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Research Article

Toxic Effects of Griseofulvin: Disease Models, Mechanisms, and Risk Assessment

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Pages 495-537 | Published online: 25 Sep 2008

References

  • Adamson R. H., Sieber S. M. Carcinogenic potential of drugs. J. Environm. Pathol. Toxicol. Oncol. 1981, 3/4: 377–385
  • Adler I. D., Brewen J. G. Effects of chemicals on chromosome aberrations production in male and female germ cells, A. Hollaender, 1982; VII: 1–35, Chemical Mutagens—Principles and Methods for their Detection
  • Albertini S., Brunner M., Würgler F. Analysis of the six additional chemicals forin vitro analysis of the European economic communities (EEC) aneuploidy programme usingSaccharomyces Cervisiae D 61 M and thein vitro porcine brain tubulin assembly assay. Env. Molec. Mutagen. 1993; 21: 180–192
  • Amacher D. E., Zelljadt I. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to. Salmonella typhimurium, Carcinogenesis 1983; 4: 291–296
  • Anthony H. M., Kenny T. E. Drugs in the etiology of cancer. A retrospective study. Int. J. Epidem. 1982; 11: 336–344
  • Atkinson R. M., Bedford C., Child K. J. Effect of particle size on blood Griseofulvin levels in man. Nature 1962; 193: 588–589
  • Aujezdska A. Effect of Griseofulvin on mouse fetal skeleton. Cesk. Hyg. 1978; 23: 5–21
  • Axelson O. A review of porphyria and cancer and the missing link with human exposure to hexachlorbenzene. C. R. Morris, J. R. P. Cabral. Publ, Lyon 1985; 77: 585–589, Hexachlorbenzene: Proceedings of an International SymposiumIARC Sci.
  • Axelson O., Hardell L., Saracci R., Simontano L. Epidemiological studies in porphyrias. C. R. Morris, J. R. P. Cabral. Publ, Lyon 1985; 77: 593–594, Hexachlorbenzene: Proceedings of an International SymposiumIARC Sci.
  • Barich L. L., Schwan J., Barich D. Oral Griseofulvin: a cocarcinogenic agent to methylcholanthrene induced cutaneous tumors. Cancer Res. 1962; 22: 53–55
  • Barich L. L., Schwarz J., Barich D. J., Horowitz M. G. Toxic liver damage in mice after prolonged intake of elevated doses of Griseofulvin. Antibiot. Chemother. 1961; 11: 566–568
  • Barrett W., Bianchine J. R. The bioavailability of ultramicrosize Griseofulvin tablets in man. Curr. Ther. Res. 1975; 18: 501–509
  • Bedford C., Busfield D., Child K. J., McGregor I., Sutherland P., Tomich E. G. Studies on the biological disposition of Griseofulvin an oral antifungal agent. Arch. Dermatol. 1960; 81: 735–745
  • Benedict W. F., Murphree A. L., Banerjee A., Spina C. A., Sparkes M. C., Sparkes R. S. Patient with chromosome 13 deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science 1983; 219: 973–975
  • Bengtsson N. O., Hardell L. Porphyrias, porphyrins and hepatocellular cancer. Br. J. Cancer 1986; 54: 115–117
  • Bennett J. E. Antimicrobial agents. Goodman and Gilman's. The Pharmacological Basis of Therapeutics8th, A. Gilman, A. S. Nies, P. Taylor, 1990; 1173–1174, Macmillan
  • Berman A., Franklin R. L. Precipitation of acute intermittent porphyria by griseofulvin therapy. J. Am. Med. Assoc. 1965; 192: 1005–1007
  • Berman J., Brown A. Incidence of hepatoma in porphyria cutanea tarda. Rev. Czech. Med. 1962; 8: 290
  • Beukeveld G J., Walthers B. G., vanSaene J. J.M., deHaan T. H.I.J., Ruyter-Buitenhuis L. W. Patterns of porphyrin exceretion in feces as determined by liquid chromatography: reference values and the effect of flora suppression. Clin. Chem. 1987; 31: 2164–2170, van SaeneR.H.F.
  • Beukeveld G. J., In't Veld G., Havinga R., Groen A. K., Wolthers B. G., Kuipers F. Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport. J. Hepatol 1996; 24: 343–52
  • Blacow N. W. Drug information centres: a hospital pharmacist's view. Proc. R. Soc. Med. 1977; 70: 250–2
  • Borenfreund E., De Harven E., Garra L. Mallory body like abnormalities in carcinomas induced by cultured transformed liver cells. Hepatology 1981; 1: 408–415
  • Borenfreund E., Higgins P. J., Bendich A. In vitro - in vivo rat liver carcinogenesis: modifications in protein synthesis and ultrastructure. Ann. N. Y. Acad. Sci. 1980; 349: 352–357
  • Borenfreund E., Higgins P J., Steinglass M., Bendich A. Carcinogen induced abnormalities in rat liver cells and their modification by chemical agents. Canc. Res. 1979; 39: 800–807
  • Brady A. M., Lock E. A. Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. Arch-Toxicol 1992; 66: 175–181
  • Brossi A., Baumann M., Gerecke M., Kyburz E. Totalsynthese vonGriseofulvin. Helv. Chim. Acta 1960; 43: 1444–1447
  • Bursch W., Lauer B., Timmermann-Trosiener I., Barthel G., Schuppler J., Schulte-Hermann R. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984; 5: 453–458
  • Bursch W., Oberhammer F., Schulte-Hermann R. Cell death by apoptosis and its protective role against disease. Trends in Pharmacological Sciences 1992; 13: 245–251
  • Cabaral F., Sobel M. E., Gottesman M. M. CHO-mutants resistant to colchicine, colchicine, or griseofulvin have an altered beta-tubulin. Cell 1980; 20: 29–36
  • Cabral J. R.P., Shubik P., Mollner T., Raitano F. Carcinogenic activity of hexachlorobenzene. Nature 1977; 269: 510–511
  • Cadrin M., Kawahara H., Ohta, Katsuma Y., Marceau N., French S. W. Mallory bodies in hepatomas and hyperplastic nodules. In vivo and in vitro studies, D. E. Stevenson, J. A. Popp, J. M. Ward, R. M. McClain, T. J. Slaga, H. C. Pitot. Alan R. Liss, New York 1990; 231–248, Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons
  • Cantoni L., Di Padova C., Rovagnatl P., Ruggieri R., Dal Fiume D., Tritapepe R. Bile secretion and liver microsomal mixed function oxidase system in mice with griseofulvin-induced hepatic protoporphyria. Toxicology 1983; 27: 27–39
  • Carrano A. V., Thompson L. H. Sister chromatid exchange and gene mutation. Cytogenet-Cell-Genet 1982; 33: 57–61
  • Cavenee W. K., Dryja T. P., Phillips R. A., Benedict W. F., Goldbart R., Gallie B. L., Murphree A. L., Strong L. C., White R. L. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 1983; 305: 779–784
  • Cerutti P. A. Prooxidant states and tumor promotion. Science 1985; 227: 375–381
  • Chen H., Rupa D. S., Tomar R., Eastmond D. A. Chromosomal loss and breakage in mouse bone marrow and spleen cells exposed to benzenein vivo. Cancer-Res 1994; 54: 3533–9
  • Chiou W. L., Riegleman S. Absorption characteristics of solid dispersed and micronized griseofulvin in man. J. Pharm. Sci. 1971; 60(9)1376–1380
  • Chiprut R. O., Viteri A., Jamroz C., Dyck W. P. intrahepatic cholestasis after griseofulvin administration. Gastroenterology 1976; 70: 1141–43
  • Choi S. W., Han J. H., Lim K. T., Chung K. W., Sun H. S., Park D. H., Kim B. S., Seo E. J. Effect of ursodeoxycholic acid on experimental hepatic porphyria induced by griseofulvin. J. Kor. Med. Sci. 1991; 6: 146–156
  • Choy W. H., Ts'o P. O.P. Induction of heteroploidy in diploid cells using antimitotic agents. J. Cell Biol. 1981; 91, 383a
  • Cohen S. M., Ellwein L. B. Genetic errors, cell proliferation, and carcinogenesis. Cancer Research 1991; 51: 6493–6505
  • Cole S. P., Marks G. S. Ferrochelatase and N-alkylated porphyrins. Mol. Cell. Biochem. 1984; 64: 127–137
  • Cole S. P., Massey T. E., Marks G. S., Racz W. J. Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes. Can. J. Physiol. Pharmacol. 1981; 59: 1155–1158
  • Columbano A., Dessi S., Ledda Columbano G. M., Chiodino C., Coni P., Pani P., Rao K. N. HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth. Toxicol. Pathol 1987; 15: 43–50
  • Cortes J. M., Oliva H., Paradines F. J., Hernandez Guio. The pathology of the liver in porphyria cutanea tarda. Histopathology 1980; 4: 471–485
  • Cripps D. J. Porphyria: genetic and acquired. C. R. Morris. Publ, Lyon 1985; 77: 549–566, Hexachlorbenzene: Proceedings of an International Symposium. IARC Sci.
  • Cripps D J., Liem H. H., Muller-Eberhard U. Griseofulvin causing hyper-hemopexinemia and hepatic proliferation in mice: anin vivo andin vitro study. J. Inv. Dermatol. 1977; 68(2)82–87
  • Crossin K. L., Carney D. H. Evidence that micro-tubule depolymerisation early in the cell cycle is sufficient to initiate DNA-synthesis. Cell 1981; 23: 61–78
  • Cullen S. I., Catalano P. M. Griseofulvin - warfarin Antagonism. J. Am. Med. Assoc. 1967; 199: 150–151
  • Curry P. T., Reed R. N., Martino R. M., Kitchin R. M. Induction of sister chromatid exchangesin vivo in mice by the mycotoxins sterigmatocystin and griseofulvin. Mut. Res. 1984; 137: 111–115
  • Daya-Grosjean L., Sarasin A., Monier R. Effect of tumor promotion on soft agar growth in Swiss 3T3 cells infected with SV40 ts-A mutants. Carcinogenesis 1982; 3(7)833–835
  • De Brabander M., Aerts F., Van de Veire R., Borgers M. Evidence against interconversion of microtubules and filaments. Nature 1975; 253: 119–120
  • De Carli L. Griseofulvin. Mutat. Res. 1988; 195: 91–126
  • De Matteis F., Abritti G., Gibbs A. H. Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5–diethoxy-carbonyl-1,4-dihydrochollidine. Studies on rats and mice. Biochem. J. 1973; 134: 717–727
  • De Matteis F., Donnelly A. J., Runge W. J. The effect of prolonged administration of griseofulvin in mice with reference to sex differences. Cancer Res 1966; 26: 721–726
  • De Matteis F. Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-diethoxycarbonyl-1,4-dihydro-collidine and related drugs: evidence for two basically different mechanisms. Biochem. J. 1975; 146: 285–287
  • De Matteis F. Hypercholesterolaemia and liver enlargement in experimental hepatic porphyria. Biochem. J. 1966; 98: 230–250
  • De Matteis F. Disturbance of porphyrin metabolism caused by griseofulvin in mice. Brit. J. Dermatol. 1963; 75: 91–104
  • Dehner L. P., Krivit W. Griseofulvin therapy as a cause of lymphnode proliferation resembling malignant histiocytosis. Pediatric Res. 1977; 11: 470
  • Denk H., Eckersdorfer R. Colchicine induced Mallory body formation in the mouse. Lab. Invest. 1977; 36: 563
  • Denk H., Abdelfattah-Gad M., Eckerstorfer R., Talcott R. E. Microsomal mixed-function oxidase and activities of some related enzymes in hyper-plastic nodules induced by long-term griseofulvin administration in mouse liver. Canc. Res. 1980; 40: 2568–2573
  • Denk H., Eckerstorfer R., Gschnait F., Konrad K., Wolff K. Experimental induction of hepato-cellular hyalin (Mallory bodies) in mice by griseofulvin treatment. 1. Light microscopic observation. Lab-Invest 1976; 35: 377–82
  • Denk H., Franke W., Dragosics B., Zeiler I. Pathology of cytoskeleton of liver cells: Demonstration of Mallory bodies in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes. Hepatology 1981a; 1: 9–20
  • Denk H., Gschnait F., Wolff K. Hepatocellular hyalin (Mallory bodies) in long term griseofulvin treated mice: a new experimental model for the study of hyalin formation. Lab. Invest. 1975; 32: 773–776
  • Denk H., Kalt R., Abdelfattah-Gad M., Meyer U. A. Effect of griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neo-plastic nodules. Canc. Res. 1981b; 41: 1535–1538
  • Denk H., Krepler R., Lackinger E., Artlieb U., Franke W. W. Immunological and biochemical characterisation of the hepatin-related component of Malloy bodies: A pathological pattern of hepatocytic cytokeratins. Liver 1982; 2: 165–175
  • Diwan B. A., Henneman J. R., Rice J. M., Nims R. W. Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene in rats at doses that cause maximal induction of CYP2B. Carcinogenesis 1996; 17: 37–43
  • Ellwein L. B., Cohen S. H. The health risks of saccharin revisited. Crit. Rev. Toxicol. 1990; 20: 311–326
  • El Mofty M. M., Khudoley V. V. Induction of hepatocellular carcinomas in the egyptian toad(Bufo regularis) by an antifungal drug (Griseofulvin). Oncology 1993; 50: 267–269
  • Epe B., Harttig U., Stopper H., Metzler M. Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation. Environm. Health Perspect., 88: 123–7, 19972
  • Epstein S. S., Andrea J., Joshi S., Mantel N. Hepatocarcinogenicity of griseofulvin following parenteral administration to infant mice. Cancer Res. 1967; 27: 1900–1906
  • Epstein S. S., Arnold E., Andrea J., Bass W., Bishop Y. Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol. Appl. Pharmacol. 1972; 23: 288–325
  • Evans H J. Human lymphocytes for the analysis of chromosome aberrations in mutagen tests. Handbook of Mutagenicity Test Procedures.2nd ed., B. J. Kilbey, M. Legator, W. Nichols, C. Ramel. Elsevier, Amsterdam 1984; 405–428
  • Faccini J. M., Butler W. R., Friedmann J. C., Hess R., Reznik G. K., Ito N., Hayashi Y., Williams G. M. IFSTP guidelines for the design and interpretation of the chronic rodent carcinogenicity bioassay. Experimental and Toxicologic Pathology 1992; 44: 443–456
  • Farber E. Hepatocyte proliferation in stepwise development of experimental liver cell cancer. Digestive Diseases and Sciences 1991; 36: 973–978
  • Franke W. W., Denk H., Schmidt E., Osborn M., Weber K. Ultrastructural, biochemical, and immunological characterisation of Mallory bodies in livers of griseofulvin treated mice. Lab. Invest. 1979; 40: 207–220
  • French S. W., Irie T., Tazawa J., Benson N. C. Electron microscopic study of hepatoma and hyper-plastic nodules induced by griseofulvin in mice. Fed. Proc. 1984; 43: 3169
  • French S., Sim J., Franks K., Burbidge E., Denton T., Caldwell M. Alcoholic hepatitis. Alcohol and the Liver, M. Fisher, J. Rankin. Plenum Press, New York 1977; 261–268
  • Friedkin M., Rozengurt E. The role of cytoplasmic microtubules in the regulation of the activity of peptide growth factors. Adv. Enz. Regul. 1981; 19: 39–59
  • Fucic A., Garaj Vrhovac V., Skara M., Dimitrovic B. X-rays, microwaves and vinyl chloride monomer: their clastogenic and aneugenic activity, using the micronucleus assay on human lymphocytes. Mutat. Res 1992; 282: 265–71
  • Fujita J., Yoshida O., Sugawara K., Ito Y. Enhanced expression of Epstein-Barr virus early antigen by agents in a lately infected human lymphoblastoid cell line. Experientia 1985; 41: 372–373
  • Gebhart E. Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing. Hum-Genet 1981; 58: 235–54
  • Gerbracht U., Bursch W., Kraus P., Pub B., Reinacher M., Timmermann-Trosiener I., Schulte-Hermann R. Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis 1990; 11: 617–624
  • Goetz H., Reichberger M. Ergebnisse einer Fragebogenaktion bei 1670 Dermatologen der Bundesrepublik Deutschland uber Nebenwirkungen derGriseofulvintherapie. Hautartzt 1972; 23: 485–492
  • Goetz H. Side effects of griseofulvin therapy after 12 years experience. Arch. Dermatol. Forsch. 1972; 244: 391–395
  • Goodman and Gilman's. Eds. The Pharmacological Basis of Therapeutics9th ed, A. Goodman Gilman. Pergamon Press, New York, 1184, Taylor1995
  • Griesbach R J., Schnabelrauch L. S., Sink K. C. Griseofulvin-induced chromosome instability and reduction in aPetunia somatic hybrid. Journal of the American Society for Horticultural Science 1983; 108: 714–716
  • Grisham L., Wilson L., Bensch K. Antimitotic action of griseofulvin does not involve disruption of microtubules. Nature 1973; 244: 294–296
  • Groden J., Thliveris A., Samowitz W., Carlson M., Gelbert L., Albertsen H., Joslyn G., Stevens J., Spirio L., Robertson M. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991; 66: 589–600
  • Grove J. F. Griseofulvin. Q. Rev. Chem. Soc. 1963; 17: 1–19
  • Gschnait F., Konrad K., Hönigsmann H., Denk H., Wolff K. Mouse model for protoporphyria. 1. The liver and hepatic protoporphyrin crystals. J. Invest. Dermatol. 1975; 65: 290–299
  • Gudi R., Ritter A. P., Putman D. L. Griseofulvin induced cell division abnormalities in Syrian hamster embryo cells. Environ. Mol. Mutagen. 1996; 27(27)26, Suppl. (abstract
  • Gupta R. S. Griseofulvin resistance mutation of Chinese hamster ovary cells that affects the apparent molecular weight of a 200 000 Dalton protein. Mol. Cell Biol. 1984; 4: 1761–1768
  • Hägermark Ö., Berlin A., Walin I., Boreus L. O. Plasma concentration of griseofulvin in healthy volunteers and patients treated for oxychomycosis. Acta Dermatovener. 1976; 56: 289–296
  • Hard G. C., Whyser J. Risk assessment of D-limonene: An example of male rat specific renal tumorigenesis. Crit. Rev. Toxicol. 1999; 24: 231–254
  • Hardell L. Aspects of primary liver cancer and its relation to porphyria cutanea trada and porphyria cutanea intermittens. C. R. Moms, J. R.P. Cabral. Publ, Lyon 1985; 77: 591–592, Hexuchlorbenzene: Proceedings of an International SymposiumARC Sci
  • Hazan R., Denk H., Lackinger E., Schiller D. L. Change of cytokeratin organization during development of Mallory bodies as revealed by a monoclonal antibody. Lab-Invest 1986; 54: 543–53
  • Heddle J. A., Hite M., Kirkhart B., Mavournin K., MacGregor J. T., Newell G. W., Salamone M. F. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 1983; 123: 61–118
  • Hendrich S., Glauert H. P., Pitot H. C. The phenotypic stability of altered hepatic foci: effects of withdrawal and subsequent readministration of phenobarbital. Carcinogenesis 1986; 7: 2041–2045
  • Hill R. N., Erdreich L. S., Paynter O. E., Roberts P. A., Rosenthal S. L., Wilkinson C. F. Thyroid follicular cell carcinogenesis. Fundam-Appl-Toxicol 1989; 12: 629–97
  • Hisia Y., Oshima M., Kitahori Y., Yuasa T., Fujita T., Iwata C. Promoting effects of 3-amino-1,2,4-triazole on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyI)nitrosamine. Carcinogenesis 1982; 3: 381–384
  • Holley A. E., Frater Y., Gibbs A. H., De Matteis F., Lamb J. H., Farmer P. B., Naylor S. Isolation of two N-monosubstituted protoporphyrins, bearing either the whole drug or a methyl group on the pyrrole nitrogen atom, from liver of mice given griseofulvin. Biochem-J 1991; 274: 843–848
  • Hoover R., Fraumeni J. F. Drug induced cancer. Cancer 1981; 47(5)1071–1080
  • Horng C. B., Bruce S. A., Ts'o P. O. A comparative study on neoplastic transformation of human and Syrian hamster cells. Proc. Natl. Sci. Counc. Rep. China 1985; 9: 255–268
  • Hoso M. Cytophotometric DNA-analysis of hepatocellular carcinoma with Mallory bodies. Virch. Arch. A Pathol. Anatomy 1989; 416: 51–55, Nakanuma
  • Huff J., Lucier G., Tritscher A. Carcinogenicity of TCDD— experimental, mechanistic, and epidemiologic evidence. Annual Review of Pharmacology and Toxicology 1994; 34: 343–372
  • IARC. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Some naturally occuring substances 1976; 10: 153–161
  • IARC. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. 1987; 7, Suppl.
  • Ihrig T. J., Benson N. C., French S. W. Liver injury due to griseofulvin: Gammaglutamyltranspeptidase induction correlated with Mallory bodies. Fed. Proc. 1980; 39: 877
  • Irie T., Benson N. C., French S. W. Relationship of Mallory bodies to the cytoskeleton of hepatocytes in griseofulvin treated mice. Lab. Invest. 1982; 47: 336–345
  • Ito N., Hananouchi M., Sugihara S., Shirai T., Tsuda H., Fukushima S., Nagasaki H. Reversibility and irreversibility of liver tumors in mice induced by the alpha isomer of 1,2,3,4,5,6- hexachlorocyclohexane. Cancer Research 1976; 36: 2227–2234
  • Jensen K., Gluud C. The Mallory body: morphological, clinical and experimental studies (part 1 of a literature survey). Hepatology 1994a; 20(4)1061–1077, No.
  • Jensen K., Gluud C. The Mallory body: theories on development and pathological significance (part 2 of a literature survey). Hepatology 1994b; 20(5)1330–1342
  • Jensen K. G., Onfelt A., Poulsen H. E., Doehmer J., Loft S. Effects of Benzo[a]pyrene and (O-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501Al or 1A2. Carcinogenesis 1993; 14: 2115–2118
  • Kappas A., Granick S. Experimental hepatic porphyria. Studies with steroids of physiological origin in man. Am. N.Y. Acad. Sci. 1968; 151: 842
  • Kappas A., Sassa S., Galbraith R. A., Nordmann. The porphyrias. The metabolic basis of inherited disease, C. R. Scriver, D. Valle. McGraw-Hill, New York 1989; 1305–1365, BaudetA.L., Eds
  • Katsuma Y., Swierenga S. H.H., Khettry U., Marceau N., French S. W. Changes in the cytokeratin intermediate filament cytoskeleton associated with Mallory body formation in mouse and human liver. Hepatology 1987; 7: 1215–1223
  • Kerler R., Rabes H. M. Preneoplastic rat liver cellsin vitro: Slow progression without promoters, hormones, or growth factors. Journal of Cancer Research and Clinical Oncology 1988; 114: 113–123
  • Kimbrough R. D., Squire R. A., Linder R. E., Strandberg J. D., Montali J., Burse V. W. Introduction of liver tumors in Sherman strain female rats by polychlorinated biphenyl Aroclor 1260. JNCI 1975; 55: 1453–1459
  • Kimoff R. J., Huang S. Immunocytochemical and immunoelectron microscopic studies on Mallory bodies. Lab-Invest 1981; 45: 491–503
  • Kinsella A. R. Elimination of metabolic cooperation and the induction of SCEs are not properties common to all promoting or cocarcinogenic agents. Carcinogenesis 1982; 3: 499–504
  • Kirby G. M., Pelkonen P., Vatanasapt V., Camus A. M., Wild C. P., Lang M. A. Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Mol-Carcinog 1994; 11: 81–89
  • Klein M. F., Beall J. R. Griseofulvin: a teratogenic study. Science 1972; 175: 1483–1484
  • Klopman G., Rosenkranz H. S. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTICASE. Mutat. Res. 1994; 305: 33–46
  • Klopman G., Rosenkranz H. S. Testing by artificial intelligence: Computational alternatives to the determination of mutagenicity. Mutat. Res. 1991; 272: 59–71
  • Knudson A. G. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 1971; 68: 820–823
  • Kochendorfer U. Stöorungen des Zellzyklus durch Anomalien des Spindelapparates. 1993, Endogene und exogene Induktion von quantitativen und qualitativen Veranderungen. Doctoral ThesisBonnFRG
  • Kociba R. J., Keyes D. G., Beyer J. E., Carreon R. M., Wade C. E., Dittenber D. A., Kalnins R. P., Frauson L. E., Park C. N., Barnard S. D., Hummel R. A., Humiston C. G. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol. 1978; 46: 279–303
  • König E., Berthold K., Hienz H. A., Brittinger G. Griseofulvin and chronic granulocytic leucemia. Helv. Med. Act. 1969; 35: 103–107
  • Kordac V., Martasek P., Zoubek V., Kalab M. Porphyria cutanea tarda. Manifestation and therapy. Ann. N.Y. Acad. Sci. 1987; 514: 335–336
  • Kraupp-Grasl B., Huber W., Taper H., Schulte-Hermann R. Increased Susceptibility of Aged Rats to Hepatocarcinogenesis by the Peroxisome Proliferator Nafenopin and the Possible Involvement of Altered Liver Foci Occurring Spontaneously. Cancer Research 1991; 51: 666–671
  • Larizza L., Doneda L., Colotta F., Mantovani A. Enhanced proliferation and prolonged in vitro life span of human monocytes in conditioned medium from a murine fibrosarcoma line. 1986; 79, Normal and Neoplastic Blood Cells: from Genes to Therapy, Symposium Abstract
  • Larizza L., Simoni G., Stefanini M., De Carli L. Induced heteroploidy and cell transformation. Biochem Exptl. Biol. 1976; 12: 433–440
  • Larizza L., Simoni G., Stefanini M., De Carli L. Spontaneous and griseofulvin-induced segregation for 8-azaguanine resistance in hybrids from a human heteroploid line. Exp. Cell Res. 1979; 120: 405–409
  • Larizza L., Simoni G., Tredici F. Griseofulvin: a potential agent of chromosomal segregation in cultured cells. Mutat-Res 1974; 25: 123–30
  • Latt S. A. Sister chromatid exchange formation. Annu-Rev-Genet 1981; 15: 11–55
  • Leonard A., Poncelet F., G rut man G., Carbonelle E., Fabry L. Mutagenicity tests with griseofulvin. Mutat. Res 1979; 68: 225–234
  • Levine A. J., Momand J., Finlay C. A. The p53 tumour suppressor gene. Nature 1991; 351: 453–6
  • Lin J. J., Gonzalez A., Banerjee S., Banerjee S. K., Li S. A. Estrogen carcinogenesis in the hamster kidney: role of cytotoxicity and cell proliferation. Environm. Health Perspect 1991; 101(5)259–64, Suppl
  • Lin C. C., Chang R., Casmer C., Symchowicz S. Effects of phenobarbital, 3-methylcholanthrene and griseofulvin on the o-demethylation of griseofulvin by liver microsomes of rats and mice. Drug. Metabol. Disp. 1973a; 1: 611–618
  • Lin C. C., Magat J., Chang R., McGlotten J., Symchowicz S. Absorption, metabolism and excretion of14C-griseofulvin in man. J. Pharmacol. Exptl. Ther. 1973b; 187: 415–422
  • Lin C. C., Symchowicz S. Absorption, distribution, metabolism and excretion of griseofulvin in man and animals. Drug Metabol. Rev. 1975; 4(1)75–95
  • Linnik A. B. Experimental study on the possible role of griseofulvin in carcinogenesis. Vestn. Derm. Vener. 1972; 46: 49–51
  • Lithner F., Wetterberg L. Hepatocellular carcinoma in patients with acute intermittent porphyria. Acta. Med. Scand. 1984; 215: 271–274
  • Lo Schiavo F., Nuti Ronchi V., Terzi M. Genetic effects of griseofulvin on plant cell cultures. Theor. Appl. Genet. 1980; 58: 43–47
  • Lowe J., Blanchard A., Morrell K., Lennox G., Reynolds L., Billett M., Landon M., Mayer R. J. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J-Pathol 1988; 155: 9–15
  • MacLeod J., Nelson W. O. Griseofulvin and human spermatogenesis. Proc. Soc. Exp. Med. Biol. 1960; 102: 259–260
  • Mailhes J. B., Marchetti F., Aardema M. J. Griseofulvin induced aneuploidy and meiotic delay in mouse oocytes: effects of dose and harvest time. Mutat. Res. 1993; 300: 155–163
  • Mallory F. B. Cirrhosis of the liver: five different lesions from which it may arise. Bull. John Hopkins Hosp. 1911; 22: 69
  • Marchetti F., Mailhes J. B. Variation of mouse oocyte sensitivity to griseofulvin induced aneuploidy during the first meiotic division. Env. Molec. Mutagens. 1994; 23: 179–185
  • Marchetti F., Mailhes J. B. Variation of mouse oocyte sensitivity to griseofulvin induced aneuploidy during the second meiotic division. Mutagenesis 1995; 10: 113–121
  • Marks G. S., Powles J., Lyon M., McCluskey S., Sutherland E., Zelt D. Patterns of porphyrin accumulation in response to xenobiotics. Parallels between results in chick embryo and rodents. Am. N.-Y. Acad. Sci 1987; 514: 113–27
  • Marvel J. R., Schlichting D. A., Denton C., Levy E. J., Cahn M. M. The effect of surfactant and of particle size on griseofulvin plasma levels. J. Invest. Dermatol. 1964; 142: 197–203
  • Matilla A., Molland E. A. A light and electron microscopic study of the liver in case of erythrohepatic protoporphyria and in griseofulvin-induced porphyria in mice. J. Clin. Pathol. 1974; 27: 698–709
  • The signifiance of hepatic microsomal enzyme induction and altered enyzyme function in rats: implications for thyroid gland neoplasia. Tonic Pathology 1989; 17: 294–306, McClain
  • McIntosh D. A.D., Topham J. C. A comparison of mouse and rat liver enzymes and their response to treatment with various compounds. Biochem. Pharmacol. 1972; 21: 1025–1029
  • MacLeod J., Nelson W. O. Griseofulvin and human spermatogenesis. Proc. Soc. Exp. Med. and Biology 1960; 102: 259–260
  • Medoff G., Kobayashi G. Mode of action of antifungal drugs. VII. Griseofulvin. Fungi Pathogenic for Humans and Animals. Part B. Pathogenicity and Detection, D. H. Howard. Marcel Dekker Inc, NY 1983; 345–355
  • Meierhenry E. F., Ruebner B. H., Gershwin M. E., Hsieh L. S., French S. W. Mallory body formation in hepatic nodules of mice ingesting dieldrin. Lab. Invest. 1981; 44: 392–396
  • Melnick R. L. Does chemically induced hepatocyte proliferation predict liver carcinogenesis. FASEB Journal 1992; 6: 2698–2706
  • Metneki J., Czeizel A. The Lancer 1987; 2: 1042, Griseofulvin teratology, May
  • Morris H. P. The experimental development and metabolism of thyroid gland tumors. Adv. Cancer Res. 1955; 3: 51–115
  • Muccinelli A., Sanguinetti F. [Effect of the administration of copper salts on cholesteremia and beta-lipoproteinemia in rats treated with griseofulvin]. Boll-Soc-Ital-Biol-Sper 1967; 43: 1651–2
  • Nagasaki H., Tomii S., Mega T., Marugami M., Ito N. Hepatocarcinogenicity of polychlorinated biphenyls in mice. GANN 1972; 63: 805
  • Nakanuma Y., Ohta G. Is mallory body formation a preneoplastic change? A study of 181 cases of liver bearing hepatocellular carcinoma and 82 cases of cirrhosis. Cancer 1985; 55: 2400–2404
  • Nakao K., Wada O., Takaku F., Sassa S., Yamo Y., Urata G. The origin of the increased protoporphyria in erythrocytes of mice with experimentally induced porphyria. J. Lab. Clin. Med. 1967; 70: 923–932
  • Namba M., Kimoto T. Cytotoxic effects of griseofulvin on human normal cellsin vitro. Kawasaki Med.J. 1976; 2: 127–134
  • Navone N. M., Buzaleh A. M., Polo C. F., Afonso S. G., Vazquez E. S., Batlle A. M. The effect of griseofulvin on the heme pathway—II. An exhaustive analysis during short and long-term challenge. Gen-Pharmacol 1991; 22: 1179–83
  • Ohmori T., Rice J. M., Williams G. M. Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure. Histochem-J 1981; 13: 85–99
  • Ohshima H., Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat-Res 1994; 305: 253–64
  • Okino K., Weibert R. T. Warfarin-Griseofulvin interaction. Drug. Intell. Clin. Pharm. 1986; 20: 291–294
  • Oshimura M., Barrett J. C. Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer. Env. Mutagen 1986; 8: 129–159
  • Otto A. M., Ulrich M. O., Zombe A., Jimenez de Asua L. Microtubule disrupting agents affect two different events regulating the initiation of DNA-synthesis in Swiss 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 1981; 78(5)3063–3067
  • Oxford A. E., Raistrick H., Simonart P. Griseofulvin—a metabolic product of. Penicilium griseofulvum dierckr., Biochem. J. 1939; 33: 240–248
  • Paget G. E., Alcock S. J. Griseofulvin and colchicine: Lack of carcinogenic action. Nature 1960; 188: 867
  • Paget G. E., Walpole A. L. Some cytological effects of griseofulvin. Nature 1958; 182: 1320–1321
  • Peters R. S. Patology of hepatocellular carcinoma. Hepatocellular Carcinoma, K. Okuda, R. Peters. Wiley & Sons, NY 1976; 107–168
  • Parzefall W., Schuppler J., Barthel G., Meyer Rogge B., Schulte Hermann R. Toxicological studies on a benzofurane derivative. I. A comparative study with phenobarbital on rat liver. Toxicol-Appl-Pharmacol 1990; 106: 482–99
  • Pierach C. A. Porphyria and hepatocellular carcinoma. Brit. J. Canc. 1987; 59: 111
  • Pilot H. C. Progression—the terminal stage in carcinogenesis. Japanese Journal of Cancer Research 1989; 80: 599–607
  • Poland A., Knudson J. C. 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annual Review of Pharmacology and Toxicology 1982; 22: 517–554
  • Preisegger K. H., Stumptner C., Riegelnegg D., Brown P. C., Silverman J. A., Thorgeirsson S. S., Denk H. Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products. Hepatology 1991; 24: 248–52
  • Preisegger K. H., Zatloukal K., Spurej G., Riegelnegg D., Denk H. Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody. Lab-Invest 1992; 66: 193–9
  • Raimondi E., Scariolo S., De Sario A., De Carli L. Aneuploidy assays on interphase nuclei by means ofin situ hybridisation with DNA-probes. Mutagenesis 1989; 4: 165–169
  • Rao K. N. The significance of the cholesterol bio-synthetic pathway in cell growth and carcinogenesis (review). Anticancer-Res 1995; 15: 309–14
  • Redeker A. G., Sterling R. E., Bronow R. S. Effect of griseofulvin in acute intermittent porphyria. J. Am. Med. Assoc 1964; 188: 466–468
  • Rimington C., Morgan P. N., Nicholls K., Everall J. D., Davies R. R. Griseofulvin administration and porphyrin metabolism. Lancet 1963; 17: 318–322, Aug
  • Rijhsinghani K. S., Abraham C., Swerdiow M. A., Rao K. V. Induction of neoplastic lesions in the livers of C57BL × C3HF1 mice by chloral hydrate. Cancer-Detect-Prev 1986; 9: 279–88
  • Roobol A., Pogson C J. Inhibition by griseofulvin of microtubule assemblyin vitro. FEBS. Lett. 1976; 67: 248–251
  • Rosa F. W., Hernandez G., Carlo W. A. Griseofulvin teratology including two thoracopagus conjoined twins. Lancet 1987; 1(8525)171
  • Rosin H., Antibiotika, Chemotherapeutika. Antiinfektiose Therapie. Allgemeine und spezielle Phamkologie und Toxikologie, W. Forth, D. Henschler, W. Rummel, K. Starke. BI-Wissenschafts-verlag. 1992; 687–688
  • Rowland M., Riegelman S., Epstein W. L. Absorption kinetics of griseofulvin in man. J. Pharmaceut. Sci. 1968; 57: 984–989
  • Rozengurt R. Growth factors, cell proliferation and cancer: an overview. Mol. Biol. Med. 1983; 1: 169–181
  • Rubin A., Dvornik D. Placental transfer of griseofulvin. Amer. J. Obstet. Gynec. 1965; 92: 882–883
  • Russel D., Russel A. D. Treatment of ringworm: old remedy vesus new. J. Infect. 1992; 24: 333
  • Rustia M., Shubik P. Thyroid tumors in rats and hepatomas in mice after griseofulvin treatment. Br. J. Canc. 1978; 38: 237–249
  • Salonpäa U P., Krause K., Pelkonen O., Raunio H. Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver. Naunyn-Schmiede-bergs Arch. Pharmacol. 1995; 351: 446–452
  • Sandow J., Rechberg W. 1990, Griseofulvin: Subchro-nische orale Verträglichkeitspriifung. Hochst Report, No. 891571
  • Schiffmann D., De Boni U. Dislocation of chromatin elements in prophase induced by diethylstilbestrol: a novel mechanism by which micronuclei can arise. Mutat. Res 1991; 246: 113–22
  • Schmaehl D. Iatrogenic carcinogenesis. J. Canc. Res. Clin. Oncol. 1981; 99: 71–75
  • Schulte-Hermann R. Induction of liver growth by xenobiotic compounds and other stimuli. Critical Rev. Toxicol. 1974; 3: 97–158
  • Schulte-Hermann R. Tumor promotion in the liver. Arch. Toxicology 1985; 57: 147–158
  • Schulte-Hermann R., Bursch W., Kraupp-Grasl B., Oberhammer F., Wagner A., Jirtle R. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environmental Health Perspectives 1993; 101: 87–90
  • Schulte-Hermann R., Ohde G., Schuppler J., Timmermann Trosiener I. Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin. Cancer Res. 1981; 41: 2556–2562
  • Schulte-Hermann R., Timmermann-Trosiener I., Schuppler J. Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds. Cancer Res. 1983; 43: 839–844
  • Schulte-Hermann R., Timmermann-Trosiener I., Barthel G., Bunch W. DNA synthesis, apoptosis and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Research 1990; 50: 5127–5135
  • Scott F. W., LaHunta A., Schultz R. D., Birkner S. I., Riis R. C. Teratogenesis in cats, associated with griseofulvin therapy. Teratology 1975; 2: 79–86
  • Seglen P. O., Gerlyng P. Growth-related alterations during liver carcinogenesis - effect of promoters. Environmental Health Perspectives 1990; 88: 197–205
  • Seif R. Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus. J. Virol. 1980; 36: 421–428
  • Sewall C. H., Flagler N., Vanden J. P., Clark G. C., Tritscher A. M., Maronpot R. M., Lucier G. W. Alterations in thyroid function in female Sprague-Dawley rats following chronic treatment with 2,3,7,8–tetrachlorodibenzo-p-dioxin. Toxicol-Appl-Pharmacol 1995; 132: 237–44
  • Shah V. P. Griseofulvin - absorption per Os and percutaneous. Medical Mycology Zbl. Bact., Suppl. 8 1980; 223–239
  • Shimoyama T., Nonaka S. Biochemical studies on griseofulvin induced protoporphyria, Ann. NY. Acad. Sci. 1987; 514: 160–169
  • Shimoyama T., Nonaka S., Honda T., Murayama F., Ohgami T., Yoshida H. A biochemical study on experimental porphyria I. The influence of griseofulvin at various concentrations on porphyrin metabolism. J. Dermatol. 1984; 11: 49–55
  • Sideropoulos A S., Kacsuta P., Betz M. K. Mutations induced by substituted quinolines in UV-irradiated bacteria. Current Microbiol. 1980; 3: 207–212
  • Siracusa G., Whittigham D. G., DeFelici M. The effect of microtubule and microfilament disrupting drugs on Preimplantation mouse embryos. J. Embr. Exp. Morph. 1980; 60: 71–82
  • Slonitskaya N. N. Embryotoxic and teratogenic effects of isogriseofulvin-forte at various stages of rat embryogenesis. Antibiotiki 1973; 18: 655–659, Mikhailets
  • Slonitskaya N. N. Teratogenic effects of griseofulvin-forte on rat fetus. Antibiotiki 1969; 11: 44–48
  • Smith A. G., De Matteis F. Drugs and the hepatic porphyrias. Clin-Haematol. 1980; 9: 399–425
  • Biochem. Pharmacol 1990; 40: 2059–68, Smith, A. G., Francis, J.E., Green, J.A., Greig, J.B., Wolf, C.R. and Manson, M.M., Sex-linked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenyls.
  • Smith A. G., Dinsdale D., Manson M. M., Cabral J. R.P. Hepatocarcinogenicity of hexachlorobenzene in rats and sex difference in hepatic iron states and development of porphyria. Carcinogenesis 1985; 6: 631–636
  • Steelman L. R. Determination of the teratogenic and mutagenic potential of griseofulvin. Toxicol. Appl. Pharmacol. 1978; 45: 343–344
  • Stolley P. D. Drugs and cancer in humans. Preventive Med. 1980; 9: 202–205
  • Stout D. L., Becker F. F. Heme enzyme patterns in rat liver nodules and tumors. Canc. Res. 1987; 47: 963–965
  • Symchowicz S., Katchen B. Griseofulvin absorption in man after single and repeated treatment and its correlation with dissolution rates. J. Pharmaceut. Sci. 1968; 57: 1383–1386
  • Tanaka K., Ohgami T., Nonaka S. Experimental murine protoporphyria induced by griseofulvin: The relationship between hepatic porphyrin levels and liver function test values in mice treated with griseofulvin. J. Dermatol., 20: 545–553, 199227.
  • Tangeras A. Effect of decreased ferrochelatase activity on iron and porphyrin content in mitochondria of mice with porphyria induced by griseofulvin. Biochim. Biophys. Acta 1986; 882: 77–84
  • Tazawa J., Ihrig T., French S. W. Mallory body formation runs parallel to gamma-glutamyl transferase induction in hepatocytes of griseofulvin mice. Hepatology 1983; 3: 989–1001
  • Terzi M., Hawkins T. S.C. Chromosomal variation and the establishment of somatic cell lines invitro. Nature 1975; 253: 361–362
  • Thomsett L. R. Fungal diseases of the skin of small animals. Brit. Vet. J. 1986; 142: 317–325
  • Tiveron C., Marchetti F., Bossoni B., Pacchierotti F. Griseofulvin induced aneuploidy and meiotic delay in female mouse germ cells, I. Cytogenetic analysis of metaphase II oocytes. Mutat. Res. 1992; 266: 143–150
  • Topham J. C., McIntosh D. A., Platt D. S. Biochemical changes in rat liver in response to treatment with drugs and other agents. Biochem-Pharmacol 1972; 21(IV)1019–24
  • Tsunoo C., Harwood T. R., Arak S., Yokoo H. Cytoskeletal alterations leading to Mallory body formation in livers of mice fed 3,5-diethoxycarbonyl-1,4-dihydrocollidine. J-Hepatol 1987; 5: 85–97
  • Udall J. A. Drug interference with warfarin therapy. Clinical Medicine 1970; 77: 20–25
  • Van Heyningen V. Wilms' tumour: reconciling genetics and biology. Trends in Genet 1992; 8: 16–21
  • Vesselinovitch S. D., Mikailovitch N. The inhibitory effect of griseofulvin on the promotion of skin carcinogenesis. Canc. Res. 1968; 28: 2463–2465
  • Wada O., Toyokawa K., Urata G., Yano Y., Nakao K. Cholesterol biosynthesis in the liver of experimentally induced porphyric mice. Biochem-Pharmacol 1969; 18: 1533–5
  • Wada O., Yano Y., Urata G., Nakao K. Behaviour of hepatic cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver. Biochem. Pharmacol. 1968; 17: 595–603
  • Wang A. Interplay of cyclic AMP and microtubules in modulating the initiation of DNA synthesis in 3T3 cells. J. Cell Biol. 1983; 96: 1743–1750, RozengurtE.
  • Wasti U. M., Lang M. A., Bursch W., Camus-Randon A. M., Schulte-Hermann R. Expression of cytochrome P450 2A5 in normal liver, preneoplastic foci and liver tumors of different mouse strains. Toxicol. Appl. Pharmacol., (submitted).
  • Watson C J., Bossenmaier I., Cardinal R. Griseofulvin and porphyrin metabolism. Arch. Derm. 1968; 98: 451–468
  • Wehland I., Herzog W., Weber K. Interaction of griseofulvin with microtubules, microtubuli protein and tubulin. J. Molec. Biol. 1977; 111: 329–342
  • Weinberg R. A. Tumor suppressors genes. Science 1991; 254: 1138–1146
  • Weston-Hurst E., Paget G. E. Protoporphyrin, cirrhosis and hepatomata in the livers of mice given griseofulvin. Brit J. Derm. 1963; 75: 105–112
  • Wetzl W. J., Alexander R. W. Fowl nodular hyperplasia of the liver with alcoholic hyaline bodies and cytologic atypia. Cancer 1979; 44: 1322–1326
  • Whittaker S. G., Wilson D., Faustmann. Griseofulvin and estramustine induce mitotic arrest in rat embryonic limb bud cultures. Toxicologist 1993; 13: 257
  • Whittaker S. G., Zimmermann F. K., Dicus B., Piegorsch W. W., Fogel S., Resnick M. A. Detection of induced mitotic chromosome loss inSaccharomyces cervisiae an interlaboratory study. Mutat. Rex 1989; 224: 31–78
  • Williams G. M., Ohmori T., Katayama S., Rice J. M. Alteration by phenobarbital of membrane associated enzymes including gamm glutamyl transpeptidase in mouse liver neoplasms. Carcinogenesis 1980; 1: 813–818
  • Williams M. T., Simonet L. Effects of griseofulvin on enzymes associated with phase I and II of drug metabolism. Biochem-Pharmacol 1986; 35: 2630–2632
  • Wilson L., Bamburg J. R., Mizel S. B., Grisham L. M., Creswell K. M. Interaction of drugs with microtubuli proteins. Fed. Proc. 1974; 33: 158–166
  • Winterhoff H., Sourgens H. The predictive value of animal experiments in the detection of side effects of drugs on thyroid function. Pharmac. Ther. 1979; 5: 325–332
  • Wong P. T.T., Cadrin M., French S. W. Distinctive infrared spectra features in liver tumor tissue of mice. Exp. Molec. Pathol. 1991; 55: 269–284, Evidence of structural modifications at the molecular level
  • Wyrobek A. J., Bruce W. R. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci. USA 1975; 72: 4425–4429
  • Wyrobek A J. The induction of sperm-shape abnormalities in mice and humans. Chemical Mutagens - Principles and Methods for their Detection, A. Hollaender, 1982; VII: 257–285, and Ed.
  • Xu G. F., O'Connell P., Viskochil D., Cawthon R., Robertson M., Culver M., Dunn D., Stevens J., Gesteland R., White R. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 1990; 62: 599–608
  • Yager J. D., Zurlo J., Nan N. Sex hormones and tumor promotion in liver. Froc. Soc. Exp. Biol. Med. 1991; 667–674
  • Yokoo H., Craig R. M., Harwood T. R., Cochrone C. Griseofulvin-induced cholestasis in Swiss Albino mice. Gastroenterology 1979; 77: 1082–1087
  • Yokoo H., Harwood T. R., Racker D., Arak S. Experimental production of Mallory bodies in mice by diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Gastroenterology 1982; 83: 109–13
  • Zatloukal K., Denk H., Lackinger E., Rainer I. Hepatocellular cytokeratins as substrates of transglutaminases. Lab-Invest 1982; 61: 603–8
  • Zatloukal K., Denk H., Spurej G., Lackinger E., Preisegger K. H., Franke W. W. High molecular weight component of Mallory bodies detected by a monoclonal antibody. Lab-Invest 1990; 62: 427–34
  • Zawirska B., Bednarz W. The particular trais of carcinogenesis induced in wister rats by Aflatoxin B1, III, Porphyrins and the activity of gamma-glutamyl-transpeptidase in hepatomas and in their tissue of origin. Neoplasma 1981; 28: 35–49
  • Zbinden G. Hyperplastic and neoplastic responses of the thyroid gland in toxicological studies. Arch. Toxicol. Suppl. 1988; 12: 98–106
  • Zhang Y. P., Sussman N., Macina O. T., Rosenkranz H. S., Klopman G. Prediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing. Environmental Health Perspectives 1996; 104(Suppl 5)1045–1050

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