25
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Multicenter Phase II Study of Oral Idarubicin in Treated and Untreated Patients with B-Chronic Lymphocytic Leukemia

, , , , , , , , , & show all
Pages 169-173 | Received 29 Aug 1999, Published online: 01 Jul 2009

References

  • Arcamone F., Bernardi L., Giardino P., Patelli B., DiMarco A., Casazza A.M., Pratesi G., Reggiani P. Synthesis and anti-tumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin and their beta anomers. Cancer Treat Rep 1976; 60(7)829–34
  • DiMarco A., Casazza A.M., Pratesi G. Antitumor activity of 4-demethoxydaunorubucin administered orally. Cancer Treat Rep 1977; 61(5)893–94
  • Harusseau J.L., Pignon B., Reiffers J., Rigal-Huguet F., Cahn J.Y., Le P.Y. Toxicity profile of idarubicin with oral and intravenous idarubicin in the treatment of leukemia. Hematology and Blood Transfusion: Acute Leukemias-Pharmacokinetics, W. Hiddemann. Springer Verlag, Berlin 1992; 625–631
  • Broggini M., Italia C., Colombo T., Marmonti L., Donelli M.G. Activity and distribution of intravenous and oral 4-demethoxydaunorubicin in murine experimental tumors. Cancer Treat Rep 1984; 68(5)739–47
  • Casazza A.M. Experimental evaluation of anthracycline analogues. Cancer Treat Rep 1979; 63(5)835–44
  • Casazza A.M., Pratesi G., Giuliani F., DiMarco A. Antileukemic activity of 4-demethoxydaunorubicin in mice. Tumori 1980; 66(5)549–44
  • Casazza A.M., Bertazzoli C., Pratesi G., Bellini O., DiMarco A. Antileukemic activity and cardiac toxicity of 4-demethoxydaunorubicin. Proc Am Assoc Cancer Res 1979; 20: 16
  • Casazza A.M., DiMarco A., Bonnadonna G., Bonfante V., Bertazzoli C., Bellini O., Pratesi G., Sala L., Ballerini L. Effects of modification in position 4 of chromophore or in the position 4′ of the aminosugar on the antitumor activity of anthracyclines. Anthracyclines: current status and new development, S.T. Crooke, S.D. Reich. academic press, New York 1980; 430
  • Bermann E., Wittes R.E., Leyland-Jones B. Phase I clinical pharmacology studies of intravenous and oral administration of 4-demethoxydaunorubicin in patients with advanced cancer. Cancer Res 1983; 43: 6096
  • Bonfante V., Ferrai L., Villani F., Bonadonna G. Phase I study of 4-demethoxydaunorubicin. Invest New Drugs 1983; 1(2)161–8
  • DiMarco A., Zunino F., Casazza A.M. Comparison of biochemical and biological methods in the evaluation of new anthracycline drugs. Antibiot Chemother 1978; 23: 12–20
  • Zaniboni A., Bolognesi A., Arnoldi E., Tabiadon D., Barni S., Intini C. Oral idarubicin and cyclophosphamide for metastatic breast cancer in elderly patients. Anticancer Drugs 1998; 9(4)295–9
  • Barnadas A., Mendiola C., Casado A., Villar A., Jimeno J., Clerigue M., Rosell R., Diaz-Rubio E., Cortes-Funes H., Garcia de Paredes M. Combination of oral idarubicin and prednimustine in advanced breast cancer: a phase II study. Eur J Cancer 1997; 33(2)312–5
  • Elbaek K., Ebbehoj E., Jakobsen A., Juul P., Rasmussen S.N., Bastholt L., Dalmark M., Steiness E. Pharmacokinetics of oral idarubicin in breast cancer patients with reference to antitumor activity and side effects. Clin Pharmacol Ther 1989; 45(6)627–34
  • Ruutu T., Almqvist A., Hallman H., Honkanen T., Jarvenpaa E., Jarventie G., Koistinen P., Koivunen E., Lahtinen R., Lehtinen M. Oral induction and consolidation of acute myeloid leukemia with etoposide, 6-thioguanine and idarubicin (ETI) in elderly patients: a randomized comparison with 5-day TAD. Finnish leukemia group. Leukemia 1994; 8(1)11–15
  • Kusnierz-Glaz C.R., Normann D., Weinberg R., Fuchs R., Flasshove M., Hiddemann W., van de Loo J., Buchner T. Subcutaneous low dose arabinosyl-cytosine and oral idarubicin in high risk adult acute myelogenous leukemia. Hematol Oncol 1993; 11(2)73–80
  • Robert J., Rigal-Huguet F., Harousseau J.L., Pris J., Huet S., Reiffers J., Hurtelopu P., Tamassia V. Pharmacokinetics of idarubicin after daily intravenous administration in leukemic patients. Leukemia Res 1987; 11: 961–964
  • Cook G., Sharp R.A., Tansey P., Franklin I.M. A phase I/II trial of Z-Dex (oral idarubicin and dexamethasone), an oral equivalent of VAD, as initial therapy at diagnosis or progression in multiple myeloma. Brit J Haematol 1996; 93: 931–934
  • Steward W.P., Smith D.B., Crowther D. Weekly oral 4-demethoxydaunorubicin in patients with relapsed low grade non-Hodgkin's lymphoma. Ann Oncol 1991; 2(8)605–6
  • Errante D., Sorio R., Zagonel V., Carbone A., Monfardini S., Tirelli U. A phase II study of oral idarubicin (4-demethoxydaunorubicin) in previously untreated elderly patients with non-Hodgkin's lymphoma. Am J Clin Oncol 1991; 14(3)243–5
  • Lopez M., DiLauro L., Papaldo P. Oral idarubicin in non Hodgkin's lymphomas. Invest New Drugs 1986; 4(3)263–7
  • Gillies H., Liang R., Rogers H., Harper P., Parapia L., Cox G., Johnson S. Phase II trial of idarubicin in patients with advanced lymphoma. Cancer Chemother Pharmacol 1988; 21: 261–4
  • Case D.C., Hayes D.M., Gerber M., Gams R., Ervin T.J., Dorsk B.M. Phase II study of oral idarubicin in favorable histology non-Hodgkin's lymphoma. Cancer Res 1990; 50(21)6833–5
  • Molica S., Levato D., DiRenzo N., La Sala A., Carotenuto M. An “all-oral” combination therapy in chronic lymphocytic leukemia including the oral idarubicin. Am J Hematol 1996; 52(3)235–6
  • Cheson B.D., Bennett J.M., Rai K.R. Guidelines for clinical protocols for chronic lymphocytic leukemia. Recommendations of the National Cancer Institute sponsored working group. Am J Hematol 1989; 29: 152–163

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.