science 1994; 265(5168)103
   PubMed Web of Science ®Google Scholar
• Schorle H., Holtschke T., Hunig T., Schimpl A., Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (London) 1991; 352(6336)621
   Google Scholar
• Kundig T. M., Schorle H., Bachmann M. F., Hengartner H., Zinkernagel R. M., Horak I. Immune responses in interleukin-2-deficient mice. Science 1993; 262(5136)1059
   Google Scholar
• Sadlack B., Merz H., Schorle H., Schimpl A., Feller A. C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene [see comments]. Cell 1993; 75(2)253
   PubMed Web of Science ®Google Scholar
• Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enterocolitis [see comments]. Cell 1993; 75(2)263
   PubMed Web of Science ®Google Scholar
• Strober W., Ehrhardt R. O. Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice [comment]. Cell 1993; 75(2)203
   Google Scholar
• DiSanto J. P., Muller W., Guy-Grand D., Fischer A., Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. U. S. A. 1995; 92(2)377
   Google Scholar
• Cao X., Shores E., Hu-Li J., Anver M., Keisail B. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2: 223
   PubMed Web of Science ®Google Scholar
• Suzuki H., Kundig T., Furionger C., Wakeham A., Taniguchi T., Page C., Mak T. Deregulated T cell activation and autoimmunity in mice lacking inteiieukin-2 receptor beta. Science 1995; 268: 1472
   PubMed Web of Science ®Google Scholar
• Kuhn R., Rajewsky K., Muller W. Generation and analysis of interleukin-4 deficient mice. Sci-ence 1991; 254(5032)707
   PubMed Web of Science ®Google Scholar
• Kopf M., Le-Gros G., Bachmann M., Lamers M. C., Bluethmann H., Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature I London) 1993; 362(6417)245
   PubMed Web of Science ®Google Scholar
• Vajdy M., Kosco V. M., Kopf M., Kohler G., Lycke N. Impaired mucosal immune responses in interleukin 4-targeted mice. J. Exp. Med. 1995; 181(1)41
   Google Scholar
• Suematsu S., Matsuda T., Aozasa K., Akira S., Nakano N., Ohno S., Miyazaki J., Yamamura K., Hirano T., Kishimoto T. Ig Gl plasmacy-tosis in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 1989; 86(19)7547
   PubMed Web of Science ®Google Scholar
• Hirota H., Yoshida K., Kishimoto T., Taga T. Continuous activation of gp 130. a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc. Nail. Acad. Sci. U. S. A. 1995; 92(11)4862
   PubMed Web of Science ®Google Scholar
• Ryffel B., Mihatsch M. J., Woerly G. Pathology induced by interleukin-6. Int. Rev. Exp. Pathol. 1993; 34: 79
   PubMedGoogle Scholar
• Ryffel B., Car B. D., Woerly G., Weber M., DiPadova F., Kammuller M., Klug S., Neubert R., Neubert D. Long-term interleukin-6 administration stimulates sustained thrombopoiesis and acute-phase protein synthesis in a small primate – the marmoset. Blood 1994; 83(8)2093
   Google Scholar
• Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethmann H., Kohler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (London) 1994; 368(6469)339
   PubMed Web of Science ®Google Scholar
• Fattori E., Cappelletti M., Costa P., Sellitto C., Cantoni L., Carelli M., Faggioni R., Fantuzzi G., Ghezzi P., Poli V. Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 1994; 180(4)1243
   Web of Science ®Google Scholar
• Ramsay A. J., Husband A. J., Ramshaw I. A., Bao S., Matthaei K. I., Koehler G., Kopf M. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 1994; 264(5158)561
   PubMed Web of Science ®Google Scholar
• Poli V., Balena R., Fattori E., Markatos A., Yamamoto M., Tanaka H., Ciliberto G., Rodan G. A., Costantini F. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. Embo. J. 1994; 13(5)1189
   PubMed Web of Science ®Google Scholar
• Tanaka T., Akira S., Yoshida K., Umemoto M., Yoneda Y., Shirafuji N., Fujiwara H., Suematsu S., Yoshida N., Kishimoto T. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 1995; 80(2)353
   Google Scholar
• Yoshida K., Taga T., Saito M., Suematsu S., Kumanogoh A., Tanaka T., Fujiwara H., Hirata M., Yamagami T., Nakahata T., Hirabayashi T., Yoneda Y., Tanaka K., Wang W. Z., Mori C., Shiota K., Yoshida N., Kishimoto T. Targeted disruption of gpl30, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. U. S. A. 1996; 93(1)407
   PubMedGoogle Scholar
• von Freeden Jeffry U., Vieira P., Lucian L. A., McNeil T., Burdach S. E., Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 1995; 181(4)1519
   Google Scholar
• Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84(12)4008
   PubMed Web of Science ®Google Scholar
• Brunda M. J. Interleukin-12. J. Leukoc. Biol. 1994; 55(2)280
   Google Scholar
• Leonard W. J., Noguchi M., Russell S. M., McBride O. W. The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c. Immunol Rev 1994; 138: 61
   PubMed Web of Science ®Google Scholar
• Hemmi S., Peghini P., Metzler M., Merlin G., Dembic Z., Aguet M. Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma. Proc. Natl. Acad. Sci. U. S. A. 1989; 86(24)9901
   Google Scholar
• Hemmi S., Bohni R., Stark G., Di-Marco F., Aguet M. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 1994; 76(5)803
   PubMed Web of Science ®Google Scholar
• Darnell J., Jr., Kerr I. M., Stark G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264(5164)1415
   PubMed Web of Science ®Google Scholar
• Dalton D. K., Pitts-Meek S., Keshav S., Figari I. S., Bradley A., Stewart T. A. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]. Science 1993; 259(5102)1739
   PubMed Web of Science ®Google Scholar
• Huang S., Hendriks W., Althage A., Hemmi S., Bluethmann H., Kamijo R., Vilcek J., Zinkernagel R. M., Aguet M. Immune response in mice that lack the interferon-gamma receptor [see comments]. Science 1993; 259(5102)1742
   PubMed Web of Science ®Google Scholar
• Muller U., Steinhoff U., Reis L. F., Hemmi S., Pavlovic J., Zinkernagel R. M., Aguet M. Functional role of type I and type II interferons in antiviral defense. Science 1994; 264(5167)1918
   PubMed Web of Science ®Google Scholar
• Dranoff G., Crawford A. D., Sadelain M., Ream B., Rashid A., Bronson R. T., Dickersin G. R., Bachurski C. J., Mark E. L., Whitsett J. A., et al. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 1994; 264(5159)713
   PubMed Web of Science ®Google Scholar
• Stanley E., Lieschke G. J., Grail D., Metcalf D., Hodgson G., Gall J. A., Maher D. W., Cebon J., Sinickas V., Dunn A. R. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. U. S. A. 1994; 91(12)5592
   PubMed Web of Science ®Google Scholar
• Lieschke G. J., Stanley E., Grail D., Hodgson G., Sinickas V., Gall J. A., Sinclair R. A., Dunn A. R. Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease. Blood 1994; 84(1)27
   Google Scholar
• Nishinakamura R., Nakayama N., Hirabazashi Y., Araai K., Miyajima A., Murray R. Mice deficient for the IL-3/GM-CSF/IL-5 beta-c receptor exhibit lung pathology and impaired immune response, while beta-IL-3 receptor deficient mice are normal. Immunity 1995; 2: 211
   PubMed Web of Science ®Google Scholar
• de-Sauvage F. J., Hass P. E., Spencer S. D., Malloy B. E., Gurney A. L., Spencer S. A., Darbonne W. C., Henzel W. J., Wong S. C., Kuang W. J., et al. Stimulation of megakaryocytopoiesis and throm-bopoiesis by the c-Mpl ligand [see comments]. Nature (London) 1994; 369(6481)533
   Google Scholar
• Gearing A. J., Beckett P., Christodoulou M., Churchill M., Clements J. M., Crimmin M., Davidson A. H., Drummond A. H., Galloway W. A., Gilbert R., et al. Matrix metalloproteinases and processing of pro-TNF-alpha. J. Leukocyte Biol 1995; 57(5)774
   Google Scholar
• Browning J. L., Ngam-Ek A., Lawton P., DeMarinis J., Tizard R., Chow E. P., Hession C., O'Brine-Greco B., Foley S. F., Ware C. F. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 1993; 72(6)847
   Google Scholar
• Crowe P. D., VanArsdale T. L., Walter B. N., Ware C. F., Hession C., Ehrenfels B., Browning J. L., Din W. S., Goodwin R. G., Smith C. A. A lymphotoxin-beta-specific receptor [see comments]. Science 1994; 264(5159)707
   Google Scholar
• Rothe J., Lesslauer W., Lotscher H., Lang Y., Koebel P., Kontgen F., Althage A., Zinkernagel R., Steinmetz M., Bluethmann H. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature (London) 1993; 364(6440)798
   PubMed Web of Science ®Google Scholar
• Pfeffer K., Matsuyama T., Kundig T. M., Wakeham A., Kishihara K., Shahinian A., Wiegmann K., Ohashi P. S., Kronke M., Mak T. W. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993; 73(3)457
   PubMed Web of Science ®Google Scholar
• Le Hir M., Bluethmann H., Kosco-Vilbois M. H., Muller M., di Padova F., Moore M., Ryffel B., Eugster H. P. Differentiation of follicular dendritic cells and full antibody responses require TNF receptor-1 signalling. J. Exp. Med. 1996, in press
   Google Scholar
• Erickson S. L., de Sauvage F. J., Kikly K., Carver-Moore K., Pitts-Meek S., Gillett N., Sheehan K. C., Schreiber R. D., Goeddel D. V., Moore M. W. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature (London) 1994; 372(6506)560
   Google Scholar
• De Togni P., Goellner J., Ruddle N. H., Streeter P. R., Fick A., Mariathasan S., Smith S. C., Carlson R., Shornick L. P., Strauss-Schoenberger J., et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin [see comments]. Science 1994; 264(5159)703
   Google Scholar
• Banks T. A., Rouse B. T., Kerley M. K., Blair P. J., Godfrey V. L., Kuklin N. K., Bouley D. M., Thomas J., Kanangat S., Mucenski M. L. Lymphotoxin-a deficient mice. J. Immunol 1995; 155: 1685
   PubMed Web of Science ®Google Scholar
• Matsumoto M., Nariathasan S., Hahm M. H., Peschon J. J., Chaplin D. D. Role of lymphotoxin and type I TNF receptor in the formation of germinal centers. Science 1996; 271: 1289
   PubMed Web of Science ®Google Scholar
• Eugster H. P., Muller M., Karrer U., Car B. D., Schnyder B., Eng V. M., Woerly G., Di Padova F., Aguet M., Zinkernagel R., Bluethmann H., Ryffel B. Multiple immune abormalities in TNF and LTa double deficient mice. It Immunol 1996; 8(1)23
   Google Scholar
• Muller M., Eugster H. P., Le Hir M., Shakhov A., Di Padova F., Maurer C., Quesniaux V. J. F., Ryffel B. Correction and transfer of immunodeficiency of TMF-LT deficiency by bone marrow transplantation. Mol. Med. 1996; 2: 247
   Google Scholar
• Renshaw B. R., Fanslow W. R., Armitage R. J., Campbell K. A., Liggitt D., Wright B., Davison B. L., Maliszewski C. R. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 1994; 180(5)1889
   PubMed Web of Science ®Google Scholar
• Castigli E., Alt F. W., Davidson L., Bottaro A., Mizoguchi E., Bhan A. K., Geha R. S. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. U. S. A. 1994; 91(25)12135
   Google Scholar
• Gordon J., Katira A., Holder M., MacDonald I., Pound J. Central role of CD40 and its ligand in B lymphocyte responses to T-dependent antigens. Cell. Mol. Biol. 1994; 1(1)1
   Google Scholar
• Takahashi T., Tanaka M., Brannan C. I., Jenkins N. A., Copeland N. G., Suda T., Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994; 76(6)969
   PubMed Web of Science ®Google Scholar
• Zheng H., Fletcher D., Kozak W., Hofmann K. J. J., Tocci M. J., Ploegh V. D. Resistance to fever induction and impaired acute-phase response in interieukin-lb-deficient mice. Immunity 1995; 3: 9
   PubMed Web of Science ®Google Scholar
• Kuida K., Lippke J., Ku G., Harding M., Livingston D., Su M. Altered cytokine export and apoptosis in mice deficient in interieukin-1 beta converting enzyme. Science 1995; 267: 2000
   PubMed Web of Science ®Google Scholar
• Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., McDowell J., Paskind M., Rodman L., Salfeld J., et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature 1L-1 beta and resistant to endotoxic shock. Celt 1995; 80(3)401
   PubMed Web of Science ®Google Scholar
• Kulkarni A. B., Karlsson S. Transforming growth factor-beta I knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am. J. Pathol. 1993; 143(1)3
   PubMed Web of Science ®Google Scholar
• Shull M. M., Ormsby I., Kier A. B., Pawlowski S., Diebold R. J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (London) 1992; 359(6397)693
   PubMed Web of Science ®Google Scholar
• Wei X., Charles I., Smith A., Ure J., Feng G. Altered immune response in mice lacking inducible nitric oxide synthase. Nature (London) 1995; 375: 408
   PubMed Web of Science ®Google Scholar
• J VlacMicking J., Nathan D., Horn D., Chartrain N., Fletscher D. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995; 81: 641
   Google Scholar
• Huang P. L., Dawson T. M., Bredt D. S., Snyder S. H., Fishman M. C. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993; 75(7)1273
   PubMed Web of Science ®Google Scholar
• Huang Z., Huang P. L., Panahian N., Dalkara T., Fishman M. C., Moskowitz M. A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994; 265(5180)1883
   PubMed Web of Science ®Google Scholar
• Stewart C. L., Kaspar P., Brunei L. J., Bhatt H., Gadi I., Kontgen F., Abbondanzo S. J. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor [see comments]. Nature (London) 1992; 359(6390)76
   PubMed Web of Science ®Google Scholar
• Escary J. L., Perreau J., Dumenil D., Ezine S., Brulet P. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature (London) 1993; 363(6427)361
   PubMedGoogle Scholar
• Springer T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76(2)301
   PubMed Web of Science ®Google Scholar
• Mayadas T. N., Johnson R. C., Rayburn H., Hynes R. O., Wagner D. D. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 1993; 74(3)541
   PubMed Web of Science ®Google Scholar
• Subramaniam M., Saffaripour S., Watson S., Mayadas T., Hynes R. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-Selectin-deficient mice. J. Exp. Med. 1995; 181: 2277
   PubMed Web of Science ®Google Scholar
• Tedder T., Steeber D., Pizcueta P. L-Selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. Exp. Med. 1995; 181: 2259
   PubMed Web of Science ®Google Scholar
• Cacalano G., Lee J., Kikly K., Ryan A. M., Pitts-Meek S., Hultgren B., Wood W. I., Moore M. W. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 1994; 265(5172)682
   PubMed Web of Science ®Google Scholar
• Xu H., Gonzalo J. A., St. Pierre Y., Williams I. R., Kupper T. S., Cotran R. S., Springer T. A., Gutierrez-Ramos J. C. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1 -deficient mice. J. Exp. Med. 1994; 180(1)95
   Google Scholar
• Billiard D., Qin L., Lorenzo I., Quinlin W., Doyle W. P-Selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J. Clin. Invest. 1995; 95: 1782
   Google Scholar
• Krege J., John S., Langenbach L., Hodgin J., Hagaman J., Bachman E. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature (London) 1995; 375: 146
   PubMed Web of Science ®Google Scholar
• Smit J. J., Schinkel A. H., Mol C. A., Majoor D., Mooi W. J., Jongsma A. P., Lincke C. R., Borst P. Tissue distribution of the human MDR3 P-glycoprotein [see comments]. Lab. Invest. 1994; 71(5)638
   Google Scholar
• Schinkel A. H., Smit J. J., van Tellingen O., Beijnen J. H., Wagenaar E., van Deemter L., Mol C. A., van der Valk M. A., Robanus-Maandag E. C., te Riele H. P., et al. Disruption of the mouse mdrl a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994; 77(4)491
   PubMed Web of Science ®Google Scholar
• Schmidt C., Bladt F., Goedecke S., Brinkmann V., Zschiesche W., Sharpe M., Gherardi E., Birchmeier C. Scatter factor/hepatocyte growth factor is essential for liver development. Nature (London) 1995; 373(6516)699
   Google Scholar
• Uehara Y., Minowa O., Mori C., Shiota K., Kuno J., Noda T., Kitamura N. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature (London) 1995; 373(6516)702
   PubMed Web of Science ®Google Scholar
• Tamemoto H., Kadowaki T., Tobe K., Yagi T., Sakura H., Hayakawa T., Terauchi Y., Ueki K., Kaburagi Y., Satoh S., et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 [see comments]. Nature (London) 1994; 372(6502)182
   PubMed Web of Science ®Google Scholar
• Araki E., Lipes M. A., Patti M. E., Bruning J. C., Haag B. R., Johnson R. S., Kahn C. R. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene [see comments]. Nature (London) 1994; 372(6502)186
   PubMed Web of Science ®Google Scholar
• Zhang S. H., Reddick R. L., Piedrahita J. A., Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258(5081)468
   PubMed Web of Science ®Google Scholar
• Ishibashi S., Brown M. S., Goldstein J. L., Gerard R. D., Hammer R. E., Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]. J. Clin. Invest. 1993; 92(2)883
   PubMed Web of Science ®Google Scholar
• Chen X. S., Sheller J. R., Johnson E. N., Funk C. D. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature (London) 1994; 372(6502)179
   Google Scholar
• Goulet J. L., Snouwaert J. N., Latour A. M., Coffman T. M., Koller B. H. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. Sci. U. S. A 1994; 91(26)12852
   PubMed Web of Science ®Google Scholar
• Morham S. G., Langenbach R., Loftin C. D., Tiano H. F., Vouloumanos N., Jennette J. C., Mahler J. F., Kluckman K. D., Ledford A., Lee C. A., et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83(3)473
   Google Scholar
• Langenbach R., Morham S. G., Tiano H. F., Loftin C. D., Ghanayem B. I., Chulada P. C., Mahler J. F., Lee C. A., Goulding E. H., Kluckman K. D., et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995; 83(3)483
   PubMed Web of Science ®Google Scholar
• Dinchuk J. E., Car B. D., Focht R. J., Johnston J. J., Jaffee B. D., Covington M. B., Contel N. R., Eng V. M., Collins R. J., Czerniak P. M., et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature (London) 1995; 378(6555)406
   PubMed Web of Science ®Google Scholar
• Grigoriadis A. E., Schellander K., Wang Z. Q., Wagner E. F. Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell. Biol. 1993; 122(3)685
   Google Scholar
• Wang Z. Q., Ovitt C., Grigoriadis A. E., Mohle-Steinlein U., Ruther U., Wagner E. F. Bone and haematopoietic defects in mice lacking c-fos. Nature (London) 1992; 360(6406)741
   PubMed Web of Science ®Google Scholar
• Veis D. J., Sorenson C. M., Shutter J. R., Korsmeyer S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993; 75(2)229
   PubMed Web of Science ®Google Scholar
• Donehower L. A., Harvey M., Slagle B. L., McArthur M. J., Montgomery C., Jr., Butel J. S., Bradley A. Mice deficient for p53 are develop-mentally normal but susceptible to spontaneous tumours. Nature (London) 1992; 356(6366)215
   PubMed Web of Science ®Google Scholar
• Kemp C. J., Donehower L. A., Bradley A., Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74(5)813
   Google Scholar
• Jacks T., Fazeli A., Schmitt E. M., Bronson R. T., Goodell M. A., Weinberg R. A. Effects of an Rb mutation in the mouse [see comments]. Nature (London) 1992; 359(6393)295
   PubMedGoogle Scholar
• Lee E. Y., Chang C. Y., Hu N., Wang Y. C., Lai C. C., Herrup K., Lee W. H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]. Nature (London) 1992; 359(6393)288
   PubMedGoogle Scholar
• Dombrowicz D., Flamand V., Brigman K. K., Koller B. H., Kinet J. P. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell 1993; 75(5)969
   PubMed Web of Science ®Google Scholar
• Takai T., Li M., Sylvestre D., Clynes R., Ravetch J. V. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 1994; 76(3)519
   PubMedGoogle Scholar
• Yu P., Kosco V. M., Richards M., Kohler G., Lamers M. C. Negative feedback regulation of IgE synthesis by murine CD23. Nature (London) 1994; 369(6483)753
   PubMed Web of Science ®Google Scholar
• Oettgen H. C., Martin T. R., Wynshaw-Boris A., Deng C., Drazen J. M., Leder P. Active anaphylaxis in IgE-deficient mice. Nature (London) 1994; 370(6488)367
   Google Scholar
• Tracey K. J., Cerami A. Tumor necrosis factor: apleiotropic cytokine and therapeutic target. Annu. Rev. Med 1994; 45: 491
   PubMed Web of Science ®Google Scholar
• Garcia I., Miyazaki Y., Araki K., Araki M., Lucas R., Grau G. E., Milon G., Belkaid Y., Montixi C., Lesslauer W., et al. Transgenic mice expressing high levels of soluble TNF-R1 fusion protein are protected from lethal septic shock and cerebral malaria, and are highly sensitive to Listeria monocytogenes and Leishmania major infections. Eur. J. Immunol 1995; 25(8)2401
   PubMed Web of Science ®Google Scholar
• Novogrodsky A., Vanichkin A., Patya M., Gazit A., Osherov N., Levitzki A. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 1994; 264(5163)1319
   Google Scholar
• Car B. D., Eng V. M., Schnyder B., Ozmen L., Huang S., Gallay P., Heumann D., Aguet M., Ryffel B. Interferon gamma receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 1994; 179(5)1437
   Google Scholar
• Baumann H., Gauldie J. The acute phase response. Immunol. Today 1994; 15(21)74
   Google Scholar
• Car B. D., Schnyder B., Aguet M., Ryffel B. Role of interferon gamma in interleukin 12 induced pathology. Am. J. Pathol. 1995, in press
   Google Scholar
• Eng V. M., Car B. D., Schnyder B., Lorenz M., Lugli S., Anderson T. A., Huang S., Aguet M., Ryffel B., Quesniaux V. F. The stimuatory effects of interleukin-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo. J. Exp. Med. 1995; 181(5)1893
   Google Scholar
• Fernandez-Salguero P., Pineau T., Hilbert D., McPhail T., Lee S. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 1995; 268: 722
   PubMed Web of Science ®Google Scholar
• Le Hir M., Su Q., Weber L., Woerly G., Granelli Piperno A., Ryffel B. In situ detection of cyclosporin A: evidence for nuclear localization of cyclosporine and cyclophilins. Lab. Invest. 1995; 73(5)727
   Google Scholar
• Ryffel B. Cyclosporin binding proteins. Identification, distribution, function and relation to FK binding proteins. Biochem. Pharmacol. 1993; 46(1)1
   Google Scholar
• Kopf M., personal communication
   Google Scholar
• Magram, et al, in preparation
   Google Scholar
• Grau G. E., et al, in preparation
   Google Scholar
• Bluthmann H., personal communication
   Google Scholar
• Labaud, et al, in preparation
   Google Scholar
• Weber L., Ryffel B., in preparation
   Google Scholar
• Gonzales, et al, in preparation
   Google Scholar