99
Views
28
CrossRef citations to date
0
Altmetric
Original Article

The t(9;14)(p13;q32) Translocation in B-Cell Non-Hodgkin's Lymphoma

, &
Pages 435-445 | Received 10 Aug 1999, Published online: 01 Jul 2009

References

  • Yunis J. J., Oken M. M., Theologides A., Howe R. B., Kaplan M. E. Recurrent chromosomal defects are found in most patients with non-Hodgkin's lymphoma. Cancer Genet. Cytogenl. 1984; 13: 17–28
  • Cline M. J. The molecular basis of leukemia. N. Engl. J. Med. 1994; 330: 328–336
  • Korsmeyer S. J. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu, Rev. Immunol. 1992; 10: 785–807
  • Rabbitts T. H. Chromosomal translocations in human cancer. Nature 1994; 372: 143–149
  • Korsmeyer S. J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992; 80: 879–886
  • Chang C.-C, Ye B. H., Chaganti R. S. K., Dalla-Favera R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 1996; 93: 6947–6952
  • Fukuda T., Yoshida T., Okada S., Hatano M., Miki T., Ish-ibashi K., Okabe S., Koseki H., Hirosawa S., Taniguchi M., Miyasaka N., Tokuhisa T. Disruption of the Bcl6 gene results in an impaired germinal center formation. J. Exp. Med. 1997; 186: 439–448
  • Offit K., Parsa N. Z., Filippa D., Jhanwar S. C., Chaganti R. S. K. t(9;14)(pl3;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation. Blood 1992; 80: 2594–2599
  • Iida S., Rao P. H., Nallasivam P., Hibshoosh H., Butler M., Louie D. C., Dyomin V., Ohno H., Chaganti R. S. K., Dalla-Favera R. The t(9;14)(pl3;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood 1996; 88: 4110–4117
  • Busslinger M., Klix N., Pfeffer P., Graninger P. G., Kozmik Z. Deregulation of PAX-5by translocation of the Eμ enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc. Natl. Acad. Sci. USA 1996; 93: 6129–6134
  • Berger R., Bernheim A., Tsapis A., Brouet J.-C., Selig-mann M. Cytogenetic studies in four cases of alpha chain disease. Cancer Genet. Cytogenet. 1986; 22: 219–223
  • Kamesaki H., Miwa H., Ohno Y., Miyanishi S., Yamabe H., Doi S., Arita Y., Ohno H., Tatsumi E., Nishikori M., Fukuhara S., Hatanaka M., Uchino H. A novel B cell line established from Ki-l-positive diffuse large cell lymphoma. Jpn. J. Cancer Res. 1988; 19: 1193–1200
  • Kawakami K., Amakawa R., Miyanishi S., Okumura A., Hayashi T., Kurata M, Ohno H., Kobashi Y., Ohno Y., Fukuhara S. A case of primary splenic large cell lymphoma with a t(9;14)(pl3;q32). Int. J. Hematol. 1998; 67: 191–198
  • Ichinohasama R., Miura I., Kobayashi N., Saitoh Y., DeCoteau J. F., Saiki Y., Mori S., Kadin M. E., Ooya K. Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and herpes C virus. Am. J. Surg. Pathol. 1998; 22: 1528–1537
  • Morrison A. M., Jager U., Chott A., Schebesta M., Haas O. A., Busslinger M. Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma. Blood 1998; 92: 3865–3878
  • Jaffe E. S., Raffeld M., Medeiros L. J., Stetler-Steven-son M. An overview of the classification of non-Hodgkin's lymphomas: an integration of morphological and phenotypical concepts. Cancer Res. 1992; 52(Suppl.)5447s–5452s
  • Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K. C., Cleary M. L., Delsol G., De Walf-Peeters C., Falini B., Gatter K. C., Grogan T. M., Isaacson P. G., Knowles D. M., Mason D. Y., Muller-Hermelink H.-K., Pileri S. A., Piris M. A., Ralfkiaer E., Warnke R. A. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392
  • Lennert K., Feller A. Histopathology of Non-Hodgkin's Lymphomas (ed. 2). Springer-Verlag, New York, NY 1992
  • Stewart A. K., Schwartz R. S. Immunoglobulin V regions and the B cell. Blood 1994; 83: 1717–1730
  • Pellet P., Berger R., Bernheim A., Brouet J. C., Tsapis A. Molecular analysis of a t(9;14)(pl I;q32) translocation occurring in a case of human alpha heavy chain disease. Oncogene 1989; 4: 653–657
  • Ohno H., Furukawa T., Fukuhara S., Zong S. Q., Kamesaki H., Shows T. B., Le Beau M. M., McKeithan T. W., Kawakami T., Honjo T. Molecular analysis of a chromosomal translocation, t(9;14)(pl3;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. Proc. Natl. Acad. Sci. USA 1990; 87: 628–632
  • Stapleton P., Weith A., Urbanek P., Kozmik Z., Busslinger M. Chromosomal localization of seven PAX genes and cloning of a novel family member. PAX-9. Nature Genet. 1993; 3: 292–298
  • Busslinger M., Urbánek P. The role of BSAP (Pax-5) in B-cell development. Curr. Opin. Genet. Dev. 1995; 5: 595–601
  • Hamada T., Yonetani N., Ueda C., Maesako Y., Akasaka H., Akasaka T., Ohno H., Kawakami K., Amakawa R., Okuma M. Expression of the PAX5/BSAP transcription factor in haematological tumour cells and further characterization of the t(9;14)(pl 3:q32) translocation in B-cell non-Hodgkin's lymphoma. Br. J. Haematol. 1998; 102: 691–700
  • Offit K., Parsa N. Z., Jhanwar S. C., Filippa D., Wachtel M., Chaganti R. S. K. Clusters of chromosome 9 aberrations are associated with clinico-pathologic subsets of non-Hodgkin's lymphoma. Genes Chromosomes Cancer 1993; 7: 1–7
  • Ohno H., Fukuhara S. Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms. Leuk. Lymphoma 1997; 27: 53–63
  • Strachan T., Read A. P. PAX genes. Curr. Opin. Genet. Dev. 1994; 4: 427–438
  • Stuart E. T., Grass P. PAX: Developmental control genes in cell growth and differentiation. Cell Growth Diff. 1996; 7: 405–412
  • Lawrence H. J., Largman C. Homeobox genes in normal hematopoiesis and leukemia. Blood 1992; 80: 2445–2453
  • Chalepakis G., Stoykova A., Wijnholds J., Tremblay P., Gruss P. Pax: gene regulators in the developing nervous system. J. Neurobiol. 1993; 24: 1367–1384
  • Baldwin C. T., Hoth C. F., Amos J. A., Da-Silva E. O., Milunsky A. An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature 1992; 355: 637–638
  • Tassabehji M., Read A. P., Newton V. E., Harris R., Balling R., Gruss P., Stachan T. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 1992; 355: 635–636
  • Glaser T., Walton D. S., Maas R. L. Genomic structure, evolutionary conservation and aniridia mutations in the human PAX gene. Nature Genet. 1992; 2: 232–238
  • Urbánek P., Wang Z.-Q., Fetka I., Wagner E. F., Busslinger M. Complete block of early B cell differentiation and altered pattering of the posterior midbrain in mice lacking Pax5/BSAP. Cell 1994; 79: 901–912
  • Adams B., Dörfler P., Aguzzi A., Kozmik Z., Urbánek P., Maurer-Fogy I., Busslinger M. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992; 6: 1589–1607
  • Neurath M. F., Stüber E. R., Strober W. BSAP: a key regulator of B-cell development and differentiation. Immonol. Today 1995; 16: 564–569
  • Mahmoud M. S., Huang N., Nobuyoshi M., Lisukov I. A., Tanaka H., Kawano M. M. Altered expression of Pax-5 gene in human myeloma cells. Blood 1996; 87: 4311–4315
  • Nutt S. L., Urbanek P., Rolink A., Busslinger M. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dew 1996; 11: 467–491
  • Wakatsuki Y., Neurath M. F., Max E. E., Strober W. The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 1994; 179: 1099–1108
  • Krenacs L., Himmelmann A. W., Quintanilla-Martinez L., Fest T, Riva A., Wellmann A., Bagdi E., Kehrl J. H., Jaffe E. S., Raffeld M. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 1998; 92: 1308–1316
  • Czerny T., Schaffer G., Busslinger M. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 1993; 7: 2048–2061
  • Neurath M. F., Strober W., Wakatsuki Y. The murine Ig 3'α enhancer is a target site with repressor function for the B cell lineage-specific transcriptional factor BSAP (NF-HB. Sα-BP). J. Immonol. 1994; 153: 730–742
  • Okabe T, Watanabe T, Kudo A. A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene. Eur. J. Immunol. 1992; 22: 37–43
  • Tian J., Okabe T, Miyazaki T., Takeshita S., Kudo A. Pax-5 is identical to EBB-1/KLP and binds to the VpreB and γ5 promoters as well as the KI and KII sites upstream of the Jκ genes. Eur. J. Immunol. 1997; 27: 750–755
  • Zwollo P., Desiderio S. Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein. J. Biol. Chem. 1994; 269: 15310–15317
  • Kehrl J. H., Riva A., Wilson G. L., Thévenin C. Molecular mechanisms regulating C.D19, CD20 and CD22 gene expression. Immunology Today 1994; 15: 432–436
  • Kozmik Z., Wang S., Dörfler P., Adams B., Busslinger M. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 1992; 12: 2662–2672
  • Tedder T. F., Zhou L.-J., Engel P. The CD19/CD21 signal transduction complex of B lymphocytes. Immunol. Today 1994; 15: 437–442
  • Nutt S. L., Morrison A. M., Dörfler P., Rolink A., Busslinger M. Identification of BSAP (Pax-5) target genes in early B-cell development by loss-and gain-of-func-tion experiments. EMBO J. 1998; 17: 2319–2333
  • Stuart E. T., Haffner R., Oren M., Gruss P. Loss of p53 function through PAX-mediated transcriptional repression. EMBO J. 1995; 14: 5638–5645
  • Cleary M. L. Oncogenic conversion of transcription factors by chromosomal translocations. Cell 1991; 66: 619–622
  • Maulbecker C. C., Gruss P. The oncogenic potential of Pax genes. EMBO J. 1993; 12: 2361–2367
  • Barr F. G. Chromosomal translocations involving paired box transcription factors in human cancer. Int. J. Bio-chem. Cell Biol. 1997; 29: 1449–1461
  • Barr F. G., Galili N., Holick J., Biegel J. A., Rovera G., Emanuel B. S. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhab-domyosarcoma. Nature Genet. 1993; 3: 113–117
  • Galili N., Davis R. J., Fredericks W. J., Mukhopadhyay S., Rauscher F. J. I., Emanuel B. S., Rovera G., Barr F. G. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nature Genet. 1993; 5: 230–235
  • Davis R. J., D'Cruz C. M., Lovell M. A., Biegel J. A., Barr F. G. Fusion of PAX7 to FKHR by the variant t(l;13)(p36;ql4) translocation in alveolar rhabdomyosarcoma. Cancer Res. 1994; 54: 2869–2872
  • Fredericks W. J., Galili N., Mukhopadhyay S., Rovera G., Bennicelli J., Barr F. G., Rauscher F. J. I. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcoma is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 1995; 15: 1522–1535
  • Cory S. Activation of cellular oncogenes in hemato-poietic cells by chromosome translocation. Adv. Cancer Res. 1986; 47: 189–234
  • McKeithan T. W., Takimoto G. S., Ohno H., Bjorling V. S., Morgan R., Hecht B. K., Dube I., Sandberg A. A., Rowley J. D. Genes Chromosomes Cancer 1997; 14: 19–72, BCL3 rearrangements and t(:) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular analysis and cytogenetic study., 20, 64
  • Onizuka T., Moriyama M., Yamochi T., Kuroda T., Kazama A., Kanazawa N., Sato K., Kato T., Ota H., Mori S. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 1995; 86: 28–37
  • Usui T., Wakatsuki Y., Matsunaga Y., Kaneko S., Kosek H., Kita T. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol. 1997; 158: 3197–3204
  • Tamaru J., Hummel M., Zemlin M., Kalvelage B., Stein H. Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VHgenes. Blood 1994; 84: 708–715
  • Kabat E. A., Wu T. T., Reid-Miller M., Perry H. M., Gottesman K. S. Sequences of proteins of immuno-logical interest (ed. 4). U.S. Department of Health and Human Services, Public Health Service, National Institute of Health. 1987

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.