81
Views
1
CrossRef citations to date
0
Altmetric
Original Article

The Janus Kinase Inhibitor, JAB/SOCS-1, Is an Interferon-γ Inducible Gene and Determines the Sensitivity to Interferons

, &
Pages 49-58 | Published online: 01 Jul 2009

References

  • Damell J. E., Jr. STATs and Gene Regulation. Science 1997; 277: 1630–1635
  • Hoey T., Schindler U. STAT structure and function in signaling. Curr, Opin. Genet. Dev. 1998; 8: 582–587
  • Liu K. D., Gaffen S. L., Goldsmith M. A. JAK/STAT signaling by cytokine receptors. Curr. Opin. Immunol. 1998; 10: 271–278
  • Leonard W. J., O'Shea J. J. Jaks and STATs: biological implications. Annu. Rev. Immunol. 1998; 16: 293–322
  • Kim T. K., Maniatis T. Regulation of inter-feron-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 1996; 273: 1717–1719
  • Strous G. J., van Kerkhof P., Govers R., Ciechanover A., Schwartz A. L. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J 1996; 15: 3806–3812
  • Callus B. A., Mathey-Prevot B. Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. Blood 1998; 91: 3182–3192
  • Wang D., Stravopodis D., Teglund S., Kitazawa J., Ihle J. N. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 1996; 16: 6141–6148
  • Azam M., Lee C., Strehlow I., Schindler C. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 1997; 6: 691–701
  • Chung C. D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduc-tion by PIAS3. Science 1997; 278: 1803–1805
  • Liu B., Liao J., Rao X., Kushner S. A., Chung C. D., Chang D. D., Shuai K. Inhibition of Statl-mediated gene activation by PIASI. Proc. Natl. Acad. Sci. USA 1998; 95: 10626–10631
  • Migone T. S., Cacalano N. A., Taylor N., Yi T., Waldmann T. A., Johnston J. A. Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc. Natl. Acad. Sci, USA 1998; 95: 3845–3850
  • David M., Chen H. E., Goelz S., Lamer A. C., Neel B. G. Differential regulation of the alphaheta inter-feron-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTPI. Mol. Cell. Biol. 1995; 15: 7050–7058
  • Shu cell protein-tyrosine phosphatase (Hcph) gene. Cell, 73: 1445–1454
  • You M., Yu D. H., Feng G. S. Shp-2 tyrosine phosphatase functions as a negative regulator of the inter-feron-stimulated Jak/STAT pathway. Mol. Cell. Biol. 1999; 19: 2416–2424
  • Liu Q., Sasaki T., Kozieradzki I., Wakeham A., Itie A., Dumont D. J., Penninger J. M. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev. 1999; 13: 786–791
  • Ueno H., Sasaki K., Miyagawa K., Honda H., Mitani K., Yazaki Y., Hirai H. Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling. J. Biol. Chem. 1997; 272: 8739–8743
  • Yoshimura A. The CIS/JAB family: novel negative regulators of JAK signaling pathways. Leukemia 1998; 12: 1851–1857
  • Yoshimura A. The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev 1998; 9: 197–204
  • Yoshimura A., Ohkubo T., Kiguchi T., Jenkins N. A., Gilbert D. J., Copeland N. G., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2 containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBOJ. 1995; 14: 2816–2826
  • Uchida K., Yoshimura A., Inazawa J., Yanagisawa K., Osada H., Masuda A., Saito T., Takahashi T., Miyajima A., Takahashi T. Molecular cloning of CISH, chromosome assignment to 3p21. 3, and analysis of expression in fetal and adult tissues. Cytogenet. Cell. Genet. 1997; 78: 209–212
  • Matsumoto A., Masuhara M., Mitsui K., Yokouchi M., Ohtsubo M., Misawa H., Miyajima A., Yoshimura A. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 1997; 89: 3148–3154
  • Verdier R., Chretien S., Muller O., Varlet P., Yoshimura A., Gisselbrecht S., Lacombe C., Mayeux P. Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation. POSSIBLE INVOLVEMENT OF THE UBIQUITINATED CIS PROTEIN. J. Biol. Chem. 1998; 273: 28185–28190
  • Matsumoto A., Seki Y., Kubo M., Ohtsuka S., Suzuki A., Hayashi I., Tsuji K., Nakahata T., Okabe M., Yamada S., Yoshimura A. Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice. Mol. Cell Biol. 1999; 19: 6396–6407
  • Udy G. B., Towers R. P., Snell R. G., Wilkins R. J., Park S. H., Ram P. A., Waxman D. J., Davey H. W. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 1997; 94: 7239–7244
  • Liu X., Robinson G. W., Wagner K. U., Garrett L., Wyn-shaw-Boris A., Hennighausen L. StatSa is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997; 11: 179–186
  • Nakajima H., Liu X. W., Wynshaw-Boris A., Rosenthal L. A., Imada K., Finbloom D. S., Hennighausen L., Leonard W. J. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for StatSa in IL-2-mediated IL-2 receptor alpha chain induction. Immunity 1997; 7: 691–701
  • Teglund S., McKay C., Schuetz E., van Deursen J. M., Stra-vopodis D., Wang D., Brown M., Bodner S., Grosveld G., Ihle J. N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998; 93: 841–850
  • Moriggl R., Topham D. J., Teglund S., Sexl V., McKay C., Wang D., Hoffmeyer A., van Deursen J., Sangster M. Y., Bunting K. D., Grosveld G. C., Ihle J. N. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999; 10: 249–259
  • Stan R., Willson T. A., Viney E. M., Murray L. J., Rayner J. R., Jenkins B. J., Gonda T. J., Alexander W. S., Metcalf D., Nicola N. A., Hilton D. J. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387: 917–921
  • Endo T. A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., Taniguchi T., Fujita T., Kanakura Y., Komiya S., Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387: 921–924
  • Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., Nishimoto N., Kajita T., Taga T., Yoshizaki K., Akira S., Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997; 387: 924–929
  • Masuhara M., Sakamoto H., Matsumoto A., Suzuki R., Yasukawa H., Mitsui K., Wakioka T., Tanimura S., Sasaki A., Misawa H., Yokouchi M., Ohtsubo M., Yoshimura A. Cloning and Characterization of Novel CIS Family Genes. Biochem. Biophys. Res. Commun. 1997; 239: 439–446
  • Hilton D. J., Richardson R. T., Alexander W. S., Viney E. M., Willson T. A., Sprigg N. S., Stan R., Nicholson S. E., Metcalf D., Nicola N. A. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 1998; 95: 114–119
  • Kamura T., Sato S., Haque D., Liu L., Kaelin W. G., Jr, Conaway R. C., Conaway J. W. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 1998; 12: 3872–3881
  • Zhang J. G., Farley A., Nicholson S. E., Willson T. A., Zugaro L. M., Simpson R. J., Moritz R. L., Cary D., Richardson R., Hausmann G., Kile B. J., Kent S. B., Alexander W. S., Metcalf D., Hilton D. J., Nicola N. A., Baca M. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 1999; 96: 2071–2076
  • Suzuki R., Sakamoto H., Yasukawa H., Masuhara M., Wakioka T., Sasaki A., Yuge K., Komiya S., Inoue A., Yoshimura A. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in MI leukemia cells. Oncogene 1998; 17: 2271–2278
  • Sakamoto H., Yasukawa H., Masuhara M., Tanimura S., Sasaki A., Yuge K., Ohtsubo M., Ohtsuka S., Fujita T., Ohta T., Furukawa Y., Iwase S., Yamada H., Yoshimura A. A Janus kinase inhibitor, JAB, is an inter-feron-gamma-inducible gene and confers resistance to inter-ferons. Blood 1998; 92: 1668–1676
  • Naka T., Matsumoto T., Narazaki M., Fujimoto M., Morita Y., Ohsawa Y., Saito H., Nagasawa T., Uchiyama Y., Kishimoto T. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc. Natl. Acad. Sci. USA 1998; 95: 15577–15582
  • Starr R., Metcalf D., Elefanty A. G., Brysha M., Willson T. A., Nicola N. A., Hilton D. J., Alexander W. S. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Nail. Acad. Sci. USA 1998; 95: 14395–14399
  • Alexander W. S., Starr R., Fenner J. E., Scott C. L., Handman E., Sprigg N. S., Corbin J. E., Cornish A. L., Darwiche R., Owczarek C. M., Kay T. W. H., Nicola N. A., Hertzog P. J., Metcalf D., Hilton D. J. SOCSl Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this. Cytokine. Cell 1999; 98: 597–608
  • Marine J. -C., Topham D. J., McKay C., Wang D., Parganas E., Stravopodis D., Yoshimura A., Ihle J. N. SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality. Cell 1999; 98: 609–616
  • Metcalf D., Alexander W. S., Elefanty A. G., Nicola N. A., Hilton D. J., Starr R., Mifsud S., Di Rago L. Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1. Leukemia 1999; 13: 926–934
  • Yasukawa H., Misawa H., Sakamoto H., Masuhara M., Sasaki A., Wakioka T., Ohtsuka S., Imaizumi T., Matsuda T., Ihle J. N., Yoshimura A. The JAK-Binding Protein JAB Inhibits Janus vrosine Kinase Activity Through Binding in the Activation Loop. EMBOJ. 1999; 18: 1309–1320
  • Nicholson S. E., Willson T. A., Farley A., Starr R., Zhang J. G., Baca M., Alexander W. S., Metcalf D., Hilton D. J., Nicola N. A. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 1999; 18: 375–385
  • Sasaki A., Yasukawa H., Suzuki A., Kamizono S., Syoda T., Kinjyo I., Sasaki M., Johnston J. A., Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes to Cells 1999; 4: 339–351
  • Marine J. -C., McKay C., Wang D., Topham D. J., Parganas E., Nakajima H., Pendeville H., Yasukawa H., Sasaki A., Yoshimura A., Ihle J. N. SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis. Cell 1999; 98: 617–627

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.