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Original Article

Role of Interferon-α and Clonally Expanded T Cells in the Immunotherapy of Chronic Myelogenous Leukemia

Pages 21-38 | Received 10 Oct 1999, Published online: 01 Jul 2009

References

  • Hasford J., Pfirrmann M., Hehlmann R., Allan N. C., Baccarani M., Kluin-Nelemans J. C., Alimena G., Steeg-mann J. L., Ansari H. A new prognostic score for patients with chronic myeloid leukemia treated with inter-feron alpha. J Natl Cancer Inst 1998; 90: 850–858
  • Ling P. D., Warren M. K., Vogal S. N. Antagonistic effect of interferon-beta on the inter-feron-gamma-induced expression of fa antigen in murine macrophages. J Immunol 1985; 135: 1857–1863
  • Siegal F. P., Kadowaki N., Shodell M., Fitzger-ald-Bacarsly P. A., Shah K., Ho S., Antonenko S., Liu Y. J. The nature of the principal type 1 inter-feron-producing cells in human blood. Science 1999; 284: 1835–1837
  • Cella M., Jarrossay D., Facchetti F., Alebardi O., Naka-jima H., Lavanzecchia A., Colonna M. Plasma-cytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type 1 interferon. Not Med 1999; 8: 919–923
  • Ghanekar S., Zheng L., Logar A., Navratil J., Borowski L., Gupta P., Rinaldo C. Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus. J Immunol 1996; 157: 4028–4036
  • Tough D. F., Borrow P., Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996; 272: 1947–1950
  • Marmont A., Horowitz M., Gale R., Sobocinski K., Ash R., van Bekkum D., Champlin R., Dicke K., Goldman J., Good R., Herzig R., Hong R., Masaoka T., Rimm A., Ringden O., Speck B., Weiner R., Borti M. T cell depletion of HLA identical transplants in leukemia. Blood 1991; 78: 2120–2130
  • Kolb H. J., Mittermuller J., Clemm C., Holler E., Ledder-rose G., Brehm G., Heim M., Wilmanns W. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1992; 76: 2462–2565
  • Smit W. M., Rijnbeek M., van Bergen C. A. M., Fibbe W. E., Willemze R., Falkenburg J. H. F. T cells recognizing leukemic CD34+ progenitor cells mediate the antileukemic effect of donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation. Proc Natl Acad Sci USA 1998; 95: 10152–10157
  • Coleman S., Fisher J., Hoy T., Burnett A. K., Lim S. H. Autologous MHC-dependent leukaemia-reactive T lymphocytes in a patient with chronic myeloid leukaemia. Leukemia 1996; 10: 483–487
  • Legha S. S. The role of interferon-alpha in the treatment of metastatic melanoma. Semin Oncol 1997; 24(Suppl. 4)S24–31
  • Weinstock-Guttman B., Ransohoff R. M., Kinkel R. P., Rudick R. A. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis [Review]. Ann. Neurol. 1995; 37: 7–15
  • Ellis T. M., McKenzie R. S., Simms P. E., Helfrich B. A., Fisher R. I. Induction of human lymphokine-activated killer cells by IFN-alpha and IFN-gamma. J Immunol 1989; 143: 4282–4286
  • Meseri A., Delwail V., Brizard A., Lecron J. C., Pelletier D., Guilhot F., Tanzer J., Goube de Laforest P. Endogenous lymphokine activated killer cell activity and cytogenetic response in chronic myelogenous leukaemia treated with alpha-interferon. Br J Haematol 1993; 83: 218–222
  • Schmidt H., Kellermann-Kegreiss E., Steiert I., Walz J., Zinser R., Muller C. A. Differential regulation of human leukocyte antigen class I genes by interferon in vivo and in vitro. J Immunother 1993; 14: 169–174
  • Gutterman J. U. Cytokine therapeutics: lessons from interferon alpha. Proc Nutl Acad Sci USA 1994; 91: 1198–1205
  • Romagnani S. Induction of TH1 and TH2 responses: a key role for the “natural” immune response?. Immunology Today 1992; 13: 379–81
  • Biron C. A. Activation and function of natural killer cell responses during viral infections. Curr Opin Immunol. 1997; 9: 24–34
  • Wenner C. A. M., Guler L., Macatonia S. E., O'Garra A., Murphy K. M. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J Immunol 1996; 156: 1442–1447
  • McRae B. L., Semnani T., Hayes M. P., van Seventer G. A. The type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J Immunol 1998; 160: 4298–4304
  • Marrack P., Kappler J., Mitchell T. Type I interferons keep activated cells alive. J Exp Med 1999; 189: 521–529
  • Haque S. J., Williams B. R. Signal transduction in the interferon system [Review]. Semin Oncol 1998; 25: 14–22
  • Cho S. S., Bacon C. M., Sudarshan C., Rees R. C., Finbloom D., Pine R., O'Shea J. J. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 1996; 154: 4781–4789
  • Mueller D. L., Seiffert S., Fang W., Behrens T. W. Differential regulation of bcl-2 and bcl-x by CD 3, CD28 and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long term survival of memory cells. J Immunol 1996; 156: 1764–1777
  • The Italian Cooperative Study Group on chronic myeloid leukemia. Interferon alpha-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med 1994; 330: 820–825
  • Hehlmann R., Heimpel H., Hasford J., Kolb H. J., Pralle H., Hossfeld D. K., Quisser W., Loffler H., Hochhaus A., Heinze B., Georgii A., Bartram C. R., Griesshammer M., Bergmann H., Walther F., Fett W., Kleeberg U. R., Kabisch A. Randomized Comparison of inter-feron-a with busulfan and hydroxyurea in chronic myelogenous leukemia. Blood 1994; 84: 4064–4077
  • Ohnishi K., Ohno R., Tomonaga M., Kamada N., Ono-zawa K., Kuramoto A., Dohy H., Mizoguchi H., Miya-waki S., Tsubaki K., Miura Y., Omine M., Kobayashi T., Naoe T., Ohshima T., Hirashima K., Ohtake S., Taka-hashi I., Morishima K., Naito K., Asou N., Tanimoto M., Sakurna A., Yamada K. A randomized trial comparing interferon-α with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase. Blood 1995; 86: 906–916
  • Silver R. T., Woolf S. H., Hehlmann R., Appelbaum F. R., Anderson J., Bennett C., Goldman J. M., Guihot F., Kantarjian H. M., Lichtin A. E., Talpaz M., Tura S. An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the american society of hematology. Blood 1999; 94: 1517–1536
  • Sawyers C. Chronic myeloid leukemia. N Engl J Med. 1999; 340: 1330–1339
  • Kantarjian H. M., Talpaz M., O'brien S., Kurzrock R., Gutterman J., Keating M. J., McCredie K. B., Freireich E. J. Chronic myelogenous leukemia-progress at the M. D. Anderson Cancer Center over the past two decades and future direction: First Emil Freireich Award Lecture. Clin Cancer Res 1997; 3: 2723–2733
  • Faderl S., Talpaz M., Estov S., Kantarjian H. M. Chronic myelogenous leukemia: biology and therapy. Ann Intern Med 1999; 131: 207–219
  • Allan N. C., Richards S. M., Shepherd P. C.A. on behalf of the UA Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukemia Results of the Medical Research Council randomized multi-centre trial of interferonanl for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. Lancet 1995; 345: 1392–1397
  • Cortes J., Talpaz M., O'brien S., Rios M. B., Majlis A., Keating M., Freireich E. J., Kantarjian H. Suppression of cytogenetic clonal evolution with interferon alfa therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. J Clin Oncol 1998; 16: 3279–3285
  • Kurzrock R., Shaltrid M., Talpaz M., Kloetzer W. S., Gutterman J. U. Expression of c-abl in Philadelphia-positive acute myelogenous leukemia. Blood 1987; 70: 1584–1588
  • Chronic Myeloid Leukemia Trialists Collaborative Group. Interferon alpha versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials. J Natl Cancer Inst 1997; 89: 1616–1620
  • Yee K., Anglin P., Keating A. Molecular approaches to the detection and monitoring of chronic myeloid leukemia: therapy and practice. Blood Reviews 1999; 13: 105–126
  • Kantarjian H. M., Smith T. L., O'Brien S., Beran M., Pierce S., Talpaz M. Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy. Ann Intern Med 1995; 122: 254–261
  • Sacchi S., Kantarjian H., O'Brien S., Cohen P. R., Pierce S., Talpaz M. Immune-mediated and unusal complications during interferon alpha therapy in chronic myelogenous leukemia. J Clin Oncol 1995; 13: 2401–2407
  • Faderl S., Talpaz M., Estrov Z., Obrien S., Kurzrock R., Kantarjian H. M. The biology of chronic myeloid leukemia. N Engl J Med. 1999; 341: 164–172
  • Hochhaus A., Reiter A., Skladny H., Reichert A., Saus-sele S., Hehlmann R. Molecular monitoring of residual disease in chronic myelogenous leukemia patients after therapy. Rec Res Cancer Res 1998; 144: 36–45
  • Muhlmann I., Thaler I., Hilbe W., Bechter O., Erdel M., Utermann G., Duba H. C. Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome- positive chronic myeloid leukemia (CML) during interferon treatment: a new strategy for remission assessment. Gene Chromosomes Cancer 1998; 21: 90–100
  • Dewald G. W., Wyatt W. A., Juneau A. L., Carlson R. O., Zinsmeister A. R., Jalal S. M., Spurbeck J. L., Silver R. T. Highly sensitive fluorescence in situ hybridization method to detect double BCWABL fusion and monitor response to therapy in chronic myeloid leukemia. Blood 1998; 91: 3357–3365
  • Buno I., Wyatt W. A., Zinsmeister A. R., Dietz-Band J., Silver R. T., Dewald G. W. A special fluorescent in situ hybridization technique to study peripheral blood and assess the effectiveness of interferon therapy in chronic myeloid leukemia. Blood 1998; 92: 2315–21
  • Lee M., Kantarjian H., Talpaz M. Association of the responsiveness to interferon (IFN) therapy with the BCR/ABL splicing patterns in Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). Blood 1992; 80: 210a, Suppl. (abstract)
  • Shepherd P., Suffolk R., Halsey J., Allan N. Analysis of molecular breakpoint and m-RNA transcripts in a prospective randomized trial of interferon in chronic myeloid leukaemia: no correlation with clinical features, cytogenetic response, duration of chronic phase or survival. Br J Haematol 1995; 89: 546–554
  • Lee M. S., Kantarjian H. M., Talpaz M., Freireich E. J., Deisseroth A., Trujillo J. M., Stass S. A. Detection of minimal residual disease by polymerase chain reaction in Philadelphia chromosome positive chronic myelogenous leukemia following interferon therapy. Blood 1992; 79: 1920–1923
  • Malinge M. C., Mahon E. X., Delfeau M. H., Daheron L., Kitzis A., Guilhot F., Tanzer J., Grandchamp B. Quantitative determination of the hybrid bcr-abl RNA in patients with chronic myelogenous leukemia under interferon therapy. Br J Haematol 1992; 82: 701–707
  • Hochhaus A., Lin F., Reiter Skladny H., van Rhee F., Shepherd P. C., Allan N. C., Hehlmann R., Goldman J. M., Cross N. C. Variable numbers of BCR-ABL transcripts persist in CML patients who achieve complete cytogenetic remission with interferon-α. Br J Haematol 1995; 91: 126–131
  • Gaiger A., Henn T., Horth E., Geissler K., Mitterbauer G., Maier-Dobersberger T., Greinix H., Mannhalter C., Haas O. A., Lechner K., Lion T. Increase of bcr-abl chimeric mRNA expression in tumour cells of patients with chronic myeloid leukemia precedes disease progression. Blood 1995; 86: 2371–2378
  • Guilhot F., Lacotte-Thierry L. Interferon-a: mechanism of action in chronic myelogenous leukemia in chronic phase. Hematol Cell Ther 1998; 40: 237–239
  • Giralt S., Kantarjian H., Talpaz M. The natural history of chronic myelogenous leukemia in the interferon era. Seminars in Hematology 1995; 32: 152–158
  • Santucci M. A., Soligo D., Pileri S., Zuffa E., Testoni N., Tura S. Interferon-alpha effects on stromal compartment of normal and chronic myeloid leukemia hematopoiesis. Leukemia., & Lymphoma 1993; 1(Suppl. 1)113–118
  • Gordon M. Y., Marley S. B., Lewis J. L., Davidson R. J., Nguyen D. X., Grand F. H., Amos T. A., Goldman J. M. Treatment with interferon-α preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM. J Clin Invest 1998; 102: 710–715
  • Cornelissen J. J., Ploemacher R. E., Wognum B. W., Bors-boom A., Kluin-Nelemans H. C., Hagemeijer A., Lowen-berg B. An in vitro model for cytogenetic conversion in CML; interferon-α preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture. J Clin Invet 1998; 102: 976–983
  • Pendergast A. M., Quilliam L. A., Cripe L. D., Bassing C. H., Dai Z., Li N., Batzer A., Rabun K. M., Der C. J., Schlessinger J., Gishizky M. L. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993; 75: 175–85
  • Contente S., Kenyon K., Rimoldi D., Friedman R. M. Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-ras. Science 1990; 249: 796–798
  • Noda M. Mechanisms of reversion [Review]. FASEB J 1993; 7: 834–840
  • Gutterman J. U. Cytokine therapeutics: lessons from interferon-α. Proc Natl Acad Sci USA 1994; 91: 1198–1205
  • Bhatia R., McCanhy J. B., Verfaillie C. M. Interferon-a restores normal PI intergrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia. Blood 1996; 87: 3883–3891
  • Upadhyaya G., Guba S. C., Sih S. A., Feinberg A. P., Talpaz M., Kantarjian H. M., Deisseroth A. B., Emerson S. G. Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells. J Clin Invest 1991; 88: 2131–2136
  • Keating A. Investigation of bcr-abl transcription by Ph-positive chronic myeloid leukemia progenitors. Stem Cells. 1993; 3: 31–33
  • Oka T., Sastry K. J., Nehete P., Schapiro S. J., Guo J. Q., Talpaz M., Arlinghaus R. B. Evidence for specific immune response against p210 BCR-ABL in long-term remission CML patients treated with interferon. Leukemia 1998; 12: 155–163
  • Jiang Y. Z., Kanfer E. J., Macdonald D., Cullis J. O., Goldman J. M., Barrett A. J. Graft-versus-leukemia following allogeneic bone marrow transplantation: emergence of cytotoxic T lymphocytes reacting to host leukaemia cells. Bone Marrow Transplant 1991; 8: 253–258
  • Datta A. R., Barrett A. J., Jiang Y. Z., Giumaraes A., Mav-roudis D. A., van Rhee F., Gordon A. A., Madrigal A. Distinct T cell populations distinguish chronic myeloid leukaemia cells from lymphocytes in the same individual: A model for separating GVHD from GVL reactions. Bone Marrow Transplant 1994; 14: 517–524
  • Fujii S. -I., Shimizu K., Fujimoto K., Kiyokawa T., Shi-momura T., Taniguchi O., Kinoshita M., Kawano F. Analysis of a vaccinated chronic myelogenous leukemia patient with leukemic dendritic cells following autologous peripheral blood stem cell transplantation. Jpn J Cancer Res 1999; 90: 1117–1129
  • Falkenburg J. H. F., Goselink H. M., van der Harst D., van Luxemburg-Heijs S. A. P., Kooy-Winkelaar Y. M. C., Faber L. M., de Kroon J., Brand A., Fibbe W. E., Willemze R., Goulmy E. Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes. J Exp Med 1991; 174: 27–33
  • Tilkin A. F., Lubin R., Soussi T., Lazar V., Janin N., Mathieu M. C., Lefrere I., Carlu C., Roy M., Kayibanda M., Bellet O., Guillet J., Paillerets B. B. Primary proliferative T cell response to wild-type p53 protein in patients with breast cancer. Eur J Immunol 1995; 25: 1765–1769
  • Jung S., Schluesener H. Human T tymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins. J Exp Med 1991; 173: 273–276
  • McGahon A., Bissonnette R., Schmitt M., Cotter K. M., Green D. R., Cotter T. G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 1994; 83: 1179–87
  • McWhirter J. R., Wang J. Y. An actin-binding function contributes to transformation by the bcr-abl onco-protein of Philadelphia chromosome-positive human leuke-mias. EMBO Journal 1993; 12: 1533–1546
  • Calabretta B., Venturelli D., Kaczmarek L., Narni F., Talpaz M., Anderson B., Beran M., Baserga R. Altered expression of G1-specific genes in human malignant myeloid cells. Proc Natl Acad Sci USA 1986; 83: 1495–1498
  • Lee S. W., Tomasetto C., Sager R. Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci USA 1991; 88: 1825–1829
  • Ten Bosch G. J., Toornvliet A. C., Friede T., Melief C. J., Leeksma O. C. Recognition of peptides corresponding to the joining region of p210 BCR-ABL protein by human T cells. Leukemia 1995; 9: 1344–1348
  • Pawelec G., Max H., Halder T., Bruserud O., Merl A., de Silva P., Kalbacher H. BCWABL leukemia onocogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low fequency in the repertoire of normal donors. Blood 1996; 88: 2118–2124
  • Chen W., Peace D. J., Rovira D. K., You S. G., Chewer M. A. T-cell immunity to the joining region of p210 BCR-ABL protein. Proc Natl Acad Sci USA 1992; 89: 1468–1472
  • Bocchia M., Korontsvit T., Xu Q., Mackinnon S., Yang S. Y., Sette A., Scheinberg D. A. Specific human cellular immunity to bcr-abl onocogene-derived peptides. Blood 1996; 87: 3587–3592
  • Mannering S. I., McKenzie J. L., Fearnley D. B., Hart D. N. J. HLA-DR1-restricted bcr-abl (b3a2)-specific CD4+ T lymphocytes respond to dendritic cells pulsed with b3a2 peptide and antigen-presenting cells exposed to b3a2 containing cell lysate. Blood 1997; 90: 290–297
  • Bocchia M., Wentworth P. A., Southwood S., Sidney J., McGraw K., Scheinberg D. A., Sette A. Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules. Blood 1995; 85: 2680–2684
  • Dermine S., Molldrem J., Parker K. C., Jiang Y. Z., Mav-round D., Hensel N., Couriel D., Mahoney M., Coligan J. E., Barret A. J. Human CD8+ T lymphocytes recognize the fusion region of BCR-ABL hybrid protein present in chronic myelogenous leukemia. Blood 1995; 86: 158, Suppl
  • Greco G., Fruci D., Accapezzato D., Barnaba V., Nisini R., Alimena G., Montefusco E., Vigneti E., Butler R., Tanigaki N., Tosi R. Two bcr-abl junction peptides bind HLA-A3 molecules and allow specific induction of human cytotoxic T lymphocytes. Leukemia 1996; 10: 693–699
  • Langlade-Demoyen P., Abastado J. P., Even J., Gourru G., Leblond V., Binet J. L., Kourilsky P. Cytotoxic T cell response against 210 kDA chimeric protein coded by the BCR-ABL fusion gene in chronic myeloid leukemia. Blood 1995; 86: 525, Suppl
  • Yasukawa M., Ohminami H., Kaneko S., Yakushijin Y., Nishimura Y., Inokuchi K., Miyakuni T., Nakao S., Kishi K., Kubonishi I., Dan K., Fujita S. CD4+cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner. Blood 1999; 92: 3355–3361
  • Ten Bosch G. J., Kessler J. H., Joosten A. M., Bres-Woemans A. A., Geluk A., Godthelp B. C., van Bergen J., Melief C. J., Leeksma O. C. A BCR-ABL onco-protein p210 b2a2 fusion sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct. Blood 1999; 94: 1038–1045
  • Jameson S. C., Carbone F. R., Bevan M. J. Clone specific T-cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med 1994; 177: 1541–1550
  • Sloan-Lancaster J., Allen P. M. Altered peptide ligand-induced partial T-cell activation: Molecular mechanisms and roles in T-cell biology. Ann Rev Immunol 1996; 14: 1–27
  • Janeway C. A., Travers P. Immonobiology: The Immune System in Health and Disease. Current Biology, London 1994
  • Shlomchik W. D., Emerson S. G. The immunobiology of T cell therapies for leukemias [Review]. Acta Haematol 1996; 96: 189–213
  • Paul W. E., Seder R. A. Lymphocyte responses and cytokines. Cell 1994; 76: 241–251
  • Rudd C. E., Janssen O., Cai Y. C., da Silva A. J., Raab M., Prasad K. V. Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyro-sine and lipid kinases. Immunology Today 1994; 15: 225–234
  • Weiss A. T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases [Review]. Cell 1993; 73: 209–212
  • Weiss A., Littman D. R. Signal transduction by lymphocyte antigen receptors [Review]. Cell 1994; 76: 263–274
  • Guinan E. C., Gribben J. G., Boussiotis V. A., Freeman G. J., Nadler L. M. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity [Review]. Blood 1994; 84: 3261–3238
  • Willcox B. E., Gao G. F., Wyer J. R., Ladbury J. E., Bell J. I., Jakobsen B. K., van der Merwe P. A. TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity 1999; 10: 357–365
  • Guinan E. C., Gribben J. G., Boussiotis V. A., Freeman G. J., Nadler L. M., Thompson C. B. The B7 and CD28 receptor families. [Review]. Immunology Today 1994; 15: 321–331
  • Boussiotis V. A., Freeman G. J., Grey G., Gribben J., Nadler L. M. B7 but not intracellular adhesion molecule-l costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med 1993; 178: 1753–1763
  • Boussiotis V. A., Gribben J., Freeman G. J., Nadler L. M. Blockade of the CD28 costimulatory pathway: A means to induce tolerance [Review]. Curr Opin Immunol 1994; 6: 797–807
  • Boussiotis V. A., Barber D. L., Nakarai T., Freeman G. J., Gribben J. G., Bernstein G. M., D'Andrea A. D., Ritz J., Nadler L. M. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science 1994; 266: 1039–1042
  • Gimmi C. D., Freeman G. J., Gribben J., Grey G., Nadler L. M. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci USA 1993; 90: 6586–6590
  • Maini M. K., Casorati G., Dellabona P., Wack A., Beverley P. C. L. T-cell clonality in immune responses. Immunology Today 1999; 20: 262–266
  • Piper H., Litwin S., Mehr R. Models for antigen receptor gene rearrangement. II. Multiple rearrangement in the TCR: Allelic exclusion or inclusion?. J Immunol 1999; 163: 1799–1808
  • Savage P. A., Boniface J. J., Davis M. M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 1999; 10: 485–492
  • Posnett D. N., Sinha R., Kabak S., Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994; 179: 609–618
  • Wack A., Montagna D., Dellabona P., Casorati G. J. An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations. J Immunol Methods 1996; 196: 181–192
  • Vavassori M., Maccario R., Moretta Comoli P., Wack A., Locatelli F., Lanzavecchia A., Maserati E., Dellabona P., Casorati G., Montagna D. Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+T cells in allogeneic bone marrow transplantation recipients. J Immunol 1996; 157: 5739–5747
  • Maryanski J. L., Jongeneel C. V., Bucher P., Casanova J. L., Walker P. R. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 1996; 4: 47–55
  • Cochet M., Pannetier C., Regnault A., Darche S., Leclerc C., Kourilsky P. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur J Immunol 1992; 22: 2639–2647
  • Mugnaini E. N., Egeland T., Syversen A. M., Spurkland A., Brinchmann J. E. Molecular analysis of the complementarity determining region 3 of the human T cell receptor beta chain. Establishment of a reference panel of CDR3 lengths from phytohaemagglutinin activated lymphocytes. J Immunol Methods 1999; 223: 207–216
  • Wack A., Cossarizza A., Heltai S., Barbieri D., D'Addato S., Fransceschi C., Dellabona P., Casorati G. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol 1998; 10: 1281–1288
  • Wedderbum L. R., Maini M. K., Patel A., Beverley P. C. L., Woo P. Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood. Int Immunol 1999; 11: 535–543
  • Yamamoto K., Sakoda H., Nakajima T., Kato T., Okubo M., Dohi M., Mizushima Y., Ito K., Nishioka K. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int Immunol 1992; 4: 1219–1223
  • Kurokawa M., Furukawa H., Yabe T., Matsui T., Toda M., Hamada C., Kasukawa R., Yamamoto K., Nishioka K., Kato T. Frequency of clonally expanded T cells evaluated by PCR from a single cell. J Immunol Methods 1999; 224: 203–208
  • Callan M. F., Tan L., Annels N., Ogg G. S., Wilson J. D., O'Callaghan C. A., Steven N., McMichael A. J., Rickinson A. B. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo. J Exp Med 1998; 187: 1395–1402
  • Callan M. F., Steven N., Krausa P., Wilson J. D., Moss P. A., Gillespie G. M., Bell J. I., Rickinson A. B., McMichael A. J. Large clonal expansions of CD8+T cells in acute infectious mononucleosis. Nat Med 1996; 2: 906–911
  • Maini M. K., Wedderburn L. R., Hall F. C., Wack A., Casorati G., Beverley P. C. A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population. Immunology. 1998; 94: 529–35
  • Algeciras A., Dockrell D. H., Lynch D. H., Paya C. V. CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis. J Exp Med 1998; 187: 711–20
  • Zimmerman C., Brduscha-Riem K., Blaser C., Zinker-nagel R. M., Pircher H. Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J Exp Med 1996; 183: 1367–75
  • Ehl S., Hoffmann-Rohrer U., Nagata S., Hengartner H., Zinkernagel R. Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo. J Immunol 1996; 156: 2357–60
  • Singer G. G., Abbas A. K. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1994; 1: 365–71
  • Sytwu H. K., Liblau R. S., McDevitt H. O. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity. 1996; 5: 17–30
  • Chambers C. A., Sullivan T. J., Allison J. P. Lym-phoproliferation in CTLA-Cdeficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity. 1997; 7: 885–95
  • Gullberg M., Smith K. A. Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. J Exp Med. 1986; 163: 270–84
  • Vella A. T., Dow S., Potter T. A., Kappler J., Marrack P. Cytokine induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci USA 1998; 95: 3810–3815
  • Zhang X., Sun S., Hwang I., Tough D. F., Sprent J. Potent and selective stimulation of memory-pheno-type CD8+ T cells in vivo by IL-15. Immunity 1998; 8: 591–599
  • Zeng W., Nakao S., Takamatsu H., Yachie A., Takami A., Kondo Y., Sugimori N., Yamazaki H., Miura Y., Shiobara S., Matsuda T. Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine- dependent aplastic anemia. Blood 1999; 93: 3008–3016
  • Coleman S., Perera P., Fisher J., Hoy T., Burnett A. K., Lim S. H. Abnormal TCR V beta repertoire in patients with chronic myeloid leukaemia. Br J Haemarol 1995; 90: 358–363
  • Shimomura T., Fujii S. -I., Ezaki I., Osato M., Fujimoto K., Takatsuki K., Yamamoto K., Kawakita M. Characeterization of T-cell receptor β chain mRNA expression in IFN-α-responsive chronic myelogenous leukaemia patients. Br J Haematol 1999; 105: 173–180
  • Rezvany M. R., Jeddi-Tehrani M., Osterborg A., Kimby E., Wigzell H., Mellstedt H. Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: major perturbations are preferentially seen within the CD4 T-cell subset. Blood 1999; 94: 1063–1069
  • Trentin L., Imberti L., Zambello R., Sottini A., Raimondi R., Facco M., Cazzavillan S., Bonoldi E., Signorini S., Bacigalupo A., Semenzato G., Rodeghiero F., Primi D. Detection of identical T-cell clono-type expansions in both the donor and recipient after allo-geneic bone marrow transplantation. Br J Haematol. 1999; 106: 119–127
  • Claret E. J., Alyea E. P., Orsini E., Pickett C. C., Collins H., Wang Y., Neuberg D., Soiffer R. J., Ritz J. Characterization of T cell repertoire in patients with graft-versus-leukemia after donor lymhpocyte infusion. J Clin Invet 1997; 4: 855–866
  • Cortes J., Fayad L., Kantarjian H., O'brien S., Lee M. -S., Talpaz M. Association of HLA phenotype and response to interferon-alpha in patients with chronic myel-ogeneous leukemia. Leukemia 1998; 12: 455–462
  • Mahon E. X., Faberes C., Pueyo S., Cony-Makhoul P., Salmi R., Boiron J. N., Marit G., Bilhou-Nabera C., Car-rere A., Montastruc M., Pigneux A., Bernard P. H., Reiffers J. Response at three months is a good predictive factor for newly diagnosed chronic myeloid leukemia patients treated by recombinant interferon-α. Blond 1998; 92: 4059–4065
  • Choudhury A., Toubert A., Douay C., Charron D., Champlin R., Claxton D. MHC restriction and preferential TCR Vβ usage in anti-leukemic T lymphocytes elicited against autologous, CML-derived dendric cells from different CML patients. Blood 1997; 90(Suppl. 1)198
  • Molldrem J. J., Lee P. P., Wang C., Champlin R. E., Davis M. M. A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. Cancer Res 1999; 59: 2675–2681
  • Falkenburg J. H. F., Wafelman A. R., Joosten P., Smit W. M., van Bergen C. A. M., Bongaerts R., Lurvink E., van der Hoorn M., Kluck P., Landegent J. E., Kluin-Nele-mans H. C., Fibbe W. E., Willemze R. Complete remission of accelerated phase chronic myeloid leukemia by treatment with leukemia-reactive cytotoxic T lymphocytes. Blood 1999; 94: 1201–1208
  • Fujii S. -I., Fujimoto K., Matsui K., Kawakita M., Takatsuki K. Induction of antitumor cytotoxic activity using CD34+ cord blood cell-derived and irradiated tumor cell-primed dendritic cells. Int J Hemarol 1998; 68: 169–182
  • Fujii S. -I., Fujimoto K., Shimizu K., Ezaki T., Kawano E., Takatsuki K., Kawakita M., Matsuno K. Presentation of tumor antigens by phagocytic dendritic cell clusters generated from human CD34+ hematopoietic progenitor cells: induction of autologous cytotoxic T lymphocytes against leukemic cells in acute myelogeneous leukemia patients. Cancer Res 1999; 59: 2150–2158
  • Fujii S. -I., Hamada H., Fujimoto K., Shimomura T., Kawakita M. Activated dendritic cells from bone marrow cells receiving cytokine-expressing tumor cells are associated with the enhanced survival of mice bearing synegenic tumors. Blood 1999; 93: 1–9
  • Nieda M., Nicol A., Kikuchi A., Kashiwase K., Taylor K., Suzuki K., Tadokoro K., Juji T. Dendritic cells stimulate the expansion of bcr-abl specific CD8+T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia. Blood 1998; 91: 977–983

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