3,535
Views
313
CrossRef citations to date
0
Altmetric
Review Article

ADAM-17: the enzyme that does it all

Pages 146-169 | Received 02 Dec 2009, Accepted 15 Jan 2010, Published online: 25 Feb 2010

References

  • Ahrens I, Ellwanger C, Smith BK, Bassler N, Chen YC, Neudorfer I, Ludwig A, Bode C and Peter K. 2008. Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes. J Leukoc Biol 83:1388–1395.
  • Alfa Cisse M, Sunyach C, Slack BE, Fisher A, Vincent B and Checler F. 2007. M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity. J Neurosci 27:4083–4092.
  • Allinson TM, Parkin ET, Turner AJ and Hooper NM. 2003. ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 74:342–352.
  • Amin AR. 1999. Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis. Osteoarthritis Cartilage 7:392–394.
  • Amour A, Slocombe PM, Webster A, Butler M, Knight CG, Smith BJ, Stephens PE, Shelley C, Hutton M, Knauper V, Docherty AJ and Murphy G. 1998. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett 435:39–44.
  • Anderson JP, Chen Y, Kim KS and Robakis NK. 1992. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. J Neurochem 59:2328–2331.
  • Arribas J, Bech-Serra JJ and Santiago-Josefat B. 2006. ADAMs, cell migration and cancer. Cancer Metastasis Rev 25:57–68.
  • Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schurmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S and Neurath MF. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6:583–588.
  • Baba Y, Yasuda O, Takemura Y, Ishikawa Y, Ohishi M, Iwanami J, Mogi M, Doe N, Horiuchi M, Maeda N, Fukuo K and Rakugi H. 2009. Timp-3 deficiency impairs cognitive function in mice. Lab Invest 89:1340–1347.
  • Bandyopadhyay S, Goldstein LE, Lahiri DK and Rogers JT. 2007. Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer’s disease. Curr Med Chem 14:2848–2864.
  • Bao J, Wolpowitz D, Role LW and Talmage DA. 2003. Back signaling by the Nrg-1 intracellular domain. J Cell Biol 161:1133–1141.
  • Bax DV, Messent AJ, Tart J, van Hoang M, Kott J, Maciewicz RA and Humphries MJ. 2004. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. J Biol Chem 279:22377–22386.
  • Bigdeli MR and Khoshbaten A. 2008. In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-alpha converting enzyme/tumor necrosis factor-alpha/nuclear factor-kappaB. Neuroscience 153:671–678.
  • Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, Nelson N, Boiani N, Schooley KA, Gerhart M, Davis R, Fitzner JN, Johnson RS, Paxton RJ, March CJ and Cerretti DP. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385:729–733.
  • Blanchot-Jossic F, Jarry A, Masson D, Bach-Ngohou K, Paineau J, Denis MG, Laboisse CL and Mosnier JF. 2005. Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. J Pathol 207:156–163.
  • Blobel CP. 2005. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6:32–43.
  • Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M and Kaether C. 2009. Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett 583:3221–3224.
  • Bohgaki T, Amasaki Y, Nishimura N, Bohgaki M, Yamashita Y, Nishio M, Sawada KI, Jodo S, Atsumi T and Koike T. 2005. Up regulated expression of tumour necrosis factor α converting enzyme in peripheral monocytes of patients with early systemic sclerosis. Ann Rheum Dis 64:1165–1173.
  • Boissy P, Lenhard TR, Kirkegaard T, Peschon JJ, Black RA, Delaisse JM and del Carmen Ovejero M. 2003. An assessment of ADAMs in bone cells: absence of TACE activity prevents osteoclast recruitment and the formation of the marrow cavity in developing long bones. FEBS Lett 553:257–261.
  • Borrell-Pages M, Rojo F, Albanell J, Baselga J and Arribas J. 2003. TACE is required for the activation of the EGFR by TGF-alpha in tumors. EMBO J 22:1114–1124.
  • Borroto A, Ruiz-Paz S, de la Torre TV, Borrell-Pages M, Merlos-Suarez A, Pandiella A, Blobel CP, Baselga J and Arribas J. 2003. Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. J Biol Chem 278:25933–25939.
  • Bridges LC and Bowditch RD. 2005. ADAM–integrin interactions: potential integrin regulated ectodomain shedding activity. Curr Pharm Des 11:837–847.
  • Briso EM, Dienz O and Rincon M. 2008. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol 180:7102–7106.
  • Brodowicz T, Wiltschke C, Budinsky AC, Krainer M, Steger GG and Zielinski CC. 1997. Soluble HER-2/neu neutralizes biologic effects of anti-HER-2/neu antibody on breast cancer cells in vitro. Int J Cancer 73:875–879.
  • Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA and Israel A. 2000. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 5:207–216.
  • Buckley CA, Rouhani FN, Kaler M, Adamik B, Hawari FI and Levine SJ. 2005. Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch. Am J Physiol Lung Cell Mol Physiol 288:L1132–1138.
  • Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC and Bulfone-Paus S. 2004. Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). J Biol Chem 279:40368–40375.
  • Burrage PS and Brinckerhoff CE. 2007. Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. Curr Drug Targets 8:293–303.
  • Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP and Black RA. 1998. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273:27765–27767.
  • Caescu CI, Jeschke GR and Turk BE. 2009. Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. Biochem J 424:79–88.
  • Calvete JJ. 2005. Structure–function correlations of snake venom disintegrins. Curr Pharm Des 11:829–835.
  • Calvete JJ, Moreno-Murciano MP, Theakston RD, Kisiel DG and Marcinkiewicz C. 2003. Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem J 372:725–734.
  • Calvete JJ, Marcinkiewicz C and Sanz L. 2007. KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin. Curr Pharm Des 13:2853–2859.
  • Camden JM, Schrader AM, Camden RE, Gonzalez FA, Erb L, Seye CI and Weisman GA. 2005. P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing. J Biol Chem 280:18696–18702.
  • Canault M, Peiretti F, Kopp F, Bonardo B, Bonzi MF, Coudeyre JC, Alessi MC, Juhan-Vague I and Nalbone G. 2006a. The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors. Atherosclerosis 187:82–91.
  • Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G and Peiretti F. 2006b. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J Cell Physiol 208:363–372.
  • Cardenas A, Moro MA, Leza JC, O’Shea E, Davalos A, Castillo J, Lorenzo P and Lizasoain I. 2002. Upregulation of TACE/ADAM17 after ischemic preconditioning is involved in brain tolerance. J Cereb Blood Flow Metab 22:1297–1302.
  • Caso JR, Lizasoain I, Lorenzo P, Moro MA and Leza JC. 2006. The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats. Neuroscience 142:59–69.
  • Cesaro A, Abakar-Mahamat A, Brest P, Lassalle S, Selva E, Filippi J, Hebuterne X, Hugot JP, Doglio A, Galland F, Naquet P, Vouret-Craviari V, Mograbi B and Hofman PM. 2009. Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 296:G1332–1343.
  • Charbonneau M, Harper K, Grondin F, Pelmus M, McDonald PP and Dubois CM. 2007. Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. J Biol Chem 282:33714–33724.
  • Charrier-Hisamuddin L, Laboisse CL and Merlin D. 2008. ADAM-15: a metalloprotease that mediates inflammation. FASEB J 22:641–653.
  • Chen B, Bronson RT, Klaman LD, Hampton TG, Wang JF, Green PJ, Magnuson T, Douglas PS, Morgan JP and Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24:296–299.
  • Chen J, Cui X, Zacharek A, Ding GL, Shehadah A, Jiang Q, Lu M and Chopp M. 2009. Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. J Cereb Blood Flow Metab 29:911–920.
  • Chen MS, Almeida EA, Huovila AP, Takahashi Y, Shaw LM, Mercurio AM and White JM. 1999. Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. J Cell Biol 144:549–561.
  • Chikaraishi Y, Shimazawa M, Yokota K, Yoshino K and Hara H. 2009. CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo. Curr Neurovasc Res 6:140–147.
  • Cho RW, Park JM, Wolff SB, Xu D, Hopf C, Kim JA, Reddy RC, Petralia RS, Perin MS, Linden DJ and Worley PF. 2008. mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Neuron 57:858–871.
  • Chokki M, Mitsuhashi H and Kamimura T. 2006. Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292. Life Sci 78:3051–3057.
  • Chung KH, Kim SH, Han KY, Sohn YD, Chang SI, Baek KH, Jang Y, Kim DS and Kang IC. 2003. Inhibitory effect of salmosin, a Korean snake venom-derived disintegrin, on the integrin alphav-mediated proliferation of SK-Mel-2 human melanoma cells. J Pharm Pharmacol 55:1577–1582.
  • Citri A, Skaria KB and Yarden Y. 2003. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 284:54–65.
  • Comabella M, Romera C, Camina M, Perkal H, Moro MA, Leza JC, Lizasoain I, Castillo M and Montalban X. 2006. TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis. J Neurol 253:701–706.
  • Cominetti MR, Ribeiro JU, Fox JW and Selistre-de-Araujo HS. 2003. BaG, a new dimeric metalloproteinase/disintegrin from the Bothrops alternatus snake venom that interacts with alpha5beta1 integrin. Arch Biochem Biophys 416:171–179.
  • Condon TP, Flournoy S, Sawyer GJ, Baker BF, Kishimoto TK and Bennett CF. 2001. ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes. Antisense Nucleic Acid Drug Dev 11:107–116.
  • Csiszar A, Ungvari Z, Koller A, Edwards JG and Kaley G. 2004. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol Genomics 17:21–30.
  • Danen EH, Marcinkiewicz C, Cornelissen IM, van Kraats AA, Pachter JA, Ruiter DJ, Niewiarowski S and van Muijen GN. 1998. The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells. Exp Cell Res 238:188–196.
  • DasGupta S, Murumkar PR, Giridhar R and Yadav MR. 2009. Current perspective of TACE inhibitors: a review. Bioorg Med Chem 17:444–459.
  • De Benedetti F, Massa M, Pignatti P, Albani S, Novick D and Martini A. 1994. Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest 93:2114–2119.
  • Dell KM, Nemo R, Sweeney WE, Jr Levin, JI, Frost P and Avner ED. 2001. A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. Kidney Int 60:1240–1248.
  • De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A and Kopan R. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518–522.
  • Diaz-Rodriguez E, Montero JC, Esparis-Ogando A, Yuste L and Pandiella A. 2002. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell 13:2031–2044.
  • Dibbs ZI, Diwan A, Nemoto S, DeFreitas G, Abdellatif M, Carabello BA, Spinale FG, Feuerstein G, Sivasubramanian N and Mann DL. 2003. Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype. Circulation 108:1002–1008.
  • Ding X, Yang LY, Huang GW, Wang W and Lu WQ. 2004. ADAM17 mRNA expression and pathological features of hepatocellular carcinoma. World J Gastroenterol 10:2735–2739.
  • Doedens JR and Black RA. 2000. Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme. J Biol Chem 275:14598–14607.
  • Doedens JR, Mahimkar RM and Black RA. 2003. TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. Biochem Biophys Res Commun 308:331–338.
  • Duan JJ, Chen L, Wasserman ZR, Lu Z, Liu RQ, Covington MB, Qian M, Hardman KD, Magolda RL, Newton RC, Christ DD, Wexler RR and Decicco CP. 2002. Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. J Med Chem 45:4954–4957.
  • Duffy MJ, McKiernan E, O’Donovan N and McGowan PM. 2009. Role of ADAMs in cancer formation and progression. Clin Cancer Res 15:1140–1144.
  • Echchannaoui H, Leib SL, Neumann U and Landmann RM. 2007. Adjuvant TACE inhibitor treatment improves the outcome of TLR2–/– mice with experimental pneumococcal meningitis. BMC Infect Dis 7:25.
  • Edwards DR, Handsley MM and Pennington CJ. 2008. The ADAM metalloproteinases. Mol Aspects Med 29:258–289.
  • Ermert M, Pantazis C, Duncker HR, Grimminger F, Seeger W and Ermert L. 2003. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine 22:89–100.
  • Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP and Takada Y. 2000. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell–cell interaction. J Biol Chem 275:34922–34930.
  • Fabre-Lafay S, Garrido-Urbani S, Reymond N, Goncalves A, Dubreuil P and Lopez M. 2005. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. J Biol Chem 280:19543–19550.
  • Fahrenholz F, Gilbert S, Kojro E, Lammich S and Postina R. 2000. Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure. Ann NY Acad Sci 920:215–222.
  • Fan H, Turck CW and Derynck R. 2003. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem 278:18617–18627.
  • Faveeuw C, Preece G and Ager A. 2001. Transendothelial migration of lymphocytes across high endothelial venules into lymph nodes is affected by metalloproteinases. Blood 98:688–695.
  • Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK and Khokha R. 2004. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation 110:2401–2409.
  • Feldmann M, Brennan FM, Elliott MJ, Williams RO and Maini RN. 1995. TNF alpha is an effective therapeutic target for rheumatoid arthritis. Ann NY Acad Sci 766:272–278.
  • Feldmann M, Brennan FM and Maini RN. 1996. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397–440.
  • Fridman JS, Caulder E, Hansbury M, Liu X, Yang G, Wang Q, Lo Y, Zhou BB, Pan M, Thomas SM, Grandis JR, Zhuo J, Yao W, Newton RC, Friedman SM, Scherle PA and Vaddi K. 2007. Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clin Cancer Res 13:1892–1902.
  • Galan JA, Sanchez EE, Rodriguez-Acosta A, Soto JG, Bashir S, McLane MA, Paquette-Straub C and Perez JC. 2008. Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon 51:1186–1196.
  • Galvin KM, Donovan MJ, Lynch CA, Meyer RI, Paul RJ, Lorenz JN, Fairchild-Huntress V, Dixon KL, Dunmore JH, Gimbrone MA, Jr Falb, D and Huszar D. 2000. A role for smad6 in development and homeostasis of the cardiovascular system. Nat Genet 24:171–174.
  • Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ and Raines EW. 2001. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 276:37993–38001.
  • Garton KJ, Gough PJ, Philalay J, Wille PT, Blobel CP, Whitehead RH, Dempsey PJ and Raines EW. 2003. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem 278:37459–37464.
  • Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, Ogimoto K, Schwartz MW and Dempsey PJ. 2008. Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology 149:6053–6064.
  • Giancotti FG and Ruoslahti E. 1999. Integrin signaling. Science 285:1028–1032.
  • Gilmore JL, King BW, Harris C, Maduskuie T, Mercer SE, Liu RQ, Covington MB, Qian M, Ribadeneria MD, Vaddi K, Trzaskos JM, Newton RC, Decicco CP and Duan JJ. 2006. Synthesis and structure–activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 16:2699–2704.
  • Gilmore JL, King BW, Asakawa N, Harrison K, Tebben A, Sheppeck JE, 2nd Liu, RQ, Covington M and Duan JJ. 2007. Synthesis and structure–activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 17:4678–4682.
  • Goddard DR, Bunning RA and Woodroofe MN. 2001. Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS. Glia 34:267–271.
  • Gomez MI, Sokol SH, Muir AB, Soong G, Bastien J and Prince AS. 2005. Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling. J Immunol 175:1930–1936.
  • Gonzales PE, Solomon A, Miller AB, Leesnitzer MA, Sagi I and Milla ME. 2004. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. J Biol Chem 279:31638–31645.
  • Gonzales PE, Galli JD and Milla ME. 2008. Identification of key sequence determinants for the inhibitory function of the prodomain of TACE. Biochemistry 47:9911–9919.
  • Gooz M, Gooz P, Luttrell LM and Raymond JR. 2006. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. J Biol Chem 281:21004–21012.
  • Gooz P, Gooz M, Baldys A and Hoffman S. 2009. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis. Biochem Biophys Res Commun 380:33–38.
  • Goto T, Ishizaka A, Kobayashi F, Kohno M, Sawafuji M, Tasaka S, Ikeda E, Okada Y, Maruyama I and Kobayashi K. 2004. Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats. Am J Respir Crit Care Med 170:1239–1246.
  • Gschwind A, Hart S, Fischer OM and Ullrich A. 2003. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 22:2411–2421.
  • Guinea-Viniegra J, Zenz R, Scheuch H, Hnisz D, Holcmann M, Bakiri L, Schonthaler HB, Sibilia M and Wagner EF. 2009. TNFα shedding and epidermal inflammation are controlled by Jun proteins. Genes Dev 23:2663–2674.
  • Haga S, Yamamoto N, Nakai-Murakami C, Osawa Y, Tokunaga K, Sata T, Sasazuki T and Ishizaka Y. 2008. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. Proc Natl Acad Sci USA 105:7809–7814.
  • Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG and Elias JA. 2008. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. J Biol Chem 283:33472–33482.
  • Hartmann D, Tournoy J, Saftig P, Annaert W and De Strooper B. 2001. Implication of APP secretases in notch signaling. J Mol Neurosci 17:171–181.
  • Higashiyama S and Nanba D. 2005. ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751:110–117.
  • Higuchi M, Yasuda O, Kawamoto H, Yotsui T, Baba Y, Ozaki T, Maeda N, Fukuo K, Rakugi H and Ogihara T. 2007. Tissue inhibitor of metalloproteinase-3 deficiency inhibits blood pressure elevation and myocardial microvascular remodeling induced by chronic administration of Nomega-nitro-L-arginine methyl ester in mice. Hypertens Res 30:563–571.
  • Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE and Lee DC. 2004. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem 279:24179–24188.
  • Hiraoka Y, Ohno M, Yoshida K, Okawa K, Tomimoto H, Kita T and Nishi E. 2007. Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin. J Neurochem 102:1595–1605.
  • Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, Toyama Y and Blobel CP. 2007. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179:2686–2689.
  • Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP and Toyama Y. 2009a. Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. J Immunol 182:2093–2101.
  • Horiuchi K, Morioka H, Takaishi H, Akiyama H, Blobel CP and Toyama Y. 2009b. Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. J Immunol 182:7408–7414.
  • Huang A, Joseph-McCarthy D, Lovering F, Sun L, Wang W, Xu W, Zhu Y, Cui J, Zhang Y and Levin JI. 2007. Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket. Bioorg Med Chem 15:6170–6181.
  • Huang J, Bridges LC and White JM. 2005. Selective modulation of integrin-mediated cell migration by distinct ADAM family members. Mol Biol Cell 16:4982–4991.
  • Huang TF, Holt JC, Lukasiewicz H and Niewiarowski S. 1987. Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. J Biol Chem 262:16157–16163.
  • Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S and Ludwig A. 2003. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102:1186–1195.
  • Huovila AP, Turner AJ, Pelto-Huikko M, Karkkainen I and Ortiz RM. 2005. Shedding light on ADAM metalloproteinases. Trends Biochem Sci 30:413–422.
  • Hurtado O, Cardenas A, Lizasoain I, Bosca L, Leza JC, Lorenzo P and Moro MA. 2001. Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices. Neuropharmacology 40:1094–1102.
  • Hurtado O, Lizasoain I, Fernandez-Tome P, Alvarez-Barrientos A, Leza JC, Lorenzo P and Moro MA. 2002. TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate. J Cereb Blood Flow Metab 22:576–585.
  • Huveneers S, Truong H and Danen HJ. 2007. Integrins: signaling, disease, and therapy. Int J Radiat Biol 83:743–751.
  • Huxley-Jones J, Clarke TK, Beck C, Toubaris G, Robertson DL and Boot-Handford RP. 2007. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evol Biol 7:63.
  • Ingram RN, Orth P, Strickland CL, Le HV, Madison V and Beyer BM. 2006. Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies. Protein Eng Des Sel 19:155–161.
  • Jackson LF, Qiu TH, Sunnarborg SW, Chang A, Zhang C, Patterson C and Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. Embo J 22:2704–2716.
  • Janssen A, Hoellenriegel J, Fogarasi M, Schrewe H, Seeliger M, Tamm E, Ohlmann A, May CA, Weber BH and Stohr H. 2008. Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci 49:2812–2822.
  • Ju CR, Xia XZ and Chen RC. 2007. Expressions of tumor necrosis factor-converting enzyme and ErbB3 in rats with chronic obstructive pulmonary disease. Chin Med J (Engl) 120:1505–1510.
  • Kalus I, Bormann U, Mzoughi M, Schachner M and Kleene R. 2006. Proteolytic cleavage of the neural cell adhesion molecule by ADAM17/TACE is involved in neurite outgrowth. J Neurochem 98:78–88.
  • Karan D, Lin FC, Bryan M, Ringel J, Moniaux N, Lin MF and Batra SK. 2003. Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. Int J Oncol 23:1365–1371.
  • Karkkainen I, Rybnikova E, Pelto-Huikko M and Huovila AP. 2000. Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS. Mol Cell Neurosci 15:547–560.
  • Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH and Khokha R. 2005. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circ Res 97:380–390.
  • Kassiri Z, Oudit GY, Kandalam V, Awad A, Wang X, Ziou X, Maeda N, Herzenberg AM and Scholey JW. 2009. Loss of TIMP3 enhances interstitial nephritis and fibrosis. J Am Soc Nephrol 20:1223–1235.
  • Katakowski M, Chen J, Zhang ZG, Santra M, Wang Y and Chopp M. 2007. Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity. J Cereb Blood Flow Metab 27:669–678.
  • Katakowski M, Jiang F, Zheng X, Gutierrez JA, Szalad A and Chopp M. 2009. Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. Cancer Sci 100:1597–1604.
  • Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Moller P, Mercurio AM, Albrechtsen R and Wewer UM. 2003. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci 116:3893–3904.
  • Kawaguchi M, Mitsuhashi Y and Kondo S. 2005. Overexpression of tumour necrosis factor-alpha-converting enzyme in psoriasis. Br J Dermatol 152:915–919.
  • Kenny PA and Bissell MJ. 2007. Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 117:337–345.
  • Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA and Chollet-Martin S. 2005. Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. Crit Care Med 33:1359–1364.
  • Kieseier BC, Pischel H, Neuen-Jacob E, Tourtellotte WW and Hartung HP. 2003. ADAM-10 and ADAM-17 in the inflamed human CNS. Glia 42:398–405.
  • Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR and Lee VM. 2008. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. J Neurosci 28:12052–12061.
  • Kini RM and Evans HJ. 1992. Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor. Toxicon 30:265–293.
  • Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C and Ludwig A. 2009. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood 113:4799–4809.
  • Kojro E and Fahrenholz F. 2005. The non-amyloidogenic pathway: structure and function of alpha-secretases. Subcell Biochem 38:105–127.
  • Kojro E, Postina R, Buro C, Meiringer C, Gehrig-Burger K and Fahrenholz F. 2006. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. Faseb J 20:512–514.
  • Kretzschmar M, Doody J and Massague J. 1997. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389:618–622.
  • Kriegler M, Perez C, DeFay K, Albert I and Lu SD. 1988. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53:45–53.
  • Kuwahara I, Lillehoj EP, Koga T, Isohama Y, Miyata T and Kim KC. 2007. The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription. Am J Respir Cell Mol Biol 37:691–698.
  • Kwak HI, Mendoza EA and Bayless KJ. 2009. ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices. Matrix Biol 28:470–479.
  • Lambert MH, Blackburn RK, Seaton TD, Kassel DB, Kinder DS, Leesnitzer MA, Bickett DM, Warner JR, Andersen MW, Badiang JG, Cowan DJ, Gaul MD, Petrov KG, Rabinowitz MH, Wiethe RW, Becherer JD, McDougald DL, Musso DL, Andrews RC and Moss ML. 2005. Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping. Comb Chem High Throughput Screen 8:327–339.
  • Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C and Fahrenholz F. 1999. Constitutive and regulated alpha-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96:3922–3927.
  • Lautrette A, Li S, Alili R, Sunnarborg SW, Burtin M, Lee DC, Friedlander G and Terzi F. 2005. Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat Med 11:867–874.
  • Lee MH, Verma V, Maskos K, Becherer JD, Knauper V, Dodds P, Amour A and Murphy G. 2002. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3. FEBS Lett 520:102–106.
  • Leib SL, Clements JM, Lindberg RL, Heimgartner C, Loeffler JM, Pfister LA, Tauber MG and Leppert D. 2001. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124:1734–1742.
  • Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE and LaFerla FM. 2002. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci USA 99:4697–4702.
  • Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E and Basbaum C. 2003. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. J Biol Chem 278:26202–26207.
  • Leonard JD, Lin F and Milla ME. 2005. Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch. Biochem J 387:797–805.
  • Lewis J. 1998. Notch signalling. A short cut to the nucleus. Nature 393:304–305.
  • Li N, Boyd K, Dempsey PJ and Vignali DA. 2007. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol 178:4214–4221.
  • Li X and Fan H. 2004. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). J Biol Chem 279:27365–27375.
  • Li X, Yan Y, Huang W, Yang Y, Wang H and Chang L. 2009. The regulation of TACE catalytic function by its prodomain. Mol Biol Rep 36:641–651.
  • Li Z, Mei Y, Liu X and Zhou M. 2007. Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners. Cell Signal 19:466–471.
  • Lovering F and Zhang Y. 2005. Therapeutic potential of TACE inhibitors in stroke. Curr Drug Targets CNS Neurol Disord 4:161–168.
  • Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O and Lee DC. 1993. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263–278.
  • Luetteke NC, Qiu TH, Fenton SE, Troyer KL, Riedel RF, Chang A and Lee DC. 1999. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126:2739–2750.
  • Madrigal JL, Hurtado O, Moro MA, Lizasoain I, Lorenzo P, Castrillo A, Bosca L and Leza JC. 2002. The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress. Neuropsychopharmacology 26:155–163.
  • Mahmoodi M, Sahebjam S, Smookler D, Khokha R and Mort JS. 2005. Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. Am J Pathol 166:1733–1740.
  • Majka S, McGuire PG and Das A. 2002. Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. Invest Ophthalmol Vis Sci 43:260–266.
  • Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL and Dunn AR. 1993. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249–261.
  • Marcinkiewicz C. 2005. Functional characteristic of snake venom disintegrins: potential therapeutic implication. Curr Pharm Des 11:815–827.
  • Marcinkiewicz C, Calvete JJ, Vijay-Kumar S, Marcinkiewicz MM, Raida M, Schick P, Lobb RR and Niewiarowski S. 1999. Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits alpha 5 beta 1 integrin. Biochemistry 38:13302–13309.
  • Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P and Reiss K. 2005. L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol 25:9040–9053.
  • Marin V, Montero-Julian F, Gres S, Bongrand P, Farnarier C and Kaplanski G. 2002. Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. Eur J Immunol 32:2965–2970.
  • Martin EL, Moyer BZ, Pape MC, Starcher B, Leco KJ and Veldhuizen RA. 2003. Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis. Am J Physiol Lung Cell Mol Physiol 285:L1222–1232.
  • Maskos K, Fernandez-Catalan C, Huber R, Bourenkov GP, Bartunik H, Ellestad GA, Reddy P, Wolfson MF, Rauch CT, Castner BJ, Davis R, Clarke HR, Petersen M, Fitzner JN, Cerretti DP, March CJ, Paxton RJ, Black RA and Bode W. 1998. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proc Natl Acad Sci USA 95:3408–3412.
  • Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL and Beyreuther K. 1985. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82:4245–4249.
  • McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O’Shea JJ and Kastner DL. 1999. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133–144.
  • McGeehan GM, Becherer JD, Bast RC, Jr Boyer, CM, Champion B, Connolly KM, Conway JG, Furdon P, Karp S, Kidao S, McElroy AB, Nichols J, Pryzwansky KM, Schoenen F, SekutL Truesdale, A, Verghese M, Warner J and Ways JP. 1994. Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. Nature 370:558–561.
  • McGowan PM, Ryan BM, Hill AD, McDermott E, O’Higgins N and Duffy MJ. 2007. ADAM-17 expression in breast cancer correlates with variables of tumor progression. Clin Cancer Res 13:2335–2343.
  • McGowan PM, McKiernan E, Bolster F, Ryan BM, Hill AD, McDermott EW, Evoy D, O’Higgins N, Crown J and Duffy MJ. 2008. ADAM-17 predicts adverse outcome in patients with breast cancer. Ann Oncol 19:1075–1081.
  • Meli DN, Loeffler JM, Baumann P, Neumann U, Buhl T, Leppert D and Leib SL. 2004. In pneumococcal meningitis a novel water-soluble inhibitor of matrix metalloproteinases and TNF-alpha converting enzyme attenuates seizures and injury of the cerebral cortex. J Neuroimmunol 151:6–11.
  • Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, Porzio O, Hribal ML, Folli F, Khokha R, Urbani A, Lauro R, Pugliese G and Federici M. 2009. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 136:663–672 e4.
  • Mercer B, Markland F and Minkin C. 1998. Contortrostatin, a homodimeric snake venom disintegrin, is a potent inhibitor of osteoclast attachment. J Bone Miner Res 13:409–414.
  • Merchant NB, Rogers CM, Trivedi B, Morrow J and Coffey RJ. 2005. Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery 138:415–421.
  • Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK and Coffey RJ. 2008. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res 14:1182–1191.
  • Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z and Derynck R. 1995. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337–341.
  • Mohler KM, Torrance DS, Smith CA, Goodwin RG, Stremler KE, Fung VP, Madani H and Widmer MB. 1993. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol 151:1548–1561.
  • Mohler KM, Sleath PR, Fitzner JN, Cerretti DP, Alderson M, Kerwar SS, Torrance DS, Otten-Evans C, Greenstreet T, Weerawarna K, Kronheim SR, Petersen M, Gerhart M, Kozlosky CJ, March CJ and Black RA. 1994. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370:218–220.
  • Moriyama H, Tsukida T, Inoue Y, Yokota K, Yoshino K, Kondo H, Miura N and Nishimura S. 2004. Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents. J Med Chem 47:1930–1938.
  • Moss ML, Jin SL, Becherer JD, Bickett DM, Burkhart W, Chen WJ, Hassler D, Leesnitzer MT, McGeehan G, Milla M, Moyer M, Rocque W, Seaton T, Schoenen F, Warner J and Willard D. 1997a. Structural features and biochemical properties of TNF-alpha converting enzyme (TACE). J Neuroimmunol 72:127–129.
  • Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Warner J, Willard D and Becherer JD. 1997b. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 385:733–736.
  • Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart PM, Gillispie PA, Stoeck A, Wildeboer D, Bartsch JW, Palmisano R and Zhou P. 2007. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem 282:35712–35721.
  • Moss ML, Sklair-Tavron L and Nudelman R. 2008. Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol 4:300–309.
  • Murali R, Brennan PJ, Kieber-Emmons T and Greene MI. 1996. Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains. Proc Natl Acad Sci USA 93:6252–6257.
  • Nakamura K, Iwamoto R and Mekada E. 1995. Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell–cell contact sites. J Cell Biol 129:1691–1705.
  • Nakamura T, Abe H, Hirata A and Shimoda C. 2004. ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell 3:27–39.
  • Nanba D, Mammoto A, Hashimoto K and Higashiyama S. 2003. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol 163:489–502.
  • Nath D, Slocombe PM, Stephens PE, Warn A, Hutchinson GR, Yamada KM, Docherty AJ and Murphy G. 1999. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. J Cell Sci 112:579–587.
  • Nelson KK, Schlondorff J and Blobel CP. 1999. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J 343:673–680.
  • Nemo R, Murcia N and Dell KM. 2005. Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease. Pediatr Res 57:732–737.
  • Newton RC and Decicco CP. 1999. Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha. J Med Chem 42:2295–2314.
  • Nishi E, Hiraoka Y, Yoshida K, Okawa K and Kita T. 2006. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. J Biol Chem 281:31164–31172.
  • Oh ST, Schramme A, Stark A, Tilgen W, Gutwein P and Reichrath J. 2009. The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. J Cutan Pathol 36:395–401.
  • Ohta S, Harigai M, Tanaka M, Kawaguchi Y, Sugiura T, Takagi K, Fukasawa C, Hara M and Kamatani N. 2001. Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis. J Rheumatol 28:1756–1763.
  • Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K and Eguchi S. 2006. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol 26:e133–137.
  • Olfa KZ, Jose L, Salma D, Amine B, Najet SA, Nicolas A, Maxime L, Raoudha Z, Kamel M, Jacques M, Jean-Marc S, Mohamed el A and Naziha M. 2005. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab Invest 85:1507–1516.
  • Papadakis KA and Targan SR. 2000. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51:289–298.
  • Patel IR, Attur MG, Patel RN, Stuchin SA, Abagyan RA, Abramson SB and Amin AR. 1998. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. J Immunol 160:4570–4579.
  • Peiretti F, Canault M, Deprez-Beauclair P, Berthet V, Bonardo B, Juhan-Vague I and Nalbone G. 2003a. Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme. Exp Cell Res 285:278–285.
  • Peiretti F, Deprez-Beauclair P, Bonardo B, Aubert H, Juhan-Vague I and Nalbone G. 2003b. Identification of SAP97 as an intracellular binding partner of TACE. J Cell Sci 116:1949–1957.
  • Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC and Lemere CA. 2007. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience 150:386–395.
  • Perez L, Kerrigan JE, Li X and Fan H. 2007. Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. Biochem Cell Biol 85:141–149.
  • Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ and Black RA. 1998. An essential role for ectodomain shedding in mammalian development. Science 282:1281–1284.
  • Planque C, Kulasingan V, Smith CR, Reckamp K, Goodglick L and Diamandis EP. 2009. Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines. Mol Cell Proteomics 8:2746–2758.
  • Plumb J, McQuaid S, Cross AK, Surr J, Haddock G, Bunning RA and Woodroofe MN. 2006. Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. Mult Scler 12:375–385.
  • Pradillo JM, Romera C, Hurtado O, Cardenas A, Moro MA, Leza JC, Davalos A, Castillo J, Lorenzo P and Lizasoain I. 2005. TNFR1 upregulation mediates tolerance after brain ischemic preconditioning. J Cereb Blood Flow Metab 25:193–203.
  • Prenzel N, Zwick E, Daub H, Leserer M, Abraham R Wallasch C and Ullrich A. 1999. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884–888.
  • Qu D, Wang Y, Esmon NL and Esmon CT. 2007. Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. J Thromb Haemost 5:395–402.
  • Rabinowitz MH, Andrews RC, Becherer JD, Bickett DM, Bubacz DG, Conway JG, Cowan DJ, Gaul M, Glennon K, Lambert MH, Leesnitzer MA, McDougald DL, Moss ML, Musso DL and Rizzolio MC. 2001. Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). J Med Chem 44:4252–4267.
  • Reddy P, Slack JL, Davis R, Cerretti DP, Kozlosky CJ, Blanton RA, Shows D, Peschon JJ and Black RA. 2000. Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem 275:14608–14614.
  • Reddy AB, Ramana KV, Srivastava S, Bhatnagar A and Srivastava SK. 2009. Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology 150:63–74.
  • Reiss K and Saftig P. 2009. The “a disintegrin and metalloprotease” (ADAM) family of sheddases: physiological and cellular functions. Semin Cell Dev Biol 20:126–137.
  • Richards WG, Sweeney WE, Yoder BK, Wilkinson JE, Woychik RP and Avner ED. 1998. Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101:935–939.
  • Robertshaw HJ and Brennan FM. 2005. Release of tumour necrosis factor alpha (TNFalpha) by TNFalpha cleaving enzyme (TACE) in response to septic stimuli in vitro. Br J Anaesth 94:222–228.
  • Romera C, Hurtado O, Botella SH, Lizasoain I, Cardenas A, Fernandez-Tome P, Leza JC, Lorenzo P and Moro MA. 2004. In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway. J Neurosci 24:1350–1357.
  • Rovida E, Paccagnini A, Del Rosso M, Peschon J and Dello Sbarba P. 2001. TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation. J Immunol 166:1583–1589.
  • Rubio-Araiz A, Arevalo-Martin A, Gomez-Torres O, Navarro-Galve B, Garcia-Ovejero D, Suetterlin P, Sanchez-Heras E, Molina-Holgado E and Molina-Holgado F. 2008. The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Mol Cell Neurosci 38:374–380.
  • Ruchatz H, Leung BP, Wei XQ, McInnes IB and Liew FY. 1998. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol 160:5654–5660.
  • Rundhaug JE. 2005. Matrix metalloproteinases and angiogenesis. J Cell Mol Med 9:267–285.
  • Sahebjam S, Khokha R and Mort JS. 2007. Increased collagen and aggrecan degradation with age in the joints of Timp3(–/–) mice. Arthritis Rheum 56:905–909.
  • Sanderson MP, Abbott CA, Tada H, Seno M, Dempsey PJ and Dunbar AJ. 2006. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. J Cell Biochem 99:609–623.
  • Sastre M, Walter J and Gentleman SM. 2008. Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 5:25.
  • Satoh M, Nakamura M, Satoh H, Saitoh H, Segawa I and Hiramori K. 2000. Expression of tumor necrosis factor-alpha-converting enzyme and tumor necrosis factor-alpha in human myocarditis. J Am Coll Cardiol 36:1288–1294.
  • Satoh M, Iwasaka J, Nakamura M, Akatsu T, Shimoda Y and Hiramori K. 2004. Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure. Eur J Heart Fail 6:869–875.
  • Satoh M, Ishikawa Y, Itoh T, Minami Y, Takahashi Y and Nakamura M. 2008. The expression of TNF-alpha converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction. Eur J Clin Invest 38:97–105.
  • Schafer B, Marg B, Gschwind A and Ullrich A. 2004. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J Biol Chem 279:47929–47938.
  • Schaff U, Mattila PE, Simon SI and Walcheck B. 2008. Neutrophil adhesion to E-selectin under shear promotes the redistribution and co-clustering of ADAM17 and its proteolytic substrate L-selectin. J Leukoc Biol 83:99–105.
  • Schlondorff J and Blobel CP. 1999. Metalloprotease-disintegrins: modular proteins capable of promoting cell–cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci 112:3603–3617.
  • Schlondorff J, Becherer JD and Blobel CP. 2000. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem J 347:131–138.
  • Schmitmeier S, Markland FS, Ritter MR, Sawcer DE and Chen TC. 2003. Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro. Cell Commun Adhes 10:1–16.
  • Schramme A, Abdel-Bakky MS, Kampfer-Kolb N, Pfeilschifter J and Gutwein P. 2008. The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun 370:311–316.
  • Schroeter EH, Kisslinger JA and Kopan R. 1998. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382–386.
  • Seifert T, Kieseier BC, Ropele S, Strasser-Fuchs S, Quehenberger F, Fazekas F and Hartung HP. 2002. TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis. Mult Scler 8:447–451.
  • Serino M, Menghini R, Fiorentino L, Amoruso R, Mauriello A, Lauro D, Sbraccia P, Hribal ML, Lauro R and Federici M. 2007. Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes. Diabetes 56:2541–2546.
  • Serwin AB, Sokolowska M and Chodynicka B. 2007. Tumour necrosis factor alpha (TNF-alpha)-converting enzyme (TACE) and soluble TNF-alpha receptor type 1 in psoriasis patients treated with narrowband ultraviolet B. Photodermatol Photoimmunol Photomed 23:130–134.
  • Shah BH and Catt KJ. 2006. TACE-dependent EGF receptor activation in angiotensin-II-induced kidney disease. Trends Pharmacol Sci 27:235–237.
  • Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG and Warburton D. 2003. TACE is required for fetal murine cardiac development and modeling. Dev Biol 261:371–380.
  • Shimoda Y, Satoh M, Nakamura M, Akatsu T and Hiramori K. 2005. Activated tumour necrosis factor-alpha shedding process is associated with in-hospital complication in patients with acute myocardial infarction. Clin Sci (Lond) 108:339–347.
  • Sibilia M and Wagner EF. 1995. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234–238.
  • Singh RJ, Mason JC, Lidington EA, Edwards DR, Nuttall RK, Khokha R, Knauper V, Murphy G and Gavrilovic J. 2005. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovasc Res 67:39–49.
  • Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A and Logeat F. 2003. The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc Natl Acad Sci USA 100:7638–7643.
  • Skovronsky DM, Fath S, Lee VM and Milla ME. 2001. Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques. J Neurobiol 49:40–46.
  • Smith KM, Gaultier A, Cousin H, Alfandari D, White JM and DeSimone DW. 2002. The cysteine-rich domain regulates ADAM protease function in vivo. J Cell Biol 159:893–902.
  • Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW and Khokha R. 2006. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J Immunol 176:721–725.
  • Solomon A, Akabayov B, Frenkel A, Milla ME and Sagi I. 2007. Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. Proc Natl Acad Sci USA 104:4931–4936.
  • Song D, Ye X, Xu H and Liu SF. 2009. Activation of endothelial intrinsic NF-κB pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood 114:2521–2529.
  • Soond SM, Everson B, Riches DW and Murphy G. 2005. ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci 118:2371–2380.
  • Spertini O, Luscinskas FW, Gimbrone MA, Jr, and Tedder TF. 1992. Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med 175:1789–1792.
  • Surena AL, de Faria GP, Studler JM, Peiretti F, Pidoux M, Camonis J, Chneiweiss H, Formstecher E and Junier MP. 2009. DLG1/SAP97 modulates transforming growth factor alpha bioavailability. Biochim Biophys Acta 1793:264–272.
  • Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S and Blobel CP. 2008. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ Res 103:916–918.
  • Tachida Y, Nakagawa K, Saito T, Saido TC, Honda T, Saito Y, Murayama S, Endo T, Sakaguchi G, Kato A, Kitazume S and Hashimoto Y. 2008. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. J Neurochem 104:1387–1393.
  • Takamune Y, Ikebe T, Nagano O and Shinohara M. 2008. Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Biochem Biophys Res Commun 365:393–398.
  • Tanabe Y, Kasahara T, Momoi T and Fujita E. 2008. Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases. Neurosci Lett 444:16–21.
  • Tanahashi H and Yoshioka K. 2008. RNA interference silencing of DRAL affects processing of amyloid precursor protein. Neurosci Lett 439:293–297.
  • Tanaka M, Nanba D, Mori S, Shiba F, Ishiguro H, Yoshino K, Matsuura N and Higashiyama S. 2004. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. J Biol Chem 279:41950–41959.
  • Tanaka Y, Miyamoto S, Suzuki SO, Oki E, Yagi H, Sonoda K, Yamazaki A, Mizushima H, Maehara Y, Mekada E and Nakano H. 2005. Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer. Clin Cancer Res 11:4783–4792.
  • Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan-Vague I, Nalbone G and Peiretti F. 2006. The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312:3969–3980.
  • Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, R. J. Coffey RJ and Magnuson T. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230–234.
  • Togashi N, Ura N, Higashiura K, Murakami H and Shimamoto K. 2002. Effect of TNF-alpha-converting enzyme inhibitor on insulin resistance in fructose-fed rats. Hypertension 39:578–580.
  • Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D and De Strooper B. 2009. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem 284:11738–11747.
  • Trifilieff A, Walker C, Keller T, Kottirsch G and Neumann U. 2002. Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation. Br J Pharmacol 135:1655–1664.
  • Trikha M, De Clerck YA and Markland FS. 1994. Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis. Cancer Res 54:4993–4998.
  • Tsai TJ, Sheu JR, Chen YM, Yen CJ, Chen CF and Huang TF. 1995. Disintegrin modulates rat glomerular mesangial cell behavior. Nephron 70:83–90.
  • Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM, Lin CD, Liao YL, Wang JL, Chau YP, Hsu MT, Hsiao M, Huang HD and Tsou AP. 2009. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 49:1571–1582.
  • Tsakadze NL, Sithu SD, Sen U, English WR, Murphy G and D’Souza SE. 2006. Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). J Biol Chem 281:3157–3164.
  • Tselepis VH, Green LJ and Humphries MJ. 1997. An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs. J Biol Chem 272:21341–21348.
  • Tsuji F, Oki K, Okahara A, Suhara H, Yamanouchi T, Sasano M, Mita S and Horiuchi M. 2002. Differential effects between marimastat, a TNF-alpha converting enzyme inhibitor, and anti-TNF-alpha antibody on murine models for sepsis and arthritis. Cytokine 17:294–300.
  • Uchiyama-Tanaka Y, Matsubara H, Nozawa Y, Murasawa S, Mori Y, Kosaki A, Maruyama K, Masaki H, Shibasaki Y, Fujiyama S, Nose A, Iba O, Hasagawa T, Tateishi E, Higashiyama S and Iwasaka T. 2001. Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int 60:2153–2163.
  • Utsugi T, Ohno T, Ohyama Y, Uchiyama T, Saito Y, Matsumura Y, Aizawa H, Itoh H, Kurabayashi M, Kawazu S, Tomono S, Oka Y, Suga T, Kuro-o M, Nabeshima Y and Nagai R. 2000. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49:1118–1123.
  • Venkatesan AM, Davis JM, Grosu GT, Baker J, Zask A, Levin JI, Ellingboe J, Skotnicki JS, Dijoseph JF, Sung A, Jin G, Xu W, McCarthy DJ and Barone D. 2004. Synthesis and structure–activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors. J Med Chem 47:6255–6269.
  • Walker EJ and Rosenberg GA. 2009. TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia. Exp Neurol 216:122–131.
  • Wang J, Al-Lamki RS, Zhang H, Kirkiles-Smith N, Gaeta ML, Thiru S, Pober JS and Bradley JR. 2003. Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool. J Biol Chem 278:21751–21760.
  • Wang X, He K, Gerhart M, Huang Y, Jiang J, Paxton RJ, Yang S, Lu C, Menon RK, Black RA, Baumann G and Frank SJ. 2002. Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site. J Biol Chem 277:50510–50519.
  • Wang X, Feuerstein GZ, Xu L, Wang H, Schumacher WA, Ogletree ML, Taub R, Duan JJ, Decicco CP and Liu RQ. 2004. Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats. Mol Pharmacol 65:890–896.
  • Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR and Frank SJ. 2008. Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity. Mol Endocrinol 22:1427–1437.
  • Wang X, Oka T, Chow FL, Cooper SB, Odenbach J, Lopaschuk GD, Kassiri Z and Fernandez-Patron C. 2009. Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Hypertension 54:575–582.
  • Wang Y, Herrera AH, Li Y, Belani KK and Walcheck B. 2009. Regulation of mature ADAM17 by redox agents for L-selectin shedding. J Immunol 182:2449–2457.
  • Weinger JG, Omari KM, Marsden K, Raine CS and Shafit-Zagardo B. 2009. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am J Pathol 175:283–293.
  • Wewer UM, Morgelin M, Holck P, Jacobsen J, Lydolph MC, Johnsen AH, Kveiborg M and Albrechtsen R. 2006. ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme. J Biol Chem 281:9418–9422.
  • Wiley HS, Woolf MF, Opresko LK, Burke PM, Will B, Morgan JR and Lauffenburger DA. 1998. Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization. J Cell Biol 143:1317–1328.
  • Wisniewska M, Goettig P, Maskos K, Belouski E, Winters D, Hecht R, Black R and Bode W. 2008. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex. J Mol Biol 381:1307–1319.
  • Wolfe MS, De Los Angeles J, Miller DD, Xia W and Selkoe DJ. 1999. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer’s disease. Biochemistry 38:11223–11230.
  • Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR and Decicco CP. 2001. Design, synthesis, and structure–activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem 44:2636–2660.
  • Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL and Gurney ME. 1999. Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity. Nature 402:533–537.
  • Yasuda H, Hirata S, Inoue K, Mashima H, Ohnishi H and Yoshiba M. 2007. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Biochem Biophys Res Commun 354:154–159.
  • Yeh CH, Peng HC, Yang RS and Huang TF. 2001. Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells. Mol Pharmacol 59:1333–1342.
  • Yin J and Yu FS. 2009. ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. Invest Ophthalmol Vis Sci 50:132–139.
  • Yoshimura T, Tomita T, Dixon MF, Axon AT, Robinson PA and Crabtree JE. 2002. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. J Infect Dis 185:332–340.
  • Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB and Grandis JR. 2006. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci USA 103:6901–6906.
  • Zhao J, Chen H, Peschon JJ, Shi W, Zhang Y, Frank SJ and Warburton D. 2001. Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. Dev Biol 232:204–218.
  • Zheng X, Jiang F, Katakowski M, Zhang ZG, Lu QE and Chopp M. 2009. ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther 8:1045–1054.
  • Zheng Y, Schlondorff J and Blobel CP. 2002. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem 277:42463–42470.
  • Zhou Q, Nakada MT, Brooks PC, Swenson SD, Ritter MR, Argounova S, Arnold C and Markland FS. 2000. Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5. Biochem Biophys Res Commun 267:350–355.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.