195
Views
18
CrossRef citations to date
0
Altmetric
Review Article

The effect of membrane domains on the G protein–phospholipase Cβ signaling pathway

&
Pages 97-105 | Received 29 Oct 2009, Accepted 06 Jan 2010, Published online: 04 Feb 2010

References

  • Aasheim HC, Pedeutour F and Smeland EB. 1997. Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc Oncogene, with strongest expression in hematopoetic tissues. Oncogene 14:1747–1752.
  • Anderson RG. 1998. The caveolae membrane system. Annu Rev Biochem 67:199–225.
  • Anderson RGW and Jacobson K. 2002. A role for lipid shells in targeting proteins to caveolae, rafts and other lipid domains. Science 296:1821–1825.
  • Angers S, Salahpour A and Bouvier M. 2002. DIMERIZATION: An emerging concept for G protein–coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 42:409–435.
  • Ballou LM, Lin HY, Fan G, Jiang YP and Lin RZ. 2003. Activated G alpha q inhibits p110 alpha phosphatidylinositol-3-kinase and Akt. J Biol Chem 278:23472–23479.
  • Ballou LM, Chattopadhyay M, Li Y, Scarlata S and Lin RZ. 2006. Gaq binds to p110a/p85a phosphoinositide 3-kinase and displaces Ras. Biochem J 393:557–562.
  • Berman D and Gilman A. 1998. Mammalian RGS proteins: Barbarians at the gate. J Biol Chem 273:1269–1272.
  • Berman D, Kozasa T and Gilman AG. 1996. The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem 271:27209–27212.
  • Berstein G, Blank JL, Jhon D-Y, Exton JH, Rhee SG and Ross EM. 1992. Phospholipase C-b1 is a GTPase-activating protein for Gq/11, its physiologic regulator. Cell 70:411–418.
  • Birnbaumer L. 2007. Expansion of signal transduction by G proteins: The second 15 years or so: From 3 to 16 [alpha] subunits plus [beta][gamma] dimers. Biochim Biophys Acta Biomembranes 1768:772–793.
  • Bunemann M, Frank M and Lohse MJ. 2003. Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci USA 100:16077–16082.
  • Chung KN, Roberts S, Kim CH, Kirassova M, Trepel J and Elwood PC. 1995. Rapid turnover and impaired cell-surface expression of the human folate receptor in mouse L(tk-) fibroblasts, a cell line defective in glycosylphosphatidylinositol tail synthesis. Arch Biochem Biophys 322:228–234.
  • Day CA and Kenworthy AK. 2009a. Tracking microdomain dynamics in cell membranes. Biochim Biophys Acta 1788:245–253.
  • Day CA and Kenworthy AK. 2009b. Tracking microdomain dynamics in cell membranes. Biochim Biophys Acta 1788:245–253.
  • Digby GJ, Lober RM, Sethi PR and Lambert NA. 2006. Some G protein heterotrimers physically dissociate in living cells. Proc Natl Acad Sci USA 103:17789–17794.
  • Dowal L, Elliott J, Popov S, Wilkie TM and Scarlata S. 2001. Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. Biochemistry 40:414–421.
  • Dowal L, Provitera P and Scarlata S. 2006. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. J Biol Chem 281:23999–24014.
  • Edinin M. 2003. The state of lipid rafts: from model membranes to cells. Annu Rev Biophys Biomolec Struc 32:257–283.
  • Frank M, Thumer L, Lohse MJ and Bunemann M. 2005. G-protein-activation without subunit dissociation depends on a Galpha i-specific region. J Biol Chem 280:24584–24589.
  • Glaser M, Wanaski S, Buser CA, Boguslavsky V, Rashidzada W, Morris A, Rebecchi M, Scarlata SF, Runnels LW, Prestwich GD, Chen J, Aderem A, Ahn J and McLaughlin S. 1996. Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains. J Biol Chem 271:26187–26193.
  • Golebiewska U and Scarlata S. 2008. G{alpha}q Binds Two Effectors Separately in Cells: Evidence for Predetermined Signaling Pathways. Biophys J 95:2575–2582.
  • Hein PRF, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse M and Buneman M. 2006. Gs activation is time-limiting in initiating receptor-mediated signaling. J Biol Chem 281:33345–33351.
  • Hildebrandt JD. 1997. Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem Pharmacol 54:325–329.
  • Hughes TE, Zhang H, Logothetis D and Berlot CH. 2001. Visualization of a functional Gaq-green fluorescent protein fusion in living cells. J Biol Chem 276:4227–4235.
  • Hynes TR, Hughes TE and Berlot CH. 2004a. Cellular localization of GFP-tagged a subunits. In: Smrcka, A, ed. G Protein Signaling, Methods and Protocols Totowa, NJ: Humana Press. p233–246
  • Hynes TR, Mervine SM, Yost EA, Sabo JL and Berlot CH. 2004b. Live cell imaging of Gs and the b2-adrenergic receptor demonstrate that both as and b1g7 internalize upon stimulation and exhibit similar trafficking patters that differ from that of the b2-adrenergic receptor. J Biol Chem 279:44101–44112.
  • Janetopoulos C, Jin T and Devreotes P. 2001. Receptor-mediated activation of heterotrimeric G -proteins in living cells. Science 291:2408–2411.
  • Jensen JB, Lyssand JS, Hague C and Hille B. 2009. Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2/7.3 K+ channels. J Gen Physiol 133:347–359.
  • Katso R, Okkenhaug K, Ahmadim K, White S, Timms J and Waterfield MD. 2001. Cellular function of phosphoinositide-3-kinases: implications for development, immunity, homeostasis and cancer. Annu Rev Cell Dev Biol 17:615–675.
  • Kenworthy AK, Nichols BJ, Remmert CL, Hendrix GM, Kumar M, Zimmerberg J and Lippincott-Schwartz J. 2004. Dynamics of putative raft-associated proteins at the cell surface. J Cell Biol 165:735–746.
  • Kim C-H, Park Y-S, Chung K-N and Elwood PC. 2002. Sorting and function of the human folate receptor is independent of the cavolein expression in Fisher rat thyriod epithelial cells. Biochem Molec Biol 35:395–402.
  • Kroeze WK, Sheffler DJ and Roth BL. 2003. G-protein-coupled receptors at a glance. J Cell Sci 116:4867–4869.
  • Lakowicz J. 1999. Principles of Fluorescence Spectroscopy, 2nd edn New York: Plenum.
  • Lenne PF, Wawrezinieck L, Conchonaud F, Wurtz O, Boned A, Guo XJ, Rigneault H, He HT and Marguet D. 2006. Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork. EMBO J 25:3245–3256.
  • Lipardi C, Mora R, Colomer V, Paladino S, Nitsch L, Rodriguez-Boulan E and Zurzolo C. 1998. Caveolin transfection results in caveolae formation but not apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins in epithelial cells. J Cell Biol 140:617–626.
  • Liu P, Rudick M and Anderson RGW. 2002. Multiple functions of caveolin-1. J Biol Chem 277:41295–41298.
  • Lu Z, Jiang Y-P, Ballou LM, Cohen IS and Lin RZ. 2005. Gaq inhibits cardiac L-type Ca2+ channels through phosphadylinositol 3-kinase. J Biol Chem 280:40347–40354.
  • Magee A. 1990. Lipid modification of proteins and its relevance to protein targeting. J Cell Sci 97:581–584.
  • McCabe JB and Berthiaume LG. 2001. N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae. Mol Biol Cell 12:3601–3617.
  • Moffett S, Brown DA and Linder ME. 2000. Lipid-dependent targeting of G proteins into rafts. J Biol Chem 275:2191–2198.
  • Mora R, Bonilha VL, Marmorstein A, Scherer PE, Brown D, Lisanti MP and Rodriguez-Boulan E. 1999. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J Biol Chem 274:25708–25717.
  • Munro S. 2003. Lipid rafts: elusive or illusive? Cell 115:377–388.
  • Murthy KS and Makhlouf GM. 2000. Heterologous desensitization mediated by G protein-specific binding to caveolin. J Biol Chem 275 (39):30211–30219.
  • Myung CS, Lim WK, Defilippo JM, Yasuda H, Neubig RR and Garrison JC. 2006. Regions in the G protein {gamma} subunit important for interaction with receptors and effectors. Mol Pharmacol 69:877–887.
  • Oh P and Schnitzer JE. 2001. Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol Biol Cell 12:685–698.
  • Philip F, Sengupta P and Scarlata S. 2007. Signaling through a G Protein Coupled Receptor and its corresponding G protein follows a stoichometrically limited model. J Biol Chem 282:19203–19216.
  • Pierce KL, Premont RT and Lefkowitz RJ. 2002. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639–650.
  • Pierini LM and Maxfield FR. 2001. Flotillas of rafts fore and aft. PNAS 98:9471–9473.
  • Pike LJ, Han X, Chung K-N and Gross RW. 2002. Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry 41:2075–2088.
  • Rebecchi M and Pentylana S. 2000. Structure, function and control of phosphoinositide-specific phospholipase C. Physiol Revi 80:1291–1335.
  • Runnels LW and Scarlata S. 1999. Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C- b effectors. Biochemistry 38:1488–1496.
  • Schlegel A, Volonte D, Engelman JA, Galbiata F, Mehta P, Zhange X-L, Scherer P and Lisanti MP. 1998. Crowded little caves: structure and function of caveolae. Cell Signal 10:457–463.
  • Sengupta P, Philip F and Scarlata S. 2008. Caveolin-1 alters Ca2+ signal duration through specific interaction with the G{alpha}q family of G proteins. J Cell Sci 121:1363–1372.
  • Silvius JR. 2003. Role of cholesterol in lipid raft formation: lessons from lipid model systems. Biochim Biophys Acta 1610:174–183.
  • Soubias O, Teague WE and Gawrisch K. 2006. Evidence for specificity in lipid–rhodopsin interactions. J Biol Chem 281:33233–33241.
  • Suh P, Park J, Manzoli L, Cocco L, Peak J, Katan M, Fukami K, Kataoka T, Yun S and Ryu S. 2008. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB reports 41:415–434.
  • Suzuki KG, Fujiwara TK, Edidin M and Kusumi A. 2007. Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2. J Cell Biol 177:731–742.
  • Wang J, Golebiewska U and Scarlata S. 2009a. A self-scaffolding model for G protein signaling. J Molec Biol 387:92–103.
  • Wang J, Sengupta P, Guo Y, Golebiewska U and Scarlata S. 2009b. Evidence for a second, high affinity Gbg binding site on Gai1(GDP) subunits. J Biol Chem 284:16909–16917.
  • Wang TY and Silvius JR. 2001. Cholesterol does not induce segregation of liquid-ordered domains in bilayers modeling the inner leaflet of the plasma membrane. Biophys J 81:2762–2773.
  • Wedegaertner P, Wilson P and Bourne H. 1995. Lipid modifications of trimeric G proteins. J Biol Chem 270:503–506.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.