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Research Article

Methoxychlor as a Model for Environmental Estrogens

Pages 367-379 | Published online: 25 Sep 2008

References

  • Haddad V., Ketchel M. M. Termination of pregnancy and occurrence of abnormalities following estrone administration during early pregnancy. Int. J. Fertility 1969; 14(1)56
  • Greenwald G. S. The antifertility effects in pregnant rats of a single injection of estradiol cyclopentyl-propionate. Endocrinology 1961; 69: 1068
  • Greenwald G. S. Species differences in egg transport in response to exogenous estrogen. Anat. Rec 1967; 157: 163
  • Yochim J. M., DeFeo V. J. Control of decidual growth in the rat by steroid hormones of the ovary. Endocrinology 1962; 71: 134
  • Yochim J. M., DeFeo V. J. Hormonal control of the onset, magnitude and duration of uterine sensitivity in the rat by steroid hormones of the ovary. Endocrinology 1963; 72: 317
  • O'Malley B. W., Tsai M-J. Molecular pathways of steroid receptor action. Biol. Reprod. 1992; 46: 163
  • Astwood E. B. A six-hour assay for the quantitative determination of estrogen. Endocrinology 1938; 23: 25
  • Cohen S., O'Malley B. W., Stastny M. Estrogen induction of ornithine decarboxylasein vivo and. in vitro, Science 1970; 170: 336
  • Notides A., Gorski J. Estrogen-induced synthesis of a specific uterine protein. Proc. Natl. Acad. Sci. U.S.A. 1966; 56: 230
  • Reiss N. A., Kaye A. M. Identification of the major component of the estrogen induced protein of rat uterus as the BB isozyme of creatine kinase. J. Biol. Chem. 1981; 256: 5741
  • Lucas F. V., Neufeld H. A., Utterback J. G., Martin A. P., Stotz E. The effect of estrogen on the production of a peroxidase in the rat uterus. J. Biol. Chem. 1955; 214: 755
  • Lyttle C. R., DeSombre E. R. Uterine peroxidase as a marker for estrogen action. Proc. Natl. Acad. Sci. U.S.A. 1977; 74(8)3162
  • Barker K. L., Warren J. C. Estrogen control of carbohydrate metabolism in the rat uterus: pathways of glucose metabolism. Endocrinology 1966; 78: 1205
  • Gorski R. A. Sexual differentiation of the brain: a model for drug-induced alterations of the reproductive system. Environ. Health Persp. 1986; 70: 163
  • McLachlan J. A., Newbold R. R., Shah H. C., Hogan M. D., Dixon R. L. Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES). Fertil. Steril. 1982; 38(3)364
  • Newbold R. R., McLachlan J. A. Diethylstil-bestrol-associated defects in murine genital tract development. Estrogens in the Environment II: Influences on Development, J. A. McLachlan. Elsevier North-Holland, New York 1985; 288
  • Burlington H., Lindeman V. F. Effect of DDT on testes and secondary sex characteristics of white leghorn cockerels. Proc. Soc. Exp. Biol. Med. 1950; 74: 48
  • Fisher A. L., Keasling H. H., Scheuler F. W. Estrogenic action of some DDT analogues. Proc. Soc. Exp. Biol. Med. 1952; 81: 439
  • Bitman J., Cecil H. C., Harris S. J., Fries G. F. Estrogenic activity ofo,p'-DDT in the mammalian uterus and avian opiduct. Science 1968; 162: 371
  • Gellert R. J., Heinrichs W. L., Swerdloff R. S. DDT homologues: estrogen-like effects on the vagina, uterus and pituitary of the rat. Endocrinology 1972; 91: 1095
  • Guzelian P. S. Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Ann. Rev. Pharmacol. Toxicol. 1982; 22: 89
  • Gellert R. J. Kepone, Mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. Environ. Res. 1978; 16: 131
  • Gellert R. J. Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environ. Res. 1978; 16: 123
  • Bitman J., Cecil H. C. Estrogenic activity of DDT analogues and polychlorinated biphenyls. J. Agric. Food Chem. 1970; 18(6)1108
  • White R., Jobling S., Hoare S. A., Sumpter J. P., Parker M. G. Environmentally persistent alkyl-phenolic compounds are estrogenic. Endocrinology 1994; 135: 175
  • Anonymous. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 1979; 259
  • Duggan R. E., Corneliussen P. E., Duggan M. G., McMahon B. M., Martin R. J. Pesticide residue levels in foods in the United States from July 1, 1969 to June 10, 1976. Food and Drug Admin, and Assoc, of Official Anal. Chem., Washington D.C 1983
  • Kapoor I. P., Metcalf R. L., Nystrom R. F., Sangha G. K. Comparative metabolism of methoxychlor, methiochlor, and DTT in mouse, insects, and in a model ecosystem. J. Agric. Food Chem. 1970; 18(6)1145
  • U.S.E.P.A. Office of Drinking Water. Methoxychlor. Rev. Environ. Contam. Toxicol. 1988; 104: 161
  • Hodge H. C., Maynard E. A., Blanchet H. J., Jr. Chronic oral toxicity tests of methoxychlor (2,2-di(p-methoxyphenyl)-1,1,1-trichloroethane) in rats and dogs. J. Pharmacol. Exp. Therapeut. 1952; 104: 60
  • Hodge H. C., Maynard E. A., Thomas J. F., Blanchet H. J., Jr., Wilt W. G., Jr., Mason K. E. Short-term oral toxicity tests of methoxychlor (2,2 di-(p-methoxyphenyl)-1,1,1-trichlorethane) in rats and dogs. J. Pharmacol. Exp. Therap. 1950; 99: 140
  • Kumar S., Pant S. C. Comparative sublethal ovarian pathology of some pesticides in the teleost. Puntius conchonius Hamilton, Bull. Environ. Contam. Toxicol. 1988; 41: 227
  • Radomski J. L., Deichmann W. B., MacDonald W. E., Glass E. M. Synergism among oral carcinogens. I. Results of the simultaneous feeding of four tumorigens to rats. Toxocol. Appl. Pharmacol. 1965; 7(5)652
  • Deichmann W. B., Keplinger M., Sala F., Glass E. Synergism among oral carcinogens. IV. The simultaneous feeding of four tumorigens to rats. Toxicol. Appl. Pharmacol. 1967; 11: 88
  • Reuber M. D. Carcinogenicity and toxicity of methoxychlor. Environ. Health Perspect. 1980; 36: 205
  • Oberly T. J., Michaelis K. C., Rexroat M. A., Bewsey B. J., Garriot M. L. A comparison of the CHO/HGPRT+ and the L5178Y/TK+/- mutation assays using suspension treatment and soft agar cloning: results for 10. chemicals. Cell Biol. Toxicol. 1993; 9: 243
  • National Cancer Institute. Bioassay of methoxychlor for possible carcinogenicity. NCI-CG-TR-35 Carcinogenesis Program 1978; 91
  • Welch R. M., Levin W., Conney A. H. Estrogenic action of DDT and its analogs. Toxicol. Appl. Pharmacol. 1969; 14: 358
  • Nelson A. Effects of dichlorophenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17β-[3H]-estradiol binding to rat uterine estrogen receptor. Biochem. Pharmacol. 1974; 23: 447
  • Kupfer D. Effects of pesticides and related compounds on steroid metabolism and function. Crit. Rev. Toxicol. 1975; 4: 83
  • Nelson J. A., Struck R. F., James R. Estrogenic activities of chlorinated hydrocarbons. J. Toxicol. Environ. Health 1978; 4: 325
  • Bulger W. H., Muccitelli R. M., Kupfer D. Interactions of methoxychlor, methoxychlor base soluble contaminant, and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor. J. Toxicol. Environ. Health 1978; 4: 881
  • Bulger W. H., Muccitelli R. M., Kupfer D. Studies on thein vivo andin vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 1978; 27: 2417
  • Kupfer D., Bulger W. H. A novelin vitro method for demonstrating proestrogens. Metabolism of methoxychlor ando,p'DDT by liver microsomes in the presence of uteri and effects on intracellular distribution of estrogen receptors. Life Sci. 1979; 25: 975
  • Ousterhout J. M., Struck R. F., Nelson J. A. Estrogenic properties of methoxychlor metabolites. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1979; 38(3 [Pt.1])537
  • Bulger W. H., Feil V. J., Kupfer D. Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Mol. Pharmacol. 1985; 27: 115
  • Harris S. J., Cecil H. C., Bitman J. Effect of several dietary levels of technical methoxychlor on reproduction in rats. J. Agric. Food Chem. 1974; 22(6)969
  • Bal H. S. Effect of methoxychlor on reproductive systems of the rat. Proc. Soc. Exp. Biol. Med. 1984; 176: 187
  • Gray L. E., Jr., Ostby J., Ferrell J., Rehnberg G., Linder R., Cooper R., Goldman J., Slott V., Laskey J. A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fund. Appl. Toxicol. 1989; 12: 92
  • Tullner W. W. Uterotropic action of the insecticide methoxychlor. Science 1961; 133: 647
  • Johnson D. C., Sen M., Dey S. K. Differential effects of dichlorodiphenyltrichloroethane analogs, chlordecone, and 2,3,7,8-tetrachlorodibenzp-p-dioxin on establishment of pregnancy in the hypophysectomized rat. Proc. Soc. Exp. Biol. Med. 1992; 199: 42
  • Gray L. E., Jr., Ostby J. S., Ferrell J. M., Sigmon E. R., Goldman J. M. Methoxychlor induces estrogen-like alterations of behavior and the reproductive tract in the female rat and hamster: effects on sex behavior, running wheel activity, and uterine morphology. Toxicol. Appl. Pharmacol. 1988; 96: 525
  • Cummings A. M., Gray L. E., Jr. Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy. Toxicol. Appl. Pharmacol. 1989; 97: 454
  • DeFeo V. J. Temporal aspect of uterine sensitivity in the pseudopregnant rat. Endocrinology 1963; 72: 305
  • DeFeo V. J. Decidualization. Cellular Biology of the Uterus, R. M. Wynn. Appleton-Century-Crofts/Meredith, New York 1967; 191.
  • Cummings A. M., Gray L. E., Jr. Methoxychlor affects the decidual cell response of the uterus but not other progestational parameters in female rats. Toxicol. Appl. Pharmacol. 1987; 90: 330
  • Cummings A. M., Perreault S. D. Methoxychlor accelerates embryo transport through the rat reproductive tract. Toxicol. Appl. Pharmacol. 1990; 102: 110
  • Cummings A. M., Metcalf J. M. Mechanisms of the stimulation of rat uterine peroxidase activity by methoxychlor. Reprod. Toxicol. 1994; 8(6)477
  • Cummings A. M., Metcalf J. M. Methoxychlor regulates rat uterine estrogen-induced protein. Toxicol. Appl. Pharmacol. 1995; 130: 154
  • Mukku V. R., Stancel G. M. Regulation of epidermal growth factor receptor by estrogen. J. Biol. Chem. 1985; 260: 9820
  • Metcalf J. L., Laws S. C., Cummings A. M. Methoxychlor mimics the action of 17β estradiol on induction of uterine epidermal growth factor receptors in immature female rats. Biol. Reprod. 1995; 52(Suppl. 1)97
  • Khera K. S., Whalen C., Trivett G. Teratogenicity studies on Linuron, Malathion, and Methoxychlor in rats. Toxicol. Appl. Pharmacol. 1978; 45: 435
  • Tullner W. W., Edgcomb J. H. Cystic tubular nephropathy and decrease in testicular weight in rats following oral methoxychlor treatment. J. Pharmacol. Exp. Ther. 1962; 138: 126
  • Goldman J. M., Cooper R. L., Rehnberg G. L., Hein J. F., McElroy W. K., Gray L. E., Jr. Effects of low subchronic doses of methoxychlor on the rat hypothalamic-pituitary reproductive axis. Toxicol. Appl Pharmacol. 1986; 86: 474
  • Cooke P. S., Eroschenko V. P. Inhibitory effects of technical-grade methoxychlor on development of neonatal mouse reproductive organs. Biol. Reprod 1990; 42: 585
  • Eroschenko V. P., Cooke P. S. Morphological and biochemical alterations in reproductive tracts of neonatal female mice treated with the pesticide methoxychlor. Biol. Reprod. 1990; 42: 573
  • Eroschenko V. P. Ultrastructure of vagina and uterus in young mice after methoxychlor exposure. Reprod. Toxicol. 1991; 5: 427
  • Martinez E. M., Swartz W. J. Effects of methoxychlor on the reproductive system of the adult female mouse. I. Gross and histological observations. Reprod. Toxicol. 1991; 5: 139
  • Swartz W. J., Corkern M. Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies. Reprod. Toxicol. 1992; 6: 431
  • Appel R. J., Eroschenko V. P. Passage of methoxychlor in milk and reproductive organs of nursing female mice. I. Light and scanning electron microscopic observations. Reprod. Toxicol. 1992; 6: 223
  • Rourke A. W., Eroschenko V. P., Washburn L. J. Protein secretions in mouse uterus after methoxychlor or estradiol exposure. Reprod. Toxicol. 1991; 5: 437
  • Swartz W. J., Wink C., Johnson W. D. Response of adult murine uterine epithelium to 50% methoxychlor. Reprod. Toxicol. 1994; 8: 81
  • Walters L. M., Rourke A. W., Eroschenko V. P. Purified methoxychlor stimulates the reproductive tract in immature female mice. Reprod. Toxicol. 1993; 7: 599
  • Eroschenko V. P., Abuel-Atta A. A., Grober M. S. Neonatal exposures to technical methoxychlor alters ovaries in adult mice. Reprod. Toxicol. 1995; 9(4)379
  • Vom Saal F. S., Nagel S. C., Palanza P., Boechler M., Parmigiani S., Welshons W. V. Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behavior in male mice. Toxicol. Lett. 1995; 77: 343

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