Signaling from the secretory granule to the nucleus

References

• Aivazian D, Stern LJ. 2000. Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition. Nat Struct Biol 7:1023–1026.
   PubMedGoogle Scholar
• Al Massadi O, Tschöp MH, Tong J. 2011. Ghrelin acylation and metabolic control. Peptides 32:2301–2308.
   PubMedGoogle Scholar
• Alam MR, Caldwell BD, Johnson RC, Darlington DN, Mains RE, Eipper BA. 1996. Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme. J Biol Chem 271:28636–28640.
   Google Scholar
• Alam MR, Johnson RC, Darlington DN, Hand TA, Mains RE, Eipper BA. 1997. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem 272:12667–12675.
   PubMedGoogle Scholar
• Albers RW, Siegel GJ, Xiw ZJ. 2012. Membrane transport. In: Basic Neurochemistry Principles of Molecular, Cellular and Medical Neurobiology, 8 ed. Waltham, MA: Elsevier Academic Press, pp 40–62.
   Google Scholar
• Araki E, Oyadomari S, Mori M. 2003. Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med (Maywood) 228:1213–1217.
   PubMed Web of Science ®Google Scholar
• Arnaoutova I, Cawley NX, Patel N, Kim T, Rathod T, Loh YP. 2008. Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Mol Endocrinol 22:1924–1934.
   Google Scholar
• Bäck N, Rajagopal C, Mains RE, Eipper BA. 2010. Secretory granule membrane protein recycles through multivesicular bodies. Traffic 11:972–986.
   Google Scholar
• Beel AJ, Sanders CR. 2008. Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci 65:1311–1334.
   PubMed Web of Science ®Google Scholar
• Beinfeld MC. 2003. Biosynthesis and processing of pro CCK: recent progress and future challenges. Life Sci 72:747–757.
   PubMed Web of Science ®Google Scholar
• Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG. 2002. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J 21:3390–3401.
   PubMed Web of Science ®Google Scholar
• Borggrefe T, Oswald F. 2009. The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci 66:1631–1646.
   PubMed Web of Science ®Google Scholar
• Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, Eipper BA, Mains RE. 2009. Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology 150:1739–1747.
   Google Scholar
• Brown MS, Goldstein JL. 2009. Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J Lipid Res 50 Suppl:S15–S27.
   PubMed Web of Science ®Google Scholar
• Brown MS, Ye J, Rawson RB, Goldstein JL. 2000. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100:391–398.
   PubMed Web of Science ®Google Scholar
• Buczek O, Bulaj G, Olivera BM. 2005. Conotoxins and the posttranslational modification of secreted gene products. Cell Mol Life Sci 62:3067–3079.
   PubMed Web of Science ®Google Scholar
• Caldwell BD, Darlington DN, Penzes P, Johnson RC, Eipper BA, Mains RE. 1999. The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem 274:34646–34656.
   Google Scholar
• Cao X, Südhof TC. 2001. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115–120.
   PubMed Web of Science ®Google Scholar
• Chen L, Johnson RC, Milgram SL. 1998. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem 273:33524–33532.
   PubMed Web of Science ®Google Scholar
• Ciccotosto GD, Schiller MR, Eipper BA, Mains RE. 1999. Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. J Cell Biol 144:459–471.
   Google Scholar
• Cuttitta F. 1993. Peptide amidation: signature of bioactivity. Anat Rec 236:87–93, 172.
   Google Scholar
• Czyzyk TA, Ning Y, Hsu MS, Peng B, Mains RE, Eipper BA, Pintar JE. 2005. Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol 287:301–313.
   PubMedGoogle Scholar
• Dyson HJ, Wright PE. 2002. Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol 12:54–60.
   PubMed Web of Science ®Google Scholar
• Eipper BA, Green CB, Campbell TA, Stoffers DA, Keutmann HT, Mains RE, Ouafik L. 1992a. Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM). J Biol Chem 267:4008–4015.
   PubMed Web of Science ®Google Scholar
• Eipper BA, Stoffers DA, Mains RE. 1992b. The biosynthesis of neuropeptides: peptide alpha-amidation. Annu Rev Neurosci 15:57–85.
   PubMed Web of Science ®Google Scholar
• El Meskini R, Galano GJ, Marx R, Mains RE, Eipper BA. 2001. Targeting of membrane proteins to the regulated secretory pathway in anterior pituitary endocrine cells. J Biol Chem 276:3384–3393.
   Google Scholar
• Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M. 2012. Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia 55:1013–1023.
   Google Scholar
• Francone VP, Ifrim MF, Rajagopal C, Leddy CJ, Wang Y, Carson JH, Mains RE, Eipper BA. 2010. Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. Mol Endocrinol 24:1543–1558.
   Google Scholar
• Fricker LD. 2010. Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins. Mol Biosyst 6:1355–1365.
   Google Scholar
• Fricker LD, Leiter EH. 1999. Peptides, enzymes and obesity: new insights from a 'dead' enzyme. Trends Biochem Sci 24:390–393.
   PubMedGoogle Scholar
• Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA, Mains RE. 2010. Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci 30:13656–13669.
   Google Scholar
• Goldstein JL, DeBose-Boyd RA, Brown MS. 2006. Protein sensors for membrane sterols. Cell 124:35–46.
   PubMed Web of Science ®Google Scholar
• Grundschober C, Malosio ML, Astolfi L, Giordano T, Nef P, Meldolesi J. 2002. Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells. J Biol Chem 277:36715–36724.
   Google Scholar
• Harashima S, Clark A, Christie MR, Notkins AL. 2005. The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proc Natl Acad Sci USA 102:8704–8709.
   PubMedGoogle Scholar
• Hass MR, Sato C, Kopan R, Zhao G. 2009. Presenilin: RIP and beyond. Semin Cell Dev Biol 20:201–210.
   PubMed Web of Science ®Google Scholar
• Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL. 2008. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. J Endocrinol 196:573–581.
   Google Scholar
• Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P. 2010. Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem 285:685–694.
   PubMed Web of Science ®Google Scholar
• Hsu JM, Lee YC, Yu CT, Huang CY. 2004. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem 279:32592–32602.
   PubMedGoogle Scholar
• Husten EJ, Eipper BA. 1991. The membrane-bound bifunctional peptidylglycine alpha-amidating monooxygenase protein. Exploration of its domain structure through limited proteolysis. J Biol Chem 266:17004–17010.
   Google Scholar
• Husten EJ, Tausk FA, Keutmann HT, Eipper BA. 1993. Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine alpha-amidating monooxygenase. J Biol Chem 268:9709–9717.
   Google Scholar
• In Y, Fujii M, Sasada Y, Ishida T. 2001. Structural studies on C-amidated amino acids and peptides: structures of hydrochloride salts of C-amidated Ile, Val, Thr, Ser, Met, Trp, Gln and Arg, and comparison with their C-unamidated counterparts. Acta Crystallogr, B 57:72–81.
   Google Scholar
• Jiang N, Kolhekar AS, Jacobs PS, Mains RE, Eipper BA, Taghert PH. 2000. PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Dev Biol 226:118–136.
   PubMedGoogle Scholar
• Jonker HR, Wechselberger RW, Pinkse M, Kaptein R, Folkers GE. 2006. Gradual phosphorylation regulates PC4 coactivator function. FEBS J 273:1430–1444.
   PubMedGoogle Scholar
• Kaether C, Schmitt S, Willem M, Haass C. 2006. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 7:408–415.
   PubMed Web of Science ®Google Scholar
• Kalthoff C, Alves J, Urbanke C, Knorr R, Ungewickell EJ. 2002. Unusual structural organization of the endocytic proteins AP180 and epsin 1. J Biol Chem 277:8209–8216.
   Google Scholar
• Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA. 2011. Endoplasmic reticulum oxidoreductin-1-like ß (ERO1lß) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in ß-cells. Endocrinology 152:2599–2608.
   PubMed Web of Science ®Google Scholar
• Kim T, Loh YP. 2006. Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol Biol Cell 17:789–798.
   Google Scholar
• Kim T, Tao-Cheng JH, Eiden LE, Loh YP. 2001. Chromogranin A, an “on/off” switch controlling dense-core secretory granule biogenesis. Cell 106:499–509.
   PubMed Web of Science ®Google Scholar
• Kohno K. 2010. Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals. J Biochem 147:27–33.
   Google Scholar
• Kopan R, Ilagan MX. 2009. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216–233.
   PubMed Web of Science ®Google Scholar
• Koshimizu H, Kim T, Cawley NX, Loh YP. 2010. Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept 160:153–159.
   Google Scholar
• Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL. 2004. Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes 53:1684–1691.
   Google Scholar
• Lee HJ, Jung KM, Huang YZ, Bennett LB, Lee JS, Mei L, Kim TW. 2002. Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277:6318–6323.
   PubMed Web of Science ®Google Scholar
• Lindau M. 2011. High resolution electrophysiological techniques for the study of calcium-activated exocytosis. Biochim Biophys Acta doi: 10.1016/j.bbagen.2011.12.011.
   Google Scholar
• Lochmatter D, Strom M, Eblé A, Petkovic V, Flück CE, Bidlingmaier M, Robinson IC, Mullis PE. 2010. Isolated GH deficiency type II: knockdown of the harmful Delta3GH recovers wt-GH secretion in rat tumor pituitary cells. Endocrinology 151:4400–4409.
   Google Scholar
• Mains RE, Eipper BA. (2012). Peptides. In: Brady ST et al. (ed). Basic Neurochemistry Principles of Molecular, Cellular and Medical Neurobiology, 8 ed. Waltham, MA: Elsevier Academic Press, pp 390–406.
   Google Scholar
• Mains RE, Alam MR, Johnson RC, Darlington DN, Bäck N, Hand TA, Eipper BA. 1999. Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells. J Biol Chem 274:2929–2937.
   Google Scholar
• Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK. 2003. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114:635–645.
   PubMed Web of Science ®Google Scholar
• Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P. 2005. ADAM10 mediates E-cadherin shedding and regulates epithelial cell–cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci USA 102:9182–9187.
   PubMed Web of Science ®Google Scholar
• Merkler DJ. 1994. C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb Technol 16:450–456.
   PubMed Web of Science ®Google Scholar
• Michaux G, Cutler DF. 2004. How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies. Traffic 5:69–78.
   Google Scholar
• Milgram SL, Johnson RC, Mains RE. 1992. Expression of individual forms of peptidylglycine alpha-amidating monooxygenase in AtT-20 cells: endoproteolytic processing and routing to secretory granules. J Cell Biol 117:717–728.
   Google Scholar
• Milgram SL, Mains RE, Eipper BA. 1993. COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cells. J Cell Biol 121:23–36.
   Google Scholar
• Morvan J, Tooze SA. 2008. Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells. Histochem Cell Biol 129:243–252.
   Google Scholar
• Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M. 2008. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci USA 105:674–679.
   PubMedGoogle Scholar
• Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkrüger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Müller S, Solimena M. 2006. Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol 8:435–445.
   PubMed Web of Science ®Google Scholar
• Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. 2001. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414:514–521.
   PubMed Web of Science ®Google Scholar
• Ni CY, Murphy MP, Golde TE, Carpenter G. 2001. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294:2179–2181.
   PubMed Web of Science ®Google Scholar
• Nishimura T, Kubosaki A, Ito Y, Notkins AL. 2009. Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. Neuroscience 159:427–437.
   Google Scholar
• Paco S, Margelí MA, Olkkonen VM, Imai A, Blasi J, Fischer-Colbrie R, Aguado F. 2009. Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes. J Neurochem 110:143–156.
   Google Scholar
• Pan H, Che FY, Peng B, Steiner DF, Pintar JE, Fricker LD. 2006. The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. J Neurochem 98:1763–1777.
   Google Scholar
• Park D, Hadžic T, Yin P, Rusch J, Abruzzi K, Rosbash M, Skeath JB, Panda S, Sweedler JV, Taghert PH. 2011. Molecular organization of Drosophila neuroendocrine cells by Dimmed. Curr Biol 21:1515–1524.
   Google Scholar
• Parks AL, Curtis D. 2007. Presenilin diversifies its portfolio. Trends Genet 23:140–150.
   PubMed Web of Science ®Google Scholar
• Perello M, Stuart R, Nillni EA. 2008. Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway. J Biol Chem 283:19936–19947.
   Google Scholar
• Rajagopal C, Stone KL, Francone VP, Mains RE, Eipper BA. 2009. Secretory granule to the nucleus: role of a multiply phosphorylated intrinsically unstructured domain. J Biol Chem 284:25723–25734.
   Google Scholar
• Rajagopal C, Stone KL, Mains RE, Eipper BA. 2010. Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J Biol Chem 285:34632–34642.
   Google Scholar
• Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519–529.
   PubMed Web of Science ®Google Scholar
• Rubio ME, Curcio C, Chauvet N, Brusés JL. 2005. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Mol Cell Neurosci 30:118–130.
   Google Scholar
• Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, Notkins AL. 2002. Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes 51:1842–1850.
   Google Scholar
• Sallese M, Giannotta M, Luini A. 2009. Coordination of the secretory compartments via inter-organelle signalling. Semin Cell Dev Biol 20:801–809.
   Google Scholar
• Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G. 2006. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127:185–197.
   PubMed Web of Science ®Google Scholar
• Schapiro FB, Soe TT, Mallet WG, Maxfield FR. 2004. Role of cytoplasmic domain serines in intracellular trafficking of furin. Mol Biol Cell 15:2884–2894.
   Google Scholar
• Scheuner D, Kaufman RJ. 2008. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 29:317–333.
   PubMed Web of Science ®Google Scholar
• Schilling S, Niestroj AJ, Rahfeld JU, Hoffmann T, Wermann M, Zunkel K, Wasternack C, Demuth HU. 2003. Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem 278:49773–49779.
   PubMed Web of Science ®Google Scholar
• Schindler AJ, Schekman R. 2009. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc Natl Acad Sci USA 106:17775–17780.
   PubMed Web of Science ®Google Scholar
• Seidah NG, Day R, Marcinkiewicz M, Chrétien M. 1993. Mammalian paired basic amino acid convertases of prohormones and proproteins. Ann N Y Acad Sci 680:135–146.
   Google Scholar
• Sobota JA, Ferraro F, Bäck N, Eipper BA, Mains RE. 2006. Not all secretory granules are created equal: Partitioning of soluble content proteins. Mol Biol Cell 17:5038–5052.
   Google Scholar
• Solimena M, Dirkx R Jr, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU. 1996. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J 15:2102–2114.
   PubMed Web of Science ®Google Scholar
• Spector S, Gordon R, Sjoerdsma A, Udenfriend S. 1967. End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis. Mol Pharmacol 3:549–555.
   Google Scholar
• Steiner H, Fluhrer R, Haass C. 2008. Intramembrane proteolysis by gamma-secretase. J Biol Chem 283:29627–29631.
   PubMed Web of Science ®Google Scholar
• Steveson TC, Keutmann HT, Mains RE, Eipper BA. 1999. Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine alpha-amidating monooxygenase. J Biol Chem 274:21128–21138.
   Google Scholar
• Steveson TC, Zhao GC, Keutmann HT, Mains RE, Eipper BA. 2001. Access of a membrane protein to secretory granules is facilitated by phosphorylation. J Biol Chem 276:40326–40337.
   Google Scholar
• Tang K, Wu H, Mahata SK, Mahata M, Gill BM, Parmer RJ, O’Connor DT. 1997. Stimulus coupling to transcription versus secretion in pheochromocytoma cells. Convergent and divergent signal transduction pathways and the crucial roles for route of cytosolic calcium entry and protein kinase C. J Clin Invest 100:1180–1192.
   PubMed Web of Science ®Google Scholar
• Tausk FA, Milgram SL, Mains RE, Eipper BA. 1992. Expression of a peptide processing enzyme in cultured cells: truncation mutants reveal a routing domain. Mol Endocrinol 6:2185–2196.
   Google Scholar
• Thinakaran G, Koo EH. 2008. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283:29615–29619.
   PubMed Web of Science ®Google Scholar
• Thomas G. 2002. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3:753–766.
   PubMed Web of Science ®Google Scholar
• Tompa P. 2002. Intrinsically unstructured proteins. Trends Biochem Sci 27:527–533.
   PubMed Web of Science ®Google Scholar
• Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M. 2004. Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells. J Cell Biol 167:1063–1074.
   Google Scholar
• Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkrüger A, Solimena M. 2008. Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem 283:33719–33729.
   Google Scholar
• Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. 2006a. Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochem Biophys Res Commun 345:951–958.
   PubMedGoogle Scholar
• Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. 2006b. Characterization of sequential N-cadherin cleavage by ADAM10 and PS1. Neurosci Lett 402:278–283.
   PubMed Web of Science ®Google Scholar
• Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G. 1998. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell 94:205–216.
   PubMedGoogle Scholar
• Webb GC, Akbar MS, Zhao C, Steiner DF. 2000. Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci USA 97:5773–5778.
   PubMed Web of Science ®Google Scholar
• Wolfe MS. 2009. Intramembrane-cleaving proteases. J Biol Chem 284:13969–13973.
   Google Scholar
• Wolfe MS, Kopan R. 2004. Intramembrane proteolysis: theme and variations. Science 305:1119–1123.
   PubMed Web of Science ®Google Scholar
• Yin P, Bousquet-Moore D, Annangudi SP, Southey BR, Mains RE, Eipper BA, Sweedler JV. 2011. Probing the production of amidated peptides following genetic and dietary copper manipulations. PLoS ONE 6:e28679.
   Google Scholar
• Yun HY, Milgram SL, Keutmann HT, Eipper BA. 1995. Phosphorylation of the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. J Biol Chem 270:30075–30083.
   Google Scholar
• Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL. 2007. RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. J Endocrinol 195:313–321.
   Google Scholar